Clinical and urodynamic effects of tolterodine in women with an overactive bladder

Wang, C.-L.; Wu, C.-H.; Liu, C.-M.; Shen, C.-J.; Lin, K.-L.; Long, C.-Y.

Taiwanese Journal of Obstetrics and Gynecology 52(3): 381-384


ISSN/ISBN: 1875-6263
PMID: 24075377
DOI: 10.1016/j.tjog.2012.06.001
Accession: 052108722

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The aim of this study was to compare the changes in urinary symptoms and urodynamic parameters after administration of tolterodine in women with an overactive bladder (OAB). Thirty-eight women diagnosed with OAB and treated with tolterodine were reviewed. Urinalysis, pelvic examination, 3-day bladder diary, urodynamic study, and a personal interview to identify urinary symptoms prior to and 3 months after treatment were recorded and interpreted. Most of our patients were menopausal (76.3%; mean age 55.7 years) and multiparous (mean parity 3.3) women. Urinary symptoms such as urinary frequency, urgency, urge incontinence, and nocturia were decreased significantly (p < 0.05). All urodynamic parameters did not change significantly except for the maximum cystometric capacity (p < 0.05), showing a significant increase after 3 months of medication. Tolterodine, at a recommended dose, improves the symptoms of OAB syndrome without causing urine retention, as proved by the changes of urodynamic parameters.