EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Clinico-radiological spectrum in enterovirus 71 infection involving the central nervous system in children


Clinico-radiological spectrum in enterovirus 71 infection involving the central nervous system in children



Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia 21(3): 416-420



ISSN/ISBN: 0967-5868

PMID: 24169271

DOI: 10.1016/j.jocn.2013.04.032

Enterovirus 71 infection causes hand, foot and mouth disease in children, and can produce diverse neurologic complications. Epidemics occurring in Korea between 2009 and 2012 resulted in the death of some patients. The present study aimed to clarify the correlation between clinical features and MRI findings in patients presenting with acute neurologic manifestations related to enterovirus 71 infection. Based on their clinical features, the patients were classified into four clinical groups: (1) brainstem encephalitis (n=17), characterized by myoclonus, tremor, ataxia, and autonomic dysregulation such as pulmonary hemorrhage; (2) aseptic meningitis (n=2); (3) encephalitis (n=2), characterized by decreased consciousness, seizure, and fever without myoclonus, tremor, ataxia, and autonomic dysregulation; and (4) acute flaccid paralysis (n=1). Thirteen of the 17 patients with brainstem encephalitis showed characteristic lesions in the dorsal brainstem and bilateral cerebellar dentate nuclei on brain MRI, whereas three had no abnormality. One of the two patients with meningitis had a small lesion in the left dorsal pons. Two patients with encephalitis had no apparent MRI abnormality. One patient with acute flaccid paralysis of the right leg had contrast-enhancement of the bilateral ventral nerve roots at the lumbar spine level on MRI. Five of 13 patients with lesions in the bilateral dentate nuclei of the cerebellum exhibited no cerebellar symptoms, while two with no cerebellar lesions developed ataxia. Although most patients presenting with neurologic manifestations of enterovirus 71 infection had characteristic clinical features together with typical MRI findings, the clinical features were not necessarily consistent with MRI findings.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052138577

Download citation: RISBibTeXText

Related references

A continuing surveillance of enterovirus infection in healthy children in six United States cities. II. Surveillance enterovirus isolates 1960-1963 and comparison with enterovirus isolates from cases of acute central nervous system disease. American Journal of Epidemiology 83(3): 455-469, 1966

The importance of polymerase chain reaction in the diagnosis of enterovirus infections of the central nervous system in children. Clinico-epidemiologic characteristics. Enfermedades Infecciosas y Microbiologia Clinica 17(5): 227-230, 1999

Cavernous malformations of the central nervous system (CNS) in children: clinico-radiological features and management outcomes of 36 cases. Child's Nervous System: Chns: Official Journal of the International Society for Pediatric Neurosurgery 30(8): 1355-1366, 2014

OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection. Nan Fang Yi Ke da Xue Xue Bao 39(4): 381-386, 2019

Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. Pediatrics 122(2): E452-E458, 2008

Heart rate variability monitoring in the detection of central nervous system complications in children with enterovirus infection. Journal of Critical Care 21(3): 280-286, 2006

A continuing surveillance of enterovirus infection in healthy children in six United States cities P, Surveillance enterovtrus isolates 1960-1963 and comparison with enterovirus isolates from cases of acute central nervous system disease. American Journal Epidemiol: 455-469, 1966

Emergence of Parechovirus A3 as the Leading Cause of Central Nervous System Infection, Surpassing Any Single Enterovirus Type, in Children in Kansas City, Missouri, USA, from 2007 to 2016. Journal of Clinical Microbiology 59(6), 2021

Infections nosocomiales à entérovirus en néonatologie: du diagnostic à la preuve, à propos d'une observation d'infection neuroméningée - Enterovirus nosocomial infections in a neonatal care unit: From diagnosis to evidence, from a clinical observation of a central nervous system infection. Archives de Pediatrie (Paris) 19(9): 921-926, 2012

A fatal central nervous system enterovirus 68 infection. Archives of Pathology and Laboratory Medicine 135(6): 793-796, 2011

Enterovirus 71 infection with central nervous system involvement, South Korea. Emerging Infectious Diseases 16(11): 1764-1766, 2010

Detection of Herpesvirus, Enterovirus, and Arbovirus infection in patients with suspected central nervous system viral infection in the Western Brazilian Amazon. Journal of Medical Virology 86(9): 1522-1527, 2014

Enterovirus infections in children with affection of the central nervous system. Infection 29(Suppl 1): 77, 2001

Enterovirus Infections of the Central Nervous System in Children: An Update. Pediatric Infectious Disease Journal 35(5): 567-569, 2016

The spectrum of computerized tomography (CT) findings in central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii in immunocompetent children. Revista do Instituto de Medicina Tropical de Sao Paulo 44(5): 283-287, 2002