+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Clinicopathological features of sudden unexpected infectious death: population-based study in children and young adults



Clinicopathological features of sudden unexpected infectious death: population-based study in children and young adults



Forensic Science International 220(1-3): 80-84



Infectious diseases are one of the major causes of sudden death, but data of sudden unexpected death from infectious diseases (SUDID) are sparse in children and young people. The aim of this study is to analyse their epidemiological, clinical, pathological and microbiological characteristics. Population observational study of all deaths due to infectious diseases in people aged 0-34 years in Biscay between 1991 and 2010. The data of Mortality Register and Forensic Pathology Service were analysed. The SUDID cases in which a forensic autopsy was performed were identified. There were 56 SUDID cases (16% of the all sudden deaths). Myocarditis (n=20) and acute bacterial bronchopneumonia/pneumonia (n=18) were the most frequent causes, followed by meningococcemia (n=5) and viral pneumonia (n=4). A chronic co-morbid condition (mainly drug abuse in young people and moderate low birth weight in infants) was recorded in one-third and prodromal symptoms in two-thirds. Seventeen young people had consumed illegal drugs and/or methadone. In 17 of the 23 autopsies where microbiological analyses were performed, the organism responsible was identified. The incidence of SUDID was 0.6/100000 inhabitants/year, representing 5% of all deaths from infectious diseases. SUDID rate was 1.87 times higher in males than in females. The highest incidence occurred in infants (3.7). SUDID is infrequent, but it represents a significant proportion of all sudden deaths in children and young people. The relationship between methadone and bronchopneumonia is noticeable. This article stresses the importance of microbiological analyses in SUDID. Investigation based on forensic pathology provides useful epidemiologic, clinico-pathological and microbiological information for prevention of infectious diseases.

(PDF emailed within 0-6 h: $19.90)

Accession: 052140001

Download citation: RISBibTeXText

PMID: 22366208

DOI: 10.1016/j.forsciint.2012.01.030


Related references

Sudden unexpected nontraumatic death in 54 young adults: A 30-year population-based study. American Journal of Cardiology 76(3): 148-152, 1995

Sudden, unexpected and natural death in young adults of age between 18 and 35 years: a clinicopathological study. Indian Journal of Pathology and Microbiology 54(1): 47-50, 2011

Population-based analysis of sudden death in children: The Oregon Sudden Unexpected Death Study. Heart Rhythm 6(11): 1618-1622, 2010

Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark. International Journal of Stroke 13(3): 285-291, 2017

Sudden unexpected nontraumatic deaths in young adults a 30 year population based study. Journal of the American College of Cardiology 17(2 SUPPL A): 265A, 1991

Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. Journal of the American College of Cardiology 47(6): 1161-1166, 2006

The Long QT and Brugada syndromes: causes of unexpected syncope and sudden cardiac death in children and young adults. Seminars in Pediatric Neurology 12(1): 15-24, 2005

Does sport activity enhance the risk of sudden death in adolescents and young adults? A prospective population-based study. Circulation 104(17 Supplement): II 346, October 23, 2001

Pathologic features of sudden death in children, adolescents, and young adults. Chest 87(4): 476-482, 1985

A Clinicopathological Analysis of Six Autopsy Cases of Sudden Unexpected Death due to Infectious Aortitis in Patients with Aortic Tears. Internal Medicine 57(10): 1375-1380, 2018

Unexpected sudden death in young adults. Nederlands Tijdschrift Voor Geneeskunde 138(24): 1248, 1994

Sudden unexpected death among young adults under the age of 30. Tidsskrift for den Norske Laegeforening 105(25): 1681-1683, 1727, 1985

A population-based post mortem study of sudden unexpected death in epilepsy. Journal of Clinical Neuroscience 23: 58-62, 2016

Sudden and unexpected natural death: IV. Sudden and unexpected natural death in infants and young children. Journal of Pediatrics 34(2): 166-173, 1949

Sudden unexpected death from natural causes in young adults. Arch Pathol 85(1): 10-17, 1968