+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology



Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology



Blood 114(14): 2878-2883



Higher levels of procoagulant factors and factor XII deficiency may be risk factors for first venous thromboembolism (VTE). We studied associations of coagulation factors IX through XIII with risk of future VTE in 2 general population samples. Using a nested case-control study combining the 21 860 participants of the Atherosclerosis Risk in Communities study and the Cardiovascular Health Study, we determined antigenic levels of these coagulation factors in primarily pre-event blood samples from 462 participants who subsequently developed VTE and 1047 participants who remained free of VTE. Only elevated levels of factors IX and XI were associated with increased risk of VTE after adjustment for age, sex, race, and study. For factor IX, the odds ratio (OR) was 1.4 (95% confidence interval [CI], 1.0-2.0) comparing the top to bottom quintile. The OR for factor XI was higher: 2.0 (95% CI, 1.4-2.9). With further adjustment for body mass index and diabetes, only elevated factor XI remained associated with VTE risk: OR 1.8 (95% CI, 1.3-2.7). Associations were similar by study and whether the thrombosis was idiopathic or secondary. Factor XII deficiency was not related to VTE risk. Among these procoagulant factors, only elevated factor XI was a risk factor for VTE.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052151239

Download citation: RISBibTeXText

PMID: 19617576

DOI: 10.1182/blood-2009-05-219915


Related references

Fibrin fragment D-dimer and the risk of future venous thrombosis The longitudinal investigation of thromboembolism etiology. Blood 98(11 Part 1): 755a, November 16, 2001

Coagulation factors, inflammation markers, and venous thromboembolism: The longitudinal investigation of thromboembolism etiology (LITE). American Journal of Medicine 113(8): 636-642, 2002

Activated Factor XI and Risk of Venous Thrombosis The Longitudinal Investigation of Thromboembolism Etiology. Blood 100(11): Abstract No 3871, November 16, 2002

Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Archives of Internal Medicine 162(10): 1182-1189, 2002

Cardiovascular risk factors and venous thromboembolism incidence The Longitudinal Investigation of Thromboembolism Etiology study. Circulation 102(18 Supplement): II 861, October 31, 2000

ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Journal of Thrombosis and Haemostasis 5(7): 1455-1461, 2007

Body size measures, hemostatic and inflammatory markers and risk of venous thrombosis: The Longitudinal Investigation of Thromboembolism Etiology. Thrombosis Research 144(): 127-132, 2016

Metabolic syndrome and risk of venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology. Journal of Thrombosis and Haemostasis 7(5): 746-751, 2009

Chronic kidney disease and risk of venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE) study. 2007

Total tissue factor pathway inhibitor and venous thrombosis. The Longitudinal Investigation of Thromboembolism Etiology. Thrombosis and Haemostasis 104(2): 207-212, 2010

Troponin T, NT-proBNP, and venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Vascular Medicine 19(1): 33-41, 2014

High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE). Blood 112(7): 2675-2680, 2008

Prospective study of γ' fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). Thrombosis Research 139(): 44-49, 2016