+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coincidence of multiple endocrine neoplasia type 2A with acromegaly



Coincidence of multiple endocrine neoplasia type 2A with acromegaly



American Journal of the Medical Sciences 340(4): 329-331



Medullary thyroid carcinoma (MTC) occurs as a part of multiple endocrine neoplasia (MEN) type 2. Acromegaly, a pituitary adenoma, occurs as a part of MEN1. Rarely, MEN2 and MEN1 coexist in a single patient simultaneously. A 40-year-old man with a history of pituitary adenomectomy for acromegaly had a surgical resection of thyroid carcinoma clinically diagnosed as MTC. His mother, who had MTC and pheochromocytoma, had a germline mutation in the RET gene that could cause the subtype, MEN2A. Identification of gene mutations in RET and MEN1 were examined in the subject. The resected tumor was pathologically diagnosed as MTC. Genomic examinations revealed the RET mutation C634F, which was identical to the mutation of his mother, but no MEN1 gene mutation was found. Although the simultaneous occurrence of both MEN2A and sporadic acromegaly may be accidental, there is evidence to suggest a genetic interaction between MEN2 and acromegaly.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052162956

Download citation: RISBibTeXText

PMID: 20739875

DOI: 10.1097/MAJ.0b013e3181e73fba


Related references

Coincidence of multiple endocrine neoplasia type IIa and type 1 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism 18(9): 925-926, 2005

Coincidence of Neurofibromatosis Type 1 and Multiple Endocrine Neoplasia Type 2. Endocrinologist 18(6): 277-281, 2008

Acromegaly in a multiple endocrine neoplasia type 1 (MEN1) family with low penetrance of the disease. European Journal of Endocrinology 153(6): 741-746, 2005

A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus at chromosome region 11q13. Journal of Clinical Endocrinology and Metabolism 82(2): 486-492, 1997

Mapping the inherited defects associated with multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma to chromosome 10 by linkage analysis. Endocrinology and Metabolism Clinics of North America 23(1): 177-185, 1994

Somatotrophinomas in multiple endocrine neoplasia type 1: A review of clinical phenotype and insulin-like growth factor-1 levels in a large multiple endocrine neoplasia type 1 kindred. American Journal of Medicine 100(5): 544-547, 1996

Coexisting acromegaly and a unilateral cortisol-producing adrenal adenoma: a possible variant of multiple endocrine neoplasia type I. Journal of Endocrinological Investigation 15(4): 297-301, 1992

Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. Genomics 9(1): 181-192, 1991

Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene. Journal of Clinical Endocrinology and Metabolism 84(1): 249-256, 1999

Multiple endocrine neoplasia type I. Review and presentation of the study group of multiple endocrine neoplasia type I (GENEM I). Archives d'Anatomie et de Cytologie Pathologiques 42(2): 77-82, 1994

Astrocytoma in a patient with multiple endocrine neoplasia type 2A syndrome. May the coexistence of glial tumors and multiple endocrine neoplasia 2A not be casual?. Endocrinologia Y Nutricion 58(9): 501-503, 2012

Insulinomas in multiple endocrine neoplasia type 1. Report of a series of 44 cases by the multiple endocrine neoplasia study group. Annales de Chirurgie 125(2): 118-123, 2000

Hereditary multiple endocrine neoplasia. New genetic data and clinical applications in type 1 multiple endocrine neoplasia. Presse Medicale 24(11): 542-546, 1995

Acromegaly caused by growth hormone-releasing hormone in a patient with multiple endocrine neoplasia type I. Japanese Journal of Clinical Oncology 26(1): 49-52, 1996

Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism 83(8): 2621-2626, 1998