+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Beasley's 1981 paper: The power of a well-designed cohort study to drive liver cancer research and prevention



Beasley's 1981 paper: The power of a well-designed cohort study to drive liver cancer research and prevention



Cancer Epidemiology 53: 195-199



The 1981 Lancet paper by Beasley et al., "Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan" is a seminal publication that clearly demonstrated that chronic infection with hepatitis B virus (HBV), as measured by seropositivity for the hepatitis B surface antigen (HBsAg), preceded the development of hepatocellular carcinoma (HCC). In doing so, this study paved the way for liver cancer prevention efforts through the implementation of hepatitis B vaccination programs. In this commentary, we will describe the discovery of HBV, which led to the study by Beasley et al.; summarize the major findings of the Beasley paper and its implications; discuss the importance of well-designed cohort studies for prevention activities; and consider the ramifications of the Beasley study and the work that has followed since.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052185968

Download citation: RISBibTeXText

PMID: 29396075

DOI: 10.1016/j.canep.2018.01.007


Related references

Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008). Cancer Causes & Control 26(2): 277-286, 2016

Adherence to the cancer prevention recommendations of the World Cancer Research Fund/American Institute for Cancer Research and mortality: a census-linked cohort. American Journal of Clinical Nutrition 104(3): 678-685, 2016

Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (CAMA) study. Public Health Nutrition 18(18): 3337-3348, 2016

Robert W. Beasley MD, ,Hand Injuries (1981) WB Saunders Co,Philadelphia 384. Annals of Emergency Medicine 11(6): 337-0, 1982

The DONALD cohort. An updated overview on 25 years of research based on the Dortmund Nutritional and Anthropometric Longitudinally Designed study. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 55(6-7): 875-884, 2012

Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. American Journal of Clinical Nutrition 96(1): 150-163, 2012

Allergy, atopy, and cancer: a prospective study of the 1981 Busselton cohort. American Journal of Epidemiology 157(7): 606-612, 2003

River drive of pulpwood: efficiency of technique. Investigation conducted by the Pulp and Paper Research Institute of Canada and the Woodlands Section, Canadian Pulp and Paper Association, under the direction of A. Koroleff. Woodl. Sect. Index Canad. Pulp Pap. Ass, 848 B-9-a, 256. Price: $4.50,, 1946

Family history of liver cancer increases the risk of liver cancer incidence: a 20-year prospective cohort study in Qidong, China. Zhonghua Gan Zang Bing Za Zhi 22(10): 752-756, 2014

A cohort study of the recovery of health and wellbeing following colorectal cancer (CREW study): protocol paper. Bmc Health Services Research 12: 90, 2012

Research in national tourist organizations. A paper presented to the 1981 PATA Travel Research Conference, Taipei, Taiwan. Research in national tourist organizations A paper presented to the 1981 PATA Travel Research Conference, Taipei, Taiwan: 24, 1981

Lung cancer death rates by smoking status: comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA. Cancer Science 96(2): 120-126, 2005

The need for research into production-related education. Paper presented at a Workshop on research priorities in Southern Africa, 23-27 November 1981, Roma, Lesotho. The need for research into production related education Paper presented at a Workshop on research priorities in Southern Africa, 23-27 November 1981, Roma, Lesotho: 17, 1981

Serum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort. Breast Cancer Research 11(4): R64, 2009

Cancer mortality among pulp and paper workers in Poland. A cohort study. International Journal of Occupational Medicine and Environmental Health 10(1): 19-29, 1997