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Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants



Comparative evaluation of efficacy and tolerance of iron polymaltose complex and ferrous sulphate for treatment of iron deficiency anemia in infants



Revista de la Facultad de Ciencias Medicas 69(2): 97-101



Iron deficiency anemia is the most common nutritional deficiency in children under 2 years, affecting to 34.1% in Argentina. Iron supplementation is the standard treatment. The aim of our study was to evaluate the efficacy and tolerability of two iron containing drugs. Randomized, double-blind, controlled trial, including children aged 6 to 18 months with iron deficiency anemia (hemoglobin < 11 g/dl, transferrine saturation < 20%). Patients were randomly assigned to one of two treatments: iron polymaltose complex (IPC) or ferrous sulphate (FS). Efficacy, tolerance and adverse events occurrence were evaluated. 60 children with iron deficiency anemia were included; 29 in the FS group and 31 in the IPC group. There were no significant differences between groups regarding hemoglobin at baseline (10,09 ± 0,92 vs. 10,26 ± 0,41; p= 0,17) and after 90 days treatment (11,26 ± 0,49 vs. 11,14 ± 0,60; p= 0,21). Also, there were no differences regarding adverse events frequency (FS: 4/29 y IPC: 9/31; p=0,2). In our study, there were no differences in efficacy and safety between FS and IPC in the treatment of children with iron deficiency anemia.

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Accession: 052212693

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PMID: 23286539


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