+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Comparing the efficacy of medications for ADHD using meta-analysis



Comparing the efficacy of medications for ADHD using meta-analysis



Medgenmed 8(4): 4



Medications used to treat attention-deficit/hyperactivity disorder (ADHD) have been well researched, but comparisons among drugs are hindered by the absence of direct comparative trials. We analyzed recent published literature on the pharmacotherapy of ADHD to describe the variability of drug-placebo effect sizes. A literature search was conducted to identify double-blind, placebo-controlled studies of ADHD youth published after 1979. Meta-analysis regression assessed the influence of medication type and study design features on medication effects. Twenty-nine trials met criteria and were included in this meta-analysis. These trials studied 15 drugs using 17 different outcome measures of hyperactive, inattentive, impulsive, or oppositional behavior. The most commonly identified treatments included both methylphenidate and amphetamine compounds. After stratifying trials on the class of drug studied (short-acting stimulant vs long-acting stimulant vs nonstimulant), we found significant drug differences for both study design variables and effect sizes. The differences among the 3 classes of drug remained significant after correcting for study design variables. Uniformity appears to be lacking in how medication effectiveness is assessed and in many study design parameters. Comparing medication effect sizes from different studies will be biased without accounting for variability in study design parameters. Although these differences obscure comparisons among specific medications, they do allow for conclusions about the differential effects of broad classes of medications used to treat ADHD.

(PDF emailed within 1 workday: $29.90)

Accession: 052222564

Download citation: RISBibTeXText

PMID: 17415287


Related references

Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. European Child and Adolescent Psychiatry 19(4): 353-364, 2010

Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews 84: 63-71, 2017

Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications: protocol for a systematic review and meta-analysis. Bmj Open 7(9): E018027, 2018

Stimulant Medications and Sleep for Youth With ADHD: A Meta-analysis. Pediatrics 136(6): 1144-1153, 2016

Association of ADHD medications with the risk of cardiovascular diseases: a meta-analysis. European Child and Adolescent Psychiatry 2018, 2018

Are ADHD medications under or over prescribed worldwide?: Protocol for a systematic review and meta-analysis. Medicine 97(24): E10923, 2018

Are ADHD medications under or over prescribed worldwide?: Protocol for a systematic review and meta-analysis: Erratum. Medicine 97(27): E11472-E11472, 2018

A meta-analysis comparing trials of antimuscarinic medications funded by industry or not. Bju International 98(2): 377-380, 2006

Comparing Executive Functioning in Children and Adolescents With Fetal Alcohol Spectrum Disorders and ADHD: A Meta-Analysis. Journal of Attention Disorders 2016, 2016

Efficacy of neurofeedback treatment in ADHD: the effects on inattention, impulsivity and hyperactivity: a meta-analysis. Clinical Eeg and Neuroscience 40(3): 180-189, 2009

Efficacy of nonvenous medications for acute convulsive seizures: A network meta-analysis. Neurology 85(21): 1859-1868, 2016

Efficacy spectrum of antishivering medications: meta-analysis of randomized controlled trials. Critical Care Medicine 40(11): 3070-3082, 2013

Efficacy of methylphenidate, psychosocial treatments and their combination in school-aged children with ADHD: a meta-analysis. Clinical Psychology Review 28(5): 783-800, 2007

Acute atomoxetine treatment of younger and older children with ADHD: a meta-analysis of tolerability and efficacy. Child and Adolescent Psychiatry and Mental Health 2(1): 25, 2008

Clinical efficacy of anti-VEGF medications for central serous chorioretinopathy: a meta-analysis. International Journal of Clinical Pharmacy 39(3): 514-521, 2017