+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of different diagnostic methods for differentiating biliary atresia from idiopathic neonatal hepatitis



Comparison of different diagnostic methods for differentiating biliary atresia from idiopathic neonatal hepatitis



Clinical Imaging 33(6): 439-446



To retrospectively analyze different methods in differentiating biliary atresia from idiopathic neonatal hepatitis. Sixty-nine infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis (INH) and biliary atresia (BA) were studied retroprospectively from January 2004 to December 2006. A thorough history and physical examination were undertaken. All cases underwent abdominal magnetic resonance cholangiography (MRCP), ultrasonography (US), hepatobiliary scintigraphy (HBS), HBS single-photon emission computer tomography (HBS SPECT), and operation or percutaneous liver biopsy. The accuracy, sensitivity, specificity, and predictive values of these various methods were compared. There were 39 girls and 30 boys, among whom 35 had INH (age, 61+/-17 days) and 34 had BA (age, 64+/-18 days). The mean age at onset of jaundice was significantly lower in cases of BA when compared to INH cases (9+/-13 vs. 20+/-21 days; P=.032). The diagnostic accuracy of different methods was as follows: liver biopsy, 97.1%; HBS SPECT, 91.30%; MRCP, 71.01%; HBS, 66.67%; US, 65.22%. Our results indicate that biopsy of the liver is considered as the most reliable method to differentiate INH from BA. The accuracy of HBS SPECT is higher than that of MRCP, HBS, and US. There was no significant difference in diagnostic accuracy among MRCP, HBS, and US.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052232364

Download citation: RISBibTeXText

PMID: 19857804

DOI: 10.1016/j.clinimag.2009.01.003


Related references

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis. African Journal of Paediatric Surgery 13(2): 63-68, 2016

Studies in neonatal hepatitis and biliary atresia. II. The effect of diagnostic laparotomy on long-term prognosis of neonatal hepatitis. American Journal of Diseases of Children 116(3): 262-270, 1968

Idiopathic neonatal hepatitis or extrahepatic biliary atresia? The role of liver biopsy. Sudanese Journal of Paediatrics 16(1): 58-62, 2016

The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. Journal of the Medical Association of Thailand 86(Suppl. 2): S189, 2003

The role of CK7, Ki-67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates. Apmis 120(7): 529-538, 2012

Differentiation of congenital biliary atresia and neonatal hepatitis by statistical methods. Progress in Pediatric Surgery 17: 189-199, 1984

Studies in neonatal hepatitis and biliary atresia. 3. Progression and regression of cirrhosis in biliary atresia. American Journal of Diseases of Children 116(3): 271-279, 1968

Identification of the plasma metabolomics as early diagnostic markers between biliary atresia and neonatal hepatitis syndrome. Plos one 9(1): E85694, 2014

Ultrasonography evaluation of infants with Alagille syndrome: In comparison with biliary atresia and neonatal hepatitis. European Journal of Radiology 85(6): 1045-1052, 2016

Serum alpha-fetoprotein levels in extrahepatic biliary atresia, idiopathic neonatal hepatitis and alpha-1-antitrypsin deficiency (PiZ). Acta Paediatrica Scandinavica 65(5): 623-629, 1976

Comparison of different noninvasive diagnostic methods for biliary atresia: a meta-analysis. World Journal of Pediatrics 12(1): 35-43, 2016

Hepatitis c serology anti hcv in patients with neonatal cholestasis neonatal hepatitis and extrahepatic biliary atresia. Hepatology 12(4 Part 2): 844, 1990

Biliary atresia and neonatal hepatitis. Differential diagnosis and therapeutic possibilities in neonatal cholestatic hepatitis. Ugeskrift for Laeger 144(22): 1589-1593, 1982

Clinical features differentiating biliary atresia from other causes of neonatal cholestasis. Annals of the Academy of Medicine Singapore 39(8): 648-654, 2010

Studies in neonatal hepatitis and biliary atresia. I. Long-term prognosis of neonatal hepatitis. American Journal of Diseases of Children 116(3): 257-261, 1968