Comparison of lateral flow technology and galactomannan and (1->3) -beta-D-glucan assays for detection of invasive pulmonary aspergillosis

Wiederhold, N.P.; Thornton, C.R.; Najvar, L.K.; Kirkpatrick, W.R.; Bocanegra, R.; Patterson, T.F.

Clinical and Vaccine Immunology Cvi 16(12): 1844-1846

2009


ISSN/ISBN: 1556-679X
PMID: 19793899
DOI: 10.1128/cvi.00268-09
Accession: 052237039

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Abstract
We compared a lateral flow device to galactomannan and (1-->3)-beta-D-glucan assays to detect invasive aspergillosis in an established guinea pig model of pulmonary disease. The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7.