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Compounds from Viburnum sargentii Koehne and evaluation of their cytotoxic effects on human cancer cell lines



Compounds from Viburnum sargentii Koehne and evaluation of their cytotoxic effects on human cancer cell lines



Molecules 15(7): 4599-4609



Compounds were isolated from a methanol extract of the dried stem barks of Viburnum sargentii Koehne. The structures of the compounds, namely 9'-O-methylvibsanol (3), furcatoside A (4) and lareciresinol (5) were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. In addition, (+)-catechin (1), (+)-epicatechin (2) were also isolated. This work also examined the cytotoxic effects of three compounds 3-5 (25-100 microM) in MCF-7 and A549 cells after 24, 48 and 72 h of exposure. Our results showed that 9'-O-methylvibsanol (3) exhibited strong concentration-dependent anticancer effects according to the MTT assay and produced morphological changes consistent with apoptosis, as confirmed by Ho3342 staining analysis revealed that more apoptotic cells were observed after 9'-Omethylvibsanol (3) treatment.

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Accession: 052269416

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PMID: 20657380

DOI: 10.3390/molecules15074599


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