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Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity



Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity



Archives of Pharmacal Research 38(5): 677-682



A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

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Accession: 052269424

Download citation: RISBibTeXText

PMID: 25005067

DOI: 10.1007/s12272-014-0432-3


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