+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells



Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells



Molecules 17(12): 15013-15021



Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052269426

Download citation: RISBibTeXText

PMID: 23250029

DOI: 10.3390/molecules171215013


Related references

Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells. Natural Product Research 2019: 1-6, 2019

Isolation and screened neuroprotective active constituents from the roots and rhizomes of Valeriana amurensis. Fitoterapia 96: 48-55, 2014

Chemical composition of the rhizomes with roots of Valeriana wolgensis from the Valeriana officinalis group. Chemistry of Natural Compounds 27(1): 125-126, 1991

Chemical composition of rhizomes and roots of valeriana wolgensis from the valeriana officinalis cycle. Khimiya Prirodnykh Soedinenii (1): 141-143, 1991

A comparative study of the process of extracting valepotriates from the rhizomes with roots of Valeriana officinalis and Valeriana alliariifolia. Chemistry of natural compoundsFeb1985 21(1): 115-116, 1985

Tableting of rhizomes with roots of Valeriana. Vestsi Natsyyanal' nai Akademii Navuk Belarusi Seryya Biyalagichnykh Navuk (4): 19-23, 2002

Peony glycosides protect against corticosterone-induced neurotoxicity in PC12 cells. Cellular and Molecular Neurobiology 29(5): 643-647, 2009

Iridoids from the rhizomes and roots of Valeriana jatamansi. Journal of Natural Products 65(12): 1949-1952, 2002

Herbal formula SYJN protect PC12 cells from neurotoxicity induced by corticosterone. Journal of Ethnopharmacology 125(3): 456-460, 2009

Composition of the essential oil from roots and rhizomes of Valeriana wallichii DC. Flavour & Fragrance Journal 12(2): 123-131, 1997

Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells. Molecules 21(4): 418, 2016

Isolation of Indian valerian oil from Valeriana wallichii DC. roots and rhizomes. Perfum essent. Oil Rec 56: 656-7. bibl. 5, 1965

Separation of alkaloids from the dried roots and rhizomes of Valeriana officinalis L. Pharmazeutische Zentralhalle für Deutschland 100: 575-584, 1961

Evaluation of rhizomes and roots of Valeriana officinalis; pharmacognostic investigations. Herba Polonica: 18 (1) 3-10, 1972

Evaluation of rhizomes and roots of Valeriana officinalis; pharmacological investigations. Herba Polonica: 18 (1) 11-17, 1972