+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Compounds with neuroprotective activity from the medicinal plant Machilus thunbergii



Compounds with neuroprotective activity from the medicinal plant Machilus thunbergii



Journal of Enzyme Inhibition and Medicinal Chemistry 24(5): 1117-1121



The dichloromethane fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. Through the activity-guided isolation from the CH(2)Cl(2) fraction, (+)-9'-hydroxygalbelgin (1), isogalcatin B (2), (7S,8S,8'R)-3',4'-dimethoxy-3,4,-methylenedioxylignan-7-ol (3), 1-hydroxy-7-hydroxymethyl-6-methoxyxanthone (4), 5,7-dimethoxy-3',4'-methylenedioxyflavan-3-ol (5), (+)-(3S,4S,6R)-3,6-dihydroxypiperitone (6), protocatechuic acid methyl ester (7) and tyrosol (8) were obtained. All of them had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from 0.1 microM to 10.0 microM and were comparable to MK-801, a well-known inhibitor of glutamate receptor.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052269458

Download citation: RISBibTeXText

PMID: 19555186

DOI: 10.1080/14756360802632971


Related references

Isolation and identification of neuroprotective compounds from Machilus thunbergii. 2007

Neuroprotective lignans from the bark of Machilus thunbergii. Planta Medica 70(1): 79-80, 2004

New neuroprotective dibenzylbutane lignans isolated from Machilus thunbergii. Natural Product Research 24(6): 562-568, 2010

Das anthelminthische Wirkprinzip von Machilus thunbergii gegen Clonorchis sinensis The Agent Responsible for the Anthelminthic Activity of Machilus thunbegii against Clonorchis sinensis. Archiv der Pharmazie 315(10): 894-895, 1982

Contrasting phylogeographical patterns of two closely related species, Machilus thunbergii and Machilus kusanoi (Lauraceae), in Taiwan. Journal of Biogeography 33(5): 936-947, 2005

Growth of Machilus thunbergii saplings planted in a coastal forest of Pinus thunbergii in northern Yamagata prefecture. Tohoku Journal of Forest Science 9(1): 1-5, 2004

Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells. Biological & Pharmaceutical Bulletin 27(8): 1305-1307, 2004

Stimulatory activity of lignans from Machilus thunbergii on osteoblast differentiation. Biological & Pharmaceutical Bulletin 30(4): 814-817, 2007

Butanolides from Machilus thunbergii and their inhibitory activity on nitric oxide synthesis in activated macrophages. PhytoTherapy Research 17(4): 372-375, 2003

Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test. Bioscience, Biotechnology, and Biochemistry 62(7): 1425-1427, 1998

meso-dihydroguaiaretic acid from Machilus thunbergii down-regulates TGF-beta1 gene expression in activated hepatic stellate cells via inhibition of AP-1 activity. Planta Medica 71(5): 393-398, 2005

New neolignans and lignans from Vietnamese medicinal plant Machilus odoratissima NEES. Chemical & Pharmaceutical Bulletin 54(3): 380-383, 2006

New Neolignans and Lignans from Vietnamese Medicinal Plant Machilus odoratissima Nees. Chemical & Pharmaceutical Bulletin 54(3): 380-383, 2006

In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera. Journal of Nutritional Science 6: E54, 2017

Lignans from machilus thunbergii. Phytochemistry 26(5): 1513-1516, 1987