+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comprehension of complex discourse in different stages of Huntington's disease



Comprehension of complex discourse in different stages of Huntington's disease



International Journal of Language and Communication Disorders 45(6): 656-669



Huntington's disease not only affects motor speech control, but also may have an impact on the ability to produce and understand language in communication. The ability to comprehend basic and complex discourse was investigated in three different stages of Huntington's disease. In this experimental group study, 18 patients with Huntington's disease completed a test that assessed basic language abilities as well as tests from a battery of tasks that explored the ability to comprehend more complex information. The test battery assessed the ability to comprehend logico-grammatical sentences, ambiguous information and inferred meaning on sentence and discourse levels. In comparison with results from pair-matched participants in a control group, matched for gender, age and education, the group of individuals with Huntington's disease had significantly more problems with all tasks requiring more complex cognitive processing. There was a correlation, as well as tendencies towards correlations, between results in the group of individuals with Huntington's disease and stage of the disease. However, results within the stage groups were heterogeneous, and some individuals in an early stage of the disease sometimes performed as well as others in a late stage. It is likely that, in complex discourse tasks, individual differences in cognitive capacity may contribute and override other differences related to stage of disease. These results indicate that it is important to assess comprehension even in early stages of Huntington's disease, with tests that are sensitive to subtle language disorders, to reduce communication problems for the individuals concerned and their conversational partners.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052269524

Download citation: RISBibTeXText

PMID: 20085535

DOI: 10.3109/13682820903494742


Related references

Comprehension of prosody in Huntington's disease. Journal of Neurology, Neurosurgery, and Psychiatry 53(7): 607-610, 1990

The neural correlates of strategic reading comprehension: cognitive control and discourse comprehension. Neuroimage 58(2): 675-686, 2011

The effect of a sentence comprehension treatment on discourse comprehension in aphasia. Aphasiology 29(11): 1289-1311, 2015

Impact of Huntington Disease across the entire disease spectrum The phases and stages of disease from the patient perspective. 2011

Impact of Huntington's across the entire disease spectrum: the phases and stages of disease from the patient perspective. Clinical Genetics 80(3): 235-239, 2011

Depression and stages of Huntington's disease. Journal of Neuropsychiatry and Clinical Neurosciences 17(4): 496-502, 2006

Depression in the early stages of Huntington disease. Neurodegenerative Disease Management 1(5): 407-414, 2012

Saccades in presymptomatic and early stages of Huntington disease. Neurology 67(3): 394-399, 2006

Discourse comprehension. Annual Review of Psychology 48: 163-189, 1997

Monitoring Huntington's disease progression through preclinical and early stages. Neurodegenerative Disease Management 2(4): 421-435, 2012

Progression of symptoms in the early and middle stages of Huntington disease. Archives of Neurology 58(2): 273-278, 2001

Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disorders 15(3): 552-560, 2000

Abnormal response to cortical activation in early stages of Huntington disease. Movement Disorders 27(7): 907-910, 2012

The relationship between cortisol and verbal memory in the early stages of Huntington's disease. Journal of Neurology 260(3): 891-902, 2013

International Huntington Association and the World Federation of Neurology Research Group on Huntington's Chorea. Guidelines for the molecular genetics predictive test in Huntington's disease. Journal of Medical Genetics 31(7): 555-559, 1994