+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity

Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity

Journal of Hypertension 30(3): 567-573

To determine, using a comprehensive MRI investigation, prevalence and vascular correlates of early left-ventricular concentric remodeling in middle-aged patients with abdominal obesity. Left-ventricular and vascular remodeling are commonly associated with hypertension, but little is known for abdominal obesity patients, a population with definite increase in cardiovascular risk and high rates of further developments of hypertension and of the metabolic syndrome. Seventy middle-aged abdominal obesity patients (56 ± 5 years, 49% women, 69% with body mass index > 30 kg/m), who had no additional cardiovascular risk factor except for untreated stage 1 hypertension (16%), and 40 controls underwent MRI for detecting concentric remodeling (increase in left-ventricular mass/end-diastolic volume ratio) and identifying potential determinants, including arterial compliance indexes [aortic pulse wave velocity and total arterial compliance (TAC)] and total peripheral vascular resistances (TPVRs). Twenty abdominal obesity patients (29%) had concentric remodeling (concentric remodeling+), whereas 50 did not (concentric remodeling-). Concentric remodeling+ patients were mostly men (85%), they frequently had stage 1 hypertension (45%) and few had left-ventricular hypertrophy (20%). When adjusted for sex, there was a step-by-step decline in TAC between controls (mean ± SEM: 2.10 ± 0.06 ml/mmHg), concentric remodeling- (1.82 ± 0.06 ml/mmHg) and concentric remodeling+ (1.42 ± 0.09 ml/mmHg, P < 0.005 for inter-group comparisons) and TPVRs were lower than controls for concentric remodeling- (14.7 ± 0.5 vs. 16.8 ± 0.5 ml/mmHg, P = 0.005) but not for concentric remodeling+ (17.5 ± 0.7 mmHg/min per l). Concentric remodeling is frequently documented by MRI in the middle-aged men with abdominal obesity and in association with a decrease in TAC no longer counter-balanced by a decrease in TPVR, suggesting a remodeling from proximal to peripheral vasculature.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052269619

Download citation: RISBibTeXText

PMID: 22227821

DOI: 10.1097/hjh.0b013e32834f6f3f

Related references

P48 Oxldl/beta2Gpi Complex As An Early Marker Of Atherosclerosis Initiation In Healthy Middle-Aged Men With Abdominal Obesity. Atherosclerosis Suppl.s 11(2): 26-27, 2010

Selection of the method of anesthesia for middle-aged and elderly patients with obesity during operations on the abdominal organs. Anesteziologiia i Reanimatologiia 1985(6): 54-57, 1985

Changes in the prevalence of obesity and abdominal obesity in middle-aged Chengdu residents during 1992 and 2007. Sichuan Da Xue Xue Bao. Yi Xue Ban 42(3): 401-4, 412, 2012

Effects of FABP2 Ala54Thr gene polymorphism on obesity and metabolic syndrome in middle-aged Korean women with abdominal obesity. Central European Journal of Public Health 27(1): 37-43, 2019

Association of 10-Year Atherosclerotic Cardiovascular Disease Risk Score with Carotid Atherosclerosis in Middle-Aged Abdominal Obesity Patients with Type 2 Diabetes Mellitus. Ultrasound in Medicine & Biology 43: S220-S221, 2017

Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in Middle-Aged Men. Mediators of Inflammation 2015: 524291, 2016

Abdominal obesity is associated with arterial stiffness in middle-aged adults. Nutrition, Metabolism, and Cardiovascular Diseases 25(5): 495-502, 2016

Masked hypertension and cardiac remodeling in middle-aged endurance athletes. Journal of Hypertension 33(6): 1276-1283, 2016

Effectiveness of aromatherapy massage on abdominal obesity among middle aged women. Taehan Kanho Hakhoe Chi 33(6): 839-846, 2004

OSA, metabolic syndrome and CPAP: effect on cardiac remodeling in subjects with abdominal obesity. Respiratory Medicine 106(1): 145-152, 2012

Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction. Journal of Molecular Medicine 89(5): 459-469, 2011

The Relationship Between Cardiorespiratory Fitness and Arterial Stiffness in Middle-Aged Men with Abdominal Obesity. Metabolic Syndrome and Related Disorders 2019, 2019

Breast size as a predictor of abdominal obesity and insulin resistance in middle-aged women. International Journal of Obesity 24(Suppl. 1): S144, 2000

The oxidized low-density lipoprotein/β2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men. Annals of Nutrition and Metabolism 62(1): 7-13, 2013

Abdominal obesity and glucose intolerance in middle-aged women in the United Arab Emirates. Journal of Public Health Medicine 17(3): 362-363, 1995