+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comprehensive Review on Natural β-Carbolines as Anti-Malarial Agents

Comprehensive Review on Natural β-Carbolines as Anti-Malarial Agents

Mini Reviews in Medicinal Chemistry 2013

Malaria is one of the major health problems in developing countries. It kills 1-2 million people every year and also it affects financially status of many countries. Developed resistance to aminoquinoline(chloroquine), quinoline methanols (Quinine, Mefloquine) created troubles in malarial chemotherapy and signs of appearance of resistance to artemisinin based combination therapy (ACT) created emergency to develop novel antimalarial agents with high efficacy before spreading of resistance to ACT. From the ages natural products played important role in antimalarial therapy, identification of natural products, semisynthetic and synthetic analogs with potent antiplasmodium activity is one of the best method to develop novel antimalarial agents. In this review, we are presenting the antimalarial activity of natural β-carboline alkaloids and special interest on manzamine alkaloids and their structure activity relationship.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 052269635

Download citation: RISBibTeXText

PMID: 24032512

Related references

Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs. Malaria Journal 15: 50, 2016

Potential Anti-Malarial Agents from Endophytic Fungi: A Review. Mini Reviews in Medicinal Chemistry 18(13): 1110-1132, 2018

Review on in-vitro anti-malarial activity of natural β-carboline alkaloids. Mini Reviews in Medicinal Chemistry 13(12): 1778-1791, 2014

Metabolism of the malarial parasite. Action of anti-malarial agents upon separated Plasmodium lophurae and upon certain isolated enzyme systems. Federation Proceedings Baltimore, 5(3): 400-405, 1946

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 30(6): 1027-1033, 2016

Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. European Journal of Pharmacology 795: 169-178, 2016

Latentiation of chemo therapeutical agents preparation of saccharide polymers of schistosomicidal and anti malarial agents. Revista de Farmacia e Bioquimica da Universidade de Sao Paulo 17(1): 28-46, 1981

Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry 15(5): 537-547, 2016

Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature. Acta Dermatovenerologica Croatica 24(3): 169-174, 2017

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Current Drug Targets 8(3): 399-411, 2007

Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents. Bioorganic and Medicinal Chemistry 12(4): 683-692, 2004

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents. Chemical Society Reviews 39(2): 435-454, 2010

Lincomycin part 8 4 alkyl 1 demethyl 4 depropylclindamycins potent anti bacterial and anti malarial agents. Journal Of Medicinal Chemistry: 780-784, 1969

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of Medicinal Chemistry 53(9): 3611-3617, 2010

Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents. Bioorganic and Medicinal Chemistry Letters 27(2): 232-236, 2016