+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comprehensive Wnt-related gene expression during cochlear duct development in chicken

Comprehensive Wnt-related gene expression during cochlear duct development in chicken

Journal of Comparative Neurology 510(4): 378-395

The avian cochlear duct houses both a vestibular and auditory sensory organ (the lagena macula and basilar papilla, respectively), which each have a distinct structure and function. Comparative mRNA in situ hybridization mapping conducted over the time course of chicken cochlear duct development reveals that Wnt-related gene expression is concomitant with various developmental processes such as regionalization, convergent extension of the cochlear duct, cell fate specification, synaptogenesis, and the establishment of planar cell polarity. Wnts mostly originate from nonsensory tissue domains, whereas the sensory primordia preferentially transcribe Frizzled receptors, suggesting that paracrine Wnt signaling predominates in the cochlear duct. Superimposed over this is the strong expression of two secreted Frizzled-related Wnt inhibitors that tend to show complementary expression patterns. Frzb (SFRP3) is confined to the nonsensory cochlear duct and the lagena macula, whereas SFRP2 is maintained in the basilar papilla along with Fzd10 and Wnt7b. Flanking the basilar papilla are Wnt7a, Wnt9a, Wnt11, and SFRP2 on the neural side and Wnt5a, Wnt5b, and Wnt7a on the abneural side. The lateral nonsensory cochlear duct continuously expresses Frzb and temporarily expresses Wnt6 and SFRP1. Characteristic for the entire lagena is the expression of Frzb; in the lagena macula are Fzd1, Fzd7, and Wnt7b, and in the nonsensory tissues are Wnt4 and Wnt5a. Auditory hair cells preferentially express Fzd2 and Fzd9, whereas the main receptors expressed in vestibular hair cells are Fzd1 and Fzd7, in addition to Fzd2 and Fzd9.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052269643

Download citation: RISBibTeXText

PMID: 18671253

DOI: 10.1002/cne.21791

Related references

Development of Corti's organ and the hearing duct in the chicken embryo. 3. Cochlear nerve. Anales de la Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay 51(1): 40-44, 1966

Development of abnormal calmodulin gene expression and related activities in genetically dystrophic chicken muscle. Society for Neuroscience Abstracts 12(2): 1399, 1986

RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome. Genome Biology 14(3): R26-R26, 2015

Age-related changes in cochlear gene expression in normal and shaker 2 mice. Journal of the Association for Research in Otolaryngology 7(3): 317-328, 2006

Comprehensive analysis of gene expression patterns of hedgehog-related genes. Bmc Genomics 7: 280-280, 2006

Identification of Cancer Related Genes Using a Comprehensive Map of Human Gene Expression. Plos One 11(6): E0157484-E0157484, 2016

Changes in gene expression during Wolffian duct development. Hormone Research 65(4): 200-209, 2006

Age-related expression profile of the SLC27A1 gene in chicken tissues. Molecular Biology Reports 38(8): 5139-5145, 2012

Widespread expression of the chicken Agouti-related protein gene. Zoological Science (Tokyo) 16(Suppl ): 6, 1999

Expression of the avidin and its related avr3 gene in chicken macrophages. Journal of Cellular Biochemistry Supplement (16 PART C): 19, 1992

Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development. Developmental Dynamics 243(3): 428-439, 2014

A comprehensive analysis of aquaporin and secretory related gene expression in neonate and adult cholangiocytes. Gene Expression Patterns 15(2): 96-103, 2015

Comprehensive gene expression changes associated with mouse postnatal kidney development. Journal of Urology 189(6): 2385-2390, 2013

Development of a comprehensive gene expression profile of myeloma cells. Blood 94(10 SUPPL 1 PART 1): 545a, Nov 15, 1999

Age-related cochlear cytokine gene expression in the BALB/cJ mouse with systemic versus intratympanic dosing of steroid drugs. Acta Oto-Laryngologica 133(7): 685-691, 2013