+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development



Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development



International Journal of Developmental Biology 54(10): 1517-1526



Specific interactions between fibroblast growth factors (Fgf1-22) and their tyrosine kinase receptors (FgfR1-4) activate different signalling pathways that are responsible for the biological processes in which Fgf signalling is implicated during embryonic development. In the chick, several Fgf ligands (Fgf2, 4, 8, 9, 10, 12, 13 and 18) and the four FgfRs (FgfR 1, 2, 3 and 4) have been reported to be expressed in the developing limb. The precise spatial and temporal expression of these transcripts is important to guide the limb bud to develop into a wing/leg. In this paper, we present a detailed and systematic analysis of the expression patterns of FgfR1, 2, 3 and 4 throughout chick wing development, by in situ hybridisation on whole mounts and sections. Moreover, we characterize for the first time the different isoforms of FGFR1-3 by analysing their differential expression in limb ectoderm and mesodermal tissues, using RT-PCR and in situ hybridisation on sections. Finally, isoform-specific sequences for FgfR1IIIb, FgfR1IIIc, FgfR3IIIb and FgfR3IIIc were determined and deposited in GenBank with the following accession numbers: GU053725, GU065444, GU053726, GU065445, respectively.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052269776

Download citation: RISBibTeXText

PMID: 21302260


Related references

Expression patterns of two fibroblast growth factor receptor genes during early chick eye development. Experimental Eye Research 58(6): 649-658, 1994

Expression pattern of fibroblast growth factor receptor 2 gene during chick eye development. Nippon Ganka Gakkai Zasshi 97(5): 563-568, 1993

Expression pattern of fibroblast growth factor receptor 1 gene during chick eye development. Nippon Ganka Gakkai Zasshi 97(3): 304-309, 1993

Expression of fibroblast growth factor receptor 3 by fibroblast growth factor 2 in cultured chick embryo chondrocytes. Cell Biology International 29(3): 203-212, 2005

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics 93(5): 573-579, 2002

Endogenous and exogenous fibroblast growth factor 2 support survival of chick retinal neurons by control of neuronal neuronal bcl-x(L) and bcl-2 expression through a fibroblast berowth factor receptor 1- and ERK-dependent pathway. Journal of Neurochemistry 75(1): 151-163, 2000

Patterns of epidermal growth factor receptor, basic fibroblast growth factor and transforming growth factor-beta3 expression in skin with chronic venous insufficiency. European Journal of Dermatology 8(5): 334-338, 1998

Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain. Journal of Comparative Neurology 462(2): 265-273, 2003

Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Developmental Dynamics 228(2): 267-272, 2003

Expression of transforming growth factor-alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met, acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis. Hepatology 18(4 PART 2): 160A, 1993

Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis. Carcinogenesis 17(5): 931-938, 1996

Expression of the fibroblast growth factor-2 gene during chick development. Molecules and Cells 7(2): 208-213, 1997

Expression of fibroblast growth factor receptors during chick brain development. Annals of the New York Academy of Sciences 638: 406-408, 1991

The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor. Cell Communication and Signaling 8: 14, 2010

Fibroblast growth factor receptor-1 is a critical component for endometrial remodeling: localization and expression of basic fibroblast growth factor and FGF-R1 in human endometrium during the menstrual cycle and decreased FGF-R1 expression in menorrhagia. Laboratory Investigation; a Journal of Technical Methods and Pathology 77(4): 389-402, 1997