Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff
Pasieka, T.J.; Menachery, V.D.; Rosato, P.C.; Leib, D.A.
Journal of Virology 86(14): 7692-7695
ISSN/ISBN: 1098-5514 PMID: 22553331 DOI: 10.1128/jvi.00761-12
Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR(-/-)) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.