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Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff

Pasieka, T.J.; Menachery, V.D.; Rosato, P.C.; Leib, D.A.

Journal of Virology 86(14): 7692-7695

2012

ISSN/ISBN: 1098-5514
PMID: 22553331
DOI: 10.1128/jvi.00761-12
Accession: 052349134
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Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR(-/-)) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.

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