+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease



Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease



Dementia and Geriatric Cognitive Disorders 28(5): 404-412



Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. We assessed the baseline MRI and maximum of 7 years clinical follow-up data of 60 MCI subjects in order to examine differences in cortical thickness (CTH) between the progressive MCI (P-MCI) and stable MCI (S-MCI) subjects. CTH was measured using an automatic computational surface-based method. During the follow-up, 15 MCI subjects converted to AD on average 1.9 +/- 1.3 years after the baseline examination, while 45 MCI subjects remained stable. The P-MCI group displayed significantly reduced CTH bilaterally in the superior and middle frontal, superior, middle and inferior temporal, fusiform and parahippocampal regions as well as the cingulate and retrosplenial cortices and also in the right precuneal and paracentral regions compared to S-MCI subjects. Analysis of CTH could be used in conjunction with neuropsychological testing to identify those subjects with imminent conversion from MCI to AD several years before dementia diagnosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052365387

Download citation: RISBibTeXText

PMID: 19907176

DOI: 10.1159/000256274


Related references

Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's disease. Journal of Alzheimer's Disease 30(4): 857-874, 2012

Cortical thickness and semantic fluency in Alzheimer's disease and mild cognitive impairment. American Journal of Alzheimer's Disease 1(2): 81-92, 2013

Association between cortical thickness and CSF biomarkers in mild cognitive impairment and Alzheimer's disease. Alzheimer's & Dementia 9(4): P223-P224, 2013

Alterations of whole-brain cortical area and thickness in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease 27(2): 281-290, 2011

Small-World Properties in Mild Cognitive Impairment and Early Alzheimer's Disease: A Cortical Thickness MRI Study. Isrn Geriatrics 2013:, 2013

The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment. Alzheimer's and Dementia 10: 301-310, 2018

Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease. Neuroimage 43(1): 103-113, 2008

Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study. Journal of Alzheimer's Disease 21(4): 1141-1151, 2010

Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment. Journal of Alzheimer's Disease 56(1): 415-428, 2017

Cortical folding analysis on patients with Alzheimer's disease and mild cognitive impairment. Medical Image Computing and Computer-Assisted Intervention 15(Pt 3): 289-296, 2012

Analysis of the Retinal Nerve Fiber Layer Thickness in Alzheimer Disease and Mild Cognitive Impairment. Korean Journal of Ophthalmology 31(6): 548-556, 2017

Differential diagnosis of mild cognitive impairment and Alzheimer's disease using structural MRI cortical thickness, hippocampal shape, hippocampal texture, and volumetry. Neuroimage. Clinical 13: 470-482, 2017

Meta-analysis of the relationship of peripheral retinal nerve fiber layer thickness to Alzheimer's disease and mild cognitive impairment. Shanghai Archives of Psychiatry 27(5): 263-279, 2015

The hard Test Your Memory. Evaluation of a short cognitive test to detect mild Alzheimer's disease and amnestic mild cognitive impairment. International Journal of Geriatric Psychiatry 29(3): 272-280, 2014

The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: a surface-based morphometric analysis. Neuropsychologia 49(14): 3931-3945, 2011