+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity

Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity

Molecules and Cells 37(5): 365-371

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052392407

Download citation: RISBibTeXText

PMID: 24781408

DOI: 10.14348/molcells.2014.0074

Related references

Adipose tissue inflammation in obesity: a metabolic or immune response?. Current Opinion in Pharmacology 37: 35-40, 2017

Adipocytes properties and crosstalk with immune system in obesity-related inflammation. Journal of Cellular Physiology 233(1): 88-97, 2017

Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism 27(3): 588-601.E4, 2018

The role of adipose tissue immune cells in obesity and low-grade inflammation. Journal of Endocrinology 222(3): R113-R127, 2014

Adipokine dysregulation and adipose tissue inflammation in human obesity. European Journal of Clinical Investigation 48(9): E12997, 2018

Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes 64(4): 1235-1248, 2015

Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver. Canadian Journal of Physiology and Pharmacology 91(11): 867-872, 2014

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and Cellular Endocrinology 314(1): 1-16, 2010

Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 68(7): 780-792, 2013

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and Molecular Life Sciences 75(4): 727-742, 2017

Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation. Experimental Gerontology 94: 59-63, 2016

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk. European Journal of Immunology 47(11): 1867-1874, 2017

Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. Plos One 8(1): E53626, 2013

Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue. Cancers 7(1): 143-178, 2015

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. Journal of Clinical Investigation 120(1): 191-202, 2010