Section 53
Chapter 52,401

Cu and Fe metallic ions-mediated oxidation of low-density lipoproteins studied by NMR, TEM and Z-scan technique

Gómez, S.L.; Monteiro, A.M.; Rabbani, S.R.; Bloise, A.C.; Carneiro, S.M.; Alves, S.; Gidlund, M.; Abdalla, D.S.P.; Neto, A.M.F.

Chemistry and Physics of Lipids 163(6): 545-551


ISSN/ISBN: 1873-2941
PMID: 20347728
DOI: 10.1016/j.chemphyslip.2010.03.008
Accession: 052400177

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In this work we report on a study of the morphological changes of LDL induced in vitro by metallic ions (Cu(2+) and Fe(3+)). These modifications were characterized by transmission electron microscopy, nuclear magnetic resonance and the Z-scan technique. The degree of oxidative modification of LDL was determined by the TBARS and lipid hydroperoxides assays. It is shown that distinct pathways for modifying lipoproteins lead to different morphological transformations of the particles characterized by changes in size and/or shape of the resulting particles, and by the tendency to induce aggregation of the particles. There were no evidence of melting of particles promoted by oxidative processes with Cu and Fe.

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