+ Translate

Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy

, : Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy. Expert Opinion on PharmacoTherapy 11(8): 1277-1293

Malaria infection during pregnancy is a major public health problem worldwide, with 50 million pregnancies exposed to the infection every year. Approximately 25,000 maternal deaths and between 75,000 and 200,000 infant deaths could be prevented each year by effective malaria control in pregnancy. Antimalarial drug treatment and prevention has been hampered by the appearance of drug resistance, which has been a particular problem in pregnancy due to the inherent safety issues. New antimalarial drugs and combinations are being studied but there is not yet sufficient information on their efficacy or, more importantly, on their safety in pregnancy. This article provides an overview of the relevance of the topic and reviews the current antimalarial drugs recommended for pregnancy, as well as the guidelines for both treatment and prevention in women living in endemic areas and for travellers. Updated information on the drugs currently used for malaria treatment and prevention in pregnancy, including new drugs under development, is provided. The gaps on efficacy and safety information for use during pregnancy are also discussed. Prevention and case management of malaria during pregnancy is based on risk-benefit criteria and poses one of the greatest challenges to current malaria control.

(PDF same-day service: $19.90)

Accession: 052409940

PMID: 20408744

DOI: 10.1517/14656561003733599

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Baranova, A.M., 2007: Current antimalarial drugs recommended by the World Health Organization for the treatment and prevention of malaria. Meditsinskaia Parazitologiia i Parazitarnye Bolezni: 56-59

Bourgeade, A.; Nosny, Y.; Delmont, J., 2001: Antimalarial drugs combinations for malaria prevention and treatment. To improve the efficacy of monotherapy, combinations of various drugs are used for the prevention or treatment of malaria, notably that of Plasmodium falciparum malaria. These regimens are prescribed for treatment and prevention, and to reduce the...

Newman, R.D.; Parise, M.E.; Slutsker, L.; Nahlen, B.; Steketee, R.W., 2003: Safety, efficacy and determinants of effectiveness of antimalarial drugs during pregnancy: implications for prevention programmes in Plasmodium falciparum-endemic sub-Saharan Africa. Plasmodium falciparum malaria in pregnancy poses substantial risk to a pregnant woman and her neonate through anaemia and low birth weight (LBW), respectively, and is responsible for up to 35% of preventable LBW in malaria-endemic areas. Chemoprop...

Cleary, K.Lawrence.; Roney, K.; Costantine, M., 2015: Challenges of studying drugs in pregnancy for off-label indications: pravastatin for preeclampsia prevention. Statins (3-hydroxy-3 methyl-glutaryl coenzyme-A reductase inhibitors) are the most commonly prescribed cholesterol-lowering medications due to their efficacy in reducing cardiovascular mortality and morbidities, tolerability, and safety profiles....

Lu, E.; Wang, B.Wei.; Guimond, C.; Synnes, A.; Sadovnick, A.Dessa.; Dahlgren, L.; Traboulsee, A.; Tremlett, H., 2013: Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance. When contemplating a pregnancy, women treated for multiple sclerosis (MS) with a disease-modifying drug must decide to discontinue their medication before conception or risk exposing their unborn child to potential drug toxicity. Few studies exist...

Rogerson, S.J.; Menendez, C., 2006: Treatment and prevention of malaria in pregnancy: opportunities and challenges. Control of malaria in pregnancy through prevention or treatment may save lives of mothers and babies. Selection of drugs for treatment of infected pregnant women, or for prevention in exposed populations is problematic owing to resistance to estab...

Laufer, M.K., 2008: Monitoring antimalarial drug efficacy: current challenges. Access to effective antimalarial therapy has increased dramatically. As malaria-endemic countries begin to use artemisinin-based combination therapy (ACT) to treat malaria, detecting the emergence and spread of resistance has become more complicat...

Chulay, J.D., 1999: Challenges in the development of antimalarial drugs with causal prophylactic activity. Transactions of the Royal Society of Tropical Medicine and Hygiene 92(6): 577-579

Chulay, J.D., 1998: Challenges in the development of antimalarial drugs with causal prophylactic activity. The requirements for causal prophylaxis of Plasmodium vivax (relapsing) and P. falciparum (non-relapsing) malaria are compared, and some of the challenges to the development of new prophylactic antimalarial drugs are reviewed.

Satgé, D.; Kempf, E.; Dubois, J-Bernard.; Nishi, M.; Trédaniel, J., 2016: Challenges in Diagnosis and Treatment of Lung Cancer in People with Intellectual Disabilities: Current State of Knowledge. NlmCategory="UNASSIGNED">As the life expectancy of people with intellectual disability (ID) has progressed, they have become similarly at risk of cancer as individuals of the general population. Epidemiological studies indicate a redu...