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DNA methylation and mechanism of action of 5-azacytidine


, : DNA methylation and mechanism of action of 5-azacytidine. Blood 111(4): 2485; Author Reply 2486-2485; Author Reply 2486



Accession: 052440277

PMID: 18263785

DOI: 10.1182/blood-2007-10-119867

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Related references

Kees, U.R.; Avramis, V.I., 1995: Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163. 1-beta-D-arabinofuranosyl-5-azacytosine (ara-AC) and 5,6-dihydro-5-azacytidine (DHAC) are two now antitumor agents under clinical investigations, which exhibit the chemical similarities found in the tumoricidal drug cytosine arabinoside (ara-C) an...

Engelborghs, I.; Swennen, R.; Sagi, L., 2000: Fluorescent AFLP analysis on azacytidine and gibberellin treated banana (Musa spp.) plants to assess differences in cytosine methylation and the mechanism of dwarfism. An interesting form of banana is the dwarf type because it is less susceptible to regular tropical storms. Different naturally occurring dwarf varieties exist, but this phenotype is often obtained by in vitro culture. Dwarf types are useful for el...

Skripal', I.G.; Babichev, V.V.; Bezuglyĭ, S.V.; Egorov, O.V.; Korobkova, E.S.; Malinovskaia, L.P.; Panchenko, L.P.; Tokovenko, I.P.; Shalamaĭ, A.S.; Alekseeva, I.V., 1993: The inhibitory action of 6-azacytidine on Mollicutes and its proposed mechanism. 6-Azacytidine (6-AC) is shown to have an inhibitory effect on the Mollicutes of the different systematic position. The growth of type strains of Mollicutes (Acholeplasma laidlawii PG-8, Mycoplasma pneumoniae FH and M. fermentans PG-18) completely...

Mohana Kumar, B.; Jin, H-F.; Kim, J-G.; Song, H-J.; Hong, Y.; Balasubramanian, S.; Choe, S-Y.; Rho, G-J., 2006: DNA methylation levels in porcine fetal fibroblasts induced by an inhibitor of methylation, 5-azacytidine. Removal of the somatic DNA methylation pattern from donor cells and remodeling of embryonic status have been suggested as integral processes for successful nuclear transfer (NT) reprogramming. This study has investigated the effects of 5-azacytidi...

Militello, K.T.; Simon, R.D.; Mandarano, A.H.; DiNatale, A.; Hennick, S.M.; Lazatin, J.C.; Cantatore, S., 2016: 5-azacytidine induces transcriptome changes in Escherichia coli via DNA methylation-dependent and DNA methylation-independent mechanisms. Escherichia coli K-12 strains contain DNA cytosine methyltransferase (Dcm), which generates 5-methylcytosine at 5'CCWGG3' sites. Although the role of 5-methylcytosine in eukaryotic gene expression is relatively well described, the role o...

Fucík, V.; Zadrazil, S.; Jurovcík, M.; Sormová, Z., 1972: Mechanism of resistance to 5-azacytidine in Bacillus subtilis. I. Isolation and some properties of mutants resistant to 5-azacytidine and 5-aza-2'-deoxycytidine. Folia Microbiologica 17(6): 517-521

Voytek, P.; Beisler, J.A.; Abbasi, M.M.; Wolpert-DeFilippes, M.K., 1977: Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine. 5,6-Dihydro-5-azacytidine hydrochloride, a chemically stable, soluble analog of 5-azacytidine, has cytostatic activity against mouse leukemic L1210 cells grown in culture, but concentrations on the order of 10 micronM, 10-fold higher, than the par...

Futterman, B.; Derr, J.; Beisler, J.A.; Abbasi, M.M.; Voytek, P., 1978: Studies on the cytostatic action, phosphorylation and deamination of 5-azacytidine and 5,6-dihydro-5-azacytidine in HeLa cells. Biochemical Pharmacology 27(6): 907-909

Kratzke, R.A.; Wang, X.; Wong, L.; Kratzke, M.G.; Green, M.R.; Vokes, E.E.; Vogelzang, N.J.; Kindler, H.L.; Kern, J.A.; Cooper, M.Robert.; Canellos, G.; Crawford, J.; Rai, K.; Carey, R.; Cooper, B.; Holland, J.; Duggan, D.; Omura, G.; Green, M.; Vogelzang, N.J.; Berkowitz, I.; Aisner, J.; Peterson, B., 2008: Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. Journal of Thoracic Oncology 3(4): 417-421

Veselý, J.; Cihák, A.; Sorm, F., 1968: Biochemical mechanism of drug resistance. VII. Inhibition of orotic acid metabolism by 5-azacytidine in leukemic mice sensitive and resistant to 5-azacytidine. Biochemical Pharmacology 17(4): 519-524