+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Dedifferentiated chondrosarcoma revisited



Dedifferentiated chondrosarcoma revisited



Journal of Surgical Orthopaedic Advances 20(2): 106-111



This article reviews recent molecular, biologic, therapeutic, and clinical findings in dedifferentiated chondrosarcoma. Dedifferentiated chondrosarcoma is one of the most malignant primary bone tumors characterized by two distinct histopathologic components: a well-differentiated chondral lesion sharply juxtaposed with a high-grade noncartilaginous component. Wide or radical surgical resection is mandatory. High-dose radiation therapy is confined to inaccessible sites and palliation. Chemotherapy is administered whenever the dedifferentiated component is chemosensitive and the patient is in good general condition. Despite this approach, metastases will result in poor survival of these patients.

(PDF emailed within 1 workday: $29.90)

Accession: 052463504

Download citation: RISBibTeXText

PMID: 21838071


Related references

Dedifferentiated chondrosarcoma mimicking a giant cell tumor. Is this low grade dedifferentiated chondrosarcoma?. Pathology, Research and Practice 210(3): 194-197, 2014

Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 cases. Cancer 58(2): 278-286, 1986

Different expression of Sox9 and Runx2 between chondrosarcoma and dedifferentiated chondrosarcoma cell line. European Journal of Cancer Prevention 19(6): 466-471, 2011

Chondrosarcoma of the larynx with additional malignant mesenchymal component (dedifferentiated chondrosarcoma). American Journal of Surgical Pathology 12(4): 314-320, 1988

Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone. Bmc Cancer 12: 375-375, 2013

Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study. Cancer 58(2): 287-298, 1986

Juxtacortical dedifferentiated chondrosarcoma from a primary periosteal chondrosarcoma. Modern Pathology 9(3): 279-283, 1996

Dedifferentiated chondrosarcoma: an aggressive variant of chondrosarcoma. Asian Cardiovascular & Thoracic Annals 23(2): 221-223, 2015

Is dedifferentiated chondrosarcoma a 'de-differentiated' chondrosarcoma?. Journal of Pathology 189(4): 445-447, 2000

Case report 347. Dedifferentiated chondrosarcoma: grade 4 fibrosarcoma arising in grade 1 chondrosarcoma (femur). Skeletal Radiology 15(1): 77-81, 1986

Dedifferentiated chondrosarcoma. Journal of Bone and Joint Surgery. American Volume 70(1): 60-69, 1988

Dedifferentiated chondrosarcoma with t(9;22)(q34;q11-12). Genes, Chromosomes & Cancer 9(2): 136-140, 1994

Dedifferentiated chondrosarcoma of the larynx. Pathology Research & Practice 185(1): 144, 1989

Dedifferentiated Chondrosarcoma of the Larynx. Head and Neck Pathology 10(3): 345-348, 2016

Mesenchymal and dedifferentiated chondrosarcoma. Vestnik Rentgenologii i Radiologii: 22-25, 1988