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Demonstration of a Marek's disease virus-specific antigen in tumour lesions of chickens with Marek's disease using monoclonal antibody against a virus phosphorylated protein


Demonstration of a Marek's disease virus-specific antigen in tumour lesions of chickens with Marek's disease using monoclonal antibody against a virus phosphorylated protein



Avian Pathology: Journal of the W.V.P.A 15(3): 503-510



ISSN/ISBN: 0307-9457

PMID: 18766550

DOI: 10.1080/03079458608436311

By use of monoclonal antibody against a Marek's disease virus (MDV) serotype 1-specific phosphorylated protein. MDV antigen-positive cells were demonstrated in tumour lesions of various visceral organs of chickens with Marek's disease. However, these tumour lesions did not appear to have the MDV glycoproteins gA and gB, which are considered to be late gene products of the virus genome. gA and gB as well as the phosphorylated protein were detected in the feather follicle epithelium, which is a permissive site for MDV replication.

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Accession: 052482721

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