EurekaMag PDF full texts Chapter 52,504

Morya, V.K.; Son, M.; Lee, H.-B.; Eun-ki, E.-k. 2014: Design and optimization of SPR-based binding assay for evaluation and screening of MITF-E-box binding inhibitor. Molecular Biotechnology 56(3): 265-273

Rasouli, F.S.; Masoudi, S.F. 2012: Design and optimization of a beam shaping assembly for BNCT based on D-T neutron generator and dose evaluation using a simulated head phantom. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 70(12): 2755-2762

Lakshmi, K.; Lakshmi, S. 2010: Design and optimization of a chemometric-assisted spectrophotometric determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage form. Journal of Young Pharmacists: Jyp 2(1): 85-89

Ji, Y.; Tian, Y.; Ahnfelt, M.; Sui, L. 2014: Design and optimization of a chromatographic purification process for Streptococcus pneumoniae serotype 23F capsular polysaccharide by a Design of Experiments approach. Journal of Chromatography. a 1348: 137-149

Liu, W.C.; Houde-Walter, S.N.; Veasey, D.L.; Peskin, A.P. 2000: Design and optimization of a diode-pumped fiber-coupled yb:er glass waveguide laser. Applied Optics 39(33): 6165-6173

Atalay, Y.T.; Witters, D.; Vermeir, S.; Vergauwe, N.; Verboven, P.; Nicolaï, B.; Lammertyn, J. 2009: Design and optimization of a double-enzyme glucose assay in microfluidic lab-on-a-chip. Biomicrofluidics 3(4): 44103

Bloom, G.; Larat, C.; Lallier, E.; Lee-Bouhours, M.-S.L.; Loiseaux, B.; Huignard, J.-P. 2011: Design and optimization of a high-efficiency array generator in the mid-IR with binary subwavelength grooves. Applied Optics 50(5): 701-709

McAllister, R.G.; Sisan, D.R.; Urbach, J.S. 2008: Design and optimization of a high-speed, high-sensitivity, spinning disk confocal microscopy system. Journal of Biomedical Optics 13(5): 054058

Zheng, X.; Deotte, J.; Alonso, M.P.; Farquar, G.R.; Weisgraber, T.H.; Gemberling, S.; Lee, H.; Fang, N.; Spadaccini, C.M. 2012: Design and optimization of a light-emitting diode projection micro-stereolithography three-dimensional manufacturing system. Review of Scientific Instruments 83(12): 125001

Zhou, S.; Yao, Z. 2014: Design and optimization of a modal- independent linear ultrasonic motor. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 61(3): 535-546

Gheber, L.A.; Hwang, J.; Edidin, M. 1998: Design and optimization of a near-field scanning optical microscope for imaging biological samples in liquid. Applied Optics 37(16): 3574-3581

Wang, L.; Dong, J.; Chen, J.; Eastoe, J.; Li, X. 2009: Design and optimization of a new self-nanoemulsifying drug delivery system. Journal of Colloid and Interface Science 330(2): 443-448

Pandit, N.T.; Patravale, V.B. 2011: Design and optimization of a novel method for extraction of genistein. Indian Journal of Pharmaceutical Sciences 73(2): 184-192

Pierce, K.E.; Mistry, R.; Reid, S.M.; Bharya, S.; Dukes, J.P.; Hartshorn, C.; King, D.P.; Wangh, L.J. 2010: Design and optimization of a novel reverse transcription linear-after-the-exponential PCR for the detection of foot-and-mouth disease virus. Journal of Applied Microbiology 109(1): 180-189

Ma, Y.; Magill, P.; Baehr-Jones, T.; Hochberg, M. 2014: Design and optimization of a novel silicon-on-insulator wavelength diplexer. Optics Express 22(18): 21521-21528

Akowuah, E.K.; Gorman, T.; Haxha, S. 2009: Design and optimization of a novel surface plasmon resonance biosensor based on Otto configuration. Optics Express 17(26): 23511-23521

Braig, C.; Löchel, H.; Mitzner, R.; Quevedo, W.; Loukas, P.; Kubin, M.; Weniger, C.; Firsov, A.; Rehanek, J.; Brzhezinskaya, M.; Wernet, P.; Föhlisch, A.; Erko, A. 2014: Design and optimization of a parallel spectrometer for ultra-fast X-ray science. Optics Express 22(10): 12583-12602

Liu, H.; Queffélec, C.ém.; Charlier, C.; Defontaine, A.; Fateh, A.; Tellier, C.; Talham, D.R.; Bujoli, B. 2014: Design and optimization of a phosphopeptide anchor for specific immobilization of a capture protein on zirconium phosphonate modified supports. Langmuir: the Acs Journal of Surfaces and Colloids 30(46): 13949-13955

Bragheri, F.; Minzioni, P.; Liberale, C.; Di Fabrizio, E.; Cristiani, I. 2008: Design and optimization of a reflection-based fiber-optic tweezers. Optics Express 16(22): 17647-17653

Monrad, J.K.; Srinivas, K.; Howard, L.R.; King, J.W. 2012: Design and optimization of a semicontinuous hot-cold extraction of polyphenols from grape pomace. Journal of Agricultural and Food Chemistry 60(22): 5571-5582

Rankovic, Z.; Cai, J.; Kerr, J.; Fradera, X.; Robinson, J.; Mistry, A.; Hamilton, E.; McGarry, G.; Andrews, F.; Caulfield, W.; Cumming, I.; Dempster, M.; Waller, J.; Scullion, P.; Martin, I.; Mitchell, A.; Long, C.; Baugh, M.; Westwood, P.; Kinghorn, E.; Bruin, J.; Hamilton, W.; Uitdehaag, J.; van Zeeland, M.; Potin, D.; Saniere, L.; Fouquet, A.; Chevallier, F.ço.; Deronzier, H.; Dorleans, C.; Nicolai, E. 2010: Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorganic and Medicinal Chemistry Letters 20(5): 1524-1527

Vaghani, S.S.; Patel, S.G.; Jivani, R.R.; Jivani, N.P.; Patel, M.M.; Borda, R. 2012: Design and optimization of a stomach-specific drug delivery system of repaglinide: application of simplex lattice design. Pharmaceutical Development and Technology 17(1): 55-65

Chen, A.; Bayly, C.; Bezençon, O.; Richard-Bildstein, S.; Dubé, D.; Dubé, L.; Gagné, S.éb.; Gallant, M.; Gaudreault, M.; Grimm, E.; Houle, R.; Lacombe, P.; Laliberté, S.éb.; Lévesque, J.-F.ço.; Liu, S.; MacDonald, D.; Mackay, B.; Martin, D.; McKay, D.; Powell, D.; Remen, L.'u.; Soisson, S.; Toulmond, S. 2010: Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension. Bioorganic and Medicinal Chemistry Letters 20(7): 2204-2209

Rainey, C.L.; Bors, D.E.; Goodpaster, J.V. 2014: Design and optimization of a total vaporization technique coupled to solid-phase microextraction. Analytical Chemistry 86(22): 11319-11325

Smajic, J.; Hafner, C.; Erni, D. 2003: Design and optimization of an achromatic photonic crystal bend. Optics Express 11(12): 1378-1384

Pilar, J.; Slezak, O.; Sikocinski, P.; Divoky, M.; Sawicka, M.; Bonora, S.; Lucianetti, A.; Mocek, T.; Jelinkova, H. 2014: Design and optimization of an adaptive optics system for a high-average-power multi-slab laser (HiLASE). Applied Optics 53(15): 3255-3261

Evans, N.C.; Shealy, D.L. 1998: Design and optimization of an irradiance profile-shaping system with a genetic algorithm method. Applied Optics 37(22): 5216-5221

Rodrigues, D.B.; Maccarini, P.F.; Salahi, S.; Oliveira, T.R.; Pereira, P.J.S.; Limao-Vieira, P.; Snow, B.W.; Reudink, D.; Stauffer, P.R. 2014: Design and optimization of an ultra wideband and compact microwave antenna for radiometric monitoring of brain temperature. IEEE Transactions on Bio-Medical Engineering 61(7): 2154-2160

Gong, Y.; Barbay, J.K.; Buntinx, M.; Li, J.; Wauwe, J.V.; Claes, C.; Lommen, G.V.; Hornby, P.J.; He, W. 2008: Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. Bioorganic and Medicinal Chemistry Letters 18(14): 3852-3855

Parks, D.J.; Parsons, W.H.; Colburn, R.W.; Meegalla, S.K.; Ballentine, S.K.; Illig, C.R.; Qin, N.; Liu, Y.; Hutchinson, T.L.; Lubin, M.L.; Stone, D.J.; Baker, J.F.; Schneider, C.R.; Ma, J.; Damiano, B.P.; Flores, C.M.; Player, M.R. 2011: Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. Journal of Medicinal Chemistry 54(1): 233-247

Ghasemi Nejad, G.R.; Rahmani, F.; Abaeiani, G.R. 2014: Design and optimization of beta-cell temperature sensor based on ⁶³Ni-Si. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 86: 46-51

Dholariya, Y.N.; Bansod, Y.B.; Vora, R.M.; Mittal, S.S.; Shirsat, A.E.; Bhingare, C.L. 2014: Design and optimization of bilayered tablet of Hydrochlorothiazide using the Quality-by-Design approach. International Journal of Pharmaceutical Investigation 4(2): 93-101

Lou, S.; Tang, Z.; Wang, L. 2011: Design and optimization of broadband and polarization-insensitive dual-core photonic crystal fiber coupler. Applied Optics 50(14): 2016-2023

Stiebeiner, A.; Garcia-Fernandez, R.; Rauschenbeutel, A. 2010: Design and optimization of broadband tapered optical fibers with a nanofiber waist. Optics Express 18(22): 22677-22685

Chang, C.-H.; Waller, L.; Barbastathis, G. 2010: Design and optimization of broadband wide-angle antireflection structures for binary diffractive optics. Optics Letters 35(7): 907-909

Elizarov, A.M.; van Dam, R.M.; Shin, Y.S.; Kolb, H.C.; Padgett, H.C.; Stout, D.; Shu, J.; Huang, J.; Daridon, A.; Heath, J.R. 2010: Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis. Journal of Nuclear Medicine: Official Publication Society of Nuclear Medicine 51(2): 282-287

Patel, M.M.; Amin, A.F. 2011: Design and optimization of colon-targeted system of theophylline for chronotherapy of nocturnal asthma. Journal of Pharmaceutical Sciences 100(5): 1760-1772

Monga, V.; Bala, R.; Mo, X. 2012: Design and optimization of color lookup tables on a simplex topology. IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society 21(4): 1981-1996

Shivakumar, H.N.; Desai, B.G.; Deshmukh, G. 2008: Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology. Indian Journal of Pharmaceutical Sciences 70(1): 22-30

Cakic, M.; Mitic, Z.; Nikolic, G.; Savic, I.; Savic, I.M. 2013: Design and optimization of drugs used to treat copper deficiency. Expert Opinion on Drug Discovery 8(10): 1253-1263

Dasgupta, D.; Suman, S.K.; Pandey, D.; Ghosh, D.; Khan, R.; Agrawal, D.; Jain, R.K.; Vadde, V.T.; Adhikari, D.K. 2013: Design and optimization of ethanol production from bagasse pith hydrolysate by a thermotolerant yeast Kluyveromyces sp. IIPE453 using response surface methodology. Springerplus 2(1): 159

Kanmani, P.; Kumar, R.Satish.; Yuvaraj, N.; Paari, K.A.; Pattukumar, V.; Arul, V. 2011: Design and optimization of fermentation medium for enhanced bacteriocin production by probiotic bacterium Enterococcus faecium MC13. Preparative Biochemistry and Biotechnology 41(1): 40-52

Zhang, W.Q.; Sharping, J.E.; White, R.T.; Monro, T.M.; Afshar V, S. 2010: Design and optimization of fiber optical parametric oscillators for femtosecond pulse generation. Optics Express 18(16): 17294-17305

Kharia, A.A.; Hiremath, S.N.; Singhai, A.K.; Omray, L.K.; Jain, S.K. 2010: Design and optimization of floating drug delivery system of acyclovir. Indian Journal of Pharmaceutical Sciences 72(5): 599-606

Hodgson, L.; Pertz, O.; Hahn, K.M. 2008: Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods in Cell Biology 85: 63-81

Zhang, Y.-N.; Ren, L.-Y.; Gong, Y.-K.; Li, X.-H.; Wang, L.-R.; Sun, C.-D. 2010: Design and optimization of highly nonlinear low-dispersion crystal fiber with high birefringence for four-wave mixing. Applied Optics 49(16): 3208-3214

Hoekstra, W.J.; Garvey, E.P.; Moore, W.R.; Rafferty, S.W.; Yates, C.M.; Schotzinger, R.J. 2014: Design and optimization of highly-selective fungal CYP51 inhibitors. Bioorganic and Medicinal Chemistry Letters 24(15): 3455-3458

Chen, X.; Lee, D.-W. 2010: Design and optimization of in-plane actuator driven cantilever with high sensitivity sensors. Journal of Nanoscience and Nanotechnology 10(5): 3236-3240

Parsai, E.I.; Shvydka, D.; Kang, J. 2010: Design and optimization of large area thin-film CdTe detector for radiation therapy imaging applications. Medical Physics 37(8): 3980-3994

Lin, N.; Jiang, L.; Wang, S.; Xiao, H.; Lu, Y.; Tsai, H.-L. 2011: Design and optimization of liquid core optical ring resonator for refractive index sensing. Applied Optics 50(20): 3615-3621

Tang, X.-L.; Sun, B.-S.; Shi, Y.-W. 2011: Design and optimization of low-loss high-birefringence hollow fiber at terahertz frequency. Optics Express 19(25): 24967-24979

Nagendra, C.L.; Viswanathan, M.; Thutupalli, G.K. 1985: Design and optimization of low-loss wideband antireflection coatings for the visible and infrared regions: a new method. Applied Optics 24(8): 1156

Bao, H.; Nielsen, K.; Rasmussen, H.K.; Jepsen, P.U.; Bang, O. 2014: Design and optimization of mechanically down-doped terahertz fiber directional couplers. Optics Express 22(8): 9486-9497

Shah, P.P.; Mashru, R.C.; Rane, Y.M.; Thakkar, A. 2008: Design and optimization of mefloquine hydrochloride microparticles for bitter taste masking. Aaps Pharmscitech 9(2): 377-389

Akatay, A.; Urey, H. 2007: Design and optimization of microlens array based high resolution beam steering system. Optics Express 15(8): 4523-4529

Li, J.; Ji, Z.; Shi, X.; You, F.; Fu, F.; Liu, R.; Xia, J.; Wang, N.; Bai, J.; Wang, Z.; Qin, X.; Dong, X. 2014: Design and optimization of multi-class series-parallel linear electromagnetic array artificial muscle. Bio-Medical Materials and Engineering 24(1): 549-555

Corminboeuf, O.; Bezençon, O.; Grisostomi, C.; Remeň, L.š; Richard-Bildstein, S.; Bur, D.; Prade, L.; Hess, P.; Strickner, P.; Fischli, W.; Steiner, B.; Treiber, A. 2010: Design and optimization of new piperidines as renin inhibitors. Bioorganic and Medicinal Chemistry Letters 20(21): 6286-6290

Tran-Minh, N.; Dong, T.; Su, Q.; Yang, Z.; Jakobsen, H.; Karlsen, F. 2011: Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical carcinoma cells. Biomedical Microdevices 13(1): 179-190

Nakamura, Y.; Sugita, C.; Meguro, M.; Miyazaki, S.; Tamaki, K.; Takahashi, M.; Nagai, Y.; Nagayama, T.; Kato, M.; Suemune, H.; Nishi, T. 2012: Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors. Bioorganic and Medicinal Chemistry Letters 22(14): 4561-4566

Liao, W.; Xu, C.; Ji, X.; Hu, G.; Ren, L.; Liu, Y.; Li, R.; Gong, P.; Sun, T. 2014: Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors. European Journal of Medicinal Chemistry 87: 508-518

Yang, F.; Zhang, T.; Wu, H.; Yang, Y.; Liu, N.; Chen, A.; Li, Q.; Li, J.; Qin, L.; Jiang, B.; Wang, X.; Pang, X.; Yi, Z.; Liu, M.; Chen, Y. 2014: Design and optimization of novel hydroxamate-based histone deacetylase inhibitors of Bis-substituted aromatic amides bearing potent activities against tumor growth and metastasis. Journal of Medicinal Chemistry 57(22): 9357-9369

Tyo, J.S.; Wang, Z.; Johnson, S.J.; Hoover, B.G. 2010: Design and optimization of partial Mueller matrix polarimeters. Applied Optics 49(12): 2326-2333

Hu, D.; Li, M.; Zhou, R.; Sun, Y. 2012: Design and optimization of photo bioreactor for O2 regulation and control by system dynamics and computer simulation. Bioresource Technology 104: 608-615

Choi, J.-K.; Fthenakis, V. 2010: Design and optimization of photovoltaics recycling infrastructure. Environmental Science and Technology 44(22): 8678-8683

Peach, M.S.; Kumbar, S.G.; James, R.; Toti, U.S.; Balasubramaniam, D.; Deng, M.; Ulery, B.; Mazzocca, A.D.; McCarthy, M.B.; Morozowich, N.L.; Allcock, H.R.; Laurencin, C.T. 2012: Design and optimization of polyphosphazene functionalized fiber matrices for soft tissue regeneration. Journal of Biomedical Nanotechnology 8(1): 107-124

Lin, W.; Skinner, C.D. 2009: Design and optimization of porous polymer enzymatic digestors for proteomics. Journal of Separation Science 32(15-16): 2642-2652

Gould, A.E.; Adams, R.; Adhikari, S.; Aertgeerts, K.; Afroze, R.; Blackburn, C.; Calderwood, E.F.; Chau, R.; Chouitar, J.; Duffey, M.O.; England, D.B.; Farrer, C.; Forsyth, N.; Garcia, K.; Gaulin, J.; Greenspan, P.D.; Guo, R.; Harrison, S.J.; Huang, S.-C.; Iartchouk, N.; Janowick, D.; Kim, M.-S.; Kulkarni, B.; Langston, S.P.; Liu, J.X.; Ma, L.-T.; Menon, S.; Mizutani, H.; Paske, E.; Renou, C.C.; Rezaei, M.; Rowland, R.S.; Sintchak, M.D.; Smith, M.D.; Stroud, S.G.; Tregay, M.; Tian, Y.; Veiby, O.P.; Vos, T.J.; Vyskocil, S.; Williams, J.; Xu, T.; Yang, J.J.; Yano, J.; Zeng, H.; Zhang, D.M.; Zhang, Q.; Galvin, K.M. 2011: Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors. Journal of Medicinal Chemistry 54(6): 1836-1846

Brown, A.; Brown, L.; Ellis, D.; Puhalo, N.; Smith, C.R.; Wallace, O.; Watson, L. 2008: Design and optimization of potent, selective antagonists of Oxytocin. Bioorganic and Medicinal Chemistry Letters 18(15): 4278-4281

Uei-Ming Jow; Ghovanloo, M. 2007: Design and optimization of printed spiral coils for efficient transcutaneous inductive power transmission. IEEE Transactions on Biomedical Circuits and Systems 1(3): 193-202

Barlind, J.G.; Bauer, U.A.; Birch, A.M.; Birtles, S.; Buckett, L.K.; Butlin, R.J.; Davies, R.D.M.; Eriksson, J.W.; Hammond, C.D.; Hovland, R.; Johannesson, P.; Johansson, M.J.; Kemmitt, P.D.; Lindmark, B.T.; Morentin Gutierrez, P.; Noeske, T.A.; Nordin, A.; O'Donnell, C.J.; Petersson, A.U.; Redzic, A.; Turnbull, A.V.; Vinblad, J. 2012: Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). Journal of Medicinal Chemistry 55(23): 10610-10629

Sasmal, S.; Balaji, G.; Kanna Reddy, H.R.; Balasubrahmanyam, D.; Srinivas, G.; Kyasa, S.; Sasmal, P.K.; Khanna, I.; Talwar, R.; Suresh, J.; Jadhav, V.P.; Muzeeb, S.; Shashikumar, D.; Harinder Reddy, K.; Sebastian, V.J.; Frimurer, T.M.; Rist, Øy.; Elster, L.; Högberg, T. 2012: Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists. Bioorganic and Medicinal Chemistry Letters 22(9): 3157-3162

Briani, M.; Germani, G.; Iannone, E.; Moroni, M.; Natalini, R. 2013: Design and optimization of reaction chamber and detection system in dynamic labs-on-chip for proteins detection. IEEE Transactions on Bio-Medical Engineering 60(8): 2161-2166

Tice, C.M.; Xu, Z.; Yuan, J.; Simpson, R.D.; Cacatian, S.T.; Flaherty, P.T.; Zhao, W.; Guo, J.; Ishchenko, A.; Singh, S.B.; Wu, Z.; Scott, B.B.; Bukhtiyarov, Y.; Berbaum, J.; Mason, J.; Panemangalore, R.; Cappiello, M.G.; Müller, D.; Harrison, R.K.; McGeehan, G.M.; Dillard, L.W.; Baldwin, J.J.; Claremon, D.A. 2009: Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorganic and Medicinal Chemistry Letters 19(13): 3541-3545

Ramrakhyani, A.K.; Mirabbasi, S.; Mu Chiao 2011: Design and optimization of resonance-based efficient wireless power delivery systems for biomedical implants. IEEE Transactions on Biomedical Circuits and Systems 5(1): 48-63

Tichopad, A.; Kitchen, R.; Riedmaier, I.; Becker, C.; Ståhlberg, A.; Kubista, M. 2009: Design and optimization of reverse-transcription quantitative PCR experiments. Clinical Chemistry 55(10): 1816-1823

Jimenez, J.-M.; Boyall, D.; Brenchley, G.; Collier, P.N.; Davis, C.J.; Fraysse, D.; Keily, S.B.; Henderson, J.; Miller, A.; Pierard, F.; Settimo, L.; Twin, H.C.; Bolton, C.M.; Curnock, A.P.; Chiu, P.; Tanner, A.J.; Young, S. 2013: Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases. Journal of Medicinal Chemistry 56(5): 1799-1810

Ahmed, O.A.A.; Badr-Eldin, S.M.; Tawfik, M.K.; Ahmed, T.A.; El-Say, K.M.; Badr, J.M. 2014: Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity. Journal of Pharmaceutical Sciences 103(2): 602-612

Villar, A.M.S.; Naveros, B.C.; Campmany, A.C.C.; Trenchs, M.A.óz.; Rocabert, C.B.é; Bellowa, L.H. 2012: Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil. International Journal of Pharmaceutics 431(1-2): 161-175

Kucharova, V.; Skancke, J.ør.; Brautaset, T.; Valla, S. 2013: Design and optimization of short DNA sequences that can be used as 5' fusion partners for high-level expression of heterologous genes in Escherichia coli. Applied and Environmental Microbiology 79(21): 6655-6664

Ghica, M.V.; Albu, M.G.; Leca, M.; Popa, L.; Moisescu, S.T. 2011: Design and optimization of some collagen-minocycline based hydrogels potentially applicable for the treatment of cutaneous wound infections. Die Pharmazie 66(11): 853-861

Rumpf, R.C.; Mehta, A.; Srinivasan, P.; Johnson, E.G. 2007: Design and optimization of space-variant photonic crystal filters. Applied Optics 46(23): 5755-5761

Basha, M.; Abd El-Alim, S.H.; Shamma, R.N.; Awad, G.E.A. 2013: Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole. Journal of Liposome Research 23(3): 203-210

Monajjemzadeh, F.; Hamishehkar, H.; Zakeri-Milani, P.; Farjami, A.; Valizadeh, H. 2013: Design and optimization of sustained-release divalproex sodium tablets with response surface methodology. Aaps Pharmscitech 14(1): 245-253

Saggin, B.; Scaccabarozzi, D. 2011: Design and optimization of the calibration procedure for a miniaturized Fourier transform spectrometer. Applied Spectroscopy 65(6): 627-633

Lampen, S.; Dubin, M.; Burge, J.H. 2013: Design and optimization of the sine condition test for measuring misaligned optical systems. Applied Optics 52(29): 7099-7108

Mandal, V.; Dewanjee, S.; Sahu, R.; Mandal, S.C. 2009: Design and optimization of ultrasound assisted extraction of curcumin as an effective alternative for conventional solid liquid extraction of natural products. Natural Product Communications 4(1): 95-100

Kim, M.; Kim, H.; Gweon, D.-G. 2012: Design and optimization of voice coil actuator for six degree of freedom active vibration isolation system using Halbach magnet array. Review of Scientific Instruments 83(10): 105117

Kargar, A.; Chao, C.-Y. 2011: Design and optimization of waveguide sensitivity in slot microring sensors. Journal of the Optical Society of America. a Optics Image Science and Vision 28(4): 596-603

Lei, X.; Wu, K.; Zhao, L.; Chai, X. 2013: Design and optimization of wireless power and data transmission for visual prosthesis. Zhongguo Yi Liao Qi Xie Za Zhi 37(6): 427-431

Korsch, D. 1980: Design and optimization technique for three-mirror telescopes. Applied Optics 19(21): 3640-3645

Chang, M.-W.; Nitzke, S.; Brown, R. 2010: Design and outcomes of a Mothers in Motion behavioral intervention pilot study. Journal of Nutrition Education and Behavior 42(3 Suppl): S11-S21

Robinson, P.W.; Pätynen, J.; Haapaniemi, A.; Kuusinen, A.; Leskinen, P.; Zan-Bi, M.; Lokki, T. 2014: Design and outcomes of an acoustic data visualization seminar. Journal of the Acoustical Society of America 135(1): El41-El46

Cole, E.; Dehdashti, P.; Petti, L.; Angert, M. 1994: Design and outcomes of computer-based cognitive prosthetics for brain injury: a field study of three subjects. Neurorehabilitation 4(3): 174-186

Denktaş, S.; Poeran, J.; van Voorst, S.F.; Vos, A.A.; de Jong-Potjer, L.C.; Waelput, A.J.M.; Birnie, E.; Bonsel, G.J.; Steegers, E.A.P. 2014: Design and outline of the Healthy Pregnancy 4 all study. Bmc Pregnancy and Childbirth 14: 253

Zhou, Y.; Klotzkin, D.J. 2008: Design and parallel fabrication of wire-grid polarization arrays for polarization-resolved imaging at 1.55 microm. Applied Optics 47(20): 3555-3560

Min, B.J.; Mayorov, A.V.; Cai, M.; Palmer, E.; Hruby, V.J. 2009: Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology 611: 187-188

Van der Weeën, P.; Baetens, J.M.; De Baets, B. 2011: Design and parameterization of a stochastic cellular automaton describing a chemical reaction. Journal of Computational Chemistry 32(9): 1952-1961

Mussulman, L.; Ellerbeck, E.F.; Cupertino, A.P.; Preacher, K.J.; Spaulding, R.; Catley, D.; Cox, L.S.; Lambart, L.; Hunt, J.J.; Nazir, N.; Shireman, T.; Richter, K.P. 2014: Design and participant characteristics of a randomized-controlled trial of telemedicine for smoking cessation among rural smokers. Contemporary Clinical Trials 38(2): 173-181

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Tamborrini, M.; Mueller, M.S.; Stoffel, S.A.; Westerfeld, N.; Vogel, D.; Boato, F.; Zurbriggen, R.; Robinson, J.A.; Pluschke, G. 2009: Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine. Malaria Journal 8: 314

Walker, L.E.; Vang, L.; Shen, X.; Livingston, B.D.; Post, P.; Sette, A.; Godin, C.S.; Newman, M.J. 2009: Design and preclinical development of a recombinant protein and DNA plasmid mixed format vaccine to deliver HIV-derived T-lymphocyte epitopes. Vaccine 27(50): 7087-7095

Kampmeier, F.; Williams, J.D.; Maher, J.; Mullen, G.E.; Blower, P.J. 2014: Design and preclinical evaluation of a 99mTc-labelled diabody of mAb J591 for SPECT imaging of prostate-specific membrane antigen (PSMA). Ejnmmi Research 4(1): 13

Krieger, A.; Csoma, C.; Iordachital, I.I.; Guion, P.; Singh, A.K.; Fichtinger, G.; Whitcomb, L.L. 2007: Design and preliminary accuracy studies of an MRI-guided transrectal prostate intervention system. Medical Image Computing and Computer-Assisted Intervention: Miccai . International Conference on Medical Image Computing and Computer-Assisted Intervention 10(Part 2): 59-67

Jin, D.; Wang, D.; Zhang, Y.-Z.; Zhang, Y.-Z.; Xiang, D.-Y.; Qin, Y.; Pei, G.-X. 2009: Design and preliminary clinical application of a new digitalized navigation template for fixation of the inferior tibiofibular joint. Nan Fang Yi Ke da Xue Xue Bao 29(7): 1364-1366

Taheri, H.; Rowe, J.B.; Gardner, D.; Chan, V.; Gray, K.; Bower, C.; Reinkensmeyer, D.J.; Wolbrecht, E.T. 2014: Design and preliminary evaluation of the FINGER rehabilitation robot: controlling challenge and quantifying finger individuation during musical computer game play. Journal of Neuroengineering and Rehabilitation 11: 10

Herman, B.ît.; Dehez, B.; Duy, K.T.; Raucent, B.ît.; Dombre, E.; Krut, S.éb. 2009: Design and preliminary in vivo validation of a robotic laparoscope holder for minimally invasive surgery. International Journal of Medical Robotics + Computer Assisted Surgery: Mrcas 5(3): 319-326

Lee, Y-Han.; Yoon, S-Jun.; Kim, H-Su.; Oh, S-Woo.; Ryu, H-Sihn.; Choo, J-A.; Kim, S-Nam.; Kim, Y-Ae.; Park, M-Suk.; Park, Y-Suk.; Kim, S-Young.; Kwon, A-Rom. 2013: Design and preliminary results of a metropolitan lifestyle intervention program for people with metabolic syndrome in South Korea. Diabetes Research and Clinical Practice 101(3): 293-302

Nascimento, B.; Rizoli, S.; Rubenfeld, G.; Lin, Y.; Callum, J.; Tien, H.C. 2011: Design and preliminary results of a pilot randomized controlled trial on a 1:1:1 transfusion strategy: the trauma formula-driven versus laboratory-guided study. Journal of Trauma 71(5 Suppl 1: S418-S426

AlHabib, K.F.; Elasfar, A.A.; AlBackr, H.; AlFaleh, H.; Hersi, A.; AlShaer, F.; Kashour, T.; AlNemer, K.; Hussein, G.A.; Mimish, L. 2011: Design and preliminary results of the heart function assessment registry trial in Saudi Arabia (HEARTS) in patients with acute and chronic heart failure. European Journal of Heart Failure 13(11): 1178-1184

Elnagar, A.Y.; Wali, V.B.; Sylvester, P.W.; El Sayed, K.A. 2010: Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion. Bioorganic and Medicinal Chemistry 18(2): 755-768

Yoon, W.J.; Brown, M.A.; Reinhall, P.G.; Park, S.; Seibel, E.J. 2012: Design and preliminary study of custom laser scanning cystoscope for automated bladder surveillance. Minimally Invasive Therapy and Allied Technologies: Mitat: Official Journal of the Society for Minimally Invasive Therapy 21(5): 320-328

Kidd, G.; Favrot, S.; Desloge, J.G.; Streeter, T.M.; Mason, C.R. 2013: Design and preliminary testing of a visually guided hearing aid. Journal of the Acoustical Society of America 133(3): El202-El207

Letechipia, J.; Alessi, A.; Rodríguez, G.; Asbun, J. 2014: Design and preliminary testing of an active intramedullary nail. Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 66(Suppl 1): S70-S78

García-Hernández, M.ía.N.; Fraga-Hernández, M.ía.E.; De Armas-Felipe, J.é M.; Aguirre-Jaime, A. 2013: Design and preliminary validation of a tool for nursing assessment and classification for pediatric patients in primary health care emergency. "VEUPAP". Revista de Enfermeria 36(11): 16-25

Aminabadi, N.A.; Sohrabi, A.; Oskouei, S.G.; Aghaee, S.; Jamali, Z.; Ghojazadeh, M. 2013: Design and preliminary validation of the verbal skill scale in the dental setting: an anxiety scale for children. Pediatric Dentistry 35(2): E43-E48

Hattori, G.; Hori, T.; Miyake, Y.; Nishibayashi, Y. 2007: Design and preparation of a chiral ligand based on a pseudorotaxane skeleton: application to rhodium-catalyzed enantioselective hydrogenation of enamides. Journal of the American Chemical Society 129(43): 12930-12931

Li, T.; Sullivan, J.E.; Rosi, N.L. 2013: Design and preparation of a core-shell metal-organic framework for selective CO2 capture. Journal of the American Chemical Society 135(27): 9984-9987

Higa, M.; Yamakawa, T. 2008: Design and preparation of a novel temperature-responsive ionic gel. 3. Valence selective control of transport modes of ions in response to temperature. Journal of Physical Chemistry. B 112(21): 6585-6593

Weiss, M.M.; Williamson, T.; Babu-Khan, S.; Bartberger, M.D.; Brown, J.; Chen, K.; Cheng, Y.; Citron, M.; Croghan, M.D.; Dineen, T.A.; Esmay, J.; Graceffa, R.F.; Harried, S.S.; Hickman, D.; Hitchcock, S.A.; Horne, D.B.; Huang, H.; Imbeah-Ampiah, R.; Judd, T.; Kaller, M.R.; Kreiman, C.R.; La, D.S.; Li, V.; Lopez, P.; Louie, S.; Monenschein, H.; Nguyen, T.T.; Pennington, L.D.; Rattan, C.; San Miguel, T.; Sickmier, E.A.; Wahl, R.C.; Wen, P.H.; Wood, S.; Xue, Q.; Yang, B.H.; Patel, V.F.; Zhong, W. 2012: Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid. Journal of Medicinal Chemistry 55(21): 9009-9024

Yapi, A.-D.és.é; Desbois, N.; Chezal, J.-M.; Chavignon, O.; Teulade, J.-C.; Valentin, A.; Blache, Y. 2010: Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities. European Journal of Medicinal Chemistry 45(7): 2854-2859

Yun, H.-s.; Kim, S.-e.; Hyeon, Y.-t. 2007: Design and preparation of bioactive glasses with hierarchical pore networks. Chemical Communications 21: 2139-2141

Bernstein, J.; Novoa, J.J.; Boese, R.; Cirkel, S.A. 2010: Design and preparation of co-crystals utilizing the R(4)(2)(8) hydrogen-bonding motif. Chemistry 16(30): 9047-9055

Wu, N.-W.; Zhang, J.; Xu, X.-D.; Yang, H.-B. 2014: Design and preparation of ethynyl-pyrene modified platinum-acetylide gelators and their application in dispersion of graphene. Chemical Communications 50(71): 10269-10272

Piccinelli, R.; Pandelova, M.; Le Donne, C.; Ferrari, M.; Schramm, K-W.; Leclercq, C. 2010: Design and preparation of market baskets of European Union commercial baby foods for the assessment of infant exposure to food chemicals and to their effects. Food Additives and Contaminants. Part A Chemistry Analysis Control Exposure and Risk Assessment 27(10): 1337-1351

Melot, B.C.; Tarascon, J.-M. 2013: Design and preparation of materials for advanced electrochemical storage. Accounts of Chemical Research 46(5): 1226-1238

Miyazaki, T.; Tanabe, Y.; Yuki, M.; Miyake, Y.; Nakajima, K.; Nishibayashi, Y. 2013: Design and preparation of molybdenum-dinitrogen complexes with ferrocenyldiphosphine and pentamethylcyclopentadienyl moieties as auxiliary ligands. Chemistry 19(36): 11874-11877

Xu, X.-D.; Zhang, J.; Yu, X.; Chen, L.-J.; Wang, D.-X.; Yi, T.; Li, F.; Yang, H.-B. 2012: Design and preparation of platinum-acetylide organogelators containing ethynyl-pyrene moieties as the main skeleton. Chemistry 18(50): 16000-16013

Lu, G.; Cui, S.-J.; Geng, X.; Ye, L.; Chen, B.; Feng, Z.-G.; Zhang, J.; Li, Z.-Z. 2013: Design and preparation of polyurethane-collagen/heparin-conjugated polycaprolactone double-layer bionic small-diameter vascular graft and its preliminary animal tests. Chinese Medical Journal 126(7): 1310-1316

Wu, D.; Xu, F.; Sun, B.; Fu, R.; He, H.; Matyjaszewski, K. 2012: Design and preparation of porous polymers. Chemical Reviews 112(7): 3959-4015

Bezençon, O.; Bur, D.; Weller, T.; Richard-Bildstein, S.; Remen, L.; Sifferlen, T.; Corminboeuf, O.; Grisostomi, C.; Boss, C.; Prade, L.; Delahaye, S.ép.; Treiber, A.; Strickner, P.; Binkert, C.; Hess, P.; Steiner, B.; Fischli, W. 2009: Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. Journal of Medicinal Chemistry 52(12): 3689-3702

Sanchez-Sanchez, A.; Akbari, S.; Moreno, A.J.; Verso, F.L.; Arbe, A.; Colmenero, J.; Pomposo, J.é A. 2013: Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos. Macromolecular Rapid Communications 34(21): 1681-1686

Gigante, F.; Kaiser, M.; Brun, R.; Gilbert, I.H. 2010: Design and preparation of sterol mimetics as potential antiparasitics. Bioorganic and Medicinal Chemistry 18(20): 7291-7301

Zhang, Y.Z.; Lu, S.; Yang, Y.; Xu, Y.Q.; Li, Y.B.; Pei, G.X. 2011: Design and primary application of computer-assisted, patient-specific navigational templates in metal-on-metal hip resurfacing arthroplasty. Journal of Arthroplasty 26(7): 1083-1087

Ding, F.; Lee, K.J.; Vahedi-Faridi, A.; Huang, T.; Xu, X.-H.N. 2011: Design and probing of efflux functions of EGFP fused ABC membrane transporters in live cells using fluorescence spectroscopy. Analytical and Bioanalytical Chemistry 400(1): 223-235

Pauwels, E.; Van Hoof, E.; Charlier, C.; Lechner, L.; De Bourdeaudhuij, I. 2012: Design and process evaluation of an informative website tailored to breast cancer survivors' and intimate partners' post-treatment care needs. Bmc Research Notes 5: 548

Paz-Pascual, C.; Pinedo, I.A.; Grandes, G.; de Gamboa, G.R.F.; Hermosilla, I.O.; de la Hera, A.B.; Gordon, J.P.; Garcia, G.M.; de Pedro, M.U. 2008: Design and process of the EMA Cohort Study: the value of antenatal education in childbirth and breastfeeding. Bmc Nursing 7: 5

Arnfast, L.ær.; Madsen, C.G.; Jorgensen, L.; Baldursdottir, S. 2014: Design and processing of nanogels as delivery systems for peptides and proteins. Therapeutic Delivery 5(6): 691-708

Willoughby, A.F.W. 2006: Design and processing of porous materials for electronic applications. Philosophical Transactions. Series A Mathematical Physical and Engineering Sciences 364(1838): 175-187

Su, S.; Moran, K.; Robar, J.L. 2014: Design and production of 3D printed bolus for electron radiation therapy. Journal of Applied Clinical Medical Physics 15(4): 4831

Bracalello, A.; Santopietro, V.; Vassalli, M.; Marletta, G.; Del Gaudio, R.; Bochicchio, B.; Pepe, A. 2011: Design and production of a chimeric resilin-, elastin-, and collagen-like engineered polypeptide. Biomacromolecules 12(8): 2957-2965

Janicki, V.; Amotchkina, T.V.; Sancho-Parramon, J.; Zorc, H.; Trubetskov, M.K.; Tikhonravov, A.V. 2011: Design and production of bicolour reflecting coatings with au metal island films. Optics Express 19(25): 25521-25527

Aquino, R.P.; Auriemma, G.; Mencherini, T.; Russo, P.; Porta, A.; Adami, R.; Liparoti, S.; Della Porta, G.; Reverchon, E.; Del Gaudio, P. 2013: Design and production of gentamicin/dextrans microparticles by supercritical assisted atomisation for the treatment of wound bacterial infections. International Journal of Pharmaceutics 440(2): 188-194

Powers, G.A.; Hudson, P.J.; Wheatcroft, M.P. 2012: Design and production of multimeric antibody fragments, focused on diabodies with enhanced clinical efficacy. Methods in Molecular Biology 907: 699-712

Anton, N.; Benoit, J-Pierre.; Saulnier, P. 2008: Design and production of nanoparticles formulated from nano-emulsion templates-a review. Journal of Controlled Release: Official Journal of the Controlled Release Society 128(3): 185-199

Schambach, A.; Swaney, W.P.; van der Loo, J.C.M. 2009: Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells. Methods in Molecular Biology 506: 191-205

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Schlegel, R.; Hänke, T.; Baumann, D.; Kaiser, M.; Nag, P.K.; Voigtländer, R.; Lindackers, D.; Büchner, B.; Hess, C. 2014: Design and properties of a cryogenic dip-stick scanning tunneling microscope with capacitive coarse approach control. Review of Scientific Instruments 85(1): 013706

Randhawa, S.; González, M.ía.U.é; Renger, J.; Enoch, S.; Quidant, R. 2010: Design and properties of dielectric surface plasmon Bragg mirrors. Optics Express 18(14): 14496-14510

Laberty-Robert, C.; Vallé, K.; Pereira, F.; Sanchez, C. 2011: Design and properties of functional hybrid organic-inorganic membranes for fuel cells. Chemical Society Reviews 40(2): 961-1005

Chapman, R.; Danial, M.; Koh, M.L.; Jolliffe, K.A.; Perrier, S.éb. 2012: Design and properties of functional nanotubes from the self-assembly of cyclic peptide templates. Chemical Society Reviews 41(18): 6023-6041

Liu, X.; Sun, Y.; Hsu, B.B.Y.; Lorbach, A.; Qi, L.; Heeger, A.J.; Bazan, G.C. 2014: Design and properties of intermediate-sized narrow band-gap conjugated molecules relevant to solution-processed organic solar cells. Journal of the American Chemical Society 136(15): 5697-5708

Van Maarseveen, E.M.; Bouma, A.; Touw, D.J.; Neef, C.; van Zanten, A.R.H. 2014: Design and prospective validation of a dosing instrument for continuous infusion of vancomycin: a within-population approach. European Journal of Clinical Pharmacology 70(11): 1353-1359

Sonntag, F.; Schilling, N.; Mader, K.; Gruchow, M.; Klotzbach, U.; Lindner, G.; Horland, R.; Wagner, I.; Lauster, R.; Howitz, S.; Hoffmann, S.; Marx, U. 2010: Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. Journal of Biotechnology 148(1): 70-75

Deslandes, S.; Baudet, A.; Berthelot, M.; Grancher, S.; Moissenet, F. 2012: Design and prototyping of a system for ankle spasticity quantification. Computer Methods in Biomechanics and Biomedical Engineering 15 Suppl. 1: 237-239

Rossotti, H.S. 1974: Design and publication of work on stability constants. Talanta 21(8): 809-829

Pontoriero, G.; Tetta, C.; Wratten, M.L.; Locatelli, F. 2001: Design and quality assurance of new dialysis centers. Saudi Journal of Kidney Diseases and Transplantation: An Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia 12(3): 413-419

Ordoñez, A.A.L.; Ordoñez, R.M.; Zampini, I.C.; Isla, M.ía.I. 2009: Design and quality control of a pharmaceutical formulation containing natural products with antibacterial, antifungal and antioxidant properties. International Journal of Pharmaceutics 378(1-2): 51-58

Grinev, V.V. 2012: Design and quality control of short interfering RNAs. Molekuliarnaia Biologiia 46(6): 827-845

Anderson, P.; Madden, R. 2011: Design and quality of ICF-compatible data items for national disability support services. Disability and Rehabilitation 33(9): 758-769

Margolis, K.L.; Kerby, T.J.; Asche, S.E.; Bergdall, A.R.; Maciosek, M.V.; O'Connor, P.J.; Sperl-Hillen, J.M. 2012: Design and rationale for Home Blood Pressure Telemonitoring and Case Management to Control Hypertension (HyperLink): a cluster randomized trial. Contemporary Clinical Trials 33(4): 794-803

Klausen, S.H.; Mikkelsen, U.R.; Hirth, A.; Wetterslev, J.ør.; Kjærgaard, H.; Søndergaard, L.; Andersen, L.L. 2012: Design and rationale for the PREVAIL study: effect of e-Health individually tailored encouragements to physical exercise on aerobic fitness among adolescents with congenital heart disease--a randomized clinical trial. American Heart Journal 163(4): 549-556

Bonaca, M.P.; Bhatt, D.L.; Braunwald, E.; Cohen, M.; Steg, P.Gabriel.; Storey, R.F.; Held, P.; Jensen, E.C.; Sabatine, M.S. 2014: Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. American Heart Journal 167(4): 437-444.E5

Lencioni, R.; Marrero, J.; Venook, A.; Ye, S.-L.; Kudo, M. 2010: Design and rationale for the non-interventional Global Investigation of Therapeutic DEcisions in Hepatocellular Carcinoma and of its Treatment with Sorafenib (GIDEON) study. International Journal of Clinical Practice 64(8): 1034-1041

Mehta, S.R.; Bassand, J.-P.; Chrolavicius, S.; Diaz, R.; Fox, K.A.A.; Granger, C.B.; Jolly, S.; Rupprecht, H.-J.; Widimsky, P.; Yusuf, S.; Mehta, S.R.; Ajani, A.; Avezum, A.; Bassand, J.P.; Boden, W.E.; Budaj, A.; Cardona, E.; Chrolavicius, S.; Col, J.; Commerford, P.; Di Pasquale, G.; Diaz, R.; Eha, J.; Eikelboom, J.W.; Faxon, D.P.; Flather, M.; Foley, D.; Fox, K.A.A.; Franzosi, M.G.; Granger, C.B.; Gupta, M.; Jolly, S.; Joyner, C.; Karatzas, N.; Kastrati, A.; Kim, J.H.; Koh, T.H.; Lanas, F.; Lewis, B.; Macaya, C.; Moccetti, T.; Montalescot, G.; Niemela, K.; Ongen, Z.; Orlandini, A.; Pais, P.; Peters, R.J.G.; Piegas, L.; Probstfield, J.; Rankin, J.; Ruda, M.; Rumboldt, Z.; Rupprecht, H.J.; Steg, P.G.; Tanguay, J.-F.; Valentin, V.; Varigos, 2008: Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy. American Heart Journal 156(6): 1080-1088.E1

Hájek, R.; Bryce, R.; Ro, S.; Klencke, B.; Ludwig, H. 2012: Design and rationale of FOCUS (PX-171-011): a randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM). Bmc Cancer 12: 415

Huisman, M.V.; Lip, G.Y.H.; Diener, H.C.; Dubner, S.J.; Halperin, J.L.; Ma, C.S.; Rothman, K.J.; Teutsch, C.; Zint, K.; Ackermann, D.; Clemens, A.; Bartels, D.B. 2014: Design and rationale of Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: a global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation. American Heart Journal 167(3): 329-334

Ando, K.; Haneda, M.; Ito, S.; Kashihara, N.; Node, K.; Nangaku, M.; Shimosawa, T.; Kishimoto, J.; Fujita, T. 2011: Design and rationale of Japanese evaluation between Formula of Azelnidipine and amlodipine add on olmesartan to get antialbuminuric effect study (J-FLAG) : evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria. Cardiovascular Drugs and Therapy 25(4): 341-347

Dean, O.M.; Turner, A.; Malhi, G.S.; Ng, C.; Cotton, S.M.; Dodd, S.; Sarris, J.; Samuni, Y.; Tanious, M.; Dowling, N.; Waterdrinker, A.; Smith, D.; Berk, M. 2015: Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression. Revista Brasileira de Psiquiatria 37(1): 3-12

Rutledge, T.; Nidich, S.; Schneider, R.H.; Mills, P.J.; Salerno, J.; Heppner, P.; Gomez, M.A.; Gaylord-King, C.; Rainforth, M. 2014: Design and rationale of a comparative effectiveness trial evaluating transcendental meditation against established therapies for PTSD. Contemporary Clinical Trials 39(1): 50-56

Dubé, M-Pierre.; Bigras, J-Luc.; Thibeault, M.; Bureau, N.; Chetaille, P.; Richter, A.; Mercier, J.; Bellavance, M.; Rohlicek, C.; Rozen, R.; Nemer, M.; Khairy, P.; Gendron, R.; Andelfinger, G. 2011: Design and rationale of a genetic cohort study on congenital cardiac disease: experiences from a multi-institutional platform in Quebec. Cardiology in the Young 21(6): 654-664

Goodrich, D.E.; Kilbourne, A.M.; Lai, Z.; Post, E.P.; Bowersox, N.W.; Mezuk, B.; Schumacher, K.; Bramlet, M.; Welsh, D.E.; Bauer, M.S. 2012: Design and rationale of a randomized controlled trial to reduce cardiovascular disease risk for patients with bipolar disorder. Contemporary Clinical Trials 33(4): 666-678

Ohye, R.G.; Gaynor, J.W.; Ghanayem, N.S.; Goldberg, C.S.; Laussen, P.C.; Frommelt, P.C.; Newburger, J.W.; Pearson, G.D.; Tabbutt, S.; Wernovsky, G.; Wruck, L.M.; Atz, A.M.; Colan, S.D.; Jaggers, J.; McCrindle, B.W.; Prakash, A.; Puchalski, M.D.; Sleeper, L.A.; Stylianou, M.P.; Mahony, L.; Pearson, G.; Pemberton, V.; Kavey, R.-E.; Massicot-Fisher, J.; Mathis, M.; Stylianou, M.; Mahony, L.; Sleeper, L.; Colan, S.D.; Connell, P.; Murtov, V.; Wruck, L.; Virzi, L.; Teitel, D.F.; Newburger, J.; Laussen, P.; del Nido, P.; Breitbart, R.; Levine, J.; McGrath, E.; Dunbar-Masterson, C.; Hsu, D.; Prakash, A.; Mosca, R.; Servedio, D.; Vetter, V.L.; Tabbutt, S.; Gaynor, J.W.; Nolan, M.; Piacentino, S.; Benson, D.W.; Dent, C.; Bogenschutz, L.; Barnard, T. 2008: Design and rationale of a randomized trial comparing the Blalock-Taussig and right ventricle-pulmonary artery shunts in the Norwood procedure. Journal of Thoracic and Cardiovascular Surgery 136(4): 968-975

Amann, B.; Lüdemann, C.; Rückert, R.; Lawall, H.; Liesenfeld, B.; Schneider, M.; Schmidt-Lucke, J. 2008: Design and rationale of a randomized, double-blind, placebo-controlled phase IIi study for autologous bone marrow cell transplantation in critical limb ischemia: the BONe Marrow Outcomes Trial in Critical Limb Ischemia (BONMOT-CLI). VASA. Zeitschrift für Gefasskrankheiten 37(4): 319-325

Zamorano, J.é; Erdine, S.; Lopez, A.P.; Kim, J.-H.; Al Khadra, A.; Westergaard, M.; Sutradhar, S.; Yunis, C.; Gamboa-Garro, R.; Moya-Rodriguez, J.; Ramirez, L.C.; Slon-Hitti, C.; Tortos-Guzman, J.E.; Vinocour-Fornieri, M.; Bokarica, D.; Bezdrov, M.; Car, I.; Cikac, T.; Cop, R.; Hrandek, B.H.; Javoric, J.; Kotur, G.; Kranjcevic, K.; Lazic, G.; Maravic, Z.; Margetic, S.; Primorac, L.; Prlina, M.; Smiciklas, N.F.; Stritof, M.; Vivoda, Z.B.; Vrdoljak, D.; Herle, P.; Kos, P.; Marek, V.; Miskovska, Z.; Moravcikova, D.; Motlikova, E.; Nejedla, A.; Seifert, B.; Skala, B.; Vecerek, M.; Winklerova, J.; Almonte, C.; Gonzalez-Medina, A.; Pichardo, R.; Chandradin, C.; Harahap, M.L.; Kusmana, D.; Lukito, A.A.; Makmun, L.H.; Martanto, E.; Rifqi, S.; Yogi 2010: Design and rationale of a real-life study to compare treatment strategies for cardiovascular risk factors: the CRUCIAL study. Postgraduate Medicine 122(2): 7-15

Curtis, L.H.; Mi, X.; Qualls, L.G.; Hammill, B.G.; Hammill, S.C.; Heidenreich, P.A.; Masoudi, F.A.; Setoguchi, S.; Hernandez, A.F.; Fonarow, G.C. 2012: Design and rationale of a retrospective clinical effectiveness study of aldosterone antagonist therapy in patients with heart failure. American Heart Journal 163(6): 946-953.E1

Ge, J.; Kim, Y.-J.; Jang, Y.-S.; Zhu, J.; Marschner, I.C.; Lam, W. 2010: Design and rationale of a study in Asia of atorvastatin pretreatment in patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndromes. Journal of Cardiology 55(3): 303-308

Jhamb, M.; Tamura, M.K.; Gassman, J.; Garg, A.X.; Lindsay, R.M.; Suri, R.S.; Ting, G.; Finkelstein, F.O.; Beach, S.; Kimmel, P.L.; Unruh, M. 2011: Design and rationale of health-related quality of life and patient-reported outcomes assessment in the Frequent Hemodialysis Network trials. Blood Purification 31(1-3): 151-158

Gaies, M.G.; Langer, M.; Alexander, J.; Steil, G.M.; Ware, J.; Wypij, D.; Laussen, P.C.; Newburger, J.W.; Goldberg, C.S.; Pigula, F.A.; Shukla, A.C.; Duggan, C.P.; Agus, M.S.D.; Costello, J.M.; Curley, M.A.; Del Nido, P.J.; Sadhwani, A.; Gaies, M.G.; Goldberg, C.S.; Langer, M.; Alexander, J.; Steil, G.M.; Ware, J.; Wypij, D.; Laussen, P.C.; Newburger, J.W.; Pigula, F.A.; Shukla, A.C.; Duggan, C.P.; Agus, M.S.D. 2013: Design and rationale of safe pediatric euglycemia after cardiac surgery: a randomized controlled trial of tight glycemic control after pediatric cardiac surgery. Pediatric Critical Care Medicine: a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14(2): 148-156

Gibson, C.Michael.; Krucoff, M.; Kirtane, A.J.; Rao, S.V.; Mackall, J.A.; Matthews, R.; Saba, S.; Waksman, R.; Holmes, D. 2014: Design and rationale of the ANALYZE ST study: a prospective, nonrandomized, multicenter ST monitoring study to detect acute coronary syndrome events in implantable cardioverter-defibrillator patients. American Heart Journal 168(4): 424-429.E1

de Andrade, P.Beraldo.; E Mattos, L.Alberto.Piva.; Tebet, M.André.; Rinaldi, Fábio.Salerno.; Esteves, Vícius.Cardozo.; Nogueira, E.Ferreira.; França, Jão.Ítalo.Dias.; de Andrade, Mônica.Vieira.Athanazio.; Barbosa, R.Alves.; Labrunie, Aé.; Abizaid, A.Antônio.Cunha.; Sousa, A.Guerra.de.Moraes.Rego. 2013: Design and rationale of the AngioSeal versus the Radial approach In acute coronary SyndromE (ARISE) trial: a randomized comparison of a vascular closure device versus the radial approach to prevent vascular access site complications in non-ST-segment elevation acute coronary syndrome patients. Trials 14: 435

Melloni, C.; Fier, I.; Roach, J.; Kosinski, A.S.; Broderick, S.; Sigmon, K.; Myles, S.; Becker, R.C.; Rao, S.V. 2009: Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary int Ervention (EMINENCE) trial. American Heart Journal 158(5): 726-733

Cho, L.; Rocco, M.; Colquhoun, D.; Sullivan, D.; Rosenson, R.S.; Dent, R.; Xue, A.; Scott, R.; Wasserman, S.M.; Stroes, E. 2014: Design and rationale of the GAUSS-2 study trial: a double-blind, ezetimibe-controlled phase 3 study of the efficacy and tolerability of evolocumab (AMG 145) in subjects with hypercholesterolemia who are intolerant of statin therapy. Clinical Cardiology 37(3): 131-139

Kohli, P.; Desai, N.R.; Giugliano, R.P.; Kim, J.B.; Somaratne, R.; Huang, F.; Knusel, B.; McDonald, S.; Abrahamsen, T.; Wasserman, S.M.; Scott, R.; Sabatine, M.S. 2012: Design and rationale of the LAPLACE-TIMi 57 trial: a phase II, double-blind, placebo-controlled study of the efficacy and tolerability of a monoclonal antibody inhibitor of PCSK9 in subjects with hypercholesterolemia on background statin therapy. Clinical Cardiology 35(7): 385-391

Straka, Z.ěk.; Budera, P.; Osmančík, P.; Vaněk, T.áš; Hulman, M.; Smíd, M.; Malý, M.; Widimský, P. 2013: Design and rationale of the PRAGUE-12 trial: a large, prospective, randomized, multicenter trial that compares cardiac surgery with left atrial surgical ablation with cardiac surgery without ablation in patients with coronary and/or valvular heart disease plus atrial fibrillation. Clinical Cardiology 36(1): 1-5

Weatherley, B.D.; Cotter, G.; Dittrich, H.C.; DeLucca, P.; Mansoor, G.A.; Bloomfield, D.M.; Ponikowski, P.; O'Connor, C.M.; Metra, M.; Massie, B.M.; Adams, K.; Allall, O.; Ambrosia, A.; Amosova, K.; Amuchastegui, M.; Aronson, D.; Arutyunov, G.; Balbi, M.; Banerjee, P.; Bart, B.; Bellersen, L.; Belohlávek, J.; Bensimhon, D.; Billberg, E.B.; Bilsker, M.; Bleyer, F.L.; Böhm, M.; Boldueva, S.; Bourge, R.; Bozkurt, B.; Butnaru, A.; Cabuay, B.; Caccavo, A.; Chandrasekaran, S.; Chiong, J.; Chung, E.; Cleland, J.G.; Cohen-Solal, A.; Colque, R.M.A.; Colvin-Adams, M.; Convens, C.; Cooke, R.; Cornel, J.H.; Czerska, B.; Dahlström, U.; Diez, M.; Dluzniewski, M.; El Allaf, D.; Dorobantu C, M.; Ducharme, A.; Dunlap, M.; Dunlap, S.; Elkayam, U.; Ez 2010: Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect on congestion and renal function. Journal of Cardiac Failure 16(1): 25-35

Alphs, L.; Mao, L.; Rodriguez, S.C.; Hulihan, J.; Starr, H.Lynn. 2014: Design and rationale of the Paliperidone Palmitate Research in Demonstrating Effectiveness (PRIDE) study: a novel comparative trial of once-monthly paliperidone palmitate versus daily oral antipsychotic treatment for delaying time to treatment failure in persons with schizophrenia. Journal of Clinical Psychiatry 75(12): 1388-1393

Melloni, C.; Rao, S.V.; Povsic, T.J.; Melton, L.; Kim, R.J.; Kilaru, R.; Patel, M.R.; Talan, M.; Ferrucci, L.; Longo, D.L.; Lakatta, E.G.; Najjar, S.S.; Harrington, R.A. 2010: Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial. American Heart Journal 160(5): 795-803.E2

Jolly, S.S.; Cairns, J.; Yusuf, S.; Meeks, B.; Shestakovska, O.; Thabane, L.; Niemelä, K.; Steg, P.G.; Bertrand, O.F.; Rao, S.V.; Avezum, A.; Cantor, W.J.; Pancholy, S.B.; Moreno, R.; Gershlick, A.; Bhindi, R.; Welsh, R.C.; Cheema, A.N.; Lavi, S.; Rokoss, M.; Džavík, V.ír. 2014: Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCi ALone in patients with ST-elevation myocardial infarction undergoing primary PCi. American Heart Journal 167(3): 315-321.E1

Klomp, M.; Beijk, M.A.M.; Verouden, N.J.W.; Tijssen, J.G.P.; de Winter, R.J.; Debbas; Benit; Coussement; Ylitalo; Sia; Teiger; Grollier; Montalescot; Gommeaux; Machecourt; Bea; von Scheidt; Pfeifer; Khattab; Rittger; Sick; Radke; Wiemer; Braun; Manginas; Manolis; Tsui; Erglis; Sim; Varma; Ionescu; Menown; Koolen; den Heijer; Schotborgh; de Winter 2009: Design and rationale of the TRI-stent adjudication study (TRIAS) program. American Heart Journal 158(4): 527-532.E1

Pang, P.S.; Tavares, M.; Collins, S.P.; Cleland, J.G.F.; Hollander, J.; Nieminen, M.; Miller, C.; Courtney, D.Mark.; Kirk, J.Douglas.; Masip, J.; Parkhomenko, A.; Macarie, C.; Peacock, W.Frank.; Spinar, J.; Nowak, R.; Raev, D.; Storrow, A.B.; Spisak, V.; Hamdy, A.; Mebazaa, A.; Gheorghiade, M. 2008: Design and rationale of the URGENT Dyspnea study: an international, multicenter, prospective study. American Journal of Therapeutics 15(4): 299-303

Scorletti, E.; Bhatia, L.; McCormick, K.G.; Clough, G.F.; Nash, K.; Calder, P.C.; Byrne, C.D. 2014: Design and rationale of the WELCOME trial: A randomised, placebo controlled study to test the efficacy of purified long chainomega-3 fatty acid treatment in non-alcoholic fatty liver disease [corrected. Contemporary Clinical Trials 37(2): 301-311

Dewilde, W.; Berg, J.ën.T. 2009: Design and rationale of the WOEST trial: what is the Optimal antiplat Elet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing (WOEST). American Heart Journal 158(5): 713-718

Gilliam, F.R.; Giudici, M.; Benn, A.; Koplan, B.; Berg, K.J.C.; Kraus, S.M.; Stolen, K.Q.; Alvarez, G.E.; Hopper, D.L.; Wilkoff, B.L. 2011: Design and rationale of the assessment of proper physiologic response with rate adaptive pacing driven by minute ventilation or accelerometer (APPROPRIATE) trial. Journal of Cardiovascular Translational Research 4(1): 21-26

Dodson, J.A.; Geda, M.; Krumholz, H.M.; Lorenze, N.; Murphy, T.E.; Allore, H.G.; Charpentier, P.; Tsang, S.W.; Acampora, D.; Tinetti, M.E.; Gill, T.M.; Chaudhry, S.I. 2014: Design and rationale of the comprehensive evaluation of risk factors in older patients with AMi (SILVER-AMI) study. Bmc Health Services Research 14: 506

Jolly, S.S.; Niemelä, K.; Xavier, D.; Widimsky, P.; Budaj, A.; Valentin, V.; Lewis, B.S.; Avezum, A.; Steg, P.G.; Rao, S.V.; Cairns, J.; Chrolavicius, S.; Yusuf, S.; Mehta, S.R. 2011: Design and rationale of the radial versus femoral access for coronary intervention (RIVAL) trial: a randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromes. American Heart Journal 161(2): 254-260.E1-4

Matsuoka, H.; Ando, K.; Ueshima, K.; Babazono, T.; Kario, K.; Tanaka, S.; Nakao, K.; Fujita, T. 2011: Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial. Clinical and Experimental Hypertension 33(7): 455-462

Chow, C.K.; Redfern, J.; Thiagalingam, A.; Jan, S.; Whittaker, R.; Hackett, M.; Graves, N.; Mooney, J.; Hillis, G.S. 2012: Design and rationale of the tobacco, exercise and diet messages (TEXT ME) trial of a text message-based intervention for ongoing prevention of cardiovascular disease in people with coronary disease: a randomised controlled trial protocol. Bmj Open 2(1): E000606

Steg, P.G.; Mehta, S.R.; Pollack, C.V.; Bode, C.; Gaudin, C.; Fanouillere, K.; Moryusef, A.; Wiviott, S.D.; Sabatine, M.S. 2012: Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy. American Heart Journal 164(6): 817-24.E13

Clark, D.O.; Keith, N.; Chrysler, L.; Perkins, A.J.; Willis, D. 2008: Design and reach of a primary care weight management program. Journal of Health Care for the Poor and Underserved 19(1): 171-179

Shen, S.; Ramer, R.; Banciu, M.; Mansour, R. 2005: Design and realisation of star-geometry dual-mode bandpass filter. Optics Express 13(24): 9753-9757

Lopresto, V.; Pinto, R.; Lodato, R.; Lovisolo, G.A.; Cavagnaro, M. 2012: Design and realisation of tissue-equivalent dielectric simulators for dosimetric studies on microwave antennas for interstitial ablation. Physica Medica: Pm: An International Journal Devoted to the Applications of Physics to Medicine and Biology: Official Journal of the Italian Association of Biomedical Physics 28(3): 245-253

Bo, T.; Cui, Y.; Qian, L.; Luo, S. 2013: Design and realization of X-ray TUBE HEAD control system in the CBCT system. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 30(4): 838-842

Sun, X.-H.; Guo, Y.-B.; Liu, N.; Ma, L.; Deng, Q.-K. 2011: Design and realization of a microarray data analysis platform. Nan Fang Yi Ke da Xue Xue Bao 31(4): 610-614

Azim, R.; Islam, M.T.; Misran, N.; Yatim, B.; Arshad, H. 2014: Design and realization of a planar ultrawideband antenna with notch band at 3.5 GHz. Thescientificworldjournal 2014: 563830

Masilamani, A.P.; Van, V. 2012: Design and realization of a two-stage microring ladder filter in silicon-on-insulator. Optics Express 20(22): 24708-24713

Becher, K.; Figueiredo, C.P.; Muhle, C.; Ruff, R.; Mendes, P.M.; Hoffmann, K.P. 2010: Design and realization of a wireless sensor gateway for health monitoring. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2010: 374-377

Becker, H.; Tonova, D.; Sundermann, M.; Ehlers, H.; Günster, S.; Ristau, D. 2014: Design and realization of advanced multi-index systems. Applied Optics 53(4): A88-A95

Li, K.; Liu, Z.; Liu, S.; He, L.; Luo, Z.; Wang, H. 2012: Design and realization of an algorithm for capsule endoscope image recognition system. Nan Fang Yi Ke da Xue Xue Bao 32(7): 948-951

Varshney, R.K.; Nagaraju, B.; Singh, A.; Pal, B.P.; Kar, A.K. 2007: Design and realization of an all-fiber broadband tunable gain equalization filter for DWDM signals. Optics Express 15(21): 13519-13530

Pfenniger, A.; Wickramarathna, L.N.; Vogel, R.; Koch, V.M. 2013: Design and realization of an energy harvester using pulsating arterial pressure. Medical Engineering and Physics 35(9): 1256-1265

Yu, X.-t.; Tang, G.-c.; Zhu, B.-k. 2010: Design and realization of reverse presumption system for public health emergencies based on symptoms and signs. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28(8): 616-617

Ji, L.; Guo, X.; Shi, H. 2013: Design and realization of the communication system for the mobile medical terminal. Zhongguo Yi Liao Qi Xie Za Zhi 37(1): 37-39

Xu, X.; Ji, X.; An, M.; Hu, X.; Hu, X. 2013: Design and realization of training methods based on sit-to-stand balance ability training apparatus. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 30(3): 534

Tan, J.H.Y.; Canals, M.; Ludeman, J.P.; Wedderburn, J.; Boston, C.; Butler, S.J.; Carrick, A.M.; Parody, T.R.; Taleski, D.; Christopoulos, A.; Payne, R.J.; Stone, M.J. 2012: Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1). Journal of Biological Chemistry 287(18): 14692-14702

Luo, X.; Bathgate, R.A.D.; Zhang, W.-J.; Liu, Y.-L.; Shao, X.-X.; Wade, J.D.; Guo, Z.-Y. 2010: Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5. Amino Acids 39(5): 1343-1352

Cao, X.; Zhang, Y.; Mao, R.; Teng, D.; Wang, X.; Wang, J. 2015: Design and recombination expression of a novel plectasin-derived peptide MP1106 and its properties against Staphylococcus aureus. Applied Microbiology and Biotechnology 99(6): 2649-2662

Stolley, M.R.; Sharp, L.K.; Arroyo, C.; Ruffin, C.; Restrepo, J.; Campbell, R. 2009: Design and recruitment of the Chicago Healthy Living Study: a study of health behaviors in a diverse cohort of adult childhood cancer survivors. Cancer 115(18 Suppl): 4385-4396

Moriuchi, T.; Hirao, T. 2012: Design and redox function of conjugated complexes with polyanilines or quinonediimines. Accounts of Chemical Research 45(3): 347-360

Vlahov, I.R.; Wang, Y.; Kleindl, P.J.; Leamon, C.P. 2008: Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides. Bioorganic and Medicinal Chemistry Letters 18(16): 4558-4561

Vlahov, I.R.; You, F.; Santhapuram, H.K.R.; Wang, Y.; Vaughn, J.F.; Hahn, S.J.; Kleindl, P.J.; Fan, M.; Leamon, C.P. 2011: Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation. Bioorganic and Medicinal Chemistry Letters 21(4): 1202-1205

Garudachari, B.; Isloor, A.M.; Satyanarayana, M.N.; Fun, H.-K.; Pavithra, N.; Kulal, A. 2013: Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents. European Journal of Medicinal Chemistry 68: 422-432

Franzen, S.; Martin, J.L. 1995: Design and regulation of efficient photoinduced electron transfer in macromolecular and photosynthetic systems. Annual Review of Physical Chemistry 46: 453-488

Zeng, Y.; Ci, L.; Carey, B.J.; Vajtai, R.; Ajayan, P.M. 2010: Design and reinforcement: vertically aligned carbon nanotube-based sandwich composites. Acs Nano 4(11): 6798-6804

Sman, A.D.; Hiller, C.E.; Imer, A.; Ocsing, A.; Burns, J.; Refshauge, K.M. 2014: Design and reliability of a novel heel rise test measuring device for plantarflexion endurance. Biomed Research International 2014: 391646

Song, K.; Qi, J.; Lin, T.; Zhang, Y. 2011: Design and research of an interface compatible non-contacting respiratory signal detection system. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 28(3): 465-469

Xu, H.-l. 2009: Design and research of hospital medical supplies management information system. Zhongguo Yi Liao Qi Xie Za Zhi 33(2): 140-143

Aitaoto, N.; Braun, K.L.; Estrella, J.; Epeluk, A.; Tsark, J. 2012: Design and results of a culturally tailored cancer outreach project by and for Micronesian women. Preventing Chronic Disease 9: E82

Comin, A.; Stegeman, J.A.; Klinkenberg, D.; Busani, L.; Marangon, S. 2011: Design and results of an intensive monitoring programme for avian influenza in meat-type turkey flocks during four epidemics in northern Italy. Zoonoses and Public Health 58(4): 244-251

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Jiang, W.X.; Xu, B.B.; Cheng, Q.; Cui, T.J.; Yu, G.X. 2013: Design and rigorous analysis of transformation-optics scaling devices. Journal of the Optical Society of America. a Optics Image Science and Vision 30(8): 1698-1702

Faulkner, J.W.; Easton, Z.M.; Zhang, W.; Geohring, L.D.; Steenhuis, T.S. 2010: Design and risk assessment tool for vegetative treatment areas receiving agricultural wastewater: preliminary results. Journal of Environmental Management 91(8): 1794-1801

Matausek, M.R.; Ribić, A.I. 2009: Design and robust tuning of control scheme based on the PD controller plus Disturbance Observer and low-order integrating first-order plus dead-time model. Isa Transactions 48(4): 410-416

Pannifex, J.; Cetiner, E.; Wilkie, T.; Kelly, A-Maree.; Babl, F.; Barrett, T.; Black, A.; Cetiner, E.; Herrington, T.; Kelly, A.M.; Krieser, D.; McLaughlin, L.; Oakley, E.; Pannifex, J.; Silk, G.; Tully, M.; Wilkie, T.; Williams, K. 2013: Design and roll out of standardised approach to paediatric procedural sedation in Victorian emergency departments. Emergency Medicine Australasia: Ema 25(6): 597-602

Tu, S-Hao.; Chen, C.; Hsieh, Y-Te.; Chang, H-Yi.; Yeh, C-Jung.; Lin, Y-Chin.; Pan, W-Harn. 2011: Design and sample characteristics of the 2005-2008 Nutrition and Health Survey in Taiwan. Asia Pacific journal of clinical nutrition 20(2): 225-237

Huang, Q.; Chen, G.; Yuan, Z.; Lan, K.K.Gordon. 2012: Design and sample size considerations for simultaneous global drug development program. Journal of Biopharmaceutical Statistics 22(5): 1060-1073

Fang, H-Bin.; Tian, G-Liang.; Li, W.; Tan, M. 2009: Design and sample size for evaluating combinations of drugs of linear and loglinear dose-response curves. Journal of Biopharmaceutical Statistics 19(4): 625-640

Krischan, J.; Makaruk, A.; Harasek, M. 2012: Design and scale-up of an oxidative scrubbing process for the selective removal of hydrogen sulfide from biogas. Journal of Hazardous Materials 215-216: 49-56

Tremblay, E.J.; Marks, D.L.; Brady, D.J.; Ford, J.E. 2012: Design and scaling of monocentric multiscale imagers. Applied Optics 51(20): 4691-4702

Chen, X.; Orser, B.A.; MacDonald, J.F. 2010: Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. European Journal of Pharmacology 648(1-3): 15-23

Georgieva, Y.; Konthur, Z.án. 2011: Design and screening of M13 phage display cDNA libraries. Molecules 16(2): 1667-1681

Heffernan, C.; Sumer, H.; Guillemin, G.J.; Manuelpillai, U.; Verma, P.J. 2012: Design and screening of a glial cell-specific, cell penetrating peptide for therapeutic applications in multiple sclerosis. Plos one 7(9): E45501

Nasheri, N.; Pezacki, J.P.; Sagan, S.M. 2013: Design and screening of si RNAs against highly structured RNA targets. Methods in Molecular Biology 942: 69-86

Hakamata, W.; Kurihara, M.; Okuda, H.; Nishio, T.; Oku, T. 2009: Design and screening strategies for alpha-glucosidase inhibitors based on enzymological information. Current Topics in Medicinal Chemistry 9(1): 3-12

Fu, X.; Gao, X.; He, S.; Huang, D.; Zhang, P.; Wang, X.; Zhang, S.; Dang, R.; Yin, S.; Du, E.; Yang, Z. 2013: Design and selection of a camelid single-chain antibody yeast two-hybrid library produced de novo for the cap protein of porcine circovirus type 2 (PCV2). Plos one 8(3): E56222

Lu, W-Cheng.; Ellington, A.D. 2014: Design and selection of a synthetic operon. Acs Synthetic Biology 3(6): 410-415

Ahn-Jarvis, J.H.; Riedl, K.M.; Schwartz, S.J.; Vodovotz, Y. 2013: Design and selection of soy breads used for evaluating isoflavone bioavailability in clinical trials. Journal of Agricultural and Food Chemistry 61(12): 3111-3120

Zhang, L.; Villalobos, A.; Beck, E.M.; Bocan, T.; Chappie, T.A.; Chen, L.; Grimwood, S.; Heck, S.D.; Helal, C.J.; Hou, X.; Humphrey, J.M.; Lu, J.; Skaddan, M.B.; McCarthy, T.J.; Verhoest, P.R.; Wager, T.T.; Zasadny, K. 2013: Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand. Journal of Medicinal Chemistry 56(11): 4568-4579

Duan, P.; Liu, M. 2009: Design and self-assembly of L-glutamate-based aromatic dendrons as ambidextrous gelators of water and organic solvents. Langmuir: the Acs Journal of Surfaces and Colloids 25(15): 8706-8713

Koley, P.; Gayen, A.; Drew, M.G.B.; Mukhopadhyay, C.; Pramanik, A. 2012: Design and self-assembly of a leucine-enkephalin analogue in different nanostructures: application of nanovesicles. Small 8(7): 984-990

Wu, T.; Lin, Y.-J.; Jin, G.-X. 2014: Design and self-assembly of variform organometallic macrocycle with terminal imidazole-based bridging ligands utilizing joints twist and rotation. Dalton Transactions 43(6): 2356-2360

Kombrink, K.; Munk, A.; Friede, T. 2013: Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data. Statistics in Medicine 32(18): 3055-3066

Sakamoto, S.; Terauchi, M.; Araki, Y.; Wada, T. 2013: Design and semisynthesis of photoactivable split-GFP by incorporation of photocleavable functionality. Biopolymers 100(6): 773-779

Airoudj, A.; Debarnot, D.; Bêche, B.; Poncin-Epaillard, F. 2008: Design and sensing properties of an integrated optical gas sensor based on a multilayer structure. Analytical Chemistry 80(23): 9188-9194

Möglich, A.; Ayers, R.A.; Moffat, K. 2009: Design and signaling mechanism of light-regulated histidine kinases. Journal of Molecular Biology 385(5): 1433-1444

Deen, M.J.; Thompson, E.D. 1989: Design and simulated performance of a CARS spectrometer for dynamic temperature measurements using electronic heterodyning. Applied Optics 28(7): 1409-1416

Varshney, S.K.; Sasaki, K.; Saitoh, K.; Koshiba, M. 2008: Design and simulation of 1310 nm and 1480 nm single-mode photonic crystal fiber Raman lasers. Optics Express 16(2): 549-559

Milder, P.A.; Bouziane, R.; Koutsoyannis, R.; Berger, C.R.; Benlachtar, Y.; Killey, R.I.; Glick, M.; Hoe, J.C. 2011: Design and simulation of 25 Gb/s optical OFDM transceiver ASICs. Optics Express 19(26): B337-B342

San, H.; Yao, S.; Wang, X.; Cheng, Z.; Chen, X. 2013: Design and simulation of GaN based Schottky betavoltaic nuclear micro-battery. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 80: 17-22

Wang, C.K.; Seidaliev, M.; Mandapaka, A.K. 2007: Design and simulation of a GEM-based TEPC as a neutron REM meter. Radiation Protection Dosimetry 126(1-4): 559-563

Chang, H.; Jiao, W.; Fu, Q.; Xie, J.; Yuan, W. 2010: Design and simulation of a MEMS control moment gyroscope for the sub-kilogram spacecraft. Sensors 10(4): 4130-4144

Baeza, D.án.; Gerdtzen, Z.P.; Salgado, C.J. 2011: Design and simulation of a controller system for metabolic shift regulation in mammalian cells. Bmc Proceedings 5(Suppl 8): P11

Van Audenhaege, K.; Vandenberghe, S.; Deprez, K.; Vandeghinste, B.; Van Holen, R. 2013: Design and simulation of a full-ring multi-lofthole collimator for brain SPECT. Physics in Medicine and Biology 58(18): 6317-6336

Taheri, A.N.; Kaatuzian, H. 2014: Design and simulation of a nanoscale electro-plasmonic 1 × 2 switch based on asymmetric metal-insulator-metal stub filters. Applied Optics 53(28): 6546-6553

Pazirandeh, A.; Torkamani, A.; Taheri, A. 2011: Design and simulation of a neutron source based on an electron linear accelerator for BNCT of skin melanoma. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 69(5): 749-755

Arazpour, M.; Chitsazan, A.; Hutchins, S.W.; Ghomshe, F.T.; Mousavi, M.E.; Takamjani, E.E.; Aminian, G.; Rahgozar, M.; Bani, M.A. 2012: Design and simulation of a new powered gait orthosis for paraplegic patients. Prosthetics and Orthotics International 36(1): 125-130

Ito, M.; Lee, J.S.; Park, M.-J.; Sim, K.-S.; Hong, S.J. 2010: Design and simulation of a novel method for determining depth-of-interaction in a PET scintillation crystal array using a single-ended readout by a multi-anode PMT. Physics in Medicine and Biology 55(13): 3827-3841

Mohammadi, H.; Boughner, D.; Millon, L.E.; Wan, W.K. 2009: Design and simulation of a poly(vinyl alcohol)-bacterial cellulose nanocomposite mechanical aortic heart valve prosthesis. Proceedings of the Institution of Mechanical Engineers. Part H Journal of Engineering in Medicine 223(6): 697-711

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Tandon, S.; Devarajan, V.; Richter, E. 2008: Design and simulation of a visual and haptic assisted biopsy (ViHAB) system. Studies in Health Technology and Informatics 132: 514-516

Yao, S.; Song, Z.; Wang, X.; San, H.; Yu, Y. 2012: Design and simulation of betavoltaic battery using large-grain polysilicon. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 70(10): 2388-2394

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Oddo, A.; Holl, R. 2012: Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue. Carbohydrate Research 359: 59-64

Zhu, S.-L.; Wu, Y.; Liu, C.-J.; Wei, C.-Y.; Tao, J.-C.; Liu, H.-M. 2013: Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents. European Journal of Medicinal Chemistry 65: 70-82

Ivanova, D.; Gronemeyer, H.; de Lera, A.R. 2011: Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells. Chemmedchem 6(8): 1518-1529

Fu, Y.; Zhang, Y.; Hu, H.; Chen, Y.; Wang, R.; Li, D.; Liu, S. 2014: Design and straightforward synthesis of novel galloyl phytosterols with excellent antioxidant activity. Food Chemistry 163: 171-177

Howard, N.I.; Dias, M.V.B.; Peyrot, F.; Chen, L.; Schmidt, M.F.; Blundell, T.L.; Abell, C. 2015: Design and structural analysis of aromatic inhibitors of type Ii dehydroquinase from Mycobacterium tuberculosis. Chemmedchem 10(1): 116-133

Lin, C.-H.; Peng, Y.-H.; Coumar, M.S.; Chittimalla, S.K.; Liao, C.-C.; Lyn, P.-C.; Huang, C.-C.; Lien, T.-W.; Lin, W.-H.; Hsu, J.T.-A.; Cheng, J.-H.; Chen, X.; Wu, J.-S.; Chao, Y.-S.; Lee, H.-J.; Juo, C.-G.; Wu, S.-Y.; Hsieh, H.-P. 2009: Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists. Journal of Medicinal Chemistry 52(8): 2618-2622

Gushchina, L.V.; Gabdulkhakov, A.G.; Filimonov, V.V. 2009: Design and structural and thermodynamic studies of a chimeric protein derived from spectrin SH3-domain. Molekuliarnaia Biologiia 43(3): 483-491

Abe, S.; Ueno, T.; Reddy, P.A.N.; Okazaki, S.; Hikage, T.; Suzuki, A.; Yamane, T.; Nakajima, H.; Watanabe, Y. 2007: Design and structure analysis of artificial metalloproteins: selective coordination of His64 to copper complexes with square-planar structure in the apo-myoglobin scaffold. Inorganic Chemistry 46(13): 5137-5139

Ayuso-Tejedor, S.; Angarica, V.E.; Bueno, M.; Campos, L.A.; Abián, O.; Bernadó, P.; Sancho, J.; Jiménez, M.A. 2010: Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins. Journal of Molecular Biology 400(4): 922-934

Phillips, C.; Roberts, L.R.; Schade, M.; Bazin, R.; Bent, A.; Davies, N.L.; Moore, R.; Pannifer, A.D.; Pickford, A.R.; Prior, S.H.; Read, C.M.; Scott, A.; Brown, D.G.; Xu, B.; Irving, S.L. 2011: Design and structure of stapled peptides binding to estrogen receptors. Journal of the American Chemical Society 133(25): 9696-9699

Zhylitskaya, H.A.; Zhabinskii, V.N.; Litvinovskaya, R.P.; Lettieri, R.; Monti, D.; Venanzi, M.; Khripach, V.A.; Drašar, P. 2012: Design and studies of novel polyoxysterol-based porphyrin conjugates. Steroids 77(11): 1169-1175

Ma, Y.; Xiao, S.; Yang, G.; Zhang, L. 2014: Design and study of a coplanar grid array CdZnTe detector for improved spatial resolution. Applied Radiation and Isotopes: Including Data Instrumentation and Methods for use in Agriculture Industry and Medicine 94: 314-318

Atheba, P.; Robert, D.; Trokourey, A.; Bamba, D.; Weber, J.-V. 2009: Design and study of a cost-effective solar photoreactor for pesticide removal from water. Water Science and Technology: a Journal of the International Association on Water Pollution Research 60(8): 2187-2193

Yu, L.; Lin, G.-y.; Qu, Y.; Wang, S.-r.; Wang, L.-q. 2011: Design and study of a high resolution vacuum ultraviolet imaging spectrometer carried by satellite. Guang Pu Xue Yu Guang Pu Fen Xi 31(12): 3417-3422

Ravi, P.R.; Ganga, S.; Saha, R.N. 2007: Design and study of lamivudine oral controlled release tablets. Aaps Pharmscitech 8(4): E101

Yokohama, N. 2013: Design and study of parallel computing environment of Monte Carlo simulation for particle therapy planning using a public cloud-computing infrastructure. Nihon Hoshasen Gijutsu Gakkai Zasshi 69(7): 773-777

Muthusamy, K.; Arvidsson, P.I.; Govender, P.; Kruger, H.G.; Maguire, G.E.M.; Govender, T. 2010: Design and study of peptide-based inhibitors of amylin cytotoxicity. Bioorganic and Medicinal Chemistry Letters 20(4): 1360-1362

Ding, F.; Lee, K.J.; Vahedi-Faridi, A.; Yoneyama, H.; Osgood, C.J.; Xu, X.-H.N. 2014: Design and study of the efflux function of the EGFP fused MexAB-OprM membrane transporter in Pseudomonas aeruginosa using fluorescence spectroscopy. Analyst 139(12): 3088-3096

Senthilkumar, S.; Vinothraj, R. 2012: Design and study of ultrasound-based automatic patient movement monitoring device for quantifying the intrafraction motion during teletherapy treatment. Journal of Applied Clinical Medical Physics 13(6): 3709

Loukopoulou, A.N.; Vardavas, C.I.; Farmakides, G.; Rossolymos, C.; Chrelias, C.; Tzatzarakis, M.N.; Tsatsakis, A.; Lymberi, M.; Connolly, G.N.; Behrakis, P.K. 2011: Design and study protocol of the maternal smoking cessation during pregnancy study, (M-SCOPE). Bmc Public Health 11: 903

Li, B.; Zhi, Y.'n.; Sun, J.; Zhang, N.; Zhou, Y.; Wang, L.; Hou, P.; Liu, L. 2013: Design and sub-beam phase measurement of Dammann grating with three-phase array output. Optics Letters 38(15): 2663-2665

El-Kurdi, M.S.; Vipperman, J.S.; Vorp, D.A. 2009: Design and subspace system identification of an ex vivo vascular perfusion system. Journal of Biomechanical Engineering 131(4): 041012

Zhang, C.-J.; Chen, Z.-W.; Lin, R.-G.; Zhang, M.-J.; Li, P.-X.; Wang, M.-S.; Guo, G.-C. 2014: Design and syntheses of electron-transfer photochromic metal-organic complexes using nonphotochromic ligands: a model compound and the roles of its ligands. Inorganic Chemistry 53(2): 847-851

Kamino, S.; Murakami, M.; Tanioka, M.; Shirasaki, Y.; Watanabe, K.; Horigome, J.; Ooyama, Y.; Enomoto, S. 2014: Design and syntheses of highly emissive aminobenzopyrano-xanthene dyes in the visible and far-red regions. Organic Letters 16(1): 258-261

Jiang, L.-L.; Zuo, Y.; Wang, Z.-F.; Tan, Y.; Wu, Q.-Y.; Xi, Z.; Yang, G.-F. 2011: Design and syntheses of novel N-(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors. Journal of Agricultural and Food Chemistry 59(11): 6172-6179

Nokihara, K.; Yajima, S.; Hirata, A. 2014: Design and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP. Prion 8(1): 117-118

Zhang, P.Y.; Wong, I.L.K.; Yan, C.S.W.; Zhang, X.Y.; Jiang, T.; Chow, L.M.C.; Wan, S.B. 2010: Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells. Journal of Medicinal Chemistry 53(14): 5108-5120

Smith, A.B.; Sugasawa, K.; Atasoylu, O.; Yang, C.-P.H.; Horwitz, S.B. 2011: Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity. Journal of Medicinal Chemistry 54(18): 6319-6327

Papahatjis, D.P.; Nahmias, V.R.; Nikas, S.P.; Schimpgen, M.; Makriyannis, A. 2010: Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids. Chemistry 16(13): 4091-4099

Jobson, N.K.; Crawford, A.R.; Dewar, D.; Pimlott, S.L.; Sutherland, A. 2009: Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters 19(17): 4996-4998

Mishra, C.B.; Sharma, D.; Prakash, A.; Kumari, N.; Kumar, N.; Luthra, P.M. 2013: Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists. Bioorganic and Medicinal Chemistry 21(19): 6077-6083

Malik, S.; Khan, S.A. 2014: Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents. Journal of Enzyme Inhibition and Medicinal Chemistry 29(4): 505-516

Das, B.C.; Mahalingam, S.M.; Evans, T.; Kabalka, G.W.; Anguiano, J.; Hema, K. 2009: Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol. Chemical Communications 16: 2133-2135

Xia, G.; Liu, L.; Liu, H.; Yu, J.; Xu, Z.; Chen, Q.; Ma, C.; Li, P.; Xiong, B.; Liu, X.; Shen, J. 2013: Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Chemmedchem 8(4): 577-581

Arjmand, F.; Sayeed, F.; Parveen, S.; Tabassum, S.; Juvekar, A.S.; Zingde, S.M. 2013: Design and synthesis of (S)- and (R)-enantiomers of [4-(2-hydroxy-1-phenylethylimino)pent-2-ol]dimethyltin(iv) and 2,2-dimethyl-4-phenyl-1,3,2-oxazastannolidine: in vitro antitumor activity against human tumor cell lines and in vivo assay of (S)-enantiomers. Dalton Transactions 42(10): 3390-3401

Takeda, R.; Kawamura, A.; Kawashima, A.; Moriwaki, H.; Sato, T.; Aceña, J.é L.; Soloshonok, V.A. 2014: Design and synthesis of (S)- and (R)-α-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of α-amino acids. Organic and Biomolecular Chemistry 12(32): 6239-6249

Das Adhikary, N.; Chattopadhyay, P. 2012: Design and synthesis of 1,2,3-triazole-fused chiral medium-ring benzo-heterocycles, scaffolds mimicking benzolactams. Journal of Organic Chemistry 77(12): 5399-5405

Kumar, A.; Tripathi, V.D.; Kumar, P.; Gupta, L.P.; Akanksha; Trivedi, R.; Bid, H.; Nayak, V.L.; Siddiqui, J.A.; Chakravarti, B.; Saxena, R.; Dwivedi, A.; Siddiquee, M.I.; Siddiqui, U.; Konwar, R.; Chattopadhyay, N. 2011: Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents. Bioorganic and Medicinal Chemistry 19(18): 5409-5419

Shi, J.; Xu, G.; Zhu, W.; Ye, H.; Yang, S.; Luo, Y.; Han, J.; Yang, J.; Li, R.; Wei, Y.; Chen, L. 2010: Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(14): 4273-4278

Choi, S.-J.; Cho, J.-H.; Im, I.; Lee, S.-D.; Jang, J.-Y.; Oh, Y.-M.; Jung, Y.-K.; Jeon, E.-S.; Kim, Y.-C. 2010: Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors. European Journal of Medicinal Chemistry 45(6): 2578-2590

Jeanty, M.; Suzenet, F.; Delagrange, P.; Nosjean, O.; Boutin, J.A.; Caignard, D.H.; Guillaumet, G.ér. 2011: Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists. Bioorganic and Medicinal Chemistry Letters 21(8): 2316-2319

Banala, A.K.; Zhang, P.; Plenge, P.; Cyriac, G.; Kopajtic, T.; Katz, J.L.; Loland, C.J.; Newman, A.H. 2013: Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites. Journal of Medicinal Chemistry 56(23): 9709-9724

Zuo, Y.; Yang, S.-G.; Luo, Y.-P.; Tan, Y.; Hao, G.-F.; Wu, Q.-Y.; Xi, Z.; Yang, G.-F. 2013: Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors. Bioorganic and Medicinal Chemistry 21(11): 3245-3255

Chien, T.-C.; Drach, J.C.; Townsend, L.B. 2008: Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides. Nucleic Acids Symposium Series 52: 593-594

Jiang, R.; Frackowiak, B.; Shin, Y.; Song, X.; Chen, W.; Lin, L.; Cameron, M.D.; Duckett, D.R.; Kamenecka, T.M. 2013: Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(9): 2683-2687

Deng, X.-Q.; Wei, C.-X.; Li, F.-N.; Sun, Z.-G.; Quan, Z.-S. 2010: Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity. European Journal of Medicinal Chemistry 45(7): 3080-3086

Zhu, J. 2013: Design and synthesis of 16-membered cyclopeptides active against vancomycin-resistant Enterococci (VRE). Chimia 67(12-13): 916-920

Kim, S.; Cho, S.-N.; Oh, T.; Kim, P. 2012: Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents. Bioorganic and Medicinal Chemistry Letters 22(22): 6844-6847

Kumar, A.; Sharma, S.; Tripathi, V.D.; Maurya, R.A.; Srivastava, S.P.; Bhatia, G.; Tamrakar, A.K.; Srivastava, A.K. 2010: Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents. Bioorganic and Medicinal Chemistry 18(11): 4138-4148

Hsin, L.-W.; Chang, L.-T.; Rothman, R.B.; Dersch, C.M.; Jacobson, A.E.; Rice, K.C. 2008: Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. Journal of Medicinal Chemistry 51(9): 2795-2806

Nikalje, A.P.G.; Khan, F.K.; Ghodke, M. 2011: Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents. European Journal of Medicinal Chemistry 46(11): 5448-5455

Rawal, R.K.; Tripathi, R.; Katti, S.B.; Pannecouque, C.; De Clercq, E. 2008: Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents. European Journal of Medicinal Chemistry 43(12): 2800-2806

Huang, S.-M.; Cheng, Y.-Y.; Chen, M.-H.; Huang, C.-H.; Huang, L.-J.; Hsu, M.-H.; Kuo, S.-C.; Lee, K.-H. 2013: Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents. Bioorganic and Medicinal Chemistry Letters 23(3): 699-701

Chang, Y.-H.; Hsu, M.-H.; Wang, S.-H.; Huang, L.-J.; Qian, K.; Morris-Natschke, S.L.; Hamel, E.; Kuo, S.-C.; Lee, K.-H. 2009: Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly. Journal of Medicinal Chemistry 52(15): 4883-4891

Qian, Y.; Bolin, D.; Conde-Knape, K.; Gillespie, P.; Hayden, S.; Huang, K.-S.; Olivier, A.ée.R.; Sato, T.; Xiang, Q.; Yun, W.; Zhang, X. 2013: Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators. Bioorganic and Medicinal Chemistry Letters 23(10): 2936-2940

Gao, Q.; Wu, X.; Jia, F.; Liu, M.; Zhu, Y.; Cai, Q.; Wu, A. 2013: Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones. Journal of Organic Chemistry 78(6): 2792-2797

Zhou, D.; Lee, H.; Rothfuss, J.M.; Chen, D.L.; Ponde, D.E.; Welch, M.J.; Mach, R.H. 2009: Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. Journal of Medicinal Chemistry 52(8): 2443-2453

Suda, A.; Kawasaki, K.-i.; Komiyama, S.; Isshiki, Y.; Yoon, D.-O.; Kim, S.-J.; Na, Y.-J.; Hasegawa, K.; Fukami, T.A.; Sato, S.; Miura, T.; Ono, N.; Yamazaki, T.; Saitoh, R.; Shimma, N.; Shiratori, Y.; Tsukuda, T. 2014: Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors. Bioorganic and Medicinal Chemistry 22(2): 892-905

Hanan, E.J.; Fucini, R.V.; Romanowski, M.J.; Elling, R.A.; Lew, W.; Purkey, H.E.; VanderPorten, E.C.; Yang, W. 2008: Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 18(19): 5186-5189

Fucini, R.V.; Hanan, E.J.; Romanowski, M.J.; Elling, R.A.; Lew, W.; Barr, K.J.; Zhu, J.; Yoburn, J.C.; Liu, Y.; Fahr, B.T.; Fan, J.; Lu, Y.; Pham, P.; Choong, I.C.; VanderPorten, E.C.; Bui, M.; Purkey, H.E.; Evanchik, M.J.; Yang, W. 2008: Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorganic and Medicinal Chemistry Letters 18(20): 5648-5652

Annadurai, S.; Martinez, R.; Canney, D.J.; Eidem, T.; Dunman, P.M.; Abou-Gharbia, M. 2012: Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. Bioorganic and Medicinal Chemistry Letters 22(24): 7719-7725

Keurulainen, L.; Salin, O.; Siiskonen, A.; Kern, J.M.; Alvesalo, J.; Kiuru, P.; Maass, M.; Yli-Kauhaluoma, J.; Vuorela, P. 2010: Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. Journal of Medicinal Chemistry 53(21): 7664-7674

La Regina, G.; Bai, R.; Rensen, W.; Coluccia, A.; Piscitelli, F.; Gatti, V.; Bolognesi, A.; Lavecchia, A.; Granata, I.; Porta, A.; Maresca, B.; Soriani, A.; Iannitto, M.L.; Mariani, M.; Santoni, A.; Brancale, A.; Ferlini, C.; Dondio, G.; Varasi, M.; Mercurio, C.; Hamel, E.; Lavia, P.; Novellino, E.; Silvestri, R. 2011: Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. Journal of Medicinal Chemistry 54(24): 8394-8406

Zhai, X.; Li, W.; Chen, D.; Lai, R.; Liu, J.; Gong, P. 2012: Design and synthesis of 2-iminothiazolidin-4-one moiety-containing compounds as potent antiproliferative agents. Archiv der Pharmazie 345(5): 360-367

Winters, T.; Sercel, A.; Suto, C.; Elliott, W.; Leopold, W.; Leopold, J.; Showalter, H. 2014: Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality. Chemical and Pharmaceutical Bulletin 62(3): 301-303

Moradi, A.; Navidpour, L.; Amini, M.; Sadeghian, H.; Shadnia, H.; Firouzi, O.; Miri, R.; Ebrahimi, S.E.S.; Abdollahi, M.; Zahmatkesh, M.H.; Shafiee, A. 2010: Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents. Archiv der Pharmazie 343(9): 509-518

Fuse, S.; Inaba, K.; Takagi, M.; Tanaka, M.; Hirokawa, T.; Johmoto, K.; Uekusa, H.; Shin-Ya, K.; Takahashi, T.; Doi, T. 2013: Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone a. European Journal of Medicinal Chemistry 66: 180-184

El Kazzouli, S.ïd.; Griffon du Bellay, A.; Berteina-Raboin, S.; Delagrange, P.; Caignard, D.-H.; Guillaumet, G.ér. 2011: Design and synthesis of 2-phenylimidazo[1,2-a]pyridines as a novel class of melatonin receptor ligands. European Journal of Medicinal Chemistry 46(9): 4252-4257

Chen, W.; Shen, Y.; Li, Z.; Zhang, M.; Lu, C.; Shen, Y. 2014: Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents. European Journal of Medicinal Chemistry 86: 782-796

Duan, Y.-T.; Wang, Z.-C.; Sang, Y.-L.; Tao, X.-X.; Teraiya, S.B.; Wang, P.-F.; Wen, Q.; Zhou, X.-J.; Ding, L.; Yang, Y.-H.; Zhu, H.-L. 2014: Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors. European Journal of Medicinal Chemistry 76: 387-396

Chandrasekharappa, A.P.; Badiger, S.E.; Dubey, P.K.; Panigrahi, S.K.; Manukonda, S.R.V.V.V. 2013: Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. Bioorganic and Medicinal Chemistry Letters 23(9): 2579-2584

Matsuo, M.; Hasegawa, A.; Takano, M.; Saito, H.; Kakuda, S.; Takagi, K.; Ochiai, E.; Horie, K.; Takimoto-Kamimura, M.; Takenouchi, K.; Sawada, D.; Kittaka, A. 2014: Design and synthesis of 2α-(tetrazolylethyl)-1α,25-dihydroxyvitamin D3 as a high affinity ligand for vitamin D receptor. Journal of Steroid Biochemistry and Molecular Biology 144 Pt A: 201-203

Choi, M.-H.; Lee, C.-K.; Kim, H.-D. 2010: Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents. Archives of Pharmacal Research 33(2): 197-202

Shi, L.-H.; Jin, D.-Z.; Zhou, W.-C.; Wang, J.; Chen, X.-H. 2009: Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities. Yao Xue Xue Bao 44(7): 747-753

Xu, J.; Ai, J.; Liu, S.; Peng, X.; Yu, L.; Geng, M.; Nan, F. 2014: Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors. Organic and Biomolecular Chemistry 12(22): 3721-3734

Choi, M.; Hwang, Y.-S.; Kumar, A.S.; Jo, H.; Jeong, Y.; Oh, Y.; Lee, J.; Yun, J.; Kim, Y.; Han, S.-B.; Jung, J.-K.; Cho, J.; Lee, H. 2014: Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors. Bioorganic and Medicinal Chemistry Letters 24(11): 2404-2407

Zhou, Z.; Zhuo, J.; Yan, S.; Ma, L. 2013: Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors. Bioorganic and Medicinal Chemistry 21(7): 2156-2162

Kumar, A.; Maurya, R.Awatar.; Sharma, S.; Ahmad, P.; Singh, A.B.; Tamrakar, A.K.; Srivastava, A.K. 2009: Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents. Bioorganic and Medicinal Chemistry 17(14): 5285-5292

Babu, M.; Pitchumani, K.; Ramesh, P. 2012: Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents. Bioorganic and Medicinal Chemistry Letters 22(2): 1263-1266

Das, B.C.; Tang, X.-Y.; Rogler, P.; Evans, T. 2012: Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs. Tetrahedron Letters 53(31): 3947-3950

Kumar, D.; Patel, G.; Vijayakrishnan, L.; Dastidar, S.G.; Ray, A. 2012: Design and synthesis of 3,5-disubstituted-1,2,4-oxadiazoles as potent inhibitors of phosphodiesterase4b2. Chemical Biology and Drug Design 79(5): 810-818

Han, S.-Y.; Choi, J.W.; Yang, J.; Chae, C.H.; Lee, J.; Jung, H.; Lee, K.; Ha, J.D.; Kim, H.R.; Cho, S.Y. 2012: Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 22(8): 2837-2842

Alagarsamy, V.; Raja Solomon, V.; Murugan, M.; Dhanabal, K.; Parthiban, P.; Anjana, G.V. 2008: Design and synthesis of 3-(4-ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as a novel class of analgesic and anti-inflammatory agents. Journal of Enzyme Inhibition and Medicinal Chemistry 23(6): 839-847

Kumar, L.; Sarswat, A.; Lal, N.; Jain, A.; Kumar, S.; Kiran Kumar, S.T.V.S.; Maikhuri, J.P.; Pandey, A.K.; Shukla, P.K.; Gupta, G.; Sharma, V.L. 2011: Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception. Bioorganic and Medicinal Chemistry Letters 21(1): 176-181

Solomon, V.R.; Haq, W.; Srivastava, K.; Puri, S.K.; Katti, S.B. 2013: Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 28(5): 1048-1053

Zebardast, T.; Zarghi, A.; Daraie, B.; Hedayati, M.; Dadrass, O.G. 2009: Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorganic and Medicinal Chemistry Letters 19(12): 3162-3165

Aiello, F.; Shabaik, Y.; Esqueda, A.; Sanchez, T.W.; Grande, F.; Garofalo, A.; Neamati, N. 2012: Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1). Chemmedchem 7(10): 1825-1839

Abdelsayed, S.; Ha Duong, N.T.; Hai, J.; Hémadi, M.; El Hage Chahine, J.M.; Verbeke, P.; Serradji, N. 2014: Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors. Bioorganic and Medicinal Chemistry Letters 24(16): 3854-3860

Hafez, H.N.; El-Gazzar, A.B.A. 2008: Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities. Bioorganic and Medicinal Chemistry Letters 18(19): 5222-5227

Miyamoto, Y.; Banno, Y.; Yamashita, T.; Fujimoto, T.; Oi, S.; Moritoh, Y.; Asakawa, T.; Kataoka, O.; Takeuchi, K.; Suzuki, N.; Ikedo, K.; Kosaka, T.; Tsubotani, S.; Tani, A.; Funami, M.; Amano, M.; Yamamoto, Y.; Aertgeerts, K.; Yano, J.; Maezaki, H. 2011: Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125. Bioorganic and Medicinal Chemistry 19(1): 172-185

Hess, M.; Schulze Elfringhoff, A.; Lehr, M. 2008: Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2alpha. Journal of Enzyme Inhibition and Medicinal Chemistry 23(6): 946-957

Wei, Y.; Zhao, Z.; Liu, J.; Xu, C.; Jiang, G.; Duan, A. 2013: Design and synthesis of 3D ordered macroporous CeO₂-supported Pt@CeO(2-δ) core-shell nanoparticle materials for enhanced catalytic activity of soot oxidation. Small 9(23): 3957-3963

Duivenvoorden, B.A.; Ghauharali, K.; Scheij, S.; Boot, R.G.; Aerts, J.M.F.G.; van der Marel, G.A.; Overkleeft, H.S.; Codée, J.D.C. 2014: Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates. Carbohydrate Research 399: 26-37

Li, H.-Q.; Li, D.-D.; Lu, X.; Xu, Y.-Y.; Zhu, H.-L. 2012: Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity. Bioorganic and Medicinal Chemistry 20(1): 317-323

Zhu, L.; Li, Y.; Qiu, L.; Su, M.; Wang, X.; Xia, C.; Qu, Y.; Li, J.; Li, J.; Xiong, B.; Shen, J. 2013: Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors. Chemmedchem 8(7): 1104-1116

Lee, B.; Kwak, J.-H.; Huang, S.-W.; Jang, J.-Y.; Lim, S.; Kwak, Y.-S.; Lee, K.; Kim, H.S.; Han, S.-B.; Hong, J.-T.; Lee, H.; Song, S.; Seo, S.-Y.; Jung, J.-K. 2012: Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. Bioorganic and Medicinal Chemistry 20(9): 2860-2868

Xiao, H.-Y.; Balog, A.; Attar, R.M.; Fairfax, D.; Fleming, L.B.; Holst, C.L.; Martin, G.S.; Rossiter, L.M.; Chen, J.; Cvjic, M.-E.; Dell-John, J.; Geng, J.; Gottardis, M.M.; Han, W.-C.; Nation, A.; Obermeier, M.; Rizzo, C.A.; Schweizer, L.; Spires, T.; Shan, W.; Gavai, A.; Salvati, M.E.; Vite, G. 2010: Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists. Bioorganic and Medicinal Chemistry Letters 20(15): 4491-4495

Li, W.; Xia, L.; Hu, A.; Liu, A.; Peng, J.; Tan, W. 2013: Design and synthesis of 4-alkyl-2-amino(acetamino)-6-aryl-1,3-thiazine derivatives as influenza neuraminidase inhibitors. Archiv der Pharmazie 346(9): 635-644

Gorja, D.R.; Shiva Kumar, K.; Kandale, A.; Meda, C.L.T.; Parsa, K.V.L.; Mukkanti, K.; Pal, M. 2012: Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: a practical access via Pd/C-Cu catalysis. Bioorganic and Medicinal Chemistry Letters 22(7): 2480-2487

Le, T.N.; Yang, S.H.; Khadka, D.B.; Van, H.T.M.; Cho, S.H.; Kwon, Y.; Lee, E.-S.; Lee, K.-T.; Cho, W.-J. 2011: Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase i inhibitors with molecular modeling. Bioorganic and Medicinal Chemistry 19(14): 4399-4404

Zhang, Y.; Jung, S.Y.; Jin, C.; Kim, N.D.; Gong, P.; Lee, Y.S. 2009: Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. Bioorganic and Medicinal Chemistry Letters 19(2): 502-507

Li, G.; Zhou, H.; Jiang, Y.; Keim, H.; Topiol, S.W.; Poda, S.B.; Ren, Y.; Chandrasena, G.; Doller, D.ío. 2011: Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands. Bioorganic and Medicinal Chemistry Letters 21(4): 1236-1242

Liu, S.; Zha, C.; Nacro, K.; Hu, M.; Cui, W.; Yang, Y.-L.; Bhatt, U.; Sambandam, A.; Isherwood, M.; Yet, L.; Herr, M.T.; Ebeltoft, S.; Hassler, C.; Fleming, L.; Pechulis, A.D.; Payen-Fornicola, A.; Holman, N.; Milanowski, D.; Cotterill, I.; Mozhaev, V.; Khmelnitsky, Y.; Guzzo, P.R.; Sargent, B.J.; Molino, B.F.; Olson, R.; King, D.; Lelas, S.; Li, Y.-W.; Johnson, K.; Molski, T.; Orie, A.; Ng, A.; Haskell, R.; Clarke, W.; Bertekap, R.; O'Connell, J.; Lodge, N.; Sinz, M.; Adams, S.; Zaczek, R.; Macor, J.E. 2014: Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. Acs Medicinal Chemistry Letters 5(7): 760-765

Malamas, M.S.; Erdei, J.; Gunawan, I.; Turner, J.; Hu, Y.; Wagner, E.; Fan, K.; Chopra, R.; Olland, A.; Bard, J.; Jacobsen, S.; Magolda, R.L.; Pangalos, M.; Robichaud, A.J. 2010: Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. Journal of Medicinal Chemistry 53(3): 1146-1158

Ramurthy, S.; Aikawa, M.; Amiri, P.; Costales, A.; Hashash, A.; Jansen, J.M.; Lin, S.; Ma, S.; Renhowe, P.A.; Shafer, C.M.; Subramanian, S.; Sung, L.; Verhagen, J. 2011: Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 21(11): 3286-3289

Ha, Y.M.; Park, Y.J.; Kim, J.-A.; Park, D.; Park, J.Y.; Lee, H.J.; Lee, J.Y.; Moon, H.R.; Chung, H.Y. 2012: Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors. European Journal of Medicinal Chemistry 49: 245-252

Hasumi, K.; Sato, S.; Saito, T.; Kato, J.-y.; Shirota, K.; Sato, J.; Suzuki, H.; Ohta, S. 2014: Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept. Bioorganic and Medicinal Chemistry 22(15): 4162-4176

Guo, L.-J.; Wei, C.-X.; Jia, J.-H.; Zhao, L.-M.; Quan, Z.-S. 2009: Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. European Journal of Medicinal Chemistry 44(3): 954-958

Ramurthy, S.; Costales, A.; Jansen, J.M.; Levine, B.; Renhowe, P.A.; Shafer, C.M.; Subramanian, S. 2012: Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 22(4): 1678-1681

Yadav, M.R.; Naik, P.P.; Gandhi, H.P.; Chauhan, B.S.; Giridhar, R. 2013: Design and synthesis of 6,7-dimethoxyquinazoline analogs as multi-targeted ligands for α1- and AII-receptors antagonism. Bioorganic and Medicinal Chemistry Letters 23(13): 3959-3966

Chen, Y.-F.; Lin, Y.-C.; Huang, P.-K.; Chan, H.-C.; Kuo, S.-C.; Lee, K.-H.; Huang, L.-J. 2013: Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorganic and Medicinal Chemistry 21(17): 5064-5075

Sato, I.; Morihira, K.; Inami, H.; Kubota, H.; Morokata, T.; Suzuki, K.; Iura, Y.; Nitta, A.; Imaoka, T.; Takahashi, T.; Takeuchi, M.; Ohta, M.; Tsukamoto, S.-I. 2008: Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition. Bioorganic and Medicinal Chemistry 16(18): 8607-8618

Lou, J.; Yang, X.; Rao, Z.; Qi, W.; Li, J.; Wang, H.; Li, Y.; Li, J.; Wang, Z.; Hu, X.; Liu, P.; Hong, X. 2014: Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors. European Journal of Medicinal Chemistry 83: 466-473

Kaller, M.R.; Zhong, W.; Henley, C.; Magal, E.; Nguyen, T.; Powers, D.; Rzasa, R.M.; Wang, W.; Xiong, X.; Norman, M.H. 2009: Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorganic and Medicinal Chemistry Letters 19(23): 6591-6594

Westaway, S.M.; Thompson, M.; Rami, H.K.; Stemp, G.; Trouw, L.S.; Mitchell, D.J.; Seal, J.T.; Medhurst, S.J.; Lappin, S.C.; Biggs, J.; Wright, J.; Arpino, S.; Jerman, J.C.; Cryan, J.E.; Holland, V.; Winborn, K.Y.; Coleman, T.; Stevens, A.J.; Davis, J.B.; Gunthorpe, M.J. 2008: Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1. Bioorganic and Medicinal Chemistry Letters 18(20): 5609-5613

Han, Q.; Li, Q.-J.; He, J.; Hu, B.; Tan, H.; Abliz, Z.; Wang, C.-H.; Yu, Y.; Yang, H.-B. 2011: Design and synthesis of 60° dendritic donor ligands and their coordination-driven self-assembly into supramolecular rhomboidal metallodendrimers. Journal of Organic Chemistry 76(23): 9660-9669

Shin, D.; Lee, S-Chul.; Heo, Y-Seok.; Lee, W-Young.; Cho, Y-Soon.; Kim, Y.Eun.; Hyun, Y-Lan.; Cho, J.Myung.; Lee, Y.Sup.; Ro, S. 2007: Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorganic and Medicinal Chemistry Letters 17(20): 5686-5689

Ariyasu, S.; Sawa, A.; Morita, A.; Hanaya, K.; Hoshi, M.; Takahashi, I.; Wang, B.; Aoki, S. 2014: Design and synthesis of 8-hydroxyquinoline-based radioprotective agents. Bioorganic and Medicinal Chemistry 22(15): 3891-3905

Song, B.; Xiao, T.; Qi, X.; Li, L.-N.; Qin, K.; Nian, S.; Hu, G.-X.; Yu, Y.; Liang, G.; Ye, F. 2012: Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. Bioorganic and Medicinal Chemistry Letters 22(4): 1739-1742

Altiparmak, B.; Lambrecht, F.Y.; Bayrak, E.; Durkan, K. 2010: Design and synthesis of 99mTc-citro-folate for use as a tumor-targeted radiopharmaceutical. International Journal of Pharmaceutics 400(1-2): 8-14

Hu, Y.; Li, X.; Sebti, S.M.; Chen, J.; Cai, J. 2011: Design and synthesis of AApeptides: a new class of peptide mimics. Bioorganic and Medicinal Chemistry Letters 21(5): 1469-1471

Wolters, J.C.; Roelfes, G.; Poolman, B. 2011: Design and synthesis of ATP-based nucleotide analogues and profiling of nucleotide-binding proteins. Bioconjugate Chemistry 22(7): 1345-1353

Liu, Y.; Wu, J.; Weissig, H.; Betancort, J.M.; Gai, W.Z.; Leventhal, P.S.; Patricelli, M.P.; Samii, B.; Szardenings, A.K.; Shreder, K.R.; Kozarich, J.W. 2008: Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta. Bioorganic and Medicinal Chemistry Letters 18(22): 5955-5958

Wångsell, F.; Russo, F.; Sävmarker, J.; Rosenquist, A.; Samuelsson, B.; Larhed, M. 2009: Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic. Bioorganic and Medicinal Chemistry Letters 19(16): 4711-4714

Chorell, E.; Pinkner, J.S.; Phan, G.; Edvinsson, S.; Buelens, F.; Remaut, H.; Waksman, G.; Hultgren, S.J.; Almqvist, F. 2010: Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. Journal of Medicinal Chemistry 53(15): 5690-5695

Singh, P.; Faridi, U.; Srivastava, S.; Kumar, J.K.; Darokar, M.P.; Luqman, S.; Shanker, K.; Chanotiya, C.S.; Gupta, A.; Gupta, M.M.; Negi, A.S. 2010: Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents. Chemical and Pharmaceutical Bulletin 58(2): 242-246

Wang, L.; Gagey-Eilstein, N.; Broussy, S.; Reille-Seroussi, M.; Huguenot, F.; Vidal, M.; Liu, W.-Q. 2014: Design and synthesis of C-terminal modified cyclic peptides as VEGFR1 antagonists. Molecules 19(10): 15391-15407

Albright, A.; Eddings, D.; Black, R.; Welch, C.J.; Gerasimchuk, N.N.; Gawley, R.E. 2011: Design and synthesis of C2-symmetric N-heterocyclic carbene precursors and metal carbenoids. Journal of Organic Chemistry 76(18): 7341-7351

Kamal, A.; Srinivasulu, V.; Nayak, V.L.; Sathish, M.; Shankaraiah, N.; Bagul, C.; Reddy, N.V.S.; Rangaraj, N.; Nagesh, N. 2014: Design and synthesis of C3-pyrazole/chalcone-linked beta-carboline hybrids: antitopoisomerase I, DNA-interactive, and apoptosis-inducing anticancer agents. Chemmedchem 9(9): 2084-2098

Kojima, N.; Suga, Y.; Hayashi, H.; Yamori, T.; Yoshimitsu, T.; Tanaka, T. 2011: Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines. Bioorganic and Medicinal Chemistry Letters 21(19): 5745-5749

Hoque, M.A.; Islam, M.N.; Islam, M.S.; Kato, T.; Nishino, N.; Ito, A.; Yoshida, M. 2014: Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry 22(15): 3850-3855

Makowska, M.łg.; Łukowska-Chojnacka, E.; Wińska, P.; Kuś, A.; Bilińska-Chomik, A.; Bretner, M. 2011: Design and synthesis of CK2 inhibitors. Molecular and Cellular Biochemistry 356(1-2): 91-96

Banday, A.H.; Giri, A.K.; Parveen, R.; Bashir, N. 2014: Design and synthesis of D-ring steroidal isoxazolines and oxazolines as potential antiproliferative agents against LNCaP, PC-3 and DU-145 cells. Steroids 87: 93-98

Rangnekar, A.; Gothelf, K.V.; LaBean, T.H. 2011: Design and synthesis of DNA four-helix bundles. Nanotechnology 22(23): 235601

Giovanni, A.; Roehr, J.; Dwyer, S.; Neuenschwander, K.; Scotese, A.; Moorcroft, N.D.; Davis, L.; Gao, Z. 2013: Design and synthesis of D₁ agonist/D₂ antagonist for treatment of schizophrenia. Bioorganic and Medicinal Chemistry Letters 23(5): 1498-1501

Petch, D.; Anderson, R.J.; Cunningham, A.; George, S.E.; Hibbs, D.E.; Liu, R.; Mackay, S.P.; Paul, A.; Small, D.A.P.; Groundwater, P.W. 2012: Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis. Bioorganic and Medicinal Chemistry 20(19): 5901-5914

Chen, J.; Zhang, P.; Fang, G.; Yi, P.; Zeng, F.; Wu, S. 2012: Design and synthesis of FRET-mediated multicolor and photoswitchable fluorescent polymer nanoparticles with tunable emission properties. Journal of Physical Chemistry. B 116(14): 4354-4362

Qian, W.-J.; Lai, C.C.; Kelley, J.A.; Burke, T.R. 2014: Design and synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the preparation of peptide prodrugs containing phosphothreonine in fully protected form. Chemistry and Biodiversity 11(5): 784-791

Zhu, T.; Fawzi, M.B.; Flint, M.; Kong, F.; Szeliga, J.; Tsao, R.; Howe, A.Y.M.; Pan, W. 2010: Design and synthesis of HCV agents with sequential triple inhibitory potentials. Bioorganic and Medicinal Chemistry Letters 20(17): 5212-5216

Kesteleyn, B.; Amssoms, K.; Schepens, W.; Hache, G.; Verschueren, W.; Van De Vreken, W.; Rombauts, K.; Meurs, G.; Sterkens, P.; Stoops, B.; Baert, L.; Austin, N.; Wegner, J.ör.; Masungi, C.; Dierynck, I.; Lundgren, S.; Jönsson, D.; Parkes, K.; Kalayanov, G.; Wallberg, H.; Rosenquist, A.; Samuelsson, B.; Van Emelen, K.; Thuring, J.W. 2013: Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application. Bioorganic and Medicinal Chemistry Letters 23(1): 310-317

Sellers, R.P.; Alexander, L.D.; Johnson, V.A.; Lin, C.-C.; Savage, J.; Corral, R.; Moss, J.; Slugocki, T.S.; Singh, E.K.; Davis, M.R.; Ravula, S.; Spicer, J.E.; Oelrich, J.L.; Thornquist, A.; Pan, C.-M.; McAlpine, S.R. 2010: Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide a derivatives. Bioorganic and Medicinal Chemistry 18(18): 6822-6856

Suzuki, Y.; Yokoyama, K. 2008: Design and synthesis of ICT-based fluorescent probe for high-sensitivity protein detection and application to rapid protein staining for SDS-PAGE. Proteomics 8(14): 2785-2790

Nagase, H.; Nemoto, T.; Matsubara, A.; Saito, M.; Yamamoto, N.; Osa, Y.; Hirayama, S.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H. 2010: Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration. Bioorganic and Medicinal Chemistry Letters 20(21): 6302-6305

Patel, B.A.; Krishnan, R.; Khadtare, N.; Gurukumar, K.R.; Basu, A.; Arora, P.; Bhatt, A.; Patel, M.R.; Dana, D.; Kumar, S.; Kaushik-Basu, N.; Talele, T.T. 2013: Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase. Bioorganic and Medicinal Chemistry 21(11): 3262-3271

Sharma, V.K.; Singh, S.K.; Bohra, K.; L, C.Shekhar.Reddy.; Khatri, V.; Olsen, C.E.; Prasad, A.K. 2013: Design and synthesis of LNA-based mercaptoacetamido-linked nucleoside dimers. Nucleosides Nucleotides and Nucleic Acids 32(5): 256-272

Lyu, A.; Fang, L.; Gou, S. 2014: Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. European Journal of Medicinal Chemistry 87: 631-642

Freskos, J.N.; Asmelash, B.; Gaston, K.R.; Karwa, A.; Marzan, T.A.; Nickols, M.A.; Rogers, T.E.; Schoenstein, T.; Sympson, C.J.; Vu, B. 2013: Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes. Bioorganic and Medicinal Chemistry Letters 23(20): 5566-5570

Li, Q.; Wang, Z.-L.; Li, G.-R.; Guo, R.; Ding, L.-X.; Tong, Y.-X. 2012: Design and synthesis of MnO₂/Mn/MnO₂ sandwich-structured nanotube arrays with high supercapacitive performance for electrochemical energy storage. Nano Letters 12(7): 3803-3807

Choi, W.J.; Lee, H.W.; Kim, H.O.; Chinn, M.; Gao, Z.-G.; Patel, A.; Jacobson, K.A.; Moon, H.R.; Jung, Y.H.; Jeong, L.S. 2009: Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. Bioorganic and Medicinal Chemistry 17(23): 8003-8011

Alexiou, P.; Nicolaou, I.; Stefek, M.; Kristl, A.; Demopoulos, V.J. 2008: Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. Bioorganic and Medicinal Chemistry 16(7): 3926-3932

Chen, C.-N.; Lv, L.-L.; Ji, F.-Q.; Chen, Q.; Xu, H.; Niu, C.-W.; Xi, Z.; Yang, G.-F. 2009: Design and synthesis of N-2,6-difluorophenyl-5-methoxyl-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor. Bioorganic and Medicinal Chemistry 17(8): 3011-3017

Barcelos, R.C.; Pastre, J.C.; Vendramini-Costa, D.éb.B.; Caixeta, V.; Longato, G.B.; Monteiro, P.A.új.; de Carvalho, J.ão.E.; Pilli, R.A. 2014: Design and synthesis of N-acylated aza-goniothalamin derivatives and evaluation of their in vitro and in vivo antitumor activity. Chemmedchem 9(12): 2725-2743

Liu, X.; Zhang, L.; Tan, J.-G.; Xu, H.-H. 2013: Design and synthesis of N-alkyl-N'-substituted 2,4-dioxo-3,4-dihydropyrimidin-1-diacylhydrazine derivatives as ecdysone receptor agonist. Bioorganic and Medicinal Chemistry 21(15): 4687-4697

Du, Y.; Ye, H.; Guo, F.; Wang, L.; Gill, T.; Khan, N.; Cuconati, A.; Guo, J.-T.; Block, T.M.; Chang, J.; Xu, X. 2013: Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus. Bioorganic and Medicinal Chemistry Letters 23(14): 4258-4262

Ma, C.; Wu, A.; Wu, Y.; Ren, X.; Cheng, M. 2013: Design and synthesis of N-aryl isothioureas as a novel class of gastric H(+) /K(+) -ATPase inhibitors. Archiv der Pharmazie 346(12): 891-900

Liu, X.-H.; Ruan, B.-F.; Liu, J.-X.; Song, B.-A.; Jing, L.-H.; Li, J.; Yang, Y.; Zhu, H.-L.; Qi, X.-B. 2011: Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents. Bioorganic and Medicinal Chemistry Letters 21(10): 2916-2920

Patel, M.R.; Pandya, K.G.; Lau-Cam, C.A.; Singh, S.; Pino, M.A.; Billack, B.; Degenhardt, K.; Talele, T.T. 2012: Design and synthesis of N-substituted indazole-3-carboxamides as poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(†). Chemical Biology and Drug Design 79(4): 488-496

Soltan, M.K.; Ghonaim, H.M.; El Sadek, M.; Kull, M.A.; El-aziz, L.A.; Blagbrough, I.S. 2009: Design and synthesis of N4,N9-disubstituted spermines for non-viral siRNA delivery--structure-activity relationship studies of si Fection efficiency versus toxicity. Pharmaceutical Research 26(2): 286-295

Kode, N.R.; Vanden Eynde, J.J.; Mayence, A.; Wang, G.; Huang, T.L. 2013: Design and synthesis of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs. Molecules 18(9): 11250-11263

Monforte, A.-M.; Ferro, S.; De Luca, L.; Lo Surdo, G.; Morreale, F.; Pannecouque, C.; Balzarini, J.; Chimirri, A. 2014: Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry 22(4): 1459-1467

Li, T.; Guo, L.; Zhang, Y.; Wang, J.; Li, Z.; Lin, L.; Zhang, Z.; Li, L.; Lin, J.; Zhao, W.; Li, J.; Wang, P.G. 2011: Design and synthesis of O-GlcNAcase inhibitors via 'click chemistry' and biological evaluations. Carbohydrate Research 346(9): 1083-1092

Joshi, A.; Véron, J.-B.; Unge, J.; Rosenquist, Ås.; Wallberg, H.; Samuelsson, B.; Hallberg, A.; Larhed, M. 2013: Design and synthesis of P1-P3 macrocyclic tertiary-alcohol-comprising HIV-1 protease inhibitors. Journal of Medicinal Chemistry 56(22): 8999-9007

Huang, H.; Wang, X. 2013: Design and synthesis of Pd-MnO2 nanolamella-graphene composite as a high-performance multifunctional electrocatalyst towards formic acid and methanol oxidation. Physical Chemistry Chemical Physics: Pccp 15(25): 10367-10375

Skouta, R.; Hayano, M.; Shimada, K.; Stockwell, B.R. 2012: Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. Bioorganic and Medicinal Chemistry Letters 22(17): 5707-5713

Schütz, M.; Müller, C.I.; Salehi, M.; Lambert, C.; Schlücker, S. 2011: Design and synthesis of Raman reporter molecules for tissue imaging by immuno-SERS microscopy. Journal of Biophotonics 4(6): 453-463

Tao, H.; Weng, Y.; Zhuo, R.; Chang, G.; Urbatsch, I.L.; Zhang, Q. 2011: Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein. Chembiochem: a European Journal of Chemical Biology 12(6): 868-873

Papanastasiou, I.; Tsotinis, A.; Zoidis, G.; Kolocouris, N.; Prathalingam, S.R.; Kelly, J.M. 2009: Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. Chemmedchem 4(7): 1059-1062

Bhaskar Reddy, M.; Shailaja, M.; Manjula, A.; Premkumar, J.R.; Sastry, G.N.; Sirisha, K.; Sarma, A.V.S. 2015: Design and synthesis of Tröger's base ditopic receptors: host-guest interactions, a combined theoretical and experimental study. Organic and Biomolecular Chemistry 13(4): 1141-1149

Werner, S.; Kasi, D.; Brummond, K.M. 2007: Design and synthesis of a 3,4-dehydroproline amide discovery library. Journal of Combinatorial Chemistry 9(4): 677-683

Fujii, T.; Shindo, Y.; Hotta, K.; Citterio, D.; Nishiyama, S.; Suzuki, K.; Oka, K. 2014: Design and synthesis of a FlAsH-type Mg2+ fluorescent probe for specific protein labeling. Journal of the American Chemical Society 136(6): 2374-2381

Roberge, J.Y.; Harikrishnan, L.S.; Kamau, M.G.; Ruan, Z.; Van Kirk, K.; Liu, Y.; Cooper, C.B.; Poss, M.A.; Dickson, J.K.; Gavai, A.V.; Chao, S.T.; Leith, L.W.; Bednarz, M.S.; Mathur, A.; Kakarla, R.; Schnur, D.M.; Vaz, R.; Lawrence, R.Michael. 2009: Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker. Journal of Combinatorial Chemistry 11(1): 72-82

Fan, B.; Li, N. 2009: Design and synthesis of a Magainin2 fusion protein gene suitable for a mammalian expression system. Transgenic Research 18(1): 99-112

Phelan, R.M.; Ostermeier, M.; Townsend, C.A. 2009: Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorganic and Medicinal Chemistry Letters 19(4): 1261-1263

Baker, Y.R.; Galloway, W.R.J.D.; Hodgkinson, J.T.; Spring, D.R. 2013: Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin. Molecules 18(10): 11783-11796

Zhong, B.; Lama, R.; Smith, K.M.; Xu, Y.; Su, B. 2011: Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76. Bioorganic and Medicinal Chemistry Letters 21(18): 5324-5327

Yuan, Y.; Arnatt, C.K.; Li, G.; Haney, K.M.; Ding, D.; Jacob, J.C.; Selley, D.E.; Zhang, Y. 2012: Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5. Organic and Biomolecular Chemistry 10(13): 2633-2646

Kannan, R.; Pillarsetty, N.; Gali, H.; Hoffman, T.J.; Barnes, C.L.; Jurisson, S.S.; Smith, C.J.; Volkert, W.A. 2011: Design and synthesis of a bombesin peptide-conjugated tripodal phosphino dithioether ligand topology for the stabilization of the fac-[M(CO)3]+ core (M=(99 m)Tc or Re). Inorganic Chemistry 50(13): 6210-6219

Aoki, S.; Sakurama, K.; Ohshima, R.; Matsuo, N.; Yamada, Y.; Takasawa, R.; Tanuma, S.-i.; Takeda, K.; Kimura, E. 2008: Design and synthesis of a caged Zn2+ probe, 8-benzenesulfonyloxy-5-N,N-dimethylaminosulfonylquinolin-2-ylmethyl-pendant 1,4,7,10-tetraazacyclododecane, and its hydrolytic uncaging upon complexation with Zn2+. Inorganic Chemistry 47(7): 2747-2754

Srinivasrao, G.; Park, J.-E.; Kim, S.; Ahn, M.; Cheong, C.; Nam, K.-Y.; Gunasekaran, P.; Hwang, E.; Kim, N.-H.; Shin, S.Y.; Lee, K.S.; Ryu, E.; Bang, J.K. 2014: Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1. Plos one 9(9): E107432

Lin, S.-L.; Kuo, P.-Y.; Yang, D.-Y. 2007: Design and synthesis of a coumarin-based acidichromic colorant. Molecules 12(7): 1316-1324

Katsara, M.; Deraos, G.; Tselios, T.; Matsoukas, M.-T.; Friligou, I.; Matsoukas, J.; Apostolopoulos, V. 2009: Design and synthesis of a cyclic double mutant peptide (cyclo(87-99)[A91,A96]MBP87-99) induces altered responses in mice after conjugation to mannan: implications in the immunotherapy of multiple sclerosis. Journal of Medicinal Chemistry 52(1): 214-218

Léo, P.-M.; Morin, C.; Philouze, C. 2010: Design and synthesis of a cyclitol-derived scaffold with axial pyridyl appendages and its encapsulation of the silver(I) cation. Beilstein Journal of Organic Chemistry 6: 1022-1024

Wang, S.; Fang, W. 2011: Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives. Molecules 16(6): 4748-4763

Ohshima, R.; Kitamura, M.; Morita, A.; Shiro, M.; Yamada, Y.; Ikekita, M.; Kimura, E.; Aoki, S. 2010: Design and synthesis of a fluorescent probe for Zn2+, 5,7-bis(N,N-dimethylaminosulfonyl)-8-hydroxyquinoline-pendant 1,4,7,10-tetraazacyclododecane and Zn2+-dependent hydrolytic and Zn2+-independent photochemical reactivation of its benzenesulfonyl-caged derivative. Inorganic Chemistry 49(3): 888-899

Zhan, Y.; Jia, G.; Wu, D.; Xu, Y.; Xu, L. 2009: Design and synthesis of a gossypol derivative with improved antitumor activities. Archiv der Pharmazie 342(4): 223-229

Li, X.; Qian, S.; He, Q.; Yang, B.; Li, J.; Hu, Y. 2010: Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells. Organic and Biomolecular Chemistry 8(16): 3627-3630

Kinoshita, K.; Asoh, K.; Furuichi, N.; Ito, T.; Kawada, H.; Hara, S.; Ohwada, J.; Miyagi, T.; Kobayashi, T.; Takanashi, K.; Tsukaguchi, T.; Sakamoto, H.; Tsukuda, T.; Oikawa, N. 2012: Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). Bioorganic and Medicinal Chemistry 20(3): 1271-1280

Hanaoka, K.; Muramatsu, Y.; Urano, Y.; Terai, T.; Nagano, T. 2010: Design and synthesis of a highly sensitive off-on fluorescent chemosensor for zinc ions utilizing internal charge transfer. Chemistry 16(2): 568-572

Hirano, K.; Macmillan, D.; Tezuka, K.; Tsuji, T.; Kajihara, Y. 2009: Design and synthesis of a homogeneous erythropoietin analogue with two human complex-type sialyloligosaccharides: combined use of chemical and bacterial protein expression methods. Angewandte Chemie 48(50): 9557-9560

Mills, A.D.; Yoo, C.; Butler, J.D.; Yang, B.; Verkman, A.S.; Kurth, M.J. 2010: Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorganic and Medicinal Chemistry Letters 20(1): 87-91

Nencini, A.; Castaldo, C.; Comery, T.A.; Dunlop, J.; Genesio, E.; Ghiron, C.; Haydar, S.; Maccari, L.; Micco, I.; Turlizzi, E.; Zanaletti, R.; Zhang, J. 2014: Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor. European Journal of Medicinal Chemistry 78: 401-418

Sunahara, H.; Urano, Y.; Kojima, H.; Nagano, T. 2007: Design and synthesis of a library of BODIPY-based environmental polarity sensors utilizing photoinduced electron-transfer-controlled fluorescence ON/OFF switching. Journal of the American Chemical Society 129(17): 5597-5604

Bhalay, G.; Albrecht, B.; Akhlaq, M.; Baettig, U.; Beer, D.; Brown, Z.; Charlton, S.; Dunstan, A.; Bradley, M.; Gedeck, P.; Glen, A.; Howe, T.; Keller, T.; Leighton-Davies, J.; Li, A.; McCarthy, C.; Mocquet, C.; Owen, C.; Nicklin, P.; Rosethorne, E. 2011: Design and synthesis of a library of chemokine antagonists. Bioorganic and Medicinal Chemistry Letters 21(21): 6249-6252

Schmitt, C.; Kail, D.; Mariano, M.; Empting, M.; Weber, N.; Paul, T.; Hartmann, R.W.; Engel, M. 2014: Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors. Plos one 9(3): E87851

Brummond, K.M.; Mao, S.; Shinde, S.N.; Johnston, P.J.; Day, B.W. 2009: Design and synthesis of a library of tetracyclic hydroazulenoisoindoles. Journal of Combinatorial Chemistry 11(3): 486-494

Huang, S.-T.; Teng, C.-J.; Lee, Y.-H.; Wu, J.-Y.; Wang, K.-L.; Lin, C.-M. 2010: Design and synthesis of a long-wavelength latent fluorogenic substrate for salicylate hydroxylase: a useful fluorimetric indicator for analyte determination by dehydrogenase-coupled biosensors. Analytical Chemistry 82(17): 7329-7334

Moromizato, S.; Hisamatsu, Y.; Suzuki, T.; Matsuo, Y.; Abe, R.; Aoki, S. 2012: Design and synthesis of a luminescent cyclometalated iridium(III) complex having N,N-diethylamino group that stains acidic intracellular organelles and induces cell death by photoirradiation. Inorganic Chemistry 51(23): 12697-12706

Yun, H.; Sim, J.; An, H.; Lee, J.; Lee, H.S.; Shin, Y.K.; Paek, S.-M.; Suh, Y.-G. 2014: Design and synthesis of a macrosphelide A-biotin chimera. Organic and Biomolecular Chemistry 12(36): 7127-7135

Sakami, S.; Kawai, K.; Maeda, M.; Aoki, T.; Fujii, H.; Ohno, H.; Ito, T.; Saitoh, A.; Nakao, K.; Izumimoto, N.; Matsuura, H.; Endo, T.; Ueno, S.; Natsume, K.; Nagase, H. 2008: Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851. Bioorganic and Medicinal Chemistry 16(17): 7956-7967

Han, J.; Lee, T.H.; Tung, C.-H.; Lee, D.Y. 2014: Design and synthesis of a mitochondria-targeting carrier for small molecule drugs. Organic and Biomolecular Chemistry 12(48): 9793-9796

Malik, R.; Qian, S.; Law, B. 2011: Design and synthesis of a near-infrared fluorescent nanofiber precursor for detecting cell-secreted urokinase activity. Analytical Biochemistry 412(1): 26-33

Sharma, M.; Chauhan, K.; Srivastava, R.K.; Singh, S.V.; Srivastava, K.; Saxena, J.K.; Puri, S.K.; Chauhan, P.M.S. 2014: Design and synthesis of a new class of 4-aminoquinolinyl- and 9-anilinoacridinyl Schiff base hydrazones as potent antimalarial agents. Chemical Biology and Drug Design 84(2): 175-181

Tang, H.; Yan, Y.; Feng, Z.; de Jesus, R.K.; Yang, L.; Levorse, D.A.; Owens, K.A.; Akiyama, T.E.; Bergeron, R.; Castriota, G.A.; Doebber, T.W.; Ellsworth, K.P.; Lassman, M.E.; Li, C.; Wu, M.S.; Zhang, B.B.; Chapman, K.T.; Mills, S.G.; Berger, J.P.; Pasternak, A. 2010: Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorganic and Medicinal Chemistry Letters 20(20): 6088-6092

Hapuarachchige, S.; Montaño, G.; Ramesh, C.; Rodriguez, D.; Henson, L.H.; Williams, C.C.; Kadavakkollu, S.; Johnson, D.L.; Shuster, C.B.; Arterburn, J.B. 2011: Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes. Journal of the American Chemical Society 133(17): 6780-6790

Wong, H-Lai.; Ko, C-Chiu.; Lam, W.Han.; Zhu, N.; Yam, V.Wing-Wah. 2009: Design and synthesis of a new class of photochromic diarylethene-containing dithieno[3,2-b:2',3'-d]pyrroles and their switchable luminescence properties. Chemistry 15(39): 10005-10009

Stragies, R.; Osterkamp, F.; Zischinsky, G.; Vossmeyer, D.; Kalkhof, H.; Reimer, U.; Zahn, G. 2007: Design and synthesis of a new class of selective integrin alpha5beta1 antagonists. Journal of Medicinal Chemistry 50(16): 3786-3794

Franceschin, M.; Nocioni, D.; Biroccio, A.; Micheli, E.; Cacchione, S.; Cingolani, C.; Venditti, A.; Zizza, P.; Bianco, A.; Altieri, A. 2014: Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage. Organic and Biomolecular Chemistry 12(47): 9572-9582

Nenajdenko, V.G.; Goldberg, A.A.; Muzalevskiy, V.M.; Balenkova, E.S.; Shastin, A.V. 2013: Design and synthesis of a new family of fluorinated liquid crystals. Chemistry 19(7): 2370-2383

Sun, Y.-L.; Ablimit, A.; Zhai, H.-F.; Bao, J.-K.; Tang, Z.-T.; Wang, X.-B.; Wang, N.-L.; Feng, C.-M.; Cao, G.-H. 2014: Design and synthesis of a new layered thermoelectric material LaPbBiS3O. Inorganic Chemistry 53(20): 11125-11129

Liu, Y.; Meng, G.; Zheng, A.; Chen, F.; Chen, W.; De Clercq, E.; Pannecouque, C.; Balzarini, J. 2014: Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 62: 334-341

Meng, G.; Liu, Y.; Zheng, A.; Chen, F.; Chen, W.; De Clercq, E.; Pannecouque, C.; Balzarini, J. 2014: Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 82: 600-611

Ye, Z.; Xiao, Y.; Song, B.; Yuan, J. 2014: Design and synthesis of a new terbium complex-based luminescent probe for time-resolved luminescence sensing of zinc ions. Journal of Fluorescence 24(5): 1537-1544

Buller, F.; Mannocci, L.; Zhang, Y.; Dumelin, C.E.; Scheuermann, Jörg.; Neri, D. 2008: Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions. Bioorganic and Medicinal Chemistry Letters 18(22): 5926-5931

Mishra, A.; Pootrakulchote, N.; Fischer, M.K.R.; Klein, C.; Nazeeruddin, M.K.; Zakeeruddin, S.M.; Bäuerle, P.; Grätzel, M. 2009: Design and synthesis of a novel anchoring ligand for highly efficient thin film dye-sensitized solar cells. Chemical Communications 46: 7146-7148

Kotha, S.; Shah, V.R.; Mishra, P.P.; Datta, A. 2008: Design and synthesis of a novel anthracene-based fluorescent probe through the application of the Suzuki-Miyaura cross-coupling reaction. Amino Acids 35(1): 169-173

Rahmat, D.; Sakloetsakun, D.; Shahnaz, G.; Perera, G.; Kaindl, R.; Bernkop-Schnürch, A. 2011: Design and synthesis of a novel cationic thiolated polymer. International Journal of Pharmaceutics 411(1-2): 10-17

Suzuki, Y.; Oishi, S.; Takei, Y.; Yasue, M.; Misu, R.; Naoe, S.; Hou, Z.; Kure, T.; Nakanishi, I.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.; Fujii, N. 2012: Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles. Organic and Biomolecular Chemistry 10(25): 4907-4915

Sasaki, H.; Hanaoka, K.; Urano, Y.; Terai, T.; Nagano, T. 2011: Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring-opening process of rhodamine derivatives. Bioorganic and Medicinal Chemistry 19(3): 1072-1078

Suzuki, Y.; Takagi, N.; Sano, T.; Chimuro, T. 2013: Design and synthesis of a novel fluorescent protein probe for easy and rapid electrophoretic gel staining by using a commonly available UV-based fluorescent imaging system. Electrophoresis 34(17): 2464-2472

Nohara, T.; Imamura, A.; Yamaguchi, M.; Hidari, K.I.P.J.; Suzuki, T.; Komori, T.; Ando, H.; Ishida, H.; Kiso, M. 2012: Design and synthesis of a novel ganglioside ligand for influenza a viruses. Molecules 17(8): 9590-9620

Le, P.T.; Cheng, H.; Ninkovic, S.; Plewe, M.; Huang, X.; Wang, H.; Bagrodia, S.; Sun, S.; Knighton, D.R.; LaFleur Rogers, C.M.; Pannifer, A.; Greasley, S.; Dalvie, D.; Zhang, E. 2012: Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorganic and Medicinal Chemistry Letters 22(15): 5098-5103

Diaz, P.; Xu, J.; Astruc-Diaz, F.; Pan, H.-M.; Brown, D.L.; Naguib, M. 2008: Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. Journal of Medicinal Chemistry 51(16): 4932-4947

Bischoff, F.; Berthelot, D.; De Cleyn, M.; Macdonald, G.; Minne, G.; Oehlrich, D.; Pieters, S.; Surkyn, M.; Trabanco, A.és.A.; Tresadern, G.; Van Brandt, S.; Velter, I.; Zaja, M.; Borghys, H.; Masungi, C.; Mercken, M.; Gijsen, H.J.M. 2012: Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators. Journal of Medicinal Chemistry 55(21): 9089-9106

Jiménez-Alonso, S.; Orellana, H.C.áv.; Estévez-Braun, A.; Ravelo, A.G.; Pérez-Sacau, E.; Machín, F. 2008: Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase Ii catalytic inhibitors. Journal of Medicinal Chemistry 51(21): 6761-6772

Huang, K.; Zhang, X.; Emge, T.J.; Hou, G.; Cao, B.; Zhang, X. 2010: Design and synthesis of a novel three-hindered quadrant bisphosphine ligand and its application in asymmetric hydrogenation. Chemical Communications 46(45): 8555-8557

Li, Y.; Cao, R.; Lippard, S.J. 2011: Design and synthesis of a novel triptycene-based ligand for modeling carboxylate-bridged diiron enzyme active sites. Organic Letters 13(19): 5052-5055

Bowers, S.; Truong, A.P.; Neitz, R.J.; Neitzel, M.; Probst, G.D.; Hom, R.K.; Peterson, B.; Galemmo, R.A.; Konradi, A.W.; Sham, H.L.; Tóth, G.; Pan, H.; Yao, N.; Artis, D.R.; Brigham, E.F.; Quinn, K.P.; Sauer, J.-M.; Powell, K.; Ruslim, L.; Ren, Z.; Bard, F.éd.ér.; Yednock, T.A.; Griswold-Prenner, I. 2011: Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorganic and Medicinal Chemistry Letters 21(6): 1838-1843

Hagiwara, Y.; Mesch, R.A.; Kawakami, T.; Okazaki, M.; Jockusch, S.; Li, Y.; Turro, N.J.; Grant Willson, C. 2013: Design and synthesis of a photoaromatization-based two-stage photobase generator for pitch division lithography. Journal of Organic Chemistry 78(5): 1730-1734

Aoki, S.; Matsuo, N.; Hanaya, K.; Yamada, Y.; Kageyama, Y. 2009: Design and synthesis of a photocleavable biotin-linker for the photoisolation of ligand-receptor complexes based on the photolysis of 8-quinolinyl sulfonates in aqueous solution. Bioorganic and Medicinal Chemistry 17(9): 3405-3413

Viehmann, P.; Hecht, S. 2012: Design and synthesis of a photoswitchable guanidine catalyst. Beilstein Journal of Organic Chemistry 8: 1825-1830

Lai, Y.; Xie, C.; Zhang, Z.; Lu, W.; Ding, J. 2010: Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs. Biomaterials 31(18): 4809-4817

Marian, C.; Huang, R.; Borch, R.F. 2011: Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold. Tetrahedron 67(52): 10216-10221

Hansen, L.H.; Bentzon-Tilia, M.; Bentzon-Tilia, S.; Norman, A.; Rafty, L.; Sørensen, S.ør.J. 2011: Design and synthesis of a quintessential self-transmissible IncX1 plasmid, pX1.0. Plos one 6(5): E19912

Liu, Z.; Zhang, C.; Wang, X.; He, W.; Guo, Z. 2012: Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach. Organic Letters 14(17): 4378-4381

Qian, W.-J.; Burke, T.R. 2013: Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form. Amino Acids 45(5): 1143-1148

Yu, X.; Zhang, R.; Ye, Z.; Song, B.; Yuan, J. 2013: Design and synthesis of a ruthenium(II) complex-based luminescent probe for highly selective and sensitive luminescence detection of nitric oxide. Journal of Fluorescence 23(6): 1113-1120

Chini, M.G.; De Simone, R.; Bruno, I.; Riccio, R.; Dehm, F.; Weinigel, C.; Barz, D.; Werz, O.; Bifulco, G. 2012: Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors. European Journal of Medicinal Chemistry 54: 311-323

Guckian, K.M.; Lin, E.Y.-S.; Silvian, L.; Friedman, J.E.; Chin, D.; Scott, D.M. 2008: Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors. Bioorganic and Medicinal Chemistry Letters 18(19): 5249-5251

Chen, S.; Zhang, X.; Wang, J.; Wan, S.; Geng, M.; Jiang, T. 2011: Design and synthesis of a series of novel bisquinazoline glycosides as epidermal growth factor receptor inhibitors. Chemical Biology and Drug Design 78(6): 1006-1013

François, I.E.; Thevissen, K.; Pellens, K.; Meert, E.M.; Heeres, J.; Freyne, E.; Coesemans, E.; Viellevoye, M.; Deroose, F.; Martinez Gonzalez, S.; Pastor, J.; Corens, D.; Meerpoel, L.; Borgers, M.; Ausma, J.; Dispersyn, G.D.; Cammue, B.P. 2009: Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen species. Chemmedchem 4(10): 1714-1721

Gong, H.; Qi, H.; Sun, W.; Zhang, Y.; Jiang, D.; Xiao, J.; Yang, X.; Wang, Y.; Li, S. 2012: Design and synthesis of a series of pyrido[2,3-d]pyrimidine derivatives as CCR4 antagonists. Molecules 17(8): 9961-9970

Ohashi, M.; Oyama, T.; Putranto, E.W.; Waku, T.; Nobusada, H.; Kataoka, K.; Matsuno, K.; Yashiro, M.; Morikawa, K.; Huh, N.-H.; Miyachi, H. 2013: Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility. Bioorganic and Medicinal Chemistry 21(8): 2319-2332

Crisóstomo, F.R.P.; Feng, Y.; Zhu, X.; Welsh, K.; An, J.; Reed, J.C.; Huang, Z. 2009: Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain. Bioorganic and Medicinal Chemistry Letters 19(22): 6413-6418

Turner, W.W.; Hartvigsen, K.; Boullier, A.; Montano, E.N.; Witztum, J.L.; VanNieuwenhze, M.S. 2012: Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. Journal of Medicinal Chemistry 55(18): 8178-8182

Zulkefeli, M.; Sogon, T.; Takeda, K.; Kimura, E.; Aoki, S. 2009: Design and synthesis of a stable supramolecular trigonal prism formed by the self-assembly of a linear tetrakis(Zn2+-cyclen) complex and trianionic trithiocyanuric acid in aqueous solution and its complexation with DNA (cyclen = 1,4,7,10-tetraazacyclododecane). Inorganic Chemistry 48(19): 9567-9578

Cui, G.; Ye, Z.; Zhang, R.; Wang, G.; Yuan, J. 2012: Design and synthesis of a terbium(III) complex-based luminescence probe for time-gated luminescence detection of mercury(II) ions. Journal of Fluorescence 22(1): 261-267

Dungan, V.J.; Ortin, Y.; Mueller-Bunz, H.; Rutledge, P.J. 2010: Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site. Organic and Biomolecular Chemistry 8(7): 1666-1673

Zhang, Y.; Liu, C.; Chou, C.J.; Wang, X.; Jia, Y.; Xu, W. 2013: Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chemical Biology and Drug Design 82(2): 125-130

Guiard, J.; Paszkiewicz, E.; Sadowska, J.; Bundle, D.R. 2013: Design and synthesis of a universal antigen to detect brucellosis. Angewandte Chemie 52(28): 7181-7185

Ye, Y.Q.; Onose, J.-i.; Abe, N.; Koshino, H.; Takahashi, S. 2012: Design and synthesis of a vialinin a analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes. Bioorganic and Medicinal Chemistry Letters 22(7): 2385-2387

Cendret, V.; François-Heude, M.; Méndez-Ardoy, A.; Moreau, V.; Fernández, J.é M.G.ía.; Djedaïni-Pilard, F. 2012: Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man8 binding affinity towards Con a. Chemical Communications 48(31): 3733-3735

Li, H.; Marcelo, F.; Bello, C.; Vogel, P.; Butters, T.D.; Rauter, A.él.P.; Zhang, Y.; Sollogoub, M.; Blériot, Y. 2009: Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors. Bioorganic and Medicinal Chemistry 17(15): 5598-5604

Lin, Y.-S.; Park, J.; De Schutter, J.W.; Huang, X.F.; Berghuis, A.M.; Sebag, M.; Tsantrizos, Y.S. 2012: Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry 55(7): 3201-3215

Eduardo-Canosa, S.; Fraga, R.ón.; Sigüeiro, R.; Marco, M.; Rochel, N.; Moras, D.; Mouriño, A. 2010: Design and synthesis of active vitamin D analogs. Journal of Steroid Biochemistry and Molecular Biology 121(1-2): 7-12

Ye, L.; Xu, A.; Cheng, C.; Zhang, L.; Huo, C.; Huang, F.; Xu, H.; Li, R. 2011: Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins. Journal of Separation Science 34(22): 3145-3150

Gim, H.J.; Li, H.; Lee, E.; Ryu, J.-H.; Jeon, R. 2013: Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists. Bioorganic and Medicinal Chemistry Letters 23(2): 513-517

Cluzeau, J.ér.ôm.; Oishi, S.; Ohno, H.; Wang, Z.; Evans, B.; Peiper, S.C.; Fujii, N. 2007: Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists. Organic and Biomolecular Chemistry 5(12): 1915-1923

Garner, J.; Harding, M.M. 2007: Design and synthesis of alpha-helical peptides and mimetics. Organic and Biomolecular Chemistry 5(22): 3577-3585

Chen, J.-C.; Uang, B.-J.; Lyu, P.-C.; Chang, J.-Y.; Liu, K.-J.; Kuo, C.-C.; Hsieh, H.-P.; Wang, H.-C.; Cheng, C.-S.; Chang, Y.-H.; Chang, M.D.-T.; Chang, W.-S.W.; Lin, C.-C. 2010: Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. Journal of Medicinal Chemistry 53(11): 4545-4549

Tan, X.; Wang, P.; Nian, S.; Wang, G. 2014: Design and synthesis of amide derivatives as S-adenosyl-L-homocysteine hydrolase inhibitors. Chemical and Pharmaceutical Bulletin 62(1): 112-117

Inokuchi, E.; Yamada, A.; Hozumi, K.; Tomita, K.; Oishi, S.; Ohno, H.; Nomizu, M.; Fujii, N. 2011: Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis. Organic and Biomolecular Chemistry 9(9): 3421-3427

Malamas, M.S.; Robichaud, A.; Erdei, J.; Quagliato, D.; Solvibile, W.; Zhou, P.; Morris, K.; Turner, J.; Wagner, E.; Fan, K.; Olland, A.; Jacobsen, S.; Reinhart, P.; Riddell, D.; Pangalos, M. 2010: Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability. Bioorganic and Medicinal Chemistry Letters 20(22): 6597-6605

Kamal, A.; Kumar, G.B.; Polepalli, S.; Shaik, A.B.; Reddy, V.S.; Reddy, M.K.; Reddy, C.R.; Mahesh, R.; Kapure, J.S.; Jain, N. 2014: Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors. Chemmedchem 9(11): 2565-2579

Zou, H.; Koh, J.-J.; Li, J.; Qiu, S.; Aung, T.T.; Lin, H.; Lakshminarayanan, R.; Dai, X.; Tang, C.; Lim, F.H.; Zhou, L.; Tan, A.L.; Verma, C.; Tan, D.T.H.; Chan, H.S.O.; Saraswathi, P.; Cao, D.; Liu, S.; Beuerman, R.W. 2013: Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity. Journal of Medicinal Chemistry 56(6): 2359-2373

Hakamata, W.; Machida, A.; Oku, T.; Nishio, T. 2011: Design and synthesis of an ER-specific fluorescent probe based on carboxylesterase activity with quinone methide cleavage process. Bioorganic and Medicinal Chemistry Letters 21(11): 3206-3209

Eerland, M.F.; Hedberg, C. 2012: Design and synthesis of an Fmoc-SPPS-compatible amino acid building block mimicking the transition state of phosphohistidine phosphatase. Journal of Organic Chemistry 77(4): 2047-2052

Kumar, N.S.; Young, R.N. 2009: Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling. Bioorganic and Medicinal Chemistry 17(15): 5388-5395

Kobayashi, T.; Iwama, S.; Fusano, A.; Kato, Y.; Ikeda, A.; Teranishi, Y.; Nishihara, A.; Tobe, M. 2014: Design and synthesis of an aminopiperidine series of γ-secretase modulators. Bioorganic and Medicinal Chemistry Letters 24(1): 378-381

Yoshino, H.; Sato, H.; Shiraishi, T.; Tachibana, K.; Emura, T.; Honma, A.; Ishikura, N.; Tsunenari, T.; Watanabe, M.; Nishimoto, A.; Nakamura, R.; Nakagawa, T.; Ohta, M.; Takata, N.; Furumoto, K.; Kimura, K.; Kawata, H. 2010: Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer. Bioorganic and Medicinal Chemistry 18(23): 8150-8157

Rutledge, R.D.; Huffman, B.J.; Cliffel, D.E.; Wright, D.W. 2008: Design and synthesis of an antigenic mimic of the Ebola glycoprotein. Journal of Materials Research 23(12): 3161-3168

Chen, J.-R.; Yang, D.-Y. 2009: Design and synthesis of an o-hydroxyphenyl-containing spiropyran thermochromic colorant. Organic Letters 11(8): 1769-1772

Midya, G.C.; Paladhi, S.; Bhowmik, S.; Saha, S.; Dash, J. 2013: Design and synthesis of an on-off "click" fluorophore that executes a logic operation and detects heavy and transition metal ions in water and living cells. Organic and Biomolecular Chemistry 11(18): 3057-3063

Dhanya, R.-P.; Sidique, S.; Sheffler, D.J.; Nickols, H.H.; Herath, A.; Yang, L.; Dahl, R.; Ardecky, R.; Semenova, S.; Markou, A.; Conn, P.J.; Cosford, N.D.P. 2011: Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. Journal of Medicinal Chemistry 54(1): 342-353

Zhou, H.-J.; Aujay, M.A.; Bennett, M.K.; Dajee, M.; Demo, S.D.; Fang, Y.; Ho, M.N.; Jiang, J.; Kirk, C.J.; Laidig, G.J.; Lewis, E.R.; Lu, Y.; Muchamuel, T.; Parlati, F.; Ring, E.; Shenk, K.D.; Shields, J.; Shwonek, P.J.; Stanton, T.; Sun, C.M.; Sylvain, C.; Woo, T.M.; Yang, J. 2009: Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). Journal of Medicinal Chemistry 52(9): 3028-3038

Marton, J.án.; Henriksen, G. 2012: Design and synthesis of an ¹⁸F-labeled version of phenylethyl orvinol ([¹⁸F]FE-PEO) for PET-imaging of opioid receptors. Molecules 17(10): 11554-11569

Zhou, J.; Geng, G.; Shi, Q.; Sauriol, F.; Wu, J.H. 2009: Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance. Journal of Medicinal Chemistry 52(17): 5546-5550

Goto, T.; Ohta, K.; Fujii, S.; Ohta, S.; Endo, Y. 2010: Design and synthesis of androgen receptor full antagonists bearing a p-carborane cage: promising ligands for anti-androgen withdrawal syndrome. Journal of Medicinal Chemistry 53(13): 4917-4926

González-Chávez, M.M.ín.; Méndez, F.; Martínez, R.; Pérez-González, C.úh.; Martínez-Gutiérrez, F. 2010: Design and synthesis of anti-MRSA benzimidazolylbenzene-sulfonamides. QSAR studies for prediction of antibacterial activity. Molecules 16(1): 175-189

Solomon, V.R.; Hu, C.; Lee, H. 2010: Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: a hybrid pharmacophore approach. Bioorganic and Medicinal Chemistry 18(4): 1563-1572

Tahoori, F.; Balalaie, S.; Sheikhnejad, R.; Sadjadi, M.; Boloori, P. 2014: Design and synthesis of anti-cancer cyclopeptides containing triazole skeleton. Amino Acids 46(4): 1033-1046

Garner, J.; Harding, M.M. 2010: Design and synthesis of antifreeze glycoproteins and mimics. Chembiochem: a European Journal of Chemical Biology 11(18): 2489-2498

Sheng, C.; Che, X.; Wang, W.; Wang, S.; Cao, Y.; Yao, J.; Miao, Z.; Zhang, W. 2011: Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping. European Journal of Medicinal Chemistry 46(5): 1706-1712

Koufaki, M.; Detsi, A. 2010: Design and synthesis of antioxidant alpha-lipoic acid hybrids. Methods in Molecular Biology 594: 297-309

Li, J.-q.; Huang, L.-y.; Chen, J.-x.; Weng, Z.-j.; Zhang, C.-n. 2007: Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities. Yao Xue Xue Bao 42(11): 1166-1175

Pabba, C.; Gregg, B.T.; Kitchen, D.B.; Chen, Z.J.; Judkins, A. 2011: Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. Bioorganic and Medicinal Chemistry Letters 21(1): 324-328

Tipparaju, S.K.; Mulhearn, D.C.; Klein, G.M.; Chen, Y.; Tapadar, S.; Bishop, M.H.; Yang, S.; Chen, J.; Ghassemi, M.; Santarsiero, B.D.; Cook, J.L.; Johlfs, M.; Mesecar, A.D.; Johnson, M.E.; Kozikowski, A.P. 2008: Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem 3(8): 1250-1268

Futatsugi, K.; Piotrowski, D.W.; Casimiro-Garcia, A.; Robinson, S.; Sammons, M.; Loria, P.M.; Banker, M.E.; Petersen, D.N.; Schmidt, N.J. 2013: Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists. Bioorganic and Medicinal Chemistry Letters 23(23): 6239-6242

Ali, S.; Rasool, N.; Ullah, A.; Nasim, F.-u.-H.; Yaqoob, A.; Zubair, M.; Rashid, U.; Riaz, M. 2013: Design and synthesis of arylthiophene-2-carbaldehydes via Suzuki-Miyaura reactions and their biological evaluation. Molecules 18(12): 14711-14725

Dhiman, R.; Sharma, S.; Singh, G.; Nepali, K.; Singh Bedi, P.M. 2013: Design and synthesis of aza-flavones as a new class of xanthine oxidase inhibitors. Archiv der Pharmazie 346(1): 7-16

Gim, H.J.; Li, H.; Jung, S.R.; Park, Y.J.; Ryu, J.-H.; Chung, K.H.; Jeon, R. 2014: Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics. European Journal of Medicinal Chemistry 85: 107-118

El-Gazzar, A.B.A.; Youssef, M.M.; Youssef, A.M.S.; Abu-Hashem, A.A.; Badria, F.A. 2009: Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities. European Journal of Medicinal Chemistry 44(2): 609-624

Qvit, N.; Hatzubai, A.; Shalev, D.E.; Ben-Neriah, Y.; Gilon, C. 2009: Design and synthesis of backbone cyclic phosphopeptides: the IkappaB model. Advances in Experimental Medicine and Biology 611: 139-140

Qvit, N.; Hatzubai, A.; Shalev, D.E.; Friedler, A.; Ben-Neriah, Y.; Gilon, C. 2009: Design and synthesis of backbone cyclic phosphorylated peptides: the IkappaB model. Biopolymers 91(2): 157-168

Tang, G.; Lin, X.; Qiu, Z.; Li, W.; Zhu, L.; Wang, L.; Li, S.; Li, H.; Lin, W.; Yang, M.; Guo, T.; Chen, L.; Lee, D.; Wu, J.Z.; Yang, W. 2011: Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors. Acs Medicinal Chemistry Letters 2(8): 603-607

Rathore, A.; Rahman, M.U.; Siddiqui, A.A.; Ali, A.; Shaharyar, M. 2014: Design and synthesis of benzimidazole analogs endowed with oxadiazole as selective COX-2 inhibitor. Archiv der Pharmazie 347(12): 923-935

Kamal, A.; Ramakrishna, G.; Lakshma Nayak, V.; Raju, P.; Subba Rao, A.V.; Viswanath, A.; Vishnuvardhan, M.V.P.S.; Ramakrishna, S.; Srinivas, G. 2012: Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents. Bioorganic and Medicinal Chemistry 20(2): 789-800

Wei, L.; Gao, X.; Warne, R.; Hao, X.; Bussiere, D.; Gu, X.-j.; Uno, T.; Liu, Y. 2010: Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1. Bioorganic and Medicinal Chemistry Letters 20(13): 3897-3902

Kotha, S.; Chavan, A.S. 2010: Design and synthesis of benzosultine-sulfone as a o-xylylene precursor via cross-enyne metathesis and rongalite: further expansion to polycyclics via regioselective Diels-Alder reaction. Journal of Organic Chemistry 75(12): 4319-4322

Gim, H.J.; Cheon, Y.-J.; Ryu, J.-H.; Jeon, R. 2011: Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists. Bioorganic and Medicinal Chemistry Letters 21(10): 3057-3061

Sun, R.; Liu, Y.; Zhang, Y.; Xiong, L.; Wang, Q. 2011: Design and synthesis of benzoylphenylureas with fluorinated substituents on the aniline ring as insect growth regulators. Journal of Agricultural and Food Chemistry 59(6): 2471-2477

Kumar, A.S.; Reddy, M.A.; Jain, N.; Kishor, C.; Murthy, T.R.; Ramesh, D.; Supriya, B.; Addlagatta, A.; Kalivendi, S.V.; Sreedhar, B. 2013: Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents. European Journal of Medicinal Chemistry 60: 305-324

Oehlrich, D.; Rombouts, F.J.R.; Berthelot, D.; Bischoff, F.ço.P.; De Cleyn, M.A.J.; Jaroskova, L.; Macdonald, G.; Mercken, M.; Surkyn, M.; Trabanco, A.és.A.; Tresadern, G.; Van Brandt, S.; Velter, A.I.; Wu, T.; Gijsen, H.J.M. 2013: Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators. Bioorganic and Medicinal Chemistry Letters 23(17): 4794-4800

Zhang, X.; Glunz, P.W.; Jiang, W.; Schmitt, A.; Newman, M.; Barbera, F.A.; Bozarth, J.M.; Rendina, A.R.; Wei, A.; Wen, X.; Rossi, K.A.; Luettgen, J.M.; Wong, P.C.; Knabb, R.M.; Wexler, R.R.; Scott Priestley, E. 2013: Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors. Bioorganic and Medicinal Chemistry Letters 23(6): 1604-1607

Aher, N.G.; Pore, V.S.; Mishra, N.N.; Shukla, P.K.; Gonnade, R.G. 2009: Design and synthesis of bile acid-based amino sterols as antimicrobial agents. Bioorganic and Medicinal Chemistry Letters 19(18): 5411-5414

Sokolova, N.V.; Latyshev, G.V.; Lukashev, N.V.; Nenajdenko, V.G. 2011: Design and synthesis of bile acid-peptide conjugates linked via triazole moiety. Organic and Biomolecular Chemistry 9(13): 4921-4926

Wang, C.; Chi, M.; Li, D.; Strmcnik, D.; van der Vliet, D.; Wang, G.; Komanicky, V.; Chang, K.-C.; Paulikas, A.P.; Tripkovic, D.; Pearson, J.; More, K.L.; Markovic, N.M.; Stamenkovic, V.R. 2011: Design and synthesis of bimetallic electrocatalyst with multilayered Pt-skin surfaces. Journal of the American Chemical Society 133(36): 14396-14403

Tada, S.; Kitajima, T.; Ito, Y. 2012: Design and synthesis of binding growth factors. International Journal of Molecular Sciences 13(5): 6053-6072

Zoidis, G.; Kolocouris, N.; Kelly, J.M.; Prathalingam, S.R.; Naesens, L.; De Clercq, E. 2010: Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines. European Journal of Medicinal Chemistry 45(11): 5022-5030

Lim, E.-K.; Haam, S.; Lee, K.; Huh, Y.-M. 2011: Design and synthesis of biofunctionalized metallic/magnetic nanomaterials. Methods in Molecular Biology 751: 583-595

Bryan, A.; Joseph, L.; Bennett, J.A.; Jacobson, H.I.; Andersen, T.T. 2011: Design and synthesis of biologically active peptides: a 'tail' of amino acids can modulate activity of synthetic cyclic peptides. Peptides 32(12): 2504-2510

Biswas, A.; Bayer, I.S.; Zhao, H.; Wang, T.; Watanabe, F.; Biris, A.S. 2010: Design and synthesis of biomimetic multicomponent all-bone-minerals bionanocomposites. Biomacromolecules 11(10): 2545-2549

Mizuhara, T.; Oishi, S.; Ohno, H.; Shimura, K.; Matsuoka, M.; Fujii, N. 2013: Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182. Bioorganic and Medicinal Chemistry 21(7): 2079-2087

Gu, M.; Yan, J.; Bai, Z.; Chen, Y.-T.; Lu, W.; Tang, J.; Duan, L.; Xie, D.; Nan, F.-J. 2010: Design and synthesis of biotin-tagged photoaffinity probes of jasmonates. Bioorganic and Medicinal Chemistry 18(9): 3012-3019

Saitoh, T.; Takeiri, M.; Gotoh, Y.; Ishikawa, Y.; Umezawa, K.; Nishiyama, S. 2011: Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components. Bioorganic and Medicinal Chemistry Letters 21(21): 6293-6296

Anraku, K.; Inoue, T.; Sugimoto, K.; Kudo, K.; Okamoto, Y.; Morii, T.; Mori, Y.; Otsuka, M. 2011: Design and synthesis of biotinylated inositol 1,3,4,5-tetrakisphosphate targeting Grp1 pleckstrin homology domain. Bioorganic and Medicinal Chemistry 19(22): 6833-6841

Anraku, K.; Inoue, T.; Sugimoto, K.; Morii, T.; Mori, Y.; Okamoto, Y.; Otsuka, M. 2008: Design and synthesis of biotinylated inositol phosphates relevant to the biotin-avidin techniques. Organic and Biomolecular Chemistry 6(10): 1822-1830

Bao, K.; Dai, Y.; Zhu, Z.-B.; Tu, F.-J.; Zhang, W.-G.; Yao, X.-S. 2010: Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors. Bioorganic and Medicinal Chemistry 18(18): 6708-6714

Lee, S.-H.; Chan, C.T.-L.; Wong, K.M.-C.; Lam, W.H.; Kwok, W.-M.; Yam, V.W.-W. 2014: Design and synthesis of bipyridine platinum(II) bisalkynyl fullerene donor-chromophore-acceptor triads with ultrafast charge separation. Journal of the American Chemical Society 136(28): 10041-10052

Jardosh, H.H.; Patel, M.P. 2013: Design and synthesis of biquinolone-isoniazid hybrids as a new class of antitubercular and antimicrobial agents. European Journal of Medicinal Chemistry 65: 348-359

Sechi, M.; Azzena, U.; Delussu, M.P.; Dallocchio, R.; Dessì, A.; Cosseddu, A.; Pala, N.; Neamati, N. 2008: Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors. Molecules 13(10): 2442-2461

Wilbur, D.S.; Park, S.I.; Chyan, M.-K.; Wan, F.; Hamlin, D.K.; Shenoi, J.; Lin, Y.; Wilbur, S.M.; Buchegger, F.; Pantelias, A.; Pagel, J.M.; Press, O.W. 2010: Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants. Bioconjugate Chemistry 21(7): 1225-1238

Kline, T.; Jackson, S.R.; Deng, W.; Verlinde, C.L.M.J.; Miller, S.I. 2008: Design and synthesis of bis-carbamate analogs of cyclic bis-(3'-5')-diguanylic acid (c-di-GMP) and the acyclic dimer PGPG. Nucleosides Nucleotides and Nucleic Acids 27(12): 1282-1300

Garre, S.; Parker, E.; Ni, B.; Headley, A.D. 2008: Design and synthesis of bistereogenic chiral ionic liquids and their use as solvents for asymmetric Baylis-Hillman reactions. Organic and Biomolecular Chemistry 6(17): 3041-3043

Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.-X. 2008: Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives. European Journal of Medicinal Chemistry 43(11): 2298-2306

Das, B.C.; Tang, X.-Y.; Evans, T. 2012: Design and synthesis of boron containing potential pan-RAR inverse agonists. Tetrahedron Letters 53(11): 1316-1318

Zhang, Y.-K.; Plattner, J.J.; Akama, T.; Baker, S.J.; Hernandez, V.S.; Sanders, V.; Freund, Y.; Kimura, R.; Bu, W.; Hold, K.M.; Lu, X.-S. 2010: Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Bioorganic and Medicinal Chemistry Letters 20(7): 2270-2274

O'Connell, D.P.; LeBlanc, D.F.; Cromley, D.; Billheimer, J.; Rader, D.J.; Bachovchin, W.W. 2012: Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorganic and Medicinal Chemistry Letters 22(3): 1397-1401

Bowers, S.; Truong, A.P.; Jeffrey Neitz, R.; Hom, R.K.; Sealy, J.M.; Probst, G.D.; Quincy, D.; Peterson, B.; Chan, W.; Galemmo, R.A.; Konradi, A.W.; Sham, H.L.; Tóth, G.; Pan, H.; Lin, M.; Yao, N.; Artis, D.R.; Zhang, H.; Chen, L.; Dryer, M.; Samant, B.; Zmolek, W.; Wong, K.; Lorentzen, C.; Goldbach, E.; Tonn, G.; Quinn, K.P.; Sauer, J-Michael.; Wright, S.; Powell, K.; Ruslim, L.; Ren, Z.; Bard, Fédérique.; Yednock, T.A.; Griswold-Prenner, I. 2011: Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorganic and Medicinal Chemistry Letters 21(18): 5521-5527

Xu, X.-D.; Zhang, J.; Chen, L.-J.; Guo, R.; Wang, D.-X.; Yang, H.-B. 2012: Design and synthesis of branched platinum-acetylide complexes possessing a porphyrin core and their self-assembly behaviour. Chemical Communications 48(91): 11223-11225

Bodiwala, H.S.; Sabde, S.; Gupta, P.; Mukherjee, R.; Kumar, R.; Garg, P.; Bhutani, K.K.; Mitra, D.; Singh, I.P. 2011: Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5. Bioorganic and Medicinal Chemistry 19(3): 1256-1263

Ikeda, S.; Kubota, T.; Wang, D.O.; Yanagisawa, H.; Umemoto, T.; Okamoto, A. 2011: Design and synthesis of caged fluorescent nucleotides and application to live-cell RNA imaging. Chembiochem: a European Journal of Chemical Biology 12(18): 2871-2880

Tanwar, J.; Datta, A.; Chauhan, K.; Kumaran, S.S.; Tiwari, A.K.; Kadiyala, K.G.; Pal, S.; Thirumal, M.; Mishra, A.K. 2014: Design and synthesis of calcium responsive magnetic resonance imaging agent: its relaxation and luminescence studies. European Journal of Medicinal Chemistry 82: 225-232

He, X.; Lam, W.H.; Zhu, N.; Yam, V.W.-W. 2009: Design and synthesis of calixarene-based bis-alkynyl-bridged dinuclear Au(I) isonitrile complexes as luminescent ion probes by the modulation of Au..au interactions. Chemistry 15(35): 8842-8851

Lee, K.Y.; Lee, K.S.; Jin, C.; Lee, Y.S. 2009: Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives. European Journal of Medicinal Chemistry 44(3): 1331-1334

Fulp, A.; Bortoff, K.; Seltzman, H.; Zhang, Y.; Mathews, J.; Snyder, R.; Fennell, T.; Maitra, R. 2012: Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity. Journal of Medicinal Chemistry 55(6): 2820-2834

Jin, G.H.; Lee, H.J.; Gim, H.J.; Ryu, J.-H.; Jeon, R. 2012: Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages. Bioorganic and Medicinal Chemistry Letters 22(9): 3301-3304

Kim, E.; Shen, G.Huan.; Hong, J.Hee. 2011: Design and synthesis of carbocyclic versions of furanoid nucleoside phosphonic Acid analogues as potential anti-hiv agents. Nucleosides Nucleotides and Nucleic Acids 30(10): 798-813

Wang, M.; Mickens, J.; Gao, M.; Miller, K.D.; Sledge, G.W.; Hutchins, G.D.; Zheng, Q.-H. 2009: Design and synthesis of carbon-11-labeled dual aromatase-steroid sulfatase inhibitors as new potential PET agents for imaging of aromatase and steroid sulfatase expression in breast cancer. Steroids 74(12): 896-905

Ohta, K.; Goto, T.; Fijii, S.; Suzuki, T.; Ohta, S.; Endo, Y. 2008: Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring. Bioorganic and Medicinal Chemistry 16(17): 8022-8028

Yang, Z.; Li, D.; Li, T. 2011: Design and synthesis of catenated rings based on toroidal DNA structures. Chemical Communications 47(43): 11930-11932

Pang, Y.; Zhu, Q.; Liu, J.; Wu, J.; Wang, R.; Chen, S.; Zhu, X.; Yan, D.; Huang, W.; Zhu, B. 2010: Design and synthesis of cationic drug carriers based on hyperbranched poly(amine-ester)s. Biomacromolecules 11(3): 575-582

Sealy, J.M.; Truong, A.P.; Tso, L.; Probst, G.D.; Aquino, J.; Hom, R.K.; Jagodzinska, B.M.; Dressen, D.; Wone, D.W.G.; Brogley, L.; John, V.; Tung, J.S.; Pleiss, M.A.; Tucker, J.A.; Konradi, A.W.; Dappen, M.S.; Toth, G.; Pan, H.; Ruslim, L.; Miller, J.; Bova, M.P.; Sinha, S.; Quinn, K.P.; Sauer, J.-M. 2009: Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorganic and Medicinal Chemistry Letters 19(22): 6386-6391

Trombino, S.; Cassano, R.; Bloise, E.; Muzzalupo, R.; Leta, S.; Puoci, F.; Picci, N. 2008: Design and synthesis of cellulose derivatives with antioxidant activity. Macromolecular Bioscience 8(1): 86-95

Hajra, S.; Bhowmick, M.; Maji, B.; Sinha, D. 2007: Design and synthesis of chiral N-chloroimidodicarbonates: application to asymmetric chlorination of silyl enol ethers. Journal of Organic Chemistry 72(13): 4872-4876

Itoh, S.; Sonoike, S.; Kitamura, M.; Aoki, S. 2014: Design and synthesis of chiral Zn2+ complexes mimicking natural aldolases for catalytic C-C bond forming reactions in aqueous solution. International Journal of Molecular Sciences 15(2): 2087-2118

Han, Z.S.; Herbage, M.A.; Mangunuru, H.P.R.; Xu, Y.; Zhang, L.; Reeves, J.T.; Sieber, J.D.; Li, Z.; DeCroos, P.; Zhang, Y.; Li, G.; Li, N.; Ma, S.; Grinberg, N.; Wang, X.; Goyal, N.; Krishnamurthy, D.; Lu, B.; Song, J.J.; Wang, G.; Senanayake, C.H. 2013: Design and synthesis of chiral oxathiozinone scaffolds: efficient synthesis of hindered enantiopure sulfinamides and sulfinyl ketimines. Angewandte Chemie 52(26): 6713-6717

Solomon, V.R.; Hu, C.; Lee, H. 2010: Design and synthesis of chloroquine analogs with anti-breast cancer property. European Journal of Medicinal Chemistry 45(9): 3916-3923

Yang, Q.; Chen, L.; He, X.; Gao, Z.; Shen, X.; Bai, D. 2008: Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors. Chemical and Pharmaceutical Bulletin 56(10): 1400-1405

Qiu, C.; Kumar, S.; Guo, J.; Yu, L.; Guo, W.; Shi, S.; Russo, J.J.; Ju, J. 2012: Design and synthesis of cleavable biotinylated dideoxynucleotides for DNA sequencing by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical Biochemistry 427(2): 193-201

Coleman, P.J.; Schreier, J.D.; McGaughey, G.B.; Bogusky, M.J.; Cox, C.D.; Hartman, G.D.; Ball, R.G.; Harrell, C.M.; Reiss, D.R.; Prueksaritanont, T.; Winrow, C.J.; Renger, J.J. 2010: Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists. Bioorganic and Medicinal Chemistry Letters 20(7): 2311-2315

Nishikawa, K.; Fukuda, H.; Abe, M.; Nakanishi, K.; Tazawa, Y.; Yamaguchi, C.; Hiradate, S.; Fujii, Y.; Okuda, K.; Shindo, M. 2013: Design and synthesis of conformationally constrained analogues of cis-cinnamic acid and evaluation of their plant growth inhibitory activity. Phytochemistry 96: 223-234

Dunsmore, C.J.; Malone, K.J.; Bailey, K.R.; Wear, M.A.; Florance, H.; Shirran, S.; Barran, P.E.; Page, A.P.; Walkinshaw, M.D.; Turner, N.J. 2011: Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans. Chembiochem: a European Journal of Chemical Biology 12(5): 802-810

Gomez, R.; Jolly, S.J.; Williams, T.; Vacca, J.P.; Torrent, M.; McGaughey, G.; Lai, M.-T.; Felock, P.; Munshi, V.; Distefano, D.; Flynn, J.; Miller, M.; Yan, Y.; Reid, J.; Sanchez, R.; Liang, Y.; Paton, B.; Wan, B.-L.; Anthony, N. 2011: Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. Journal of Medicinal Chemistry 54(22): 7920-7933

Rebolledo, C.L.; Sotelo-Hitschfeld, P.; Brauchi, S.án.; Olavarría, M.Z.ár. 2013: Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists. European Journal of Medicinal Chemistry 66: 193-203

Brink, M.; Dahlén, A.; Olsson, T.; Polla, M.; Svensson, T. 2014: Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorganic and Medicinal Chemistry 22(7): 2261-2268

Prieto, G.; Beijer, S.; Smith, M.L.; He, M.; Au, Y.; Wang, Z.; Bruce, D.A.; de Jong, K.P.; Spivey, J.J.; de Jongh, P.E. 2014: Design and synthesis of copper-cobalt catalysts for the selective conversion of synthesis gas to ethanol and higher alcohols. Angewandte Chemie 53(25): 6397-6401

Yang, Y.; Liu, Q.-W.; Shi, Y.; Song, Z.-G.; Jin, Y.-H.; Liu, Z.-Q. 2014: Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA. European Journal of Medicinal Chemistry 84: 1-7

Mizukami, S.; Okada, S.; Kimura, S.; Kikuchi, K. 2009: Design and synthesis of coumarin-based Zn(2+) probes for ratiometric fluorescence imaging. Inorganic Chemistry 48(16): 7630-7638

Zhang, X.; Tian, Y.; Li, Z.; Tian, X.; Sun, H.; Liu, H.; Moore, A.; Ran, C. 2013: Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease. Journal of the American Chemical Society 135(44): 16397-16409

Tsuzuki, T.; Sakaguchi, N.; Kudoh, T.; Takano, S.; Uehara, M.; Murayama, T.; Sakurai, T.; Hashii, M.; Higashida, H.; Weber, K.; Guse, A.H.; Kameda, T.; Hirokawa, T.; Kumaki, Y.; Potter, B.V.L.; Fukuda, H.; Arisawa, M.; Shuto, S. 2013: Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angewandte Chemie 52(26): 6633-6637

Fang, W.-J.; Kulkarni, S.S.; Murray, T.F.; Aldrich, J.V. 2009: Design and synthesis of cyclic arodyn analogues by ring-closing metathesis (RCM) for kappa opioid receptor (KOP) antagonists. Advances in Experimental Medicine and Biology 611: 279-280

Kiefer, L.; Gorojankina, T.; Dauban, P.; Faure, H.él.èn.; Ruat, M.; Dodd, R.H. 2010: Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists. Bioorganic and Medicinal Chemistry Letters 20(24): 7483-7487

Gomez-Paloma, L.; Bruno, I.; Cini, E.; Khochbin, S.; Rodriquez, M.; Taddei, M.; Terracciano, S.; Sadoul, K. 2007: Design and synthesis of cyclopeptide analogues of the potent histone deacetylase inhibitor FR235222. Chemmedchem 2(10): 1511-1519

Chen, H.; Li, Y.; Sheng, C.; Lv, Z.; Dong, G.; Wang, T.; Liu, J.; Zhang, M.; Li, L.; Zhang, T.; Geng, D.; Niu, C.; Li, K. 2013: Design and synthesis of cyclopropylamide analogues of combretastatin-A4 as novel microtubule-stabilizing agents. Journal of Medicinal Chemistry 56(3): 685-699

Sun, L.; Veith, J.M.; Pera, P.; Bernacki, R.J.; Ojima, I. 2010: Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel. Bioorganic and Medicinal Chemistry 18(19): 7101-7112

Li, Y.-F.; Morcos, P.A. 2008: Design and synthesis of dendritic molecular transporter that achieves efficient in vivo delivery of morpholino antisense oligo. Bioconjugate Chemistry 19(7): 1464-1470

Madhuri, V.; Kumar, V.A. 2012: Design and synthesis of dephosphono DNA analogues containing 1,2,3-triazole linker and their UV-melting studies with DNA/RNA. Nucleosides Nucleotides and Nucleic Acids 31(2): 97-111

Wang, X-Feng.; Tian, X-Tao.; Ohkoshi, E.; Qin, B.; Liu, Y-Nan.; Wu, P-Chi.; Hour, M-Jen.; Hung, H-Yi.; Qian, K.; Huang, R.; Bastow, K.F.; Janzen, W.P.; Jin, J.; Morris-Natschke, S.L.; Lee, K-Hsiung.; Xie, L. 2012: Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents. Bioorganic and Medicinal Chemistry Letters 22(19): 6224-6228

Darout, E.; Robinson, R.P.; McClure, K.F.; Corbett, M.; Li, B.; Shavnya, A.; Andrews, M.P.; Jones, C.S.; Li, Q.; Minich, M.L.; Mascitti, V.; Guimarães, C.R.W.; Munchhof, M.J.; Bahnck, K.B.; Cai, C.; Price, D.A.; Liras, S.; Bonin, P.D.; Cornelius, P.; Wang, R.; Bagdasarian, V.; Sobota, C.P.; Hornby, S.; Masterson, V.M.; Joseph, R.M.; Kalgutkar, A.S.; Chen, Y. 2013: Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119. Journal of Medicinal Chemistry 56(1): 301-319

Pettersson, M.; Johnson, D.S.; Subramanyam, C.; Bales, K.R.; am Ende, C.W.; Fish, B.A.; Green, M.E.; Kauffman, G.W.; Lira, R.; Mullins, P.B.; Navaratnam, T.; Sakya, S.M.; Stiff, C.M.; Tran, T.P.; Vetelino, B.C.; Xie, L.; Zhang, L.; Pustilnik, L.R.; Wood, K.M.; O'Donnell, C.J. 2012: Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators. Bioorganic and Medicinal Chemistry Letters 22(8): 2906-2911

Dandu, R.; Zulli, A.L.; Bacon, E.R.; Underiner, T.; Robinson, C.; Chang, H.; Miknyoczki, S.; Grobelny, J.; Ruggeri, B.A.; Yang, S.; Albom, M.S.; Angeles, T.S.; Aimone, L.D.; Hudkins, R.L. 2008: Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases. Bioorganic and Medicinal Chemistry Letters 18(6): 1916-1921

Fang, X.; Fang, L.; Gou, S.; Cheng, L. 2013: Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin. Bioorganic and Medicinal Chemistry Letters 23(5): 1297-1301

Abramova, T.V.; Vasileva, S.V.; Koroleva, L.S.; Kasatkina, N.S.; Silnikov, V.N. 2008: Design and synthesis of dinucleotide 5'-triphosphates with expanded functionality. Bioorganic and Medicinal Chemistry 16(20): 9127-9132

Gudasheva, T.A.; Tarasiuk, A.V.; Pomogaĭbo, S.V.; Logvinov, I.O.; Povarnina, P.I.; Antipova, T.A.; Seredenin, S.B. 2012: Design and synthesis of dipeptide mimetics of brain-derived neurotrophic factor. Bioorganicheskaia Khimiia 38(3): 280-290

Guay, D.; Beaulieu, C.; Truchon, J.-F.; Jagadeeswar Reddy, T.; Zamboni, R.; Bayly, C.I.; Methot, N.; Rubin, J.; Ethier, D.; David Percival, M. 2009: Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorganic and Medicinal Chemistry Letters 19(18): 5392-5396

Chonan, T.; Tanaka, H.; Yamamoto, D.; Yashiro, M.; Oi, T.; Wakasugi, D.; Ohoka-Sugita, A.; Io, F.; Koretsune, H.; Hiratate, A. 2010: Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(13): 3965-3968

Hom, R.K.; Bowers, S.; Sealy, J.M.; Truong, A.P.; Probst, G.D.; Neitzel, M.L.; Neitz, R.J.; Fang, L.; Brogley, L.; Wu, J.; Konradi, A.W.; Sham, H.L.; Tóth, G.; Pan, H.; Yao, N.; Artis, D.R.; Quinn, K.; Sauer, J.-M.; Powell, K.; Ren, Z.; Bard, F.éd.ér.; Yednock, T.A.; Griswold-Prenner, I. 2010: Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorganic and Medicinal Chemistry Letters 20(24): 7303-7307

Xu, L.; Jiang, Z.; Qing, Q.; Mai, L.; Zhang, Q.; Lieber, C.M. 2013: Design and synthesis of diverse functional kinked nanowire structures for nanoelectronic bioprobes. Nano Letters 13(2): 746-751

Helmy, S.; Oh, S.; Leibfarth, F.A.; Hawker, C.J.; Read de Alaniz, J. 2014: Design and synthesis of donor-acceptor Stenhouse adducts: a visible light photoswitch derived from furfural. Journal of Organic Chemistry 79(23): 11316-11329

Jadhav, T.; Maragani, R.; Misra, R.; Sreeramulu, V.; Rao, D.N.; Mobin, S.M. 2013: Design and synthesis of donor-acceptor pyrazabole derivatives for multiphoton absorption. Dalton Transactions 42(13): 4340-4342

La Buscató, E.; Blöcher, R.é; Lamers, C.; Klingler, F.-M.; Hahn, S.; Steinhilber, D.; Schubert-Zsilavecz, M.; Proschak, E. 2012: Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. Journal of Medicinal Chemistry 55(23): 10771-10775

Chen, J.-B.; Chern, T.-R.; Wei, T.-T.; Chen, C.-C.; Lin, J.-H.; Fang, J.-M. 2013: Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase for cancer treatment. Journal of Medicinal Chemistry 56(9): 3645-3655

Chen, H.; Li, M.; Wan, T.; Zheng, Q.; Cheng, M.; Huang, S.; Wang, Y. 2012: Design and synthesis of dual-ligand modified chitosan as a liver targeting vector. Journal of Materials Science. Materials in Medicine 23(2): 431-441

Oh, C.Hyun.; Liu, L.Jin.; Hong, J.Hee. 2010: Design and synthesis of dually branched 5'-norcarbocyclic adenosine phosphonodiester analogue as a new anti-HIV prodrug. Nucleosides Nucleotides and Nucleic Acids 29(10): 721-733

Hsueh, Y.-S.; Savitha, S.; Sadhasivam, S.; Lin, F.-H.; Shieh, M.-J. 2014: Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration. Materials Science and Engineering. C Materials for Biological Applications 38: 119-126

Arjmand, F.; Muddassir, M.; Yousuf, I. 2014: Design and synthesis of enantiomeric (R)- and (S)-copper(II) and diorganotin(IV)-based antitumor agents: their in vitro DNA binding profile, cleavage efficiency and cytotoxicity studies. Journal of Photochemistry and Photobiology. B Biology 136: 62-71

Roy, S.; Basak, A. 2010: Design and synthesis of enediyne-based peptide with selective peptide-cleaving activity. Chemical Communications 46(13): 2283-2285

Peixoto, P.A.; Boulangé, A.; Ball, M.; Naudin, B.; Alle, T.; Cosette, P.; Karuso, P.; Franck, X. 2014: Design and synthesis of epicocconone analogues with improved fluorescence properties. Journal of the American Chemical Society 136(43): 15248-15256

Demizu, Y.; Okuhira, K.; Motoi, H.; Ohno, A.; Shoda, T.; Fukuhara, K.; Okuda, H.; Naito, M.; Kurihara, M. 2012: Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy. Bioorganic and Medicinal Chemistry Letters 22(4): 1793-1796

Nakamura, H.; Ueda, N.; Ban, H.S.; Ueno, M.; Tachikawa, S. 2012: Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy. Organic and Biomolecular Chemistry 10(7): 1374-1380

De Ornellas, S.; Slattery, J.M.; Edkins, R.M.; Beeby, A.; Baumann, C.G.; Fairlamb, I.J.S. 2015: Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing π-extended diarylacetylene motifs. Organic and Biomolecular Chemistry 13(1): 68-72

Lansdell, M.I.; Burring, D.J.; Hepworth, D.; Strawbridge, M.; Graham, E.; Guyot, T.; Betson, M.S.; Hart, J.D. 2008: Design and synthesis of fluorescent SGLT2 inhibitors. Bioorganic and Medicinal Chemistry Letters 18(18): 4944-4947

Chorell, E.; Pinkner, J.S.; Bengtsson, C.; Edvinsson, S.; Cusumano, C.K.; Rosenbaum, E.; Johansson, L.B.Å; Hultgren, S.J.; Almqvist, F. 2012: Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry 18(15): 4522-4532

Kaneda, M.; Misu, R.; Ohno, H.; Hirasawa, A.; Ieda, N.; Uenoyama, Y.; Tsukamura, H.; Maeda, K.-i.; Oishi, S.; Fujii, N. 2014: Design and synthesis of fluorescent probes for GPR54. Bioorganic and Medicinal Chemistry 22(13): 3325-3330

Ma, Y.; Roy, S.; Kong, X.; Chen, Y.; Liu, D.; Hider, R.C. 2012: Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake. Journal of Medicinal Chemistry 55(5): 2185-2195

Kong, W.-Y.; Chen, X.-F.; Shi, J.; Baloch, S.K.; Qi, J.-L.; Zhu, H.-L.; Wang, X.-M.; Yang, Y.-H. 2013: Design and synthesis of fluoroacylshikonin as an anticancer agent. Chirality 25(11): 757-762

Yen, C.-T.; Nakagawa-Goto, K.; Hwang, T.-L.; Morris-Natschke, S.L.; Bastow, K.F.; Wu, Y.-C.; Lee, K.-H. 2012: Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. Bioorganic and Medicinal Chemistry Letters 22(12): 4018-4022

Zhang, K.; Schweizer, F. 2009: Design and synthesis of glucose-templated proline-lysine chimera: polyfunctional amino acid chimera with high prolyl cis amide rotamer population. Carbohydrate Research 344(5): 576-585

Wang, H.; Huang, W.; Orwenyo, J.; Banerjee, A.; Vasta, G.R.; Wang, L.-X. 2013: Design and synthesis of glycoprotein-based multivalent glyco-ligands for influenza hemagglutinin and human galectin-3. Bioorganic and Medicinal Chemistry 21(7): 2037-2044

Norgren, A.S.; Arvidsson, P.I. 2008: Design and synthesis of glycosylated beta3-peptides capable of folding into the 3(14)-helical conformation in water. Journal of Organic Chemistry 73(14): 5272-5278

Adane, L.; Bhagat, S.; Arfeen, M.; Bhatia, S.; Sirawaraporn, R.; Sirawaraporn, W.; Chakraborti, A.K.; Bharatam, P.V. 2014: Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme. Bioorganic and Medicinal Chemistry Letters 24(2): 613-617

Misra, A.; Kumar, P.; Gupta, K.C. 2007: Design and synthesis of hairpin probe for specific mis-match discrimination. Nucleic Acids Symposium Series 51: 311-312

Pawar, V.U.; Ghosh, S.; Chopade, B.A.; Shinde, V.S. 2010: Design and synthesis of harzialactone analogues: promising anticancer agents. Bioorganic and Medicinal Chemistry Letters 20(24): 7243-7245

Chow, C.-F.; Lam, M.H.W.; Wong, W.-Y. 2013: Design and synthesis of heterobimetallic Ru(II)-Ln(III) complexes as chemodosimetric ensembles for the detection of biogenic amine odorants. Analytical Chemistry 85(17): 8246-8253

Arjmand, F.; Muddassir, M. 2010: Design and synthesis of heterobimetallic topoisomerase i and Ii inhibitor complexes: in vitro DNA binding, interaction with 5'-GMP and 5'-TMP and cleavage studies. Journal of Photochemistry and Photobiology. B Biology 101(1): 37-46

Chai, Y.; Paul, A.; Rettig, M.; Wilson, W.D.; Boykin, D.W. 2014: Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences. Journal of Organic Chemistry 79(3): 852-866

Hou, Y.; Cheng, Y.; Hobson, T.; Liu, J. 2010: Design and synthesis of hierarchical MnO2 nanospheres/carbon nanotubes/conducting polymer ternary composite for high performance electrochemical electrodes. Nano Letters 10(7): 2727-2733

Rackham, M.D.; Brannigan, J.A.; Rangachari, K.; Meister, S.; Wilkinson, A.J.; Holder, A.A.; Leatherbarrow, R.J.; Tate, E.W. 2014: Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). Journal of Medicinal Chemistry 57(6): 2773-2788

Sarkar, D.; Mandal, M.; Mandal, K. 2013: Design and synthesis of high performance multifunctional ultrathin hematite nanoribbons. Acs Applied Materials and Interfaces 5(22): 11995-12004

Maric, H.M.; Kasaragod, V.B.; Haugaard-Kedström, L.; Hausrat, T.J.; Kneussel, M.; Schindelin, H.; Strømgaard, K. 2015: Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors. Angewandte Chemie 54(2): 490-494

Ogata, M.; Yano, M.; Umemura, S.; Murata, T.; Park, E.Y.; Kobayashi, Y.; Asai, T.; Oku, N.; Nakamura, N.; Matsuo, I.; Usui, T. 2012: Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties. Bioconjugate Chemistry 23(1): 97-105

Fang, Z.; Gu, Z.; Zhu, W.; Zhong, X. 2009: Design and synthesis of high-quality CdS/ZnSe type-Ii core/shell nanocrystals. Journal of Nanoscience and Nanotechnology 9(10): 5880-5886

Zhang, W.; Chen, G.; Wang, J.; Ye, B.-C.; Zhong, X. 2009: Design and synthesis of highly luminescent near-infrared-emitting water-soluble CdTe/CdSe/ZnS core/shell/shell quantum dots. Inorganic Chemistry 48(20): 9723-9731

Bojinov, V.B.; Georgiev, N.I.; Bosch, P. 2009: Design and synthesis of highly photostable yellow-green emitting 1,8-naphthalimides as fluorescent sensors for metal cations and protons. Journal of Fluorescence 19(1): 127-139

Qiu, X.; Zhao, G.-D.; Tang, L.-Q.; Liu, Z.-P. 2014: Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands. Bioorganic and Medicinal Chemistry Letters 24(11): 2465-2468

Zheng, K.; Iqbal, S.; Hernandez, P.; Park, H.; LoGrasso, P.V.; Feng, Y. 2014: Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives. Journal of Medicinal Chemistry 57(23): 10013-10030

Bach, A.; Chi, C.N.; Pang, G.F.; Olsen, L.; Kristensen, A.S.; Jemth, P.; Strømgaard, K. 2009: Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. Angewandte Chemie 48(51): 9685-9689

Taylor, M.T.; Blackman, M.L.; Dmitrenko, O.; Fox, J.M. 2011: Design and synthesis of highly reactive dienophiles for the tetrazine-trans-cyclooctene ligation. Journal of the American Chemical Society 133(25): 9646-9649

Bowers, S.; Truong, A.P.; Ye, M.; Aubele, D.L.; Sealy, J.M.; Neitz, R.J.; Hom, R.K.; Chan, W.; Dappen, M.S.; Galemmo, R.A.; Konradi, A.W.; Sham, H.L.; Zhu, Y.L.; Beroza, P.; Tonn, G.; Zhang, H.; Hoffman, J.; Motter, R.; Fauss, D.; Tanaka, P.; Bova, M.P.; Ren, Z.; Tam, D.; Ruslim, L.; Baker, J.; Pandya, D.; Diep, L.; Fitzgerald, K.; Artis, D.R.; Anderson, J.P.; Bergeron, M. 2013: Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorganic and Medicinal Chemistry Letters 23(9): 2743-2749

Fujikawa, Y.; Urano, Y.; Komatsu, T.; Hanaoka, K.; Kojima, H.; Terai, T.; Inoue, H.; Nagano, T. 2008: Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells. Journal of the American Chemical Society 130(44): 14533-14543

Matsumoto, K.; Takahashi, N.; Suzuki, A.; Morii, T.; Saito, Y.; Saito, I. 2011: Design and synthesis of highly solvatochromic fluorescent 2'-deoxyguanosine and 2'-deoxyadenosine analogs. Bioorganic and Medicinal Chemistry Letters 21(4): 1275-1278

Singh, S.; Prasad, N.R.; Chufan, E.E.; Patel, B.A.; Wang, Y.-J.; Chen, Z.-S.; Ambudkar, S.V.; Talele, T.T. 2014: Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid. Journal of Medicinal Chemistry 57(10): 4058-4072

Cagnoni, A.J.; Kovensky, J.é; Uhrig, M.ía.L. 2014: Design and synthesis of hydrolytically stable multivalent ligands bearing thiodigalactoside analogues for peanut lectin and human galectin-3 binding. Journal of Organic Chemistry 79(14): 6456-6467

Sadakiyo, M.; Kasai, H.; Kato, K.; Takata, M.; Yamauchi, M. 2014: Design and synthesis of hydroxide ion-conductive metal-organic frameworks based on salt inclusion. Journal of the American Chemical Society 136(5): 1702-1705

Ng, R.A.; Sun, M.; Bowers, S.; Hom, R.K.; Probst, G.D.; John, V.; Fang, L.Y.; Maillard, M.; Gailunas, A.; Brogley, L.; Neitz, R.J.; Tung, J.S.; Pleiss, M.A.; Konradi, A.W.; Sham, H.L.; Dappen, M.S.; Adler, M.; Yao, N.; Zmolek, W.; Nakamura, D.; Quinn, K.P.; Sauer, J.-M.; Bova, M.P.; Ruslim, L.; Artis, D.R.; Yednock, T.A. 2013: Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorganic and Medicinal Chemistry Letters 23(16): 4674-4679

Probst, G.D.; Bowers, S.; Sealy, J.M.; Stupi, B.; Dressen, D.; Jagodzinska, B.M.; Aquino, J.; Gailunas, A.; Truong, A.P.; Tso, L.; Xu, Y.-Z.; Hom, R.K.; John, V.; Tung, J.S.; Pleiss, M.A.; Tucker, J.A.; Konradi, A.W.; Sham, H.L.; Jagodzinski, J.; Toth, G.; Brecht, E.; Yao, N.; Pan, H.; Lin, M.; Artis, D.R.; Ruslim, L.; Bova, M.P.; Sinha, S.; Yednock, T.A.; Gauby, S.; Zmolek, W.; Quinn, K.P.; Sauer, J.-M. 2010: Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. Bioorganic and Medicinal Chemistry Letters 20(20): 6034-6039

Li, D.-F.; Hu, P.-P.; Liu, M.-S.; Kong, X.-L.; Zhang, J.-C.; Hider, R.C.; Zhou, T. 2013: Design and synthesis of hydroxypyridinone-L-phenylalanine conjugates as potential tyrosinase inhibitors. Journal of Agricultural and Food Chemistry 61(27): 6597-6603

Huang, S.; Qing, J.; Wang, S.; Wang, H.; Zhang, L.; Tang, Y. 2014: Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C-H arylation. Organic and Biomolecular Chemistry 12(15): 2344-2348

Kamal, A.; Balakrishna, M.; Nayak, V.L.; Shaik, T.B.; Faazil, S.; Nimbarte, V.D. 2014: Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents. Chemmedchem 9(12): 2766-2780

Wang, K.; Xu, W.; Liu, Y.; Zhang, W.; Wang, W.; Shen, J.; Wang, Y. 2013: Design and synthesis of imidazole and triazole derivatives as Lp-PLA₂ inhibitors and the unexpected discovery of highly potent quaternary ammonium salts. Bioorganic and Medicinal Chemistry Letters 23(5): 1187-1192

Ma, Y.; Sun, S.-X.; Cheng, X.-C.; Wang, S.-Q.; Dong, W.-L.; Wang, R.-L.; Xu, W.-R. 2013: Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase. Chemical Biology and Drug Design 82(5): 595-602

Kim, O.; Jeong, Y.; Lee, H.; Hong, S.-S.; Hong, S. 2011: Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis. Journal of Medicinal Chemistry 54(7): 2455-2466

Huang, T.; Zhu, Y.-l.; Dai, X.-q.; Zhang, Q.; Huang, Y. 2011: Design and synthesis of imine compound for metal cation logical gates recognition and setup of double-control fluorescent molecule switch. Guang Pu Xue Yu Guang Pu Fen Xi 31(7): 1834-1837

Shen, Y.-D.; Zhang, S.-W.; Lei, H.-T.; Wang, H.; Xiao, Z.-L.; Jiang, Y.-M.; Sun, Y.-M. 2008: Design and synthesis of immunoconjugates and development of an indirect ELISA for rapid detection of 3, 5-dinitrosalicyclic Acid hydrazide. Molecules 13(9): 2238-2248

Sathe, M.; Merwyn, S.; Ghorpade, R.; Agarwal, G.S.; Rao, M.K.; Rai, G.P.; Kaushik, M.P. 2011: Design and synthesis of immunoconjugates and development of competition inhibition enzyme-linked immunosorbent assay (CIEIA) for the detection of O-isopropyl methylphosphonofluoridate (sarin): an organophosphorous toxicant. Journal of Hazardous Materials 192(3): 1720-1728

Kang, I.-J.; Wang, L.-W.; Hsu, S.-J.; Lee, C.-C.; Lee, Y.-C.; Wu, Y.-S.; Hsu, T.-A.; Yueh, A.; Chao, Y.-S.; Chern, J.-H. 2009: Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors. Bioorganic and Medicinal Chemistry Letters 19(15): 4134-4138

Arisawa, M.; Kasaya, Y.; Obata, T.; Sasaki, T.; Nakamura, T.; Araki, T.; Yamamoto, K.; Sasaki, A.; Yamano, A.; Ito, M.; Abe, H.; Ito, Y.; Shuto, S. 2012: Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity. Journal of Medicinal Chemistry 55(18): 8152-8163

Millan, D.S.; Bunnage, M.E.; Burrows, J.L.; Butcher, K.J.; Dodd, P.G.; Evans, T.J.; Fairman, D.A.; Hughes, S.J.; Kilty, I.C.; Lemaitre, A.; Lewthwaite, R.A.; Mahnke, A.; Mathias, J.P.; Philip, J.; Smith, R.T.; Stefaniak, M.H.; Yeadon, M.; Phillips, C. 2011: Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Journal of Medicinal Chemistry 54(22): 7797-7814

Winkler, J.D.; Isaacs, A.é; Holderbaum, L.; Tatard, V.ér.; Dahmane, N. 2009: Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine. Organic Letters 11(13): 2824-2827

Yu, Z.; Brannigan, J.A.; Moss, D.K.; Brzozowski, A.Marek.; Wilkinson, A.J.; Holder, A.A.; Tate, E.W.; Leatherbarrow, R.J. 2012: Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. Journal of Medicinal Chemistry 55(20): 8879-8890

Dou, D.; Mandadapu, S.R.; Alliston, K.R.; Kim, Y.; Chang, K.-O.; Groutas, W.C. 2011: Design and synthesis of inhibitors of noroviruses by scaffold hopping. Bioorganic and Medicinal Chemistry 19(19): 5749-5755

Geotti-Bianchini, P.; Beyrath, J.; Chaloin, O.; Formaggio, F.; Bianco, A. 2008: Design and synthesis of intrinsically cell-penetrating nucleopeptides. Organic and Biomolecular Chemistry 6(20): 3661-3663

Hsieh, C.-H.; Wu, F.-I.; Fan, C.-H.; Huang, M.-J.; Lu, K.-Y.; Chou, P.-Y.; Yang, Y.-H.O.; Wu, S.-H.; Chen, I.-C.; Chou, S.-H.; Wong, K.-T.; Cheng, C.-H. 2011: Design and synthesis of iridium bis(carbene) complexes for efficient blue electrophosphorescence. Chemistry 17(33): 9180-9187

Roqué Rosell, N.úr.R.; Mokhlesi, L.; Milton, N.E.; Sweeney, T.R.; Zunszain, P.A.; Curry, S.; Leatherbarrow, R.J. 2014: Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease. Bioorganic and Medicinal Chemistry Letters 24(2): 490-494

Ito, H.; Kato, T.; Sawamura, M. 2007: Design and synthesis of isocyanide ligands for catalysis: application to Rh-catalyzed hydrosilylation of ketones. Chemistry An Asian Journal 2(11): 1436-1446

Lavieri, R.; Scott, S.A.; Lewis, J.A.; Selvy, P.E.; Armstrong, M.D.; Alex Brown, H.; Lindsley, C.W. 2009: Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity. Bioorganic and Medicinal Chemistry Letters 19(8): 2240-2243

Yoshimura, Y.; Asami, K.; Imamichi, T.; Okuda, T.; Shiraki, K.; Takahata, H. 2010: Design and synthesis of isonucleosides constructed on a 2-oxa-6-thiabicyclo[3.2.0]heptane scaffold. Journal of Organic Chemistry 75(12): 4161-4171

Buchstaller, H.-P.; Burgdorf, L.; Finsinger, D.; Stieber, F.; Sirrenberg, C.; Amendt, C.; Grell, M.; Zenke, F.; Krier, M. 2011: Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 21(8): 2264-2269

Khaybullin, R.N.; Zhang, M.; Fu, J.; Liang, X.; Li, T.; Katritzky, A.R.; Okunieff, P.; Qi, X. 2014: Design and synthesis of isosteviol triazole conjugates for cancer therapy. Molecules 19(11): 18676-18689

Barnes-Seeman, D.; Boiselle, C.; Capacci-Daniel, C.; Chopra, R.; Hoffmaster, K.; Jones, C.T.; Kato, M.; Lin, K.; Ma, S.; Pan, G.; Shu, L.; Wang, J.; Whiteman, L.; Xu, M.; Zheng, R.; Fu, J. 2014: Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Bioorganic and Medicinal Chemistry Letters 24(16): 3979-3985

Ohta, T.; Fukuda, T.; Ishibashi, F.; Iwao, M. 2009: Design and synthesis of lamellarin D analogues targeting topoisomerase i. Journal of Organic Chemistry 74(21): 8143-8153

An, P.; Yu, Z.; Lin, Q. 2013: Design and synthesis of laser-activatable tetrazoles for a fast and fluorogenic red-emitting 1,3-dipolar cycloaddition reaction. Organic Letters 15(21): 5496-5499

Tateishi, H.; Anraku, K.; Koga, R.; Okamoto, Y.; Fujita, M.; Otsuka, M. 2014: Design and synthesis of lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate derivatives exhibiting high-affinity binding for the HIV-1 MA domain. Organic and Biomolecular Chemistry 12(27): 5006-5022

Liang, X.; Li, X.; Jing, L.; Xue, P.; Jiang, L.; Ren, Q.; Dai, Z. 2013: Design and synthesis of lipidic organoalkoxysilanes for the self-assembly of liposomal nanohybrid cerasomes with controlled drug release properties. Chemistry 19(47): 16113-16121

Osornio, Y.M.; Uebelhart, P.; Bosshard, S.; Konrad, F.; Siegel, J.S.; Landau, E.M. 2012: Design and synthesis of lipids for the fabrication of functional lipidic cubic-phase biomaterials. Journal of Organic Chemistry 77(23): 10583-10595

Millan, D.S.; Ballard, S.A.; Chunn, S.; Dybowski, J.A.; Fulton, C.K.; Glossop, P.A.; Guillabert, E.; Hewson, C.A.; Jones, R.M.; Lamb, D.J.; Napier, C.M.; Payne-Cook, T.A.; Renery, E.R.; Selby, M.D.; Tutt, M.F.; Yeadon, M. 2011: Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma. Bioorganic and Medicinal Chemistry Letters 21(19): 5826-5830

He, X.; Zhu, N.; Yam, V.W.-W. 2011: Design and synthesis of luminescence chemosensors based on alkynyl phosphine gold(I)-copper(I) aggregates. Dalton Transactions 40(38): 9703-9710

Khan, M.F.; Maurya, C.K.; Dev, K.; Arha, D.; Rai, A.K.; Tamrakar, A.K.; Maurya, R. 2014: Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells. Bioorganic and Medicinal Chemistry Letters 24(12): 2674-2679

Hanessian, S.; Larsson, A.; Fex, T.; Knecht, W.; Blomberg, N. 2010: Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Bioorganic and Medicinal Chemistry Letters 20(23): 6925-6928

Xiao, B.; Yin, J.; Park, M.; Liu, J.; Li, J.Lin.; Kim, E.La.; Hong, J.; Chung, H.Young.; Jung, J.H. 2012: Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists. Bioorganic and Medicinal Chemistry 20(16): 4954-4961

Majik, M.S.; Rodrigues, C.; Mascarenhas, S.; D'Souza, L. 2014: Design and synthesis of marine natural product-based 1H-indole-2,3-dione scaffold as a new antifouling/antibacterial agent against fouling bacteria. Bioorganic Chemistry 54: 89-95

Brown, N.; Gao, G.; Minatoya, M.; Xie, B.; Vandervelde, D.; Lushington, G.H.; Perchellet, J.-P.H.; Perchellet, E.M.; Crow, K.R.; Buszek, K.R. 2008: Design and synthesis of medium-ring lactam libraries inspired by octalactin a. a convergent-divergent approach. Journal of Combinatorial Chemistry 10(5): 628-631

Oishi, S.; Kodera, Y.; Nishikawa, H.; Kamitani, H.; Watabe, T.; Ohno, H.; Tochikura, T.; Shimane, K.; Kodama, E.; Matsuoka, M.; Mizukoshi, F.; Tsujimoto, H.; Fujii, N. 2009: Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus. Bioorganic and Medicinal Chemistry 17(14): 4916-4920

Krishna, P.M.; Reddy, N.B.G.; Kottam, N.; Yallur, B.C.; Katreddi, H.R. 2013: Design and synthesis of metal complexes of (2E)-2-[(2E)-3-phenylprop-2-en-1-ylidene]hydrazinecarbothioamide and their photocatalytic degradation of methylene blue. Thescientificworldjournal 2013: 828313

Tang, T.; Zhang, L.; Fu, W.; Ma, Y.; Xu, J.; Jiang, J.; Fang, G.; Xiao, F.-S. 2013: Design and synthesis of metal sulfide catalysts supported on zeolite nanofiber bundles with unprecedented hydrodesulfurization activities. Journal of the American Chemical Society 135(31): 11437-11440

Perry, J.J.; Perman, J.A.; Zaworotko, M.J. 2009: Design and synthesis of metal-organic frameworks using metal-organic polyhedra as supermolecular building blocks. Chemical Society Reviews 38(5): 1400-1417

Sorto, N.A.; Painter, P.P.; Fettinger, J.C.; Tantillo, D.J.; Shaw, J.T. 2013: Design and synthesis of mimics of the T7-loop of FtsZ. Organic Letters 15(11): 2700-2703

Li, Z.; Hao, P.; Li, L.; Tan, C.Y.J.; Cheng, X.; Chen, G.Y.J.; Sze, S.K.; Shen, H.-M.; Yao, S.Q. 2013: Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angewandte Chemie 52(33): 8551-8556

Perro, A.; Meng, G.; Fung, J.; Manoharan, V.N. 2009: Design and synthesis of model transparent aqueous colloids with optimal scattering properties. Langmuir: the Acs Journal of Surfaces and Colloids 25(19): 11295-11298

Coughlin, J.E.; Henson, Z.B.; Welch, G.C.; Bazan, G.C. 2014: Design and synthesis of molecular donors for solution-processed high-efficiency organic solar cells. Accounts of Chemical Research 47(1): 257-270

Sharma, L.K.; Cupit, P.M.; Goronga, T.; Webb, T.R.; Cunningham, C. 2014: Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel. Bioorganic and Medicinal Chemistry Letters 24(11): 2469-2472

Mehdinia, A.; Aziz-Zanjani, M.O.; Ahmadifar, M.; Jabbari, A. 2013: Design and synthesis of molecularly imprinted polypyrrole based on nanoreactor SBA-15 for recognition of ascorbic acid. Biosensors and Bioelectronics 39(1): 88-93

Hoque, M.A.; Islam, M.S.; Islam, M.N.; Kato, T.; Nishino, N.; Ito, A.; Yoshida, M. 2014: Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases. Amino Acids 46(10): 2435-2444

Traina, C.A.; Bakus, R.C.; Bazan, G.C. 2011: Design and synthesis of monofunctionalized, water-soluble conjugated polymers for biosensing and imaging applications. Journal of the American Chemical Society 133(32): 12600-12607

Fish, P.V.; Deur, C.; Gan, X.; Greene, K.; Hoople, D.; Mackenny, M.; Para, K.S.; Reeves, K.; Ryckmans, T.; Stiff, C.; Stobie, A.; Wakenhut, F.; Whitlock, G.A. 2008: Design and synthesis of morpholine derivatives. SAR for dual serotonin and noradrenaline reuptake inhibition. Bioorganic and Medicinal Chemistry Letters 18(8): 2562-2566

Brinãs, R.P.; Sundgren, A.; Sahoo, P.; Morey, S.; Rittenhouse-Olson, K.; Wilding, G.E.; Deng, W.; Barchi, J.J. 2012: Design and synthesis of multifunctional gold nanoparticles bearing tumor-associated glycopeptide antigens as potential cancer vaccines. Bioconjugate Chemistry 23(8): 1513-1523

Ding, F.; Ji, L.; William, R.; Chai, H.; Liu, X.-W. 2014: Design and synthesis of multivalent neoglycoconjugates by click conjugations. Beilstein Journal of Organic Chemistry 10: 1325-1332

Leclerc, V.ér.; Ettaoussi, M.; Rami, M.; Farce, A.; Boutin, J.A.; Delagrange, P.; Caignard, D.-H.; Renard, P.; Berthelot, P.; Yous, S.ïd. 2011: Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3. European Journal of Medicinal Chemistry 46(5): 1622-1629

Xu, K.; Xiao, Z.; Tang, Y.B.; Huang, L.; Chen, C.-H.; Ohkoshi, E.; Lee, K.-H. 2012: Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. Bioorganic and Medicinal Chemistry Letters 22(8): 2772-2774

Qin, Z.; Luo, J.; VandeVrede, L.; Tavassoli, E.; Fa', M.; Teich, A.F.; Arancio, O.; Thatcher, G.R.J. 2012: Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. Journal of Medicinal Chemistry 55(15): 6784-6801

Carvalho, S.A.; Feitosa, L.O.; Soares, M.ár.; Costa, T.E.M.M.; Henriques, M.G.; Salomão, K.; de Castro, S.L.; Kaiser, M.; Brun, R.; Wardell, J.L.; Wardell, S.M.S.V.; Trossini, G.H.G.; Andricopulo, A.D.; da Silva, E.F.; Fraga, C.A.M. 2012: Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European Journal of Medicinal Chemistry 54: 512-521

Zarghi, A.; Zebardast, T.; Hajighasemali, F.; Alipoor, E.; Daraie, B.; Hedayati, M. 2012: Design and synthesis of new 1,3-benzdiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Archiv der Pharmazie 345(4): 257-264

Zarghi, A.; Zebardast, T.; Daraie, B.; Hedayati, M. 2009: Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorganic and Medicinal Chemistry 17(15): 5369-5373

Iman, M.; Davood, A.; Nematollahi, A.R.; Dehpoor, A.R.; Shafiee, A. 2011: Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker. Archives of Pharmacal Research 34(9): 1417-1426

Zhang, R.; Gong, Q.; Emge, T.J.; Banerjee, D.; Li, J. 2013: Design and synthesis of new 1D and 2D R-isophthalic acid-based coordination polymers (R = hydrogen or bromine). Chimia 67(6): 393-396

Abdel-Wahab, B.F.; Abdel-Latif, E.; Mohamed, H.A.; Awad, G.E.A. 2012: Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents. European Journal of Medicinal Chemistry 52: 263-268

Zhao, X.-B.; Goto, M.; Song, Z.-L.; Morris-Natschke, S.L.; Zhao, Y.; Wu, D.; Yang, L.; Li, S.-G.; Liu, Y.-Q.; Zhu, G.-X.; Wu, X.-B.; Lee, K.-H. 2014: Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorganic and Medicinal Chemistry Letters 24(16): 3850-3853

Hayallah, A.K.M.; Talhouni, A.A.; Alim, A.A.M.A. 2012: Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents. Archives of Pharmacal Research 35(8): 1355-1368

Boechat, N.; Pinheiro, L.C.S.; Santos-Filho, O.A.; Silva, I.C. 2011: Design and synthesis of new N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes. Molecules 16(9): 8083-8097

Yen, C.-T.; Hwang, T.-L.; Wu, Y.-C.; Hsieh, P.-W. 2009: Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. European Journal of Medicinal Chemistry 44(5): 1933-1940

Tsotinis, A.; Gourgourinis, J.; Eleutheriades, A.; Davidson, K.; Sugden, D. 2007: Design and synthesis of new N-OMe fluoro-indole melatoninergics. Medicinal Chemistry 3(6): 561-571

Jiang, M.; Tang, D.; Zhao, X.; Li, Q.; Zhuang, Y.; Wei, X.; Li, X.; Liu, Y.; Wu, X-Yan.; Shao, Z.; Gong, B.; Shen, Y-Mei. 2014: Design and synthesis of new acid cleavable linkers for DNA sequencing by synthesis. Nucleosides Nucleotides and Nucleic Acids 33(12): 774-785

Papanastasiou, I.; Prousis, K.C.; Georgikopoulou, K.; Pavlidis, T.; Scoulica, E.; Kolocouris, N.; Calogeropoulou, T. 2010: Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids. Bioorganic and Medicinal Chemistry Letters 20(18): 5484-5487

Liu, Y.; Yu, H.; Zhao, L.; Zhang, H. 2013: Design and synthesis of new agents for neuronal nicotinic acetylcholine receptor (nAChRs) imaging. Nuclear Medicine and Biology 40(1): 126-134

Ganesan, M.; Madhukarrao, R.V.; Ramesh, N.G. 2010: Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of alpha-galactosidase. Organic and Biomolecular Chemistry 8(7): 1527-1530

El-Deeb, I.M.; Lee, S.H. 2010: Design and synthesis of new anticancer pyrimidines with multiple-kinase inhibitory effect. Bioorganic and Medicinal Chemistry 18(11): 3860-3874

Le Roux, A.; Kuzmanovski, I.; Habrant, D.; Meunier, S.ép.; Bischoff, P.; Nadal, B.; Thetiot-Laurent, S.A.-L.; Le Gall, T.; Wagner, A.; Novič, M. 2011: Design and synthesis of new antioxidants predicted by the model developed on a set of pulvinic acid derivatives. Journal of Chemical Information and Modeling 51(12): 3050-3059

Maji, B.; Kumar, K.; Kaulage, M.; Muniyappa, K.; Bhattacharya, S. 2014: Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells. Journal of Medicinal Chemistry 57(16): 6973-6988

Prezzavento, O.; Arena, E.; Parenti, C.; Pasquinucci, L.; Aricò, G.; Scoto, G.M.; Grancara, S.; Toninello, A.; Ronsisvalle, S. 2013: Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity. Journal of Medicinal Chemistry 56(6): 2447-2455

Barve, I.J.; Chen, C.-Y.; Salunke, D.B.; Chung, W.-S.; Sun, C.-M. 2012: Design and synthesis of new biprivileged molecular scaffolds: indolo-fused benzodiazepinyl/quinoxalinyl benzimidazoles. Chemistry An Asian Journal 7(7): 1684-1690

Da Silva, G.D.; da Silva, M.G.; Souza, E.M.P.V.E.; Barison, A.; Simões, S.C.; Varotti, F.P.; Barbosa, L.A.; Viana, G.H.R.; Villar, J.é A.F.P. 2012: Design and synthesis of new chacones substituted with azide/triazole groups and analysis of their cytotoxicity towards Hela cells. Molecules 17(9): 10331-10343

Shintani, R.; Narui, R.; Tsutsumi, Y.; Hayashi, S.; Hayashi, T. 2011: Design and synthesis of new chiral phosphorus-olefin bidentate ligands and their use in the rhodium-catalyzed asymmetric addition of organoboroxines to N-sulfonyl imines. Chemical Communications 47(21): 6123-6125

Radwan, A.A.; Alanazi, F.K. 2014: Design and synthesis of new cholesterol-conjugated 5-Fluorouracil: a novel potential delivery system for cancer treatment. Molecules 19(9): 13177-13187

Kotera, N.; Delacour, L.éa.; Traoré, T.én.; Tassali, N.; Berthault, P.; Buisson, D.-A.; Dognon, J.-P.; Rousseau, B. 2011: Design and synthesis of new cryptophanes with intermediate cavity sizes. Organic Letters 13(9): 2153-2155

Suzuki, Y.; Takagi, N.; Chimuro, T.; Shinohara, A.; Sakaguchi, N.; Hiratsuka, A.; Yokoyama, K. 2011: Design and synthesis of new fluorescent probe for rapid and highly sensitive detection of proteins via electrophoretic gel stain. Electrophoresis 32(12): 1403-1413

Wilson, J.L.; Fayad Kobeissi, S.; Oudir, S.; Haas, B.; Michel, B.; Dubois Randé, J.-L.; Ollivier, A.; Martens, T.; Rivard, M.; Motterlini, R.; Foresti, R. 2014: Design and synthesis of new hybrid molecules that activate the transcription factor Nrf2 and simultaneously release carbon monoxide. Chemistry 20(45): 14698-14704

Kim, J.Jin.; Kim, H.Rae.; Arai, H.; Lee, S.Hyup. 2012: Design and synthesis of new mitomycin dimers containing a seven-membered cyclic disulfide and a diol linkers. Archives of Pharmacal Research 35(8): 1413-1420

Malik, S.; Ahuja, P.; Sahu, K.; Khan, S.A. 2014: Design and synthesis of new of 3-(benzo[d]isoxazol-3-yl)-1-substituted pyrrolidine-2, 5-dione derivatives as anticonvulsants. European Journal of Medicinal Chemistry 84: 42-50

El-Deeb, I.M.; Lee, S.H. 2010: Design and synthesis of new potent anticancer pyrazoles with high FLT3 kinase inhibitory selectivity. Bioorganic and Medicinal Chemistry 18(11): 3961-3973

Iwahashi, M.; Takahashi, E.; Tanaka, M.; Matsunaga, Y.; Okada, Y.; Matsumoto, R.; Nambu, F.; Nakai, H.; Toda, M. 2011: Design and synthesis of new prostaglandin D₂ receptor antagonists. Bioorganic and Medicinal Chemistry 19(18): 5361-5371

Zarghi, A.; Rao, P.N.P.; Knaus, E.E. 2007: Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere. Journal of Pharmacy and Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences Societe Canadienne des Sciences Pharmaceutiques 10(2): 159-167

Rachid, Z.; Macphee, M.; Williams, C.; Todorova, M.; Jean-Claude, B.J. 2009: Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2. Bioorganic and Medicinal Chemistry Letters 19(18): 5505-5509

Tian, Y.; Uchida, K.; Kurata, H.; Hirao, Y.; Nishiuchi, T.; Kubo, T. 2014: Design and synthesis of new stable fluorenyl-based radicals. Journal of the American Chemical Society 136(36): 12784-12793

Foroughinia, F.; Javidnia, K.; Amirghofran, Z.; Mehdipour, A.; Miri, R. 2008: Design and synthesis of new symmetrical derivatives of dihydropyridine containing a pyridyl group on the 3, 5-positions and evaluation of their cytotoxic and multidrug resistance reversal activity. Journal of Pharmacy and Pharmacology 60(11): 1481-1489

Escribano, A.; Mateo, A.I.; Martin de la Nava, E.M.; Mayhugh, D.R.; Cockerham, S.L.; Beyer, T.P.; Schmidt, R.J.; Cao, G.; Zhang, Y.; Jones, T.M.; Borel, A.G.; Sweetana, S.A.; Cannady, E.A.; Mantlo, N.B. 2012: Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors. Bioorganic and Medicinal Chemistry Letters 22(11): 3671-3675

De Bona, P.; Giuffrida, M.L.; Caraci, F.; Copani, A.; Pignataro, B.; Attanasio, F.; Cataldo, S.; Pappalardo, G.; Rizzarelli, E. 2009: Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity. Journal of Peptide Science: An Official Publication of the European Peptide Society 15(3): 220-228

Konno, S.; Thanigaimalai, P.; Yamamoto, T.; Nakada, K.; Kakiuchi, R.; Takayama, K.; Yamazaki, Y.; Yakushiji, F.; Akaji, K.; Kiso, Y.; Kawasaki, Y.; Chen, S.-E.; Freire, E.; Hayashi, Y. 2013: Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety. Bioorganic and Medicinal Chemistry 21(2): 412-424

Gu, W.; Chen, B.; Ge, M. 2014: Design and synthesis of new vancomycin derivatives. Bioorganic and Medicinal Chemistry Letters 24(10): 2305-2308

Peng, S.-P.; Yu, L.-P.; Li, J.-Q. 2009: Design and synthesis of nitrogen-containing benzoheterocyclic derivatives and their antipsychotic activities. Yao Xue Xue Bao 44(9): 994-1001

Fujigaya, T.; Uchinoumi, T.; Kaneko, K.; Nakashima, N. 2011: Design and synthesis of nitrogen-containing calcined polymer/carbon nanotube hybrids that act as a platinum-free oxygen reduction fuel cell catalyst. Chemical Communications 47(24): 6843-6845

Subramanian, T.; Ren, H.; Subramanian, K.Leela.; Sunkara, M.; Onono, F.O.; Morris, A.J.; Spielmann, H.Peter. 2014: Design and synthesis of non-hydrolyzable homoisoprenoid α-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases. Bioorganic and Medicinal Chemistry Letters 24(18): 4414-4417

Rawls, K.A.; Grundner, C.; Ellman, J.A. 2010: Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic and Biomolecular Chemistry 8(18): 4066-4070

Fujii, S.; Yamada, A.; Nakano, E.; Takeuchi, Y.; Mori, S.; Masuno, H.; Kagechika, H. 2014: Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C'-diphenylcarborane scaffold as a hydrophobic pharmacophore. European Journal of Medicinal Chemistry 84: 264-277

Kim, E.; Liu, L.Jin.; Lee, W.; Hong, J.Hee. 2012: Design and synthesis of novel 1',3'-dioxolane 5'-deoxyphosphonic acid purine analogues as potent antiviral agents. Nucleosides Nucleotides and Nucleic Acids 31(2): 85-96

Khazir, J.; Hyder, I.; Gayatri, J.L.; Prasad Yandrati, L.; Nalla, N.; Chasoo, G.; Mahajan, A.; Saxena, A.K.; Alam, M.S.; Qazi, G.N.; Sampath Kumar, H.M. 2014: Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds. European Journal of Medicinal Chemistry 82: 255-262

Duan, Y.-C.; Ma, Y.-C.; Zhang, E.; Shi, X.-J.; Wang, M.-M.; Ye, X.-W.; Liu, H.-M. 2013: Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents. European Journal of Medicinal Chemistry 62: 11-19

Ma, L.-Y.; Pang, L.-P.; Wang, B.; Zhang, M.; Hu, B.; Xue, D.-Q.; Shao, K.-P.; Zhang, B.-L.; Liu, Y.; Zhang, E.; Liu, H.-M. 2014: Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents. European Journal of Medicinal Chemistry 86: 368-380

Fujishima, T.; Nozaki, T.; Suenaga, T. 2013: Design and synthesis of novel 1,25-dihydroxyvitamin D3 analogues having a spiro-oxetane fused at the C2 position in the A-ring. Bioorganic and Medicinal Chemistry 21(17): 5209-5217

Mohamed, L.W.; El-Yamany, M.F. 2012: Design and synthesis of novel 1,4-benzodiazepine derivatives and their biological evaluation as cholinesterase inhibitors. Archives of Pharmacal Research 35(8): 1369-1377

Jeong, L.S.; Choi, Y.N.; Tosh, D.K.; Choi, W.J.; Kim, H.O.; Choi, J. 2008: Design and synthesis of novel 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents. Bioorganic and Medicinal Chemistry 16(23): 9891-9897

Lv, Z.; Zhang, Y.; Zhang, M.; Chen, H.; Sun, Z.; Geng, D.; Niu, C.; Li, K. 2013: Design and synthesis of novel 2'-hydroxy group substituted 2-pyridone derivatives as anticancer agents. European Journal of Medicinal Chemistry 67: 447-453

Alagarsamy, V.; Parthiban, P. 2013: Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents. Journal of Enzyme Inhibition and Medicinal Chemistry 28(1): 65-71

Qin, M.; Zhai, X.; Xie, H.; Ma, J.; Lu, K.; Wang, Y.; Wang, L.; Gu, Y.; Gong, P. 2014: Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents. European Journal of Medicinal Chemistry 81: 47-58

Liu, X.-H.; Jia, Y.-M.; Song, B.-A.; Pang, Z.-x.; Yang, S. 2013: Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(3): 720-723

Bansal, S.; Bala, M.; Suthar, S.K.; Choudhary, S.; Bhattacharya, S.; Bhardwaj, V.; Singla, S.; Joseph, A. 2014: Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity. European Journal of Medicinal Chemistry 80: 167-174

Chang, S.; Yin, S.-L.; Wang, J.; Jing, Y.-K.; Dong, J.-H. 2009: Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells. Molecules 14(10): 4166-4179

Verissimo, E.; Berry, N.; Gibbons, P.; Cristiano, M.L.S.; Rosenthal, P.J.; Gut, J.; Ward, S.A.; O'Neill, P.M. 2008: Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorganic and Medicinal Chemistry Letters 18(14): 4210-4214

Kushwaha, K.; Kaushik, N.; Lata; Jain, S.C. 2014: Design and synthesis of novel 2H-chromen-2-one derivatives bearing 1,2,3-triazole moiety as lead antimicrobials. Bioorganic and Medicinal Chemistry Letters 24(7): 1795-1801

Comes Franchini, M.; Bonini, B.F.; Camaggi, C.M.; Gentili, D.; Pession, A.; Rani, M.; Strocchi, E. 2010: Design and synthesis of novel 3,4-disubstituted pyrazoles for nanomedicine applications against malignant gliomas. European Journal of Medicinal Chemistry 45(5): 2024-2033

Razzaghi-Asl, N.; Firuzi, O.; Hemmateenejad, B.; Javidnia, K.; Edraki, N.; Miri, R. 2013: Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors. Bioorganic and Medicinal Chemistry 21(22): 6893-6909

Cho, S.Y.; Lee, B.H.; Jung, H.; Yun, C.S.; Ha, J.D.; Kim, H.R.; Chae, C.H.; Lee, J.H.; Seo, H.W.; Oh, K.-S. 2013: Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorganic and Medicinal Chemistry Letters 23(24): 6711-6716

Raval, S.; Raval, P.; Bandyopadhyay, D.; Soni, K.; Yevale, D.; Jogiya, D.; Modi, H.; Joharapurkar, A.; Gandhi, N.; Jain, M.R.; Patel, P.R. 2008: Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands. Bioorganic and Medicinal Chemistry Letters 18(14): 3919-3924

Tang, L.; Zhao, L.; Hong, L.; Yang, F.; Sheng, R.; Chen, J.; Shi, Y.; Zhou, N.; Hu, Y. 2013: Design and synthesis of novel 3-substituted-indole derivatives as selective H3 receptor antagonists and potent free radical scavengers. Bioorganic and Medicinal Chemistry 21(19): 5936-5944

Suthar, S.K.; Bansal, S.; Lohan, S.; Modak, V.; Chaudhary, A.; Tiwari, A. 2013: Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over i and Ii with potential anticancer activity. European Journal of Medicinal Chemistry 66: 372-379

Cai, J.; Sun, M.; Wu, X.; Chen, J.; Wang, P.; Zong, X.; Ji, M. 2013: Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents. European Journal of Medicinal Chemistry 63: 702-712

Xie, W.; Xie, S.; Zhou, Y.; Tang, X.; Liu, J.; Yang, W.; Qiu, M. 2014: Design and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents. European Journal of Medicinal Chemistry 81: 22-27

Liu, X.-H.; Li, J.; Shi, J.B.; Song, B.-A.; Qi, X.-B. 2012: Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents. European Journal of Medicinal Chemistry 51: 294-299

El-Azab, A.S.; Eltahir, K.E.H. 2012: Design and synthesis of novel 7-aminoquinazoline derivatives: antitumor and anticonvulsant activities. Bioorganic and Medicinal Chemistry Letters 22(5): 1879-1885

Li, Z.; Zhou, Z.-L.; Miao, Z.-H.; Lin, L.-P.; Feng, H.-J.; Tong, L.-J.; Ding, J.; Li, Y.-C. 2009: Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents. Journal of Medicinal Chemistry 52(16): 5115-5123

Trujillo, J.I.; Huang, W.; Hughes, R.O.; Rogier, D.J.; Turner, S.R.; Devraj, R.; Morton, P.A.; Xue, C.-B.; Chao, G.; Covington, M.B.; Newton, R.C.; Metcalf, B. 2011: Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs. Bioorganic and Medicinal Chemistry Letters 21(6): 1827-1831

Zhang, B.-L.; Zhang, E.; Pang, L.-P.; Song, L.-X.; Li, Y.-F.; Yu, B.; Liu, H.-M. 2013: Design and synthesis of novel D-ring fused steroidal heterocycles. Steroids 78(12-13): 1200-1208

Okaniwa, M.; Hirose, M.; Imada, T.; Ohashi, T.; Hayashi, Y.; Miyazaki, T.; Arita, T.; Yabuki, M.; Kakoi, K.; Kato, J.; Takagi, T.; Kawamoto, T.; Yao, S.; Sumita, A.; Tsutsumi, S.; Tottori, T.; Oki, H.; Sang, B.-C.; Yano, J.; Aertgeerts, K.; Yoshida, S.; Ishikawa, T. 2012: Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds. Journal of Medicinal Chemistry 55(7): 3452-3478

Okaniwa, M.; Imada, T.; Ohashi, T.; Miyazaki, T.; Arita, T.; Yabuki, M.; Sumita, A.; Tsutsumi, S.; Higashikawa, K.; Takagi, T.; Kawamoto, T.; Inui, Y.; Yoshida, S.; Ishikawa, T. 2012: Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption. Bioorganic and Medicinal Chemistry 20(15): 4680-4692

Hirose, M.; Okaniwa, M.; Miyazaki, T.; Imada, T.; Ohashi, T.; Tanaka, Y.; Arita, T.; Yabuki, M.; Kawamoto, T.; Tsutsumi, S.; Sumita, A.; Takagi, T.; Sang, B.-C.; Yano, J.; Aertgeerts, K.; Yoshida, S.; Ishikawa, T. 2012: Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives. Bioorganic and Medicinal Chemistry 20(18): 5600-5615

Wu, X.; Li, M.; Qu, Y.; Tang, W.; Zheng, Y.; Lian, J.; Ji, M.; Xu, L. 2010: Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity. Bioorganic and Medicinal Chemistry 18(11): 3812-3822

Frlan, R.; Kovac, A.; Blanot, D.; Gobec, S.; Pecar, S.; Obreza, A. 2008: Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents. Molecules 13(1): 11-30

Johnson, T.W.; Tanis, S.P.; Butler, S.L.; Dalvie, D.; Delisle, D.M.; Dress, K.R.; Flahive, E.J.; Hu, Q.; Kuehler, J.E.; Kuki, A.; Liu, W.; McClellan, G.A.; Peng, Q.; Plewe, M.B.; Richardson, P.F.; Smith, G.L.; Solowiej, J.; Tran, K.T.; Wang, H.; Yu, X.; Zhang, J.; Zhu, H. 2011: Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors. Journal of Medicinal Chemistry 54(9): 3393-3417

Adrian Meredith, J.; Wallberg, H.; Vrang, L.; Oscarson, S.; Parkes, K.; Hallberg, A.; Samuelsson, B. 2010: Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors. European Journal of Medicinal Chemistry 45(1): 160-170

Chen, T.; Jiang, B.; Guo, L. 2010: Design and synthesis of novel PPARgamma agonists. Sichuan da Xue Xue Bao. Yi Xue Ban 41(4): 700-702

Liu, L.Jin.; Hong, J.Hee. 2010: Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides. Nucleosides Nucleotides and Nucleic Acids 29(3): 257-266

Isshiki, Y.; Kohchi, Y.; Iikura, H.; Matsubara, Y.; Asoh, K.; Murata, T.; Kohchi, M.; Mizuguchi, E.; Tsujii, S.; Hattori, K.; Miura, T.; Yoshimura, Y.; Aida, S.; Miwa, M.; Saitoh, R.; Murao, N.; Okabe, H.; Belunis, C.; Janson, C.; Lukacs, C.; Schück, V.; Shimma, N. 2011: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent. Bioorganic and Medicinal Chemistry Letters 21(6): 1795-1801

Ashton, K.S.; St Jean, D.J.; Poon, S.F.; Lee, M.R.; Allen, J.G.; Zhang, S.; Lofgren, J.A.; Zhang, X.; Fotsch, C.; Hungate, R. 2011: Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorganic and Medicinal Chemistry Letters 21(18): 5191-5196

Tashima, T.; Murata, H.; Kodama, H. 2014: Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors. Bioorganic and Medicinal Chemistry 22(14): 3720-3731

Mallesham, G.; Balaiah, S.; Ananth Reddy, M.; Sridhar, B.; Singh, P.; Srivastava, R.; Bhanuprakash, K.; Jayathirtha Rao, V. 2014: Design and synthesis of novel anthracene derivatives as n-type emitters for electroluminescent devices: a combined experimental and DFT study. Photochemical and Photobiological Sciences: Official Journal of the European Photochemistry Association and the European Society for Photobiology 13(2): 342-357

Shams, H.Z.; Mohareb, R.M.; Helal, M.H.; Mahmoud, A.E.-S. 2011: Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems. Molecules 16(8): 6271-6305

Tiruveedhula, V.V.N.P.B.; Witzigmann, C.M.; Verma, R.; Kabir, M.S.; Rott, M.; Schwan, W.R.; Medina-Bielski, S.; Lane, M.; Close, W.; Polanowski, R.L.; Sherman, D.; Monte, A.; Deschamps, J.R.; Cook, J.M. 2013: Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis. Bioorganic and Medicinal Chemistry 21(24): 7830-7840

Seo, H.J.; Park, E.-J.; Kim, M.J.; Kang, S.Y.; Lee, S.H.; Kim, H.J.; Lee, K.N.; Jung, M.E.; Lee, M.; Kim, M.-S.; Son, E.-J.; Park, W.-K.; Kim, J.; Lee, J. 2011: Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. Journal of Medicinal Chemistry 54(18): 6305-6318

Bourguet, C.B.; Boulay, P.-L.; Claing, A.; Lubell, W.D. 2014: Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells. Bioorganic and Medicinal Chemistry Letters 24(15): 3361-3365

Zhang, H.-Y.; Wang, B.; Sheng, L.; Li, D.; Zhang, D.-F.; Lin, Z.-Y.; Lu, Y.; Li, Y.; Huang, H.-H. 2014: Design and synthesis of novel benzimidazole derivatives as anti-tuberculosis agents. Yao Xue Xue Bao 49(5): 644-651

Luo, Y.; Yao, J.-P.; Yang, L.; Feng, C.-L.; Tang, W.; Wang, G.-F.; Zuo, J.-P.; Lu, W. 2010: Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus. Bioorganic and Medicinal Chemistry 18(14): 5048-5055

Hamaguchi, W.; Masuda, N.; Isomura, M.; Miyamoto, S.; Kikuchi, S.; Amano, Y.; Honbou, K.; Mihara, T.; Watanabe, T. 2013: Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorganic and Medicinal Chemistry 21(24): 7612-7623

Chen, Q.; Tian, W.; Han, G.; Qi, J.; Zheng, C.; Zhou, Y.; Ding, L.; Zhao, J.; Zhu, J.; Lv, J.; Sheng, C. 2013: Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping. European Journal of Medicinal Chemistry 59: 176-182

Pingali, H.; Jain, M.; Shah, S.; Zaware, P.; Makadia, P.; Pola, S.; Thube, B.; Patel, D.; Patil, P.; Priyadarshini, P.; Suthar, D.; Shah, M.; Giri, S.; Patel, P. 2010: Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists. Bioorganic and Medicinal Chemistry Letters 20(3): 1156-1161

Sarkis, M.; Tran, D.N.; Kolb, S.ép.; Miteva, M.A.; Villoutreix, B.O.; Garbay, C.; Braud, E. 2012: Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition. Bioorganic and Medicinal Chemistry Letters 22(24): 7345-7350

Arns, S.; Gibe, R.; Moreau, A.; Monzur Morshed, M.; Young, R.N. 2012: Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis. Bioorganic and Medicinal Chemistry 20(6): 2131-2140

Liu, Y-Qian.; Dai, W.; Yang, L.; Li, H-Yu. 2011: Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents. Natural Product Research 25(19): 1817-1826

Oh, C.Hyun.; Kim, E.; Hong, J.Hee. 2011: Design and synthesis of novel carbocyclic versions of 2'-spirocyclopropyl ribonucleosides as potent anti-HCV agents. Nucleosides Nucleotides and Nucleic Acids 30(6): 423-439

Li, Y.; Zhou, Y.; Ma, Y.; Li, X. 2011: Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU. Carbohydrate Research 346(13): 1714-1720

Yang, K.; Wang, Q.; Su, L.; Fang, H.; Wang, X.; Gong, J.; Wang, B.; Xu, W. 2009: Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors. Bioorganic and Medicinal Chemistry 17(11): 3810-3817

Venkateswararao, E.; Sharma, V.K.; Lee, K.-C.; Roh, E.; Kim, Y.; Jung, S.-H. 2013: Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors. Bioorganic and Medicinal Chemistry 21(9): 2543-2550

El-Gamel, N.E.A.; Farghaly, T.A. 2013: Design and synthesis of novel complexes containing N-phenyl-1H-pyrazole moiety: Ni complex as potential antifungal and antiproliferative compound. Spectrochimica Acta. Part a Molecular and Biomolecular Spectroscopy 115: 469-475

Fukai, R.; Zheng, X.; Motoshima, K.; Tai, A.; Yazama, F.; Kakuta, H. 2011: Design and synthesis of novel cyclooxygenase-1 inhibitors as analgesics: 5-amino-2-ethoxy-N-(substituted-phenyl)benzamides. Chemmedchem 6(3): 550-560

Li, H.-Q.; Luo, Y.; Lv, P.-C.; Shi, L.; Liu, C.-H.; Zhu, H.-L. 2010: Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents. Bioorganic and Medicinal Chemistry Letters 20(6): 2025-2028

Schinke, C.; Goel, S.; Bhagat, T.D.; Zhou, L.; Mo, Y.; Gallagher, R.; Kabalka, G.W.; Platanias, L.C.; Verma, A.; Das, B. 2010: Design and synthesis of novel derivatives of all-trans retinoic acid demonstrate the combined importance of acid moiety and conjugated double bonds in its binding to PML-RAR-alpha oncogene in acute promyelocytic leukemia. Leukemia and Lymphoma 51(6): 1108-1114

Dehnhardt, C.M.; Venkatesan, A.M.; Chen, Z.; Ayral-Kaloustian, S.; Dos Santos, O.; Delos Santos, E.; Curran, K.; Follettie, M.T.; Diesl, V.; Lucas, J.; Geng, Y.; Dejoy, S.Q.; Petersen, R.; Chaudhary, I.; Brooijmans, N.; Mansour, T.S.; Arndt, K.; Chen, L. 2010: Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition. Journal of Medicinal Chemistry 53(2): 897-910

Nikalje, A.P.G.; Ghodke, M.; Girbane, A. 2012: Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants. Archiv der Pharmazie 345(1): 57-64

Li, C.; Ma, C.; Zhang, J.; Qian, N.; Ding, J.; Qiao, R.; Zhao, Y. 2014: Design and synthesis of novel distamycin-modified nucleoside analogues as HIV-1 reverse transcriptase inhibitors. Antiviral Research 102: 54-60

Chen, J.-B.; Liu, E.M.; Chern, T.-R.; Yang, C.-W.; Lin, C.-I.; Huang, N.-K.; Lin, Y.-L.; Chern, Y.; Lin, J.-H.; Fang, J.-M. 2011: Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. Chemmedchem 6(8): 1390-1400

Lee, M.; Brockway, O.; Dandavati, A.; Tzou, S.; Sjoholm, R.; Nickols, A.; Babu, B.; Chavda, S.; Satam, V.; Hartley, R.M.; Westbrook, C.; Mooberry, S.L.; Fraley, G.; Lee, M. 2011: Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4. Bioorganic and Medicinal Chemistry Letters 21(7): 2087-2091

Sawant, R.R.; Torchilin, V.P. 2011: Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications. Methods in Molecular Biology 751: 357-378

Canzoneri, J.C.; Chen, P.C.; Oyelere, A.K. 2009: Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide. Bioorganic and Medicinal Chemistry Letters 19(23): 6588-6590

Ishikawa, T.; Seto, M.; Banno, H.; Kawakita, Y.; Oorui, M.; Taniguchi, T.; Ohta, Y.; Tamura, T.; Nakayama, A.; Miki, H.; Kamiguchi, H.; Tanaka, T.; Habuka, N.; Sogabe, S.; Yano, J.; Aertgeerts, K.; Kamiyama, K. 2011: Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. Journal of Medicinal Chemistry 54(23): 8030-8050

Ghosh, S.; Pignot-Paintrand, I.; Dumy, P.; Defrancq, E. 2009: Design and synthesis of novel hybrid metal complex-DNA conjugates: key building blocks for multimetallic linear DNA nanoarrays. Organic and Biomolecular Chemistry 7(13): 2729-2737

Thanigaimalai, P.; Lee, K.-C.; Sharma, V.K.; Yun, J.-H.; Kim, Y.; Jung, S.-H. 2010: Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity. Bioorganic and Medicinal Chemistry 18(13): 4625-4629