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Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182



Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182



Bioorganic and Medicinal Chemistry 21(7): 2079-2087



To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives. In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182.

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Accession: 052503711

Download citation: RISBibTeXText

PMID: 23403297

DOI: 10.1016/j.bmc.2013.01.016


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