EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Design, biometric simulation and optimization of a nano-enabled scaffold device for enhanced delivery of dopamine to the brain


Design, biometric simulation and optimization of a nano-enabled scaffold device for enhanced delivery of dopamine to the brain



International Journal of Pharmaceutics 382(1-2): 277-290



ISSN/ISBN: 0378-5173

PMID: 19703530

DOI: 10.1016/j.ijpharm.2009.08.021

This study focused on the design, biometric simulation and optimization of an intracranial nano-enabled scaffold device (NESD) for the site-specific delivery of dopamine (DA) as a strategy to minimize the peripheral side-effects of conventional forms of Parkinson's disease therapy. The NESD was modulated through biometric simulation and computational prototyping to produce a binary crosslinked alginate scaffold embedding stable DA-loaded cellulose acetate phthalate (CAP) nanoparticles optimized in accordance with Box-Behnken statistical designs. The physicomechanical properties of the NESD were characterized and in vitro and in vivo release studies performed. Prototyping predicted a 3D NESD model with enhanced internal micro-architecture. SEM and TEM revealed spherical, uniform and non-aggregated DA-loaded nanoparticles with the presence of CAP (FTIR bands at 1070, 1242 and 2926 cm(-1)). An optimum nanoparticle size of 197 nm (PdI=0.03), a zeta potential of -34.00 mV and a DEE of 63% was obtained. The secondary crosslinker BaCl(2) imparted crystallinity resulting in significant thermal shifts between native CAP (T(g)=160-170 degrees C; T(m)=192 degrees C) and CAP nanoparticles (T(g)=260 degrees C; T(m)=268 degrees C). DA release displayed an initial lag phase of 24 h and peaked after 3 days, maintaining favorable CSF (10 microg/mL) versus systemic concentrations (1-2 microg/mL) over 30 days and above the inherent baseline concentration of DA (1 microg/mL) following implantation in the parenchyma of the frontal lobe of the Sprague-Dawley rat model. The strategy of coupling polymeric scaffold science and nanotechnology enhanced the site-specific delivery of DA from the NESD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052507517

Download citation: RISBibTeXText

Related references

Design and pharmaceutical evaluation of a nano-enabled crosslinked multipolymeric scaffold for prolonged intracranial release of Zidovudine. Journal of Pharmacy and Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences Societe Canadienne des Sciences Pharmaceutiques 16(3): 470-485, 2013

Nano-enabled delivery systems across the blood-brain barrier. Archives of Pharmacal Research 37(1): 24-30, 2014

Inclusion of robustness into design using optimization-enabled transient simulation. IEEE Transactions on Power Delivery 20(3): 1991-1997, 2005

An optimization-enabled electromagnetic transient simulation-based methodology for HVDC controller design. IEEE Transactions on Power Delivery 22(4): 2559-2566, 2007

Control system design for HVDC systems using optimization-enabled electromagnetic transient simulation. International Conference on Ac-Dc Power Transmission: 46-49, 2006

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer. Beilstein Journal of Nanotechnology 6: 1666-1676, 2015

Nano-enabled drug delivery systems for brain cancer and Alzheimer's disease: research patterns and opportunities. Nanomedicine: Nanotechnology Biology and Medicine 11(7): 1763-1771, 2015

Design, Optimization and Characterization of Granisetron HCl Loaded Nano-gel for Transdermal Delivery. Pharmaceutical Nanotechnology 5(4): 317-328, 2017

Formulation and optimization of nano-sized ethosomes for enhanced transdermal delivery of cromolyn sodium. Journal of Pharmacy and Bioallied Sciences 4(4): 333-340, 2012

Optimization of polymeric nano drug delivery system using 3(2) full factorial design. Current Drug Delivery 10(4): 394-403, 2013

Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box-Behnken statistical design. Drug Development and Industrial Pharmacy 44(11): 1871-1884, 2018

De-esterified tragacanth-chitosan nano-hydrogel for methotrexate delivery; optimization of the formulation by Taguchi design. Artificial Cells Nanomedicine and Biotechnology 46(Sup2): 883-893, 2018

Design, simulation, and optimization of a miniaturized device for size-fractioned DNA extraction. Electrophoresis 28(24): 4661-4667, 2007

Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device. Human Gene Therapy Methods 23(3): 157-168, 2012

Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation. Aaps Pharmscitech 18(8): 2898-2909, 2017