Home
  >  
Section 53

EurekaMag Full Text Articles Chapter 52,509



References:

Popsavin, V.; Srećo, B.; Benedeković, G.; Francuz, J.; Popsavin, M.; Kojić, V.; Bogdanović, G. 2010: Design, synthesis and antiproliferative activity of styryl lactones related to (+)-goniofufurone. European Journal of Medicinal Chemistry 45(7): 2876-2883
Popsavin, V.; Srećo, B.; Benedeković, G.; Popsavin, M.; Francuz, J.; Kojić, V.; Bogdanović, G. 2008: Design, synthesis and antiproliferative activity of two new heteroannelated (-)-muricatacin mimics. Bioorganic and Medicinal Chemistry Letters 18(19): 5182-5185
Duan, Y.-C.; Zheng, Y.-C.; Li, X.-C.; Wang, M.-M.; Ye, X.-W.; Guan, Y.-Y.; Liu, G.-Z.; Zheng, J.-X.; Liu, H.-M. 2013: Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole-dithiocarbamate-urea hybrids. European Journal of Medicinal Chemistry 64: 99-110
Lee, C.-C.; Chang, D.-M.; Huang, K.-F.; Chen, C.-L.; Chen, T.-C.; Lo, Y.; Guh, J.-H.; Huang, H.-S. 2013: Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase i inhibitory properties. Bioorganic and Medicinal Chemistry 21(22): 7125-7133
Mavrova, A.T.; Wesselinova, D.; Vassilev, N.; Tsenov, J.A. 2013: Design, synthesis and antiproliferative properties of some new 5-substituted-2-iminobenzimidazole derivatives. European Journal of Medicinal Chemistry 63: 696-701
Rane, R.A.; Sahu, N.U.; Shah, C.P.; Shah, N.K. 2014: Design, synthesis and antistaphylococcal activity of marine pyrrole alkaloid derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 29(3): 401-407
Yang, X.-Z.; Diao, X.-J.; Yang, W.-H.; Li, F.; He, G.-W.; Gong, G.-Q.; Xu, Y.-G. 2013: Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate. Bioorganic and Medicinal Chemistry Letters 23(7): 2089-2092
Das, S.Kumar.; Panda, G.; Chaturvedi, V.; Manju, Y.S.; Gaikwad, A.K.; Sinha, S. 2007: Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives. Bioorganic and Medicinal Chemistry Letters 17(20): 5586-5589
Yempala, T.; Sridevi, J.P.; Yogeeswari, P.; Sriram, D.; Kantevari, S. 2013: Design, synthesis and antitubercular evaluation of novel 2-substituted-3H-benzofuro benzofurans via palladium-copper catalysed Sonagashira coupling reaction. Bioorganic and Medicinal Chemistry Letters 23(19): 5393-5396
Patel, K.N.; Telvekar, V.N. 2014: Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl)phenyl]cinnamamide derivatives. European Journal of Medicinal Chemistry 75: 43-56
Zhan, W.; Li, Y.; Huang, W.; Zhao, Y.; Yao, Z.; Yu, S.; Yuan, S.; Jiang, F.; Yao, S.; Li, S. 2012: Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors. Bioorganic and Medicinal Chemistry 20(14): 4323-4329
Yu, B.; Tang, L.-d.; Li, Y.-L.; Song, S.-H.; Ji, X.-L.; Lin, M.-S.; Wu, C.-F. 2012: Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase. Bioorganic and Medicinal Chemistry Letters 22(1): 110-114
Ren, L.; Du, X.; Hu, M.; Yan, C.; Liang, T.; Li, Q. 2013: Design, synthesis and antitumor activity of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives. Molecules 18(4): 4158-4169
El-Nezhawy, A.O.H.; Adly, F.G.; Eweas, A.F.; Hanna, A.G.; el-Kholy, Y.M.; el-Syed, S.H.; el-Naggar, T.B.A. 2011: Design, synthesis and antitumor activity of novel D-glucuronic acid derivatives. Medicinal Chemistry 7(6): 624-638
Xie, L.; Zhai, X.; Ren, L.; Meng, H.; Liu, C.; Zhu, W.; Zhao, Y. 2011: Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach. Chemical and Pharmaceutical Bulletin 59(8): 984-990
Qin, A.-F.; Li, Y.; Song, H.-R.; Chen, X.-G.; Jin, X.-F.; Wang, K.; Zhang, L.-J.; Huo, L.-C.; Feng, Z.-Q. 2012: Design, synthesis and antitumor activity of sorafenib analogues containing 2-picolinylhydrazide moiety. Yao Xue Xue Bao 47(12): 1623-1629
Yuan, M.; Li, J.-M.; He, G.-W.; Zhong, G.-C.; Zhang, Y.-C. 2013: Design, synthesis and antitumor activity of valproic acid salicylanilide esters. Yao Xue Xue Bao 48(6): 874-880
Marvania, B.; Lee, P.-C.; Chaniyara, R.; Dong, H.; Suman, S.; Kakadiya, R.; Chou, T.-C.; Lee, T.-C.; Shah, A.; Su, T.-L. 2011: Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates. Bioorganic and Medicinal Chemistry 19(6): 1987-1998
Li, S.; Huang, Q.; Liu, Y.; Zhang, X.; Liu, S.; He, C.; Gong, P. 2013: Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety. European Journal of Medicinal Chemistry 64: 62-73
Kim, M.K.; Yoon, H.; Barnard, D.L.; Chong, Y. 2013: Design, synthesis and antiviral activity of 2-(3-amino-4-piperazinylphenyl)chromone derivatives. Chemical and Pharmaceutical Bulletin 61(4): 486-488
Wang, Z.; Wang, M.; Yao, X.; Li, Y.; Tan, J.; Wang, L.; Qiao, W.; Geng, Y.; Liu, Y.; Wang, Q. 2012: Design, synthesis and antiviral activity of novel pyridazines. European Journal of Medicinal Chemistry 54: 33-41
Wang, Z.; Wang, M.; Yao, X.; Li, Y.; Tan, J.; Wang, L.; Qiao, W.; Geng, Y.; Liu, Y.; Wang, Q. 2012: Design, synthesis and antiviral activity of novel quinazolinones. European Journal of Medicinal Chemistry 53: 275-282
Bao, B.; Meng, Z.; Li, N.; Meng, Z.; Zhang, L.; Cao, Y.; Yao, W.; Shan, M.; Ding, A. 2013: Design, synthesis and antiviral activity studies of schizonepetin derivatives. International Journal of Molecular Sciences 14(8): 17193-17203
Ghosh, A.K.; Gong, G.; Grum-Tokars, V.; Mulhearn, D.C.; Baker, S.C.; Coughlin, M.; Prabhakar, B.S.; Sleeman, K.; Johnson, M.E.; Mesecar, A.D. 2008: Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorganic and Medicinal Chemistry Letters 18(20): 5684-5688
Reddi Mohan Naidu, K.; Satheesh Krishna, B.; Anil Kumar, M.; Arulselvan, P.; Ibrahim Khalivulla, S.; Lasekan, O. 2012: Design, synthesis and antiviral potential of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes using an efficient polymer-supported catalyst. Molecules 17(6): 7543-7555
Zhang, C.; Qu, Y.; Wu, X.; Song, D.; Ling, Y.; Yang, X. 2015: Design, synthesis and aphicidal activity of N-terminal modified insect kinin analogs. Peptides 68: 233-238
Maltezos, A.; Platis, D.; Vlachakis, D.; Kossida, S.; Marinou, M.; Labrou, N.E. 2014: Design, synthesis and application of benzyl-sulfonate biomimetic affinity adsorbents for monoclonal antibody purification from transgenic corn. Journal of Molecular Recognition: Jmr 27(1): 19-31
Van den Bossche, J.; Shin, J.; Shum, P.; Thompson, D.H. 2006: Design, synthesis and application of vinyl ether compounds for gene and drug delivery. Journal of Controlled Release: Official Journal of the Controlled Release Society 116(2): E1-E3
Wang, R.; Shi, H.-F.; Zhao, J.-F.; He, Y.-P.; Zhang, H.-B.; Liu, J.-P. 2013: Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives. Bioorganic and Medicinal Chemistry Letters 23(6): 1760-1762
Haddoub, R.; Rützler, M.; Robin, A.él.; Flitsch, S.L. 2009: Design, synthesis and assaying of potential aquaporin inhibitors. Handbook of Experimental Pharmacology 190: 385-402
Bolchi, C.; Valoti, E.; Binda, M.; Fasoli, F.; Ferrara, R.; Fumagalli, L.; Gotti, C.; Matucci, R.; Vistoli, G.; Pallavicini, M. 2013: Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorganic and Medicinal Chemistry Letters 23(23): 6481-6485
Cao, B.; Hutt, O.E.; Zhang, Z.; Li, S.; Heazlewood, S.Y.; Williams, B.; Smith, J.A.; Haylock, D.N.; Savage, G.P.; Nilsson, S.K. 2014: Design, synthesis and binding properties of a fluorescent α₉β₁/α₄β₁ integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Organic and Biomolecular Chemistry 12(6): 965-978
Pellizzaro, M.L.; Barrett, S.A.; Fisher, J.; Wilson, A.J. 2012: Design, synthesis and binding studies of a novel quadruple ADDA hydrogen-bond array. Organic and Biomolecular Chemistry 10(25): 4899-4906
Li, W.-Q.; Zhang, Z.-J.; Nan, X.; Liu, Y.-Q.; Hu, G.-F.; Yu, H.-T.; Zhao, X.-B.; Wu, D.; Yan, L.-T. 2014: Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives. Pest Management Science 70(4): 667-673
Cui, Z.; Su, H.; Jiang, J.; Yang, X.; Nishida, Y. 2014: Design, synthesis and bioactivity of N-glycosyl-N'-(5-substituted phenyl-2-furoyl) hydrazide derivatives. International Journal of Molecular Sciences 15(4): 6741-6756
Zheng, Y.-Y.; Xie, P.; Zhang, J.; Li, J.-Q.; Guo, L.; Yu, L.-P.; Zhou, B. 2012: Design, synthesis and bioactivity of aryl piperazine benzo[b][1,4]oxazine derivatives. Yao Xue Xue Bao 47(6): 755-763
Roy, B.; Chakraborty, A.; Ghosh, S.K.; Basak, A. 2009: Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules. Bioorganic and Medicinal Chemistry Letters 19(24): 7007-7010
Zong, G.; Zhao, H.; Jiang, R.; Zhang, J.; Liang, X.; Li, B.; Shi, Y.; Wang, D. 2014: Design, synthesis and bioactivity of novel glycosylthiadiazole derivatives. Molecules 19(6): 7832-7849
Varela, C.L.; Amaral, C.; Correia-da-Silva, G.; Carvalho, R.A.; Teixeira, N.ér.A.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.ár.J. 2013: Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors. Steroids 78(7): 662-669
Luo, Y.; Deng, Y.-Q.; Wang, J.; Long, Z.-J.; Tu, Z.-C.; Peng, W.; Zhang, J.-Q.; Liu, Q.; Lu, G. 2014: Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora a kinase inhibitors. European Journal of Medicinal Chemistry 78: 65-71
Barile, E.; Wang, S.; Das, S.K.; Noberini, R.; Dahl, R.; Stebbins, J.L.; Pasquale, E.B.; Fisher, P.B.; Pellecchia, M. 2014: Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system. Chemmedchem 9(7): 1403-1412
Fu, R.-G.; You, Q.-D.; Yang, L.; Wu, W.-T.; Jiang, C.; Xu, X.-L. 2010: Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. Bioorganic and Medicinal Chemistry 18(22): 8035-8043
Sun, J.; Zhang, S.; Yu, C.; Hou, G.; Zhang, X.; Li, K.; Zhao, F. 2014: Design, synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties. Chemical Biology and Drug Design 83(4): 392-400
Yadav, Y.; Maclean, E.D.; Bhattacharyya, A.; Parmar, V.S.; Balzarini, J.; Barden, C.J.; Too, C.K.L.; Jha, A. 2011: Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators. European Journal of Medicinal Chemistry 46(9): 3858-3866
Youssef, D.; Potter, E.; Jha, M.; De Clercq, E.; Balzarini, J.; Stables, J.P.; Jha, A. 2009: Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorganic and Medicinal Chemistry Letters 19(22): 6364-6367
Li, Y.; Zhou, Y.; Qian, P.; Wang, Y.; Jiang, F.; Yao, Z.; Hu, W.; Zhao, Y.; Li, S. 2013: Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors. Bioorganic and Medicinal Chemistry Letters 23(1): 179-182
Qin, B-jie.; Zhou, T.; Lu, H.; Jiang, S-bo.; Xie, L. 2009: Design, synthesis and biologic evaluation of diarylbenzimidazole derivatives as novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Yao Xue Xue Bao 44(11): 1233-1243
Pan, X.; Wang, F.; Zhang, Y.; Gao, H.; Hu, Z.; Wang, S.; Zhang, J. 2013: Design, synthesis and biological activities of Nilotinib derivates as antitumor agents. Bioorganic and Medicinal Chemistry 21(9): 2527-2534
Basoglu, S.; Demirbas, A.; Ulker, S.; Alpay-Karaoglu, S.; Demirbas, N. 2013: Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives. European Journal of Medicinal Chemistry 69: 622-631
Yao, J.; He, Z.; Chen, J.; Sun, W.; Fang, H.; Xu, W. 2012: Design, synthesis and biological activities of sorafenib derivatives as antitumor agents. Bioorganic and Medicinal Chemistry Letters 22(21): 6549-6553
Yao, J.; Chen, J.; He, Z.; Sun, W.; Xu, W. 2012: Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents. Bioorganic and Medicinal Chemistry 20(9): 2923-2929
Wang, D.-M.; Liu, X.-H.; Guo, H.; Huang, J.-H.; Wang, L. 2013: Design, synthesis and biological activity evaluation of adenosine analogues. Yao Xue Xue Bao 48(6): 881-886
Chen, Y.; Wang, G.; Xu, X.; Liu, B.-F.; Li, J.; Zhang, G. 2011: Design, synthesis and biological activity evaluation of arylpiperazine derivatives for the treatment of neuropathic pain. Molecules 16(7): 5785-5806
Lin, Y.; Wang, Y.; Sima, L.-F.; Wang, D.-H.; Cao, X.-H.; Chen, L.-G.; Chen, B. 2013: Design, synthesis and biological activity evaluation of desloratadine analogues as H1 receptor antagonists. Bioorganic and Medicinal Chemistry 21(14): 4178-4185
Zhang, J.; Wang, J.-L.; Zhou, Z.-M.; Li, Z.-H.; Xue, W.-Z.; Xu, D.; Hao, L.-P.; Han, X.-F.; Fei, F.; Liu, T.; Liang, A.-H. 2012: Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin Ii AT₁ receptor antagonists. Bioorganic and Medicinal Chemistry 20(14): 4208-4216
Hu, L.; Li, Z.; Wang, Z.; Liu, G.; He, X.; Wang, X.; Zeng, C. 2015: Design, synthesis and biological activity of aromatic diketone derivatives as HIV-1 integrase inhibitors. Medicinal Chemistry 11(2): 180-187
Xie, W.; Liu, J.; Qiu, M.; Yuan, J.; Xu, A. 2010: Design, synthesis and biological activity of cell-penetrating peptide-modified octreotide analogs. Journal of Peptide Science: An Official Publication of the European Peptide Society 16(2): 105-109
Ma, M.-L.; Li, M.; Gou, J.-J.; Ruan, T.-Y.; Jin, H.-S.; Zhang, L.-H.; Wu, L.-C.; Li, X.-Y.; Hu, Y.-H.; Wen, K.; Zhao, Z. 2014: Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. Bioorganic and Medicinal Chemistry 22(21): 6117-6123
Bag, S.; Ghosh, S.; Tulsan, R.; Sood, A.; Zhou, W.; Schifone, C.; Foster, M.; LeVine, H.; Török, B.él.; Török, M. 2013: Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 23(9): 2614-2618
Kwiatkowska, A.; Ptach, M.; Borovičková, L.; Slaninová, J.ři.; Lammek, B.; Prahl, A. 2012: Design, synthesis and biological activity of new neurohypophyseal hormones analogues conformationally restricted in the N-terminal part of the molecule. Highly potent OT receptor antagonists. Amino Acids 43(2): 617-627
Li, M.; Liu, C.-L.; Yang, J.-C.; Li, L.; Li, Z.-N.; Zhang, H.; Li, Z.-M. 2009: Design, synthesis and biological activity of new strobilurin derivatives with a 1H-pyrazol-5-oxy side chain. Natural Product Communications 4(9): 1215-1220
Storgaard, M.; Henriksen, S.T.; Zaragoza, F.; Peschke, B.; Tanner, D. 2011: Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors. Bioorganic and Medicinal Chemistry Letters 21(13): 3918-3922
Gaggini, F.; Laleu, B.ît.; Orchard, M.; Fioraso-Cartier, L.; Cagnon, L.èn.; Houngninou-Molango, S.; Gradia, A.; Duboux, G.; Merlot, C.éd.; Heitz, F.; Szyndralewiez, C.éd.; Page, P. 2011: Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorganic and Medicinal Chemistry 19(23): 6989-6999
Xie, Y.; Kai, Z.P.; Tobe, S.S.; Deng, X.L.; Ling, Y.; Wu, X.Q.; Huang, J.; Zhang, L.; Yang, X.L. 2011: Design, synthesis and biological activity of peptidomimetic analogs of insect allatostatins. Peptides 32(3): 581-586
Wu, Y.; Min, X.; Zhuang, C.; Li, J.; Yu, Z.; Dong, G.; Yao, J.; Wang, S.; Liu, Y.; Wu, S.; Zhu, S.; Sheng, C.; Wei, Y.; Zhang, H.; Zhang, W.; Miao, Z. 2014: Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents. European Journal of Medicinal Chemistry 82: 545-551
Qi, J.; Zhang, F.; Mi, Y.; Fu, Y.; Xu, W.; Zhang, D.; Wu, Y.; Du, X.; Jia, Q.; Wang, K.; Zhang, H. 2011: Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. European Journal of Medicinal Chemistry 46(3): 934-943
Raje, M.R.; Knott, K.; Kharel, Y.; Bissel, P.; Lynch, K.R.; Santos, W.L. 2012: Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic and Medicinal Chemistry 20(1): 183-194
Liu, Y.; Jing, F.; Xu, Y.; Xie, Y.; Shi, F.; Fang, H.; Li, M.; Xu, W. 2011: Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors. Bioorganic and Medicinal Chemistry 19(7): 2342-2348
Kikuchi, K. 2010: Design, synthesis and biological application of chemical probes for bio-imaging. Chemical Society Reviews 39(6): 2048-2053
Mizukami, S.; Kikuchi, K. 2010: Design, synthesis and biological application of chemical probes for imaging protein functions. Seikagaku. Journal of Japanese Biochemical Society 82(1): 21-29
Ma, Y.-H.; Xu, B.; Cui, J.-R.; Yang, Z.-J.; Zhang, L.-R.; Zhang, L.-H. 2012: Design, synthesis and biological assay of novel tripeptidic tetrazoles as inhibitors of 20S proteasome. Yao Xue Xue Bao 47(4): 472-478
Lee, C.; Lo, S.-T.; Lim, J.; da Costa, V.C.P.; Ramezani, S.; Öz, O.K.; Pavan, G.M.; Annunziata, O.; Sun, X.; Simanek, E.E. 2013: Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 Paclitaxel groups and 8 PEG groups. Molecular Pharmaceutics 10(12): 4452-4461
Luo, W.; Yu, Q.-s.; Salcedo, I.; Holloway, H.W.; Lahiri, D.K.; Brossi, A.; Tweedie, D.; Greig, N.H. 2011: Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity. Bioorganic and Medicinal Chemistry 19(13): 3965-3972
Dong, M.; Si, Y.-Q.; Sun, S.-Y.; Pu, X.-P.; Yang, Z.-J.; Zhang, L.-R.; Zhang, L.-H.; Leung, F.P.; Lam, C.M.C.; Kwong, A.K.Y.; Yue, J.; Zhou, Y.; Kriksunov, I.A.; Hao, Q.; Lee, H.C. 2011: Design, synthesis and biological characterization of novel inhibitors of CD38. Organic and Biomolecular Chemistry 9(9): 3246-3257
D'Ascenzio, M.; Bizzarri, B.; De Monte, C.; Carradori, S.; Bolasco, A.; Secci, D.; Rivanera, D.; Faulhaber, N.; Bordón, C.; Jones-Brando, L. 2014: Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii. European Journal of Medicinal Chemistry 86: 17-30
Li, X.; Qu, B.; Jin, X.; Hai, L.; Wu, Y. 2014: Design, synthesis and biological evaluation for docetaxel-loaded brain targeting liposome with "lock-in" function. Journal of Drug Targeting 22(3): 251-261
Rodrigues, F.A.R.; Bomfim, I.d.S.; Cavalcanti, B.C.; Pessoa, C.d.Ó; Wardell, J.L.; Wardell, S.M.S.V.; Pinheiro, A.C.; Kaiser, C.R.; Nogueira, T.C.M.; Low, J.N.; Gomes, L.R.; de Souza, M.V.N. 2014: Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl)quinoxalines, a promising and potent new class of anticancer agents. Bioorganic and Medicinal Chemistry Letters 24(3): 934-939
Yin, Y.; Qiao, F.; Jiang, L.-Y.; Wang, S.-F.; Sha, S.; Wu, X.; Lv, P.-C.; Zhu, H.-L. 2014: Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors. Bioorganic and Medicinal Chemistry 22(15): 4285-4292
Jha, K.K.; Samad, A.; Kumar, Y.; Shaharyar, M.; Khosa, R.L.; Jain, J.; Kumar, V.; Singh, P. 2010: Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives. European Journal of Medicinal Chemistry 45(11): 4963-4967
Li, Z.; Jia, L.; Wang, J.; Wu, X.; Hao, H.; Xu, H.; Wu, Y.; Shi, G.; Lu, C.; Shen, Y. 2014: Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors. European Journal of Medicinal Chemistry 85: 359-370
Quintiliani, M.; Persoons, L.; Solaroli, N.; Karlsson, A.; Andrei, G.; Snoeck, R.; Balzarini, J.; McGuigan, C. 2011: Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides. Bioorganic and Medicinal Chemistry 19(14): 4338-4345
Ha, Y.M.; Park, Y.J.; Lee, J.Y.; Park, D.; Choi, Y.J.; Lee, E.K.; Kim, J.M.; Kim, J.-A.; Park, J.Y.; Lee, H.J.; Moon, H.R.; Chung, H.Y. 2012: Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. Biochimie 94(2): 533-540
Chekanov, M.O.; Ostrynska, O.V.; Tarnavskyi, S.S.; Synyugin, A.R.; Briukhovetska, N.V.; Bdzhola, V.G.; Pashenko, A.E.; Fokin, A.A.; Yarmoluk, S.M. 2014: Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 29(5): 639-646
Al-Suwaidan, I.A.; Alanazi, A.M.; Abdel-Aziz, A.A.-M.; Mohamed, M.A.; El-Azab, A.S. 2013: Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: molecular docking study. Bioorganic and Medicinal Chemistry Letters 23(13): 3935-3941
Gopinath, V.S.; Pinjari, J.; Dere, R.T.; Verma, A.; Vishwakarma, P.; Shivahare, R.; Moger, M.; Kumar Goud, P.S.; Ramanathan, V.; Bose, P.; Rao, M.V.S.; Gupta, S.; Puri, S.K.; Launay, D.; Martin, D. 2013: Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents. European Journal of Medicinal Chemistry 69: 527-536
Das, B.C.; Madhukumar, A.V.; Anguiano, J.; Mani, S. 2009: Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorganic and Medicinal Chemistry Letters 19(15): 4204-4206
Kamal, A.; Reddy, J.Surendranadha.; Ramaiah, M.Janaki.; Dastagiri, D.; Bharathi, E.Vijaya.; Azhar, M.Ameruddin.; Sultana, F.; Pushpavalli, S.N.C.V.L.; Pal-Bhadra, M.; Juvekar, A.; Sen, S.; Zingde, S. 2010: Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents. European Journal of Medicinal Chemistry 45(9): 3924-3937
Romagnoli, R.; Baraldi, P.G.; Lopez-Cara, C.; Salvador, M.K.; Preti, D.; Tabrizi, M.A.; Balzarini, J.; Nussbaumer, P.; Bassetto, M.; Brancale, A.; Fu, X.-H.; Yang-Gao; Li, J.; Zhang, S.-Z.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G. 2014: Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents. Bioorganic and Medicinal Chemistry 22(18): 5097-5109
Liu, Y.; Tan, H.; Yan, H.; Song, X. 2013: Design, synthesis and biological evaluation of 3,9-diazatetraasteranes as novel matrilysin inhibitors. Chemical Biology and Drug Design 82(5): 567-578
Liu, J.; Yi, W.; Hu, J.; Wu, F.; Zhao, L.; Song, H.; Wang, Z. 2010: Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents. Chemical and Pharmaceutical Bulletin 58(9): 1127-1131
Inam, A.; Siddiqui, S.M.; Macedo, T.ís.S.; Moreira, D.R.M.; Leite, A.C.L.; Soares, M.B.P.; Azam, A. 2014: Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. European Journal of Medicinal Chemistry 75: 67-76
Rai, D.; Chen, W.; Tian, Y.; Chen, X.; Zhan, P.; De Clercq, E.; Pannecouque, C.; Balzarini, J.; Liu, X. 2013: Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs. Bioorganic and Medicinal Chemistry 21(23): 7398-7405
He, X.-Y.; Zou, P.; Qiu, J.; Hou, L.; Jiang, S.; Liu, S.; Xie, L. 2011: Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors. Bioorganic and Medicinal Chemistry 19(22): 6726-6734
Rilova, E.; Erdmann, A.; Gros, C.; Masson, V.ér.; Aussagues, Y.; Poughon-Cassabois, V.ér.; Rajavelu, A.; Jeltsch, A.; Menon, Y.; Novosad, N.; Gregoire, J.-M.; Vispé, S.ép.; Schambel, P.; Ausseil, F.éd.; Sautel, F.ço.; Arimondo, P.B.; Cantagrel, F.éd.ér. 2014: Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. Chemmedchem 9(3): 590-601
Yang, W.; Li, L.; Ji, X.; Wu, X.; Su, M.; Sheng, L.; Zang, Y.; Li, J.; Liu, H. 2014: Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry 22(21): 6146-6155
Rezaee Zavareh, E.; Hedayati, M.; Hoghooghi Rad, L.; Shahhosseini, S.; Faizi, M.; Tabatabai, S.A. 2014: Design, synthesis and biological evaluation of 4-benzamidobenzoic Acid hydrazide derivatives as novel soluble epoxide hydrolase inhibitors. Iranian Journal of Pharmaceutical Research: Ijpr 13(Suppl): 51-59
Wang, R.; Liu, Z.; Du, L.; Li, M. 2014: Design, synthesis and biological evaluation of 4-chromanone derivatives as IKr inhibitors. Drug Discoveries and Therapeutics 8(2): 76-83
Ji, X.; Xia, C.; Wang, J.; Su, M.; Zhang, L.; Dong, T.; Li, Z.; Wan, X.; Li, J.; Li, J.; Zhao, L.; Gao, Z.; Jiang, H.; Liu, H. 2014: Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. European Journal of Medicinal Chemistry 86: 242-256
Nicolotti, O.; Catto, M.; Giangreco, I.; Barletta, M.; Leonetti, F.; Stefanachi, A.; Pisani, L.; Cellamare, S.; Tortorella, P.; Loiodice, F.; Carotti, A. 2012: Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. European Journal of Medicinal Chemistry 58: 368-376
Zarghi, A.; Sabakhi, I.; Topuzyan, V.; Hajimahdi, Z.; Daraie, B. 2014: Design, synthesis and biological evaluation of 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives as selective cyclooxygenase-2 inhibitors. Iranian Journal of Pharmaceutical Research: Ijpr 13(Suppl): 61-69
Nikpour, M.; Sadeghian, H.; Saberi, M.R.; Nick, R.S.; Seyedi, S.M.; Hosseini, A.; Parsaee, H.; Bozorg, A.T.D. 2010: Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors. Bioorganic and Medicinal Chemistry 18(2): 855-862
Wilson, S.C.; Atrash, B.; Barlow, C.; Eccles, S.; Fischer, P.M.; Hayes, A.; Kelland, L.; Jackson, W.; Jarman, M.; Mirza, A.; Moreno, J.; Nutley, B.P.; Raynaud, F.I.; Sheldrake, P.; Walton, M.; Westwood, R.; Whittaker, S.; Workman, P.; McDonald, E. 2011: Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. Bioorganic and Medicinal Chemistry 19(22): 6949-6965
Wang, J.-L.; Zhang, J.; Zhou, Z.-M.; Li, Z.-H.; Xue, W.-Z.; Xu, D.; Hao, L.-P.; Han, X.-F.; Fei, F.; Liu, T.; Liang, A.-H. 2012: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin Ii AT1 receptor antagonists. European Journal of Medicinal Chemistry 49: 183-190
Bie, J.; Liu, S.; Zhou, J.; Xu, B.; Shen, Z. 2014: Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorganic and Medicinal Chemistry 22(6): 1850-1862
Han, Y.Taek.; Yang, S-Mei.; Wang, X-Yuan.; Li, F-Nan. 2014: Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists. Archives of Pharmacal Research 37(4): 440-451
Tang, K.; Huang, Q.; Zeng, J.; Wu, G.; Huang, J.; Pan, J.; Lu, W. 2014: Design, synthesis and biological evaluation of C6-modified celastrol derivatives as potential antitumor agents. Molecules 19(7): 10177-10188
Tu, G.; Xiong, F.; Huang, H.; Kuang, B.; Li, S. 2011: Design, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 26(2): 222-230
Fang, L.; Fang, X.; Gou, S.; Lupp, A.; Lenhardt, I.; Sun, Y.; Huang, Z.; Chen, Y.; Zhang, Y.; Fleck, C. 2014: Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents. European Journal of Medicinal Chemistry 76: 376-386
Zhou, T.; Hider, R.C.; Jenner, P.; Campbell, B.; Hobbs, C.J.; Rose, S.; Jairaj, M.; Tayarani-Binazir, K.A.; Syme, A. 2010: Design, synthesis and biological evaluation of L-dopa amide derivatives as potential prodrugs for the treatment of Parkinson's disease. European Journal of Medicinal Chemistry 45(9): 4035-4042
Zhao, P.; Li, Y.; Gao, G.; Wang, S.; Yan, Y.; Zhan, X.; Liu, Z.; Mao, Z.; Chen, S.; Wang, L. 2014: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3β (GSK-3β) phosphorylation inhibitors. European Journal of Medicinal Chemistry 86: 165-174
Li, T.; Yang, Y.; Cheng, C.; Tiwari, A.K.; Sodani, K.; Zhao, Y.; Abraham, I.; Chen, Z.-S. 2012: Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. Bioorganic and Medicinal Chemistry Letters 22(23): 7268-7271
Zhang, H.; Lu, X.; Zhang, L.-R.; Liu, J.-J.; Yang, X.-H.; Wang, X.-M.; Zhu, H.-L. 2012: Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors. Bioorganic and Medicinal Chemistry 20(4): 1411-1416
Zhao, M.; Yu, Y.; Hua, Y.; Feng, F.; Tong, Y.; Yang, X.; Xiao, J.; Song, H. 2013: Design, synthesis and biological evaluation of N-sulfonyl homoserine lactone derivatives as inhibitors of quorum sensing in Chromobacterium violaceum. Molecules 18(3): 3266-3278
Chen, W.; Zhan, P.; De Clercq, E.; Pannecouque, C.; Balzarini, J.; Jiang, X.; Liu, X. 2013: Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs. Bioorganic and Medicinal Chemistry 21(22): 7091-7100
Elkaim, J.; Lamblin, M.; Laguerre, M.; Rosenbaum, J.; Lestienne, P.; Eloy, L.; Cresteil, T.; Felpin, F.ço.-X.; Dessolin, J. 2014: Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach. Bioorganic and Medicinal Chemistry Letters 24(11): 2512-2516
Spinks, D.; Torrie, L.S.; Thompson, S.; Harrison, J.R.; Frearson, J.A.; Read, K.D.; Fairlamb, A.H.; Wyatt, P.G.; Gilbert, I.H. 2012: Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors. Chemmedchem 7(1): 95-106
Elicio, P.D.; Chao, M.ía.N.; Galizzi, M.; Li, C.; Szajnman, S.H.; Docampo, R.; Moreno, S.N.J.; Rodriguez, J.B. 2013: Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. European Journal of Medicinal Chemistry 69: 480-489
Mathew, S.C.; Ghosh, N.; By, Y.; Berthault, A.él.; Virolleaud, M.-A.; Carrega, L.; Chouraqui, G.ël.; Commeiras, L.; Condo, J.; Attolini, M.; Gaudel-Siri, A.; Ruf, J.; Parrain, J.-L.; Rodriguez, J.; Guieu, R.ég. 2009: Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist. Bioorganic and Medicinal Chemistry Letters 19(23): 6736-6739
Liu, Z.; Myers, M.C.; Shah, P.P.; Beavers, M.Pat.; Benedetti, P.A.; Diamond, S.L.; Smith, A.B.; Huryn, D.M. 2010: Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. Combinatorial Chemistry and High Throughput Screening 13(4): 337-351
Tran, T.A.; Rosik, D.; Abrahmsén, L.; Sandström, M.; Sjöberg, A.; Wållberg, H.; Ahlgren, S.; Orlova, A.; Tolmachev, V. 2009: Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging. European Journal of Nuclear Medicine and Molecular Imaging 36(11): 1864-1873
Zhu, J.; Ning, M.; Guo, C.; Zhang, L.; Pan, G.; Leng, Y.; Shen, J. 2013: Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold. European Journal of Medicinal Chemistry 69: 55-68
Puthiyapurayil, P.; Poojary, B.; Chikkanna, C.; Buridipad, S.K. 2012: Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents. European Journal of Medicinal Chemistry 53: 203-210
Zhang, R.; Wu, X.; Guziec, L.J.; Guziec, F.S.; Chee, G.-L.; Yalowich, J.C.; Hasinoff, B.B. 2010: Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents. Bioorganic and Medicinal Chemistry 18(11): 3974-3984
Wang, G.; Li, C.; He, L.; Lei, K.; Wang, F.; Pu, Y.; Yang, Z.; Cao, D.; Ma, L.; Chen, J.; Sang, Y.; Liang, X.; Xiang, M.; Peng, A.; Wei, Y.; Chen, L. 2014: Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents. Bioorganic and Medicinal Chemistry 22(7): 2060-2079
Mehanna, A.S.; Belani, J.D.; Kelley, C.J.; Pallansc, L.A. 2007: Design, synthesis and biological evaluation of a series of thioamides as non-nucleoside reverse transcriptase inhibitors. Medicinal Chemistry 3(6): 513-519
Qi, J.; Blanden, A.R.; Bane, S.; Kingston, D.G.I. 2011: Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin. Bioorganic and Medicinal Chemistry 19(17): 5247-5254
Suryawanshi, S.N.; Kumar, S.; Shivahare, R.; Pandey, S.; Tiwari, A.; Gupta, S. 2013: Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents. Bioorganic and Medicinal Chemistry Letters 23(18): 5235-5238
Romagnoli, R.; Baraldi, P.G.; Salvador, M.K.; Chayah, M.; Camacho, M.E.; Prencipe, F.; Hamel, E.; Consolaro, F.; Basso, G.; Viola, G. 2014: Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents. European Journal of Medicinal Chemistry 81: 394-407
Zhang, L.; Chai, X.; Wang, B.; Yu, S.; Hu, H.; Zou, Y.; Zhao, Q.; Meng, Q.; Wu, Q. 2013: Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. Bioorganic and Medicinal Chemistry Letters 23(18): 5057-5060
Tan, C.-M.; Chen, G.S.; Chen, C.-S.; Chang, P.-T.; Chern, J.-W. 2011: Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. Bioorganic and Medicinal Chemistry 19(21): 6316-6328
Catto, M.; Berezin, A.A.; Lo Re, D.; Loizou, G.; Demetriades, M.; De Stradis, A.; Campagna, F.; Koutentis, P.A.; Carotti, A. 2012: Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase. European Journal of Medicinal Chemistry 58: 84-97
Zhang, P.; Hu, H.-R.; Bian, S.-H.; Huang, Z.-H.; Chu, Y.; Ye, D.-Y. 2013: Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β). European Journal of Medicinal Chemistry 61: 95-103
Kim, M.; Lee, J.; Jung, K.; Kim, H.; Aman, W.; Ryu, J.-S.; Hah, J.-M. 2014: Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors. Bioorganic and Medicinal Chemistry Letters 24(15): 3600-3604
Xu, Z.-C.; Wang, X.-B.; Yu, W.-Y.; Xie, S.-S.; Li, S.-Y.; Kong, L.-Y. 2014: Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 24(10): 2368-2373
Arora, I.; Kashyap, V.K.; Singh, A.K.; Dasgupta, A.; Kumar, B.; Shaw, A.K. 2014: Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors. Organic and Biomolecular Chemistry 12(35): 6855-6868
Bey, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Frotscher, M.; Werth, R.; Oster, A.; Algül, O.; Neugebauer, A.; Hartmann, R.W. 2008: Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. Bioorganic and Medicinal Chemistry 16(12): 6423-6435
Zhao, Y.; Qu, B.; Wu, X.; Li, X.; Liu, Q.; Jin, X.; Guo, L.; Hai, L.; Wu, Y. 2014: Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with "lock-in" function. European Journal of Medicinal Chemistry 82: 314-323
Fan, W.; Wu, Y.; Li, X.-K.; Yao, N.; Li, X.; Yu, Y.-G.; Hai, L. 2011: Design, synthesis and biological evaluation of brain-specific glucosyl thiamine disulfide prodrugs of naproxen. European Journal of Medicinal Chemistry 46(9): 3651-3661
Chen, Q.-H.; Ganesh, T.; Brodie, P.; Slebodnick, C.; Jiang, Y.; Banerjee, A.; Bane, S.; Snyder, J.P.; Kingston, D.G.I. 2008: Design, synthesis and biological evaluation of bridged epothilone D analogues. Organic and Biomolecular Chemistry 6(24): 4542-4552
Bernardes, G.ça.J.L.; Kikkeri, R.; Maglinao, M.; Laurino, P.; Collot, M.; Hong, S.Y.; Lepenies, B.; Seeberger, P.H. 2010: Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting. Organic and Biomolecular Chemistry 8(21): 4987-4996
Castellano, S.; Milite, C.; Ragno, R.; Simeoni, S.; Mai, A.; Limongelli, V.; Novellino, E.; Bauer, I.; Brosch, G.; Spannhoff, A.; Cheng, D.; Bedford, M.T.; Sbardella, G. 2010: Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Chemmedchem 5(3): 398-414
Wang, L.-J.; Chen, H.; Ma, Y.-B.; Huang, X.-Y.; Geng, C.-A.; Zhang, X.-M.; Chen, J.-J. 2015: Design, synthesis and biological evaluation of caudatin analogs as potent hepatitis B virus inhibitors. Medicinal Chemistry 11(2): 165-179
Uppal, J.K.; Hazari, P.P.; Raunak; Chuttani, K.; Allard, M.; Kaushik, N.K.; Mishra, A.K. 2011: Design, synthesis and biological evaluation of choline based SPECT imaging agent: Ga(III)-DO3A-EA-Choline. Organic and Biomolecular Chemistry 9(5): 1591-1599
Lv, P.-C.; Wang, K.-R.; Li, Q.-S.; Chen, J.; Sun, J.; Zhu, H.-L. 2010: Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents. Bioorganic and Medicinal Chemistry 18(3): 1117-1123
Lin, H.-Y.; Chen, W.; Shi, J.; Kong, W.-Y.; Qi, J.-L.; Wang, X.-M.; Yang, Y.-H. 2013: Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives. Chemical Biology and Drug Design 81(2): 275-283
Catto, M.; Pisani, L.; Leonetti, F.; Nicolotti, O.; Pesce, P.; Stefanachi, A.; Cellamare, S.; Carotti, A. 2013: Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. Bioorganic and Medicinal Chemistry 21(1): 146-152
Gu, S.-X.; Yang, S.-Q.; He, Q.-Q.; Ma, X.-D.; Chen, F.-E.; Dai, H.-F.; Clercq, E.D.; Balzarini, J.; Pannecouque, C. 2011: Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. Bioorganic and Medicinal Chemistry 19(23): 7093-7099
Ning, C.; Bi, Y.; He, Y.; Huang, W.; Liu, L.; Li, Y.; Zhang, S.; Liu, X.; Yu, N. 2013: Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(23): 6432-6435
Sriram, M.; Hall, J.J.; Grohmann, N.C.; Strecker, T.E.; Wootton, T.; Franken, A.; Trawick, M.L.; Pinney, K.G. 2008: Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy. Bioorganic and Medicinal Chemistry 16(17): 8161-8171
Wei, J.; Shi, J.; Zhang, J.; He, G.; Pan, J.; He, J.; Zhou, R.; Guo, L.; Ouyang, L. 2013: Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases. Bioorganic and Medicinal Chemistry 21(14): 4192-4200
Provencher-Mandeville, J.ée.; Debnath, C.; Mandal, S.K.; Leblanc, V.ér.; Parent, S.; Asselin, E.; Bérubé, G. 2011: Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: comparative molecular modeling study of three distinct families of hybrids. Steroids 76(1-2): 94-103
Gupta, A.; Saha, P.; Descôteaux, C.; Leblanc, V.ér.; Asselin, E.; Bérubé, G. 2010: Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. Bioorganic and Medicinal Chemistry Letters 20(5): 1614-1618
Paige, M.; Kosturko, G.; Bulut, G.ül.; Miessau, M.; Rahim, S.; Toretsky, J.A.; Brown, M.L.; Üren, A. 2014: Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorganic and Medicinal Chemistry 22(1): 478-487
Shi, Z.-H.; Li, N.-G.; Shi, Q.-P.; Tang, H.-; Tang, Y.-P.; Li, W.-; Yin, L.-; Yang, J.-P.; Duan, J.-A. 2013: Design, synthesis and biological evaluation of ferulic Acid amides as selective matrix metalloproteinase inhibitors. Medicinal Chemistry 9(7): 947-954
Li, G.; Han, W.-J.; Jin, J.; Wang, X.-J.; Xiao, Q.; Zhou, W.-Q.; Yin, D.-L.; Chen, X.-G. 2014: Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety. Yao Xue Xue Bao 49(6): 896-904
Li, N.-G.; Shen, M.-Z.; Wang, Z.-J.; Tang, Y.-P.; Shi, Z.-H.; Fu, Y.-F.; Shi, Q.-P.; Tang, H.; Duan, J.-A. 2013: Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo. Bioorganic and Medicinal Chemistry Letters 23(1): 102-106
More, S.S.; Vince, R. 2008: Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs. Journal of Medicinal Chemistry 51(15): 4581-4588
Ji, X.; Su, M.; Wang, J.; Deng, G.; Deng, S.; Li, Z.; Tang, C.; Li, J.; Li, J.; Zhao, L.; Jiang, H.; Liu, H. 2014: Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. European Journal of Medicinal Chemistry 75: 111-122
Zhang, Y.-B.; Wang, X.-L.; Liu, W.; Yang, Y.-S.; Tang, J.-F.; Zhu, H.-L. 2012: Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors. Bioorganic and Medicinal Chemistry 20(21): 6356-6365
Massarico Serafim, R.A.; Gonçalves, J.é E.; de Souza, F.P.; de Melo Loureiro, A.P.; Storpirtis, S.; Krogh, R.; Andricopulo, A.D.; Dias, L.C.; Ferreira, E.I. 2014: Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity. European Journal of Medicinal Chemistry 82: 418-425
Wang, X.; Wang, L.; Sheng, X.; Huang, Z.; Li, T.; Zhang, M.; Xu, J.; Ji, H.; Yin, J.; Zhang, Y. 2014: Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Organic and Biomolecular Chemistry 12(31): 5995-6004
Chen, X.; Wang, L.; Du, Y.; Wu, Y.; Jia, X.; Yang, Y.; Hong, B. 2011: Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents. Molecules 16(11): 9178-9193
Chen, Z.; Cai, D.; Mou, D.; Yan, Q.; Sun, Y.; Pan, W.; Wan, Y.; Song, H.; Yi, W. 2014: Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors. Bioorganic and Medicinal Chemistry 22(13): 3279-3284
Yi, W.; Cao, R.-H.; Chen, Z.-Y.; Yu, L.; Ma, L.; Song, H.-C. 2009: Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical and Pharmaceutical Bulletin 57(11): 1273-1277
Li, S.-Y.; Wang, X.-B.; Kong, L.-Y. 2014: Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. European Journal of Medicinal Chemistry 71: 36-45
Catto, M.; Aliano, R.; Carotti, A.; Cellamare, S.; Palluotto, F.; Purgatorio, R.; De Stradis, A.; Campagna, F. 2010: Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors. European Journal of Medicinal Chemistry 45(4): 1359-1366
Zhou, M.; Ning, C.; Liu, R.; He, Y.; Yu, N. 2013: Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(11): 3200-3203
Huang, W.; Zuo, T.; Jin, H.; Liu, Z.; Yang, Z.; Yu, X.; Zhang, L.; Zhang, L. 2013: Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. Molecular Diversity 17(2): 221-243
Hruby, V.J.; Cai, M.; Cain, J.P.; Mayorov, A.V.; Dedek, M.M.; Trivedi, D. 2007: Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry 7(11): 1107-1119
Schwardt, O.; Rabbani, S.; Hartmann, M.; Abgottspon, D.; Wittwer, M.; Kleeb, S.; Zalewski, A.; Smieško, M.; Cutting, B.; Ernst, B. 2011: Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists. Bioorganic and Medicinal Chemistry 19(21): 6454-6473
Wang, G.; Peng, F.; Cao, D.; Yang, Z.; Han, X.; Liu, J.; Wu, W.; He, L.; Ma, L.; Chen, J.; Sang, Y.; Xiang, M.; Peng, A.; Wei, Y.; Chen, L. 2013: Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors. Bioorganic and Medicinal Chemistry 21(21): 6844-6854
Wu, S.; Cao, Q.; Wang, X.; Cheng, K.; Cheng, Z. 2014: Design, synthesis and biological evaluation of mitochondria targeting theranostic agents. Chemical Communications 50(64): 8919-8922
Qu, B.; Li, X.; Guan, M.; Li, X.; Hai, L.; Wu, Y. 2014: Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes. European Journal of Medicinal Chemistry 72: 110-118
Zhang, W.; Chen, L.; Ma, Z.; Du, L.; Li, M. 2014: Design, synthesis and biological evaluation of naphthalimide-based fluorescent probes for α1-adrenergic receptors. Drug Discoveries and Therapeutics 8(1): 11-17
Gryshchenko, A.A.; Levchenko, K.V.; Bdzhola, V.G.; Ruban, T.P.; Lukash, L.L.; Yarmoluk, S.M. 2015: Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 30(1): 126-132
Oshima, N.; Akizawa, H.; Zhao, S.; Zhao, Y.; Nishijima, K.-i.; Kitamura, Y.; Arano, Y.; Kuge, Y.; Ohkura, K. 2014: Design, synthesis and biological evaluation of negatively charged ¹¹¹In-DTPA-octreotide derivatives. Bioorganic and Medicinal Chemistry 22(4): 1377-1382
Arfaie, S.; Zarghi, A. 2010: Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors. European Journal of Medicinal Chemistry 45(9): 4013-4017
Ghodsi, R.; Zarghi, A.; Daraei, B.; Hedayati, M. 2010: Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors. Bioorganic and Medicinal Chemistry 18(3): 1029-1033
Szymański, P.; Janik, A.; Zurek, E.; Mikiciuk-Olasik, E. 2011: Design, synthesis and biological evaluation of new 2-benzoxazolinone derivatives as potential cholinesterase inhibitors for therapy of alzheimer's disease. Die Pharmazie 66(6): 399-403
Zarghi, A.; Javid, F.Sattary.; Ghodsi, R.; Dadrass, O.G.; Daraei, B.; Hedayati, M. 2011: Design, synthesis and biological evaluation of new 5,5-diarylhydantoin derivatives as selective cyclooxygenase-2 inhibitors. Scientia Pharmaceutica 79(3): 449-460
Zhu, W.; Da, Y.; Wu, D.; Zheng, H.; Zhu, L.; Wang, L.; Yan, Y.; Chen, Z. 2014: Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities. Bioorganic and Medicinal Chemistry 22(7): 2294-2302
Blau, L.; Menegon, R.F.; Trossini, G.H.G.; Molino, J.ão.V.D.; Vital, D.G.; Cicarelli, R.M.B.; Passerini, G.D.ó; Bosquesi, P.L.; Chin, C.M. 2013: Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry 67: 142-151
Jin, J.; Wang, X.-B.; Kong, L.-Y. 2011: Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. Bioorganic and Medicinal Chemistry Letters 21(3): 909-911
Perspicace, E.; Jouan-Hureaux, V.ér.; Ragno, R.; Ballante, F.; Sartini, S.; La Motta, C.; Da Settimo, F.; Chen, B.; Kirsch, G.; Schneider, S.; Faivre, B.éa.; Hesse, S.ép. 2013: Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). European Journal of Medicinal Chemistry 63: 765-781
Vo, D.D.; Gautier, F.; Barillé-Nion, S.; Juin, P.; Levoin, N.; Grée, R.é 2014: Design, synthesis and biological evaluation of new inhibitors of Bax/Bcl-xL interaction in cancer cells. Bioorganic and Medicinal Chemistry Letters 24(7): 1758-1761
Srivastava, A.K.; Dohare, P.; Ray, M.; Panda, G. 2010: Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia. European Journal of Medicinal Chemistry 45(5): 1964-1971
Minarini, A.; Milelli, A.; Tumiatti, V.; Ferruzzi, L.; Marton, M.-R.; Turrini, E.; Hrelia, P.; Fimognari, C. 2012: Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality. European Journal of Medicinal Chemistry 48: 124-131
Ventosa-Andrés, P.; Valdivielso, A.M.; Pappos, I.; García-López, M.T.; Tsopanoglou, N.E.; Herranz, R. 2012: Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1. European Journal of Medicinal Chemistry 58: 98-111
Park, B.S.; El-Deeb, I.M.; Yoo, K.H.; Oh, C.-H.; Cho, S.J.; Han, D.K.; Lee, H.-S.; Lee, J.Y.; Lee, S.H. 2009: Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor. Bioorganic and Medicinal Chemistry Letters 19(16): 4720-4723
Chaulet, C.; Croix, C.éc.; Alagille, D.; Normand, S.; Delwail, A.; Favot, L.; Lecron, J.-C.; Viaud-Massuard, M.-C. 2011: Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors. Bioorganic and Medicinal Chemistry Letters 21(3): 1019-1022
Jenkins, P.R.; Wilson, J.; Emmerson, D.; Garcia, M.D.; Smith, M.R.; Gray, S.J.; Britton, R.G.; Mahale, S.; Chaudhuri, B. 2008: Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorganic and Medicinal Chemistry 16(16): 7728-7739
Hodgkinson, J.T.; Galloway, W.R.J.D.; Wright, M.; Mati, I.K.; Nicholson, R.L.; Welch, M.; Spring, D.R. 2012: Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa. Organic and Biomolecular Chemistry 10(30): 6032-6044
Androutsou, M.-E.; Saifeddine, M.; Hollenberg, M.D.; Matsoukas, J.; Agelis, G. 2010: Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. Amino Acids 38(4): 985-990
Zhou, Y.; Ting, K.Y.; Lam, C.M.C.; Kwong, A.K.Y.; Xia, J.; Jin, H.; Liu, Z.; Zhang, L.; Cheung Lee, H.; Zhang, L. 2012: Design, synthesis and biological evaluation of noncovalent inhibitors of human CD38 NADase. Chemmedchem 7(2): 223-228
Li, Q.-S.; Li, C.-Y.; Lu, X.; Zhang, H.; Zhu, H.-L. 2012: Design, synthesis and biological evaluation of novel (E)-α-benzylsulfonyl chalcone derivatives as potential BRAF inhibitors. European Journal of Medicinal Chemistry 50: 288-295
Zhang, X.; Zhang, J.; Zhang, L.; Feng, J.; Xu, Y.; Yuan, Y.; Fang, H.; Xu, W. 2011: Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors. Bioorganic and Medicinal Chemistry 19(20): 6015-6025
Yang, Z.-M.; Huang, J.; Qin, J.-K.; Dai, Z.-K.; Lan, W.-L.; Su, G.-F.; Tang, H.; Yang, F. 2014: Design, synthesis and biological evaluation of novel 1-hydroxyl-3-aminoalkoxy xanthone derivatives as potent anticancer agents. European Journal of Medicinal Chemistry 85: 487-497
Ramachandran, R.; Rani, M.; Kabilan, S. 2009: Design, synthesis and biological evaluation of novel 2-[(2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazono]-1,3-thiazolidin-4-ones as a new class of antimicrobial agents. Bioorganic and Medicinal Chemistry Letters 19(10): 2819-2823
He, J.; Feng, L.; Li, J.; Tao, R.; Wang, F.; Liao, X.; Sun, Q.; Long, Q.; Ren, Y.; Wan, J.; He, H. 2012: Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1. Bioorganic and Medicinal Chemistry 20(5): 1665-1670
Wang, W.; Shangguan, S.; Qiu, N.; Hu, C.; Zhang, L.; Hu, Y. 2013: Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 1. Bioorganic and Medicinal Chemistry 21(11): 2879-2885
Wang, W.; Lv, D.; Qiu, N.; Zhang, L.; Hu, C.; Hu, Y. 2013: Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 2. Bioorganic and Medicinal Chemistry 21(11): 2886-2894
Ronga, L.; Del Favero, M.; Cohen, A.; Soum, C.; Le Pape, P.; Savrimoutou, S.èn.; Pinaud, N.ël.; Mullié, C.; Daulouede, S.; Vincendeau, P.; Farvacques, N.; Agnamey, P.; Pagniez, F.; Hutter, S.éb.; Azas, N.; Sonnet, P.; Guillon, J. 2014: Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part IIi. European Journal of Medicinal Chemistry 81: 378-393
Zhang, X.; Peng, T.; Ji, X.; Li, J.; Tong, L.; Li, Z.; Yang, W.; Xu, Y.; Li, M.; Ding, J.; Jiang, H.; Xie, H.; Liu, H. 2013: Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor. Bioorganic and Medicinal Chemistry 21(24): 7988-7998
Mao, J.-L.; Ran, X.-K.; Tian, J.-Z.; Jiao, B.; Zhou, H.-L.; Chen, L.; Wang, Z.-G. 2011: Design, synthesis and biological evaluation of novel 4-hydroxybenzene acrylic acid derivatives. Bioorganic and Medicinal Chemistry Letters 21(5): 1549-1553
Zhu, Q.-F.; Gong, Y.-X.; Zhong, J.-Q.; Liu, L.-F.; Li, X.-F.; Zhao, X.-Y. 2014: Design, synthesis and biological evaluation of novel 4-substituted-3-nitrobenzamide derivatives. Yao Xue Xue Bao 49(8): 1143-1149
Wang, S.; Zhao, Y.; Zhang, G.; Lv, Y.; Zhang, N.; Gong, P. 2011: Design, synthesis and biological evaluation of novel 4-thiazolidinones containing indolin-2-one moiety as potential antitumor agent. European Journal of Medicinal Chemistry 46(8): 3509-3518
Wang, S.-F.; Zhu, Y.-L.; Zhu, P.-T.; Makawana, J.A.; Zhang, Y.-L.; Zhao, M.-Y.; Lv, P.-C.; Zhu, H.-L. 2014: Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAF(V600E) inhibitors. Bioorganic and Medicinal Chemistry 22(21): 6201-6208
Liu, Z.; Wang, R.; Guo, R.; Hu, J.; Li, R.; Zhao, Y.; Gong, P. 2014: Design, synthesis and biological evaluation of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 4-oxo-3,4-dihydrophthalazine-1-carboxamide moieties as c-Met kinase inhibitors. Bioorganic and Medicinal Chemistry 22(14): 3642-3653
Ji, X.; Peng, T.; Zhang, X.; Li, J.; Yang, W.; Tong, L.; Qu, R.; Jiang, H.; Ding, J.; Xie, H.; Liu, H. 2014: Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors. Bioorganic and Medicinal Chemistry 22(7): 2366-2378
Gulcan, H.O.; Unlu, S.; Esiringu, I.; Ercetin, T.; Sahin, Y.; Oz, D.; Sahin, M.F. 2014: Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors. Bioorganic and Medicinal Chemistry 22(19): 5141-5154
Xie, S.-S.; Wang, X.-B.; Li, J.-Y.; Kong, L.-Y. 2013: Design, synthesis and biological evaluation of novel 7-mercaptocoumarin derivatives as α(1)-adrenoceptor antagonists. Chemical and Pharmaceutical Bulletin 61(1): 16-24
Pan, H.; Yang, K.; Zhang, J.; Xu, Y.; Jiang, Y.; Yuan, Y.; Zhang, X.; Xu, W. 2013: Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 28(4): 717-726
Su, L.; Fang, H.; Yang, K.; Xu, Y.; Xu, W. 2011: Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors. Bioorganic and Medicinal Chemistry 19(2): 900-906
Li, S.; Yao, Z.; Zhao, Y.; Chen, W.; Wang, H.; Kuang, X.; Zhan, W.; Yao, S.; Yu, S.; Hu, W. 2012: Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR-ABL kinase. Bioorganic and Medicinal Chemistry Letters 22(16): 5279-5282
Song, D.; Yang, J.S.; Kim, S.J.; Kim, B.-K.; Park, S.-K.; Won, M.; Lee, K.; Kim, H.M.; Choi, K.-Y.; Lee, K.; Han, G. 2013: Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents. Bioorganic and Medicinal Chemistry 21(3): 788-794
Su, L.; Jia, Y.; Zhang, L.; Xu, Y.; Fang, H.; Xu, W. 2012: Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors. Bioorganic and Medicinal Chemistry 20(12): 3807-3815
Jadav, P.; Bahekar, R.; Shah, S.R.; Patel, D.; Joharapurkar, A.; Jain, M.; Sairam, K.V.V.M.; Singh, P.K. 2014: Design, synthesis and biological evaluation of novel aminomethyl-piperidones based DPP-IV inhibitors. Bioorganic and Medicinal Chemistry Letters 24(8): 1918-1922
Décor, A.; Grand-Maître, C.; Hucke, O.; O'Meara, J.; Kuhn, C.; Constantineau-Forget, L.éa.; Brochu, C.; Malenfant, E.; Bertrand-Laperle, M.ég.; Bordeleau, J.ée.; Ghiro, E.; Pesant, M.; Fazal, G.; Gorys, V.; Little, M.; Boucher, C.; Bordeleau, S.; Turcotte, P.; Guo, T.; Garneau, M.; Spickler, C.; Gauthier, A. 2013: Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus. Bioorganic and Medicinal Chemistry Letters 23(13): 3841-3847
Kandimalla, E.R.; Bhagat, L.; Wang, D.; Yu, D.; Sullivan, T.; La Monica, N.; Agrawal, S. 2013: Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. Nucleic Acids Research 41(6): 3947-3961
Khoshneviszadeh, M.; Ghahremani, M.H.; Foroumadi, A.; Miri, R.; Firuzi, O.; Madadkar-Sobhani, A.; Edraki, N.; Parsa, M.; Shafiee, A. 2013: Design, synthesis and biological evaluation of novel anti-cytokine 1,2,4-triazine derivatives. Bioorganic and Medicinal Chemistry 21(21): 6708-6717
Yang, S.; Liang, N.; Li, H.; Xue, W.; Hu, D.; Jin, L.; Zhao, Q.; Yang, S. 2012: Design, synthesis and biological evaluation of novel betulinic acid derivatives. Chemistry Central Journal 6(1): 141
Filosa, R.; Carmela Fulco, M.; Marinozzi, M.; Giacchè, N.; Macchiarulo, A.; Peduto, A.; Massa, A.; de Caprariis, P.; Thomsen, C.; Christoffersen, C.T.; Pellicciari, R. 2009: Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Bioorganic and Medicinal Chemistry 17(1): 242-250
Zhang, H.; Liu, J.-J.; Sun, J.; Yang, X.-H.; Zhao, T.-T.; Lu, X.; Gong, H.-B.; Zhu, H.-L. 2012: Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents. Bioorganic and Medicinal Chemistry 20(10): 3212-3218
Su, H.; Nebbioso, A.; Carafa, V.; Chen, Y.; Yang, B.; Altucci, L.; You, Q. 2008: Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents. Bioorganic and Medicinal Chemistry 16(17): 7992-8002
Jakopin, Ži.; Corsini, E.; Gobec, M.; Mlinarič-Raščan, I.; Dolenc, M.S. 2011: Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs. European Journal of Medicinal Chemistry 46(9): 3762-3777
Xi, Y-Yue.; Jin, J.; Sun, Y.; Chen, X-Guang.; Song, H-Rui.; Xu, B-Ling. 2013: Design, synthesis and biological evaluation of novel diaryl ethers bearing a pyrimidine motif as human Pin1 inhibitors. Yao Xue Xue Bao 48(8): 1266-1272
Zhu, Y.; Xiao, K.; Ma, L.; Xiong, B.; Fu, Y.; Yu, H.; Wang, W.; Wang, X.; Hu, D.; Peng, H.; Li, J.; Gong, Q.; Chai, Q.; Tang, X.; Zhang, H.; Li, J.; Shen, J. 2009: Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. Bioorganic and Medicinal Chemistry 17(4): 1600-1613
Zhang, X.; Zuo, Z.; Tang, J.; Wang, K.; Wang, C.; Chen, W.; Li, C.; Xu, W.; Xiong, X.; Yuntai, K.; Huang, J.; Lan, X.; Zhou, H.-B. 2013: Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes. Bioorganic and Medicinal Chemistry Letters 23(13): 3793-3797
Lu, H.-F.; Sun, X.; Xu, L.; Lou, L.-G.; Lin, G.-Q. 2009: Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues. European Journal of Medicinal Chemistry 44(2): 482-491
Shi, D.-K.; Zhang, W.; Ding, N.; Li, M.; Li, Y.-X. 2012: Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase Ii inhibitors. European Journal of Medicinal Chemistry 47(1): 424-431
Wang, X.-Q.; Liu, L.-X.; Li, Y.; Sun, C.-J.; Chen, W.; Li, L.; Zhang, H.-B.; Yang, X.-D. 2013: Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents. European Journal of Medicinal Chemistry 62: 111-121
Zhu, Q.; Wang, X.; Chu, Z.; He, G.; Dong, G.; Xu, Y. 2013: Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 23(7): 1993-1996
Liu, Y.; Jiang, C.; Wu, H.; Wu, P.; Si, M.; Hu, Y.; Liu, T. 2013: Design, synthesis and biological evaluation of novel imidazolone derivatives as dipeptidyl peptidase 4 inhibitors. Medicinal Chemistry 9(7): 938-946
Lee, S.-C.; Kim, H.T.; Park, C.-H.; Lee, D.Y.; Chang, H.-J.; Park, S.; Cho, J.M.; Ro, S.; Suh, Y.-G. 2012: Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3β inhibitors. Bioorganic and Medicinal Chemistry Letters 22(13): 4221-4224
Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R.; Fairlamb, A.H.; Gilbert, I.H. 2011: Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1. Chemmedchem 6(2): 302-308
Dunkern, T.; Chavan, S.; Bankar, D.; Patil, A.; Kulkarni, P.; Kharkar, P.S.; Prabhu, A.; Goebel, H.; Rolser, E.; Burckhard-Boer, W.; Arumugam, P.; Makhija, M.T. 2014: Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 29(3): 408-419
Martins, F.; Santos, S.; Ventura, C.; Elvas-Leitão, R.; Santos, L.íd.; Vitorino, S.; Reis, M.; Miranda, V.; Correia, H.F.; Aires-de-Sousa, J.ão.; Kovalishyn, V.; Latino, D.A.R.S.; Ramos, J.; Viveiros, M. 2014: Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity. European Journal of Medicinal Chemistry 81: 119-138
Huang, Z.-H.; Zhuo, S.-T.; Li, C.-Y.; Xie, H.-T.; Li, D.; Tan, J.-H.; Ou, T.-M.; Huang, Z.-S.; Gu, L.-Q.; Huang, S.-L. 2013: Design, synthesis and biological evaluation of novel mansonone e derivatives prepared via CuAAC click chemistry as topoisomerase Ii inhibitors. European Journal of Medicinal Chemistry 68: 58-71
Çakmak, R.şi.; Durdagi, S.; Ekinci, D.; Sentürk, M.; Topal, G. 2011: Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorganic and Medicinal Chemistry Letters 21(18): 5398-5402
Tandon, V.K.; Maurya, H.K.; Mishra, N.N.; Shukla, P.K. 2009: Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. European Journal of Medicinal Chemistry 44(8): 3130-3137
Zhang, J.; Shen, L.; Wang, J.; Luo, P.; Hu, Y. 2014: Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors. Medicinal Chemistry 10(1): 38-45
Yao, H.-P.; Zhu, Z.-X.; Ji, M.; Chen, X.-G.; Xu, B.-L. 2014: Design, synthesis and biological evaluation of novel para-substituted 1-benzyl-quinazoline-2, 4 (1H, 3H)-diones as human PARP-1 inhibitors. Yao Xue Xue Bao 49(4): 497-503
Yang, B.; Mei, Y.; Wang, X.; Deng, X.; Qian, H.; Huang, W. 2014: Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents. European Journal of Medicinal Chemistry 73: 105-111
Liu, T.; Weng, Z.; Dong, X.; Chen, L.; Ma, L.; Cen, S.; Zhou, N.; Hu, Y. 2013: Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists. Plos one 8(1): E53636
Abadi, A.H.; Ibrahim, T.M.; Abouzid, K.M.; Lehmann, J.; Tinsley, H.N.; Gary, B.D.; Piazza, G.A. 2009: Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Bioorganic and Medicinal Chemistry 17(16): 5974-5982
Mao, Y.; Zhu, W.; Kong, X.; Wang, Z.; Xie, H.; Ding, J.; Terrett, N.K.; Shen, J.; Shen, J. 2013: Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors. Bioorganic and Medicinal Chemistry 21(11): 3090-3104
Alafeefy, A.M.; Ashour, A.E. 2012: Design, synthesis and biological evaluation of novel quinazoline derivatives as potential anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 27(4): 541-545
El-Azab, A.S.; Al-Omar, M.A.; Abdel-Aziz, A.A.-M.; Abdel-Aziz, N.I.; el-Sayed, M.A.-A.; Aleisa, A.M.; Sayed-Ahmed, M.M.; Abdel-Hamide, S.G. 2010: Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study. European Journal of Medicinal Chemistry 45(9): 4188-4198
Zhang, J.-Q.; Zhang, Z.-W.; Hui, L.; Tian, X. 2010: Design, synthesis and biological evaluation of novel spin-labeled derivatives of podophyllotoxin. Natural Product Communications 5(2): 241-244
Yu, B.; Shi, X.-J.; Qi, P.-P.; Yu, D.-Q.; Liu, H.-M. 2014: Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents. Journal of Steroid Biochemistry and Molecular Biology 141: 121-134
Kliachyna, M.; Santoni, G.; Nussbaum, V.; Renou, J.; Sanson, B.; Colletier, J.-P.; Arboléas, M.él.; Loiodice, M.él.; Weik, M.; Jean, L.; Renard, P.-Y.; Nachon, F.; Baati, R. 2014: Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. European Journal of Medicinal Chemistry 78: 455-467
Lv, P.-C.; Wang, K.-R.; Yang, Y.; Mao, W.-J.; Chen, J.; Xiong, J.; Zhu, H.-L. 2009: Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. Bioorganic and Medicinal Chemistry Letters 19(23): 6750-6754
Liu, Z.; Wang, Y.; Lin, H.; Zuo, D.; Wang, L.; Zhao, Y.; Gong, P. 2014: Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents. European Journal of Medicinal Chemistry 85: 215-227
Nevagi, R.J.; Dhake, A.S.; Narkhede, H.I.; Kaur, P. 2014: Design, synthesis and biological evaluation of novel thiosemicarbazide analogues as potent anticonvulsant agents. Bioorganic Chemistry 54: 68-72
Abdellatif, K.R.A.; Belal, A.; Omar, H.A. 2013: Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues. Bioorganic and Medicinal Chemistry Letters 23(17): 4960-4963
Upadhayaya, R.S.; Kulkarni, G.M.; Vasireddy, N.R.; Vandavasi, J.K.; Dixit, S.S.; Sharma, V.; Chattopadhyaya, J. 2009: Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry 17(13): 4681-4692
Zhang, J.; Cao, J.; Xu, L.; Zhou, Y.; Liu, T.; Li, J.; Hu, Y. 2014: Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors. Bioorganic and Medicinal Chemistry 22(11): 2955-2965
Itoh, Y.; Kitaguchi, R.; Ishikawa, M.; Naito, M.; Hashimoto, Y. 2011: Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorganic and Medicinal Chemistry 19(22): 6768-6778
Ramachary, D.B.; Reddy, Y.V.; Banerjee, A.; Banerjee, S. 2011: Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors. Organic and Biomolecular Chemistry 9(21): 7282-7286
Xie, R.; Zhao, Q.; Zhang, T.; Fang, J.; Mei, X.; Ning, J.; Tang, Y. 2013: Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors. Bioorganic and Medicinal Chemistry 21(1): 278-282
Chen, X.-X.; Gao, F.; Wang, Q.; Huang, X.; Wang, D. 2014: Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures. Fitoterapia 92: 111-115
Jia, Y.; Zhang, J.; Feng, J.; Xu, F.; Pan, H.; Xu, W. 2014: Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents. Chemical Biology and Drug Design 83(3): 306-316
Zhou, T.; Hider, R.C.; Jenner, P.; Campbell, B.; Hobbs, C.J.; Rose, S.; Jairaj, M.; Tayarani-Binazir, K.A.; Syme, A. 2013: Design, synthesis and biological evaluation of peptide derivatives of L-dopa as anti-parkinsonian agents. Bioorganic and Medicinal Chemistry Letters 23(19): 5279-5282
Zhang, J.; Han, M.; Ma, X.; Xu, L.; Cao, J.; Zhou, Y.; Li, J.; Liu, T.; Hu, Y. 2014: Design, synthesis and biological evaluation of peptidyl epoxyketone proteasome inhibitors composed of β-amino acids. Chemical Biology and Drug Design 84(5): 497-504
Bhattacharya, A.K.; Rana, K.C. 2011: Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors. Bioorganic and Medicinal Chemistry 19(23): 7129-7135
McGuigan, C.; Bourdin, C.; Derudas, M.; Hamon, N.èg.; Hinsinger, K.; Kandil, S.; Madela, K.; Meneghesso, S.; Pertusati, F.; Serpi, M.; Slusarczyk, M.; Chamberlain, S.; Kolykhalov, A.; Vernachio, J.; Vanpouille, C.; Introini, A.; Margolis, L.; Balzarini, J. 2013: Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70: 326-340
Wang, T.; Duncan, L.; Gu, W.; O'Dowd, H.; Wei, Y.; Perola, E.; Parsons, J.; Gross, C.H.; Moody, C.S.; Arends, S.J.R.; Charifson, P.S. 2012: Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones. Bioorganic and Medicinal Chemistry Letters 22(11): 3699-3703
Gu, W.; Wang, T.; Maltais, F.; Ledford, B.; Kennedy, J.; Wei, Y.; Gross, C.H.; Parsons, J.; Duncan, L.; Arends, S.J.R.; Moody, C.; Perola, E.; Green, J.; Charifson, P.S. 2012: Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides. Bioorganic and Medicinal Chemistry Letters 22(11): 3693-3698
Yang, P.-Y.; Wang, M.; Li, L.; Wu, H.; He, C.Y.; Yao, S.Q. 2012: Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents. Chemistry 18(21): 6528-6541
Strocchi, E.; Fornari, F.; Minguzzi, M.; Gramantieri, L.; Milazzo, M.; Rebuttini, V.; Breviglieri, S.; Camaggi, C.M.; Locatelli, E.; Bolondi, L.; Comes-Franchini, M. 2012: Design, synthesis and biological evaluation of pyrazole derivatives as potential multi-kinase inhibitors in hepatocellular carcinoma. European Journal of Medicinal Chemistry 48: 391-401
Qiu, K.-M.; Wang, H.-H.; Wang, L.-M.; Luo, Y.; Yang, X.-H.; Wang, X.-M.; Zhu, H.-L. 2012: Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorganic and Medicinal Chemistry 20(6): 2010-2018
Pan, X.; Dong, J.; Gao, H.; Wang, F.; Zhang, Y.; Wang, S.; Zhang, J. 2014: Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chemical Biology and Drug Design 83(5): 592-599
Lu, X.; Zhang, H.; Li, X.; Chen, G.; Li, Q.-S.; Luo, Y.; Ruan, B.-F.; Chen, X.-W.; Zhu, H.-L. 2011: Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors. Bioorganic and Medicinal Chemistry 19(22): 6827-6832
Yang, Y.; Shi, L.; Zhou, Y.; Li, H.-Q.; Zhu, Z.-W.; Zhu, H.-L. 2010: Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorganic and Medicinal Chemistry Letters 20(22): 6653-6656
Qin, X.; Han, X.; Hu, L.; Li, Z.; Geng, Z.; Wang, Z.; Zeng, C.; Xiao, X. 2015: Design, synthesis and biological evaluation of quinoxalin-2(1H)-one derivatives as EGFR tyrosine kinase inhibitors. Anti-Cancer Agents in Medicinal Chemistry 15(2): 267-273
Cui, J.; Jin, J.; Hsieh, Y.-H.; Yang, H.; Ke, B.; Damera, K.; Tai, P.C.; Wang, B. 2013: Design, synthesis and biological evaluation of rose bengal analogues as SecA inhibitors. Chemmedchem 8(8): 1384-1393
Menche, D.; Li, P.; Irschik, H. 2010: Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien. Bioorganic and Medicinal Chemistry Letters 20(3): 939-941
Altendorfer, M.; Irschik, H.; Menche, D. 2012: Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien. Bioorganic and Medicinal Chemistry Letters 22(17): 5731-5734
Yang, J.; Yang, J.X.; Zhang, F.; Chen, G.; Pan, W.; Yu, R.; Wu, S.; Tien, P. 2014: Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H(5)N(1). Bioorganic and Medicinal Chemistry Letters 24(12): 2680-2684
Lalonde, J.M.; Elban, M.A.; Courter, J.R.; Sugawara, A.; Soeta, T.; Madani, N.; Princiotto, A.M.; Kwon, Y.D.; Kwong, P.D.; Schön, A.; Freire, E.; Sodroski, J.; Smith, A.B. 2011: Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorganic and Medicinal Chemistry 19(1): 91-101
Favre-Besse, F.-C.; Poirel, O.; Bersot, T.; Kim-Grellier, E.; Daumas, S.; El Mestikawy, S.; Acher, F.C.; Pietrancosta, N. 2014: Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors. European Journal of Medicinal Chemistry 78: 236-247
Arya, N.; Dwivedi, J.; Khedkar, V.M.; Coutinho, E.C.; Jain, K.S. 2013: Design, synthesis and biological evaluation of some 2-azetidinone derivatives as potential antihyperlipidemic agents. Archiv der Pharmazie 346(12): 872-881
Singh, L.K.; Priyanka; Singh, V.; Katiyar, D. 2015: Design, synthesis and biological evaluation of some new coumarin derivatives as potential antimicrobial agents. Medicinal Chemistry 11(2): 128-134
Jain, P.; Sharma, P.K.; Rajak, H.; Pawar, R.S.; Patil, U.K.; Singour, P.K. 2010: Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity. Archives of Pharmacal Research 33(7): 971-980
Alanazi, A.M.; Abdel-Aziz, A.A.-M.; Al-Suwaidan, I.A.; Abdel-Hamide, S.G.; Shawer, T.Z.; El-Azab, A.S. 2014: Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents. European Journal of Medicinal Chemistry 79: 446-454
Rizk, O.H.; Shaaban, O.G.; El-Ashmawy, I.M. 2012: Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents. European Journal of Medicinal Chemistry 55: 85-93
Wang, Y.-Q.; Li, X.-H.; He, Q.; Chen, Y.; Xie, Y.-Y.; Ding, J.; Miao, Z.-H.; Yang, C.-H. 2011: Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents. European Journal of Medicinal Chemistry 46(12): 5878-5884
Wang, J.; Wang, Y.; Li, Z.; Zhan, P.; Bai, R.; Pannecouque, C.; Balzarini, J.; De Clercq, E.; Liu, X. 2014: Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction. Medicinal Chemistry 10(7): 738-746
Gangjee, A.; Namjoshi, O.A.; Yu, J.; Ihnat, M.A.; Thorpe, J.E.; Warnke, L.A. 2008: Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorganic and Medicinal Chemistry 16(10): 5514-5528
Sanki, A.K.; Boucau, J.; Umesiri, F.E.; Ronning, D.R.; Sucheck, S.J. 2009: Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Molecular Biosystems 5(9): 945-956
Yu, Z.; Zhuang, C.; Wu, Y.; Guo, Z.; Li, J.; Dong, G.; Yao, J.; Sheng, C.; Miao, Z.; Zhang, W. 2014: Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. International Journal of Molecular Sciences 15(9): 15741-15753
Recher, M.; Barboza, A.P.; Li, Z.-H.; Galizzi, M.; Ferrer-Casal, M.; Szajnman, S.H.; Docampo, R.; Moreno, S.N.J.; Rodriguez, J.B. 2013: Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. European Journal of Medicinal Chemistry 60: 431-440
Zhang, W.; Sun, T.; Ma, Z.; Li, Y. 2014: Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors. Marine Drugs 12(4): 2308-2325
Xu, Q.; Huang, L.; Liu, J.; Ma, L.; Chen, T.; Chen, J.; Peng, F.; Cao, D.; Yang, Z.; Qiu, N.; Qiu, J.; Wang, G.; Liang, X.; Peng, A.; Xiang, M.; Wei, Y.; Chen, L. 2012: Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type Ii diabetes. European Journal of Medicinal Chemistry 52: 70-81
Lv, P.-C.; Zhou, C.-F.; Chen, J.; Liu, P.-G.; Wang, K.-R.; Mao, W.-J.; Li, H.-Q.; Yang, Y.; Xiong, J.; Zhu, H.-L. 2010: Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorganic and Medicinal Chemistry 18(1): 314-319
Song, P.; Peng, P.; Han, M.; Cao, X.; Ma, X.; Liu, T.; Zhou, Y.; Hu, Y. 2014: Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors. Bioorganic and Medicinal Chemistry 22(17): 4882-4892
Blomberg, D.; Fex, T.; Xue, Y.; Brickmann, K.; Kihlberg, J. 2007: Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold. Organic and Biomolecular Chemistry 5(16): 2599-2605
Fortuna, C.G.; Barresi, V.; Musumarra, G. 2010: Design, synthesis and biological evaluation of trans 2-(thiophen-2-yl)vinyl heteroaromatic iodides. Bioorganic and Medicinal Chemistry 18(12): 4516-4523
Gu, J.; Anumala, U.R.; Heyny-von Haußen, R.; Hölzer, J.; Goetschy-Meyer, V.ér.; Mall, G.; Hilger, I.; Czech, C.; Schmidt, B. 2013: Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium. Chemmedchem 8(6): 891-897
Zhu, Y.; Yao, S.; Xu, B.; Ge, Z.; Cui, J.; Cheng, T.; Li, R. 2009: Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors. Bioorganic and Medicinal Chemistry 17(19): 6851-6861
Shahin, M.I.; Abou El Ella, D.A.; Ismail, N.S.M.; Abouzid, K.A.M. 2014: Design, synthesis and biological evaluation of type-Ii VEGFR-2 inhibitors based on quinoxaline scaffold. Bioorganic Chemistry 56: 16-26
Zhang, Y.; Feng, J.; Liu, C.; Fang, H.; Xu, W. 2011: Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors. Bioorganic and Medicinal Chemistry 19(15): 4437-4444
Li, Z.-L.; Li, Q.-S.; Zhang, H.-J.; Hu, Y.; Zhu, D.-D.; Zhu, H.-L. 2011: Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors. Bioorganic and Medicinal Chemistry 19(15): 4413-4420
Axford, L.C.; Agarwal, P.K.; Anderson, K.H.; Andrau, L.N.; Atherall, J.; Barker, S.; Bennett, J.M.; Blair, M.; Collins, I.; Czaplewski, L.G.; Davies, D.T.; Gannon, C.T.; Kumar, D.; Lancett, P.; Logan, A.; Lunniss, C.J.; Mitchell, D.R.; Offermann, D.A.; Palmer, J.T.; Palmer, N.; Pitt, G.R.W.; Pommier, S.ép.; Price, D.; Narasinga Rao, B.; Saxena, R.; Shukla, T.; Singh, A.K.; Singh, M.; Srivastava, A.; Steele, C.; Stokes, N.R.; Thomaides-Brears, H.B.; Tyndall, E.M.; Watson, D.; Haydon, D.J. 2013: Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type Ii topoisomerase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(24): 6598-6603
Sharma, S.; Ahmad, M.; Bhat, J.A.; Kumar, A.; Kumar, M.; Zargar, M.A.; Hamid, A.; Shah, B.A. 2014: Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death. Bioorganic and Medicinal Chemistry Letters 24(19): 4729-4734
Xin, B.; Tang, W.; Wang, Y.; Lin, G.; Liu, H.; Jiao, Y.; Zhu, Y.; Yuan, H.; Chen, Y.; Lu, T. 2012: Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase. Bioorganic and Medicinal Chemistry Letters 22(14): 4783-4786
Miyauchi, R.; Kawakami, K.; Ito, M.; Matsuhashi, N.; Ohki, H.; Inagaki, H.; Takahashi, H.; Takemura, M. 2009: Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorganic and Medicinal Chemistry 17(19): 6879-6889
El-Hawash, S.A.M.; Soliman, R.; Youssef, A.M.; Ragab, H.M.A.; Elzahhar, P.A.S.; El-Ashmawey, I.M.; Abdel Wahab, A.E.; Shaat, I.A. 2014: Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents. Medicinal Chemistry 10(3): 318-338
Sun, Y.; Pandit, B.; Chettiar, S.N.; Etter, J.P.; Lewis, A.; Johnsamuel, J.; Li, P.-K. 2013: Design, synthesis and biological studies of novel tubulin inhibitors. Bioorganic and Medicinal Chemistry Letters 23(15): 4465-4468
Chettiar, S.N.; Cooley, J.V.; Park, I.-H.; Bhasin, D.; Chakravarti, A.; Li, P.-K.; Li, C.; Jacob, N.K. 2013: Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle. Bioorganic and Medicinal Chemistry Letters 23(19): 5429-5433
Ibrahim, D.A.; Ismail, N.S.M. 2011: Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors. European Journal of Medicinal Chemistry 46(12): 5825-5832
Das, B.C.; Zhao, X.; Tang, X.-Y.; Yang, F. 2011: Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors. Bioorganic and Medicinal Chemistry Letters 21(18): 5638-5641
Peura, L.; Malmioja, K.; Huttunen, K.; Leppänen, J.; Hämäläinen, M.; Forsberg, M.M.; Gynther, M.; Rautio, J.; Laine, K. 2013: Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine. Pharmaceutical Research 30(10): 2523-2537
García-Beltrán, O.; Mena, N.; Yañez, O.; Caballero, J.; Vargas, V.íc.; Nuñez, M.T.; Cassels, B.K. 2013: Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+. European Journal of Medicinal Chemistry 67: 60-63
Coppola, C.; Paciello, A.; Mangiapia, G.; Licen, S.; Boccalon, M.; De Napoli, L.; Paduano, L.; Tecilla, P.; Montesarchio, D. 2010: Design, synthesis and characterisation of a fluorescently labelled CyPLOS ionophore. Chemistry 16(46): 13757-13772
Simeone, L.; Milano, D.; De Napoli, L.; Irace, C.; Di Pascale, A.; Boccalon, M.; Tecilla, P.; Montesarchio, D. 2011: Design, synthesis and characterisation of guanosine-based amphiphiles. Chemistry 17(49): 13854-13865
Son, Y.-A.; Lee, J.; Kim, H.; Yu, H.; Kim, S.-H.; Jun, K.; Lee, D.-H. 2013: Design, synthesis and characteristics on novel D-pi-A dye chromophore: fluorochromism effects. Journal of Nanoscience and Nanotechnology 13(2): 1484-1487
Kulkarni, R.G.; Laufer, S.; Mangannavar, C.; Garlapati, A. 2013: Design, synthesis and characterization of N', N"-diaryl ureas as p38 kinase inhibitors. Medicinal Chemistry ) 9(2): 213-221
Peifer, C.; Bühler, S.; Hauser, D.; Kinkel, K.; Totzke, F.; Schächtele, C.; Laufer, S. 2009: Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. European Journal of Medicinal Chemistry 44(4): 1788-1793
Szeto, K.C.; Kongshaug, K.O.; Jakobsen, S.ør.; Tilset, M.; Lillerud, K.P. 2008: Design, synthesis and characterization of a Pt-Gd metal-organic framework containing potentially catalytically active sites. Dalton Transactions 15: 2054-2060
Dos Santos, G.P.; da Silva, B.F.; Garrido, S.S.; Mascini, M.; Yamanaka, H. 2014: Design, synthesis and characterization of a hexapeptide bio-inspired by acetylcholinesterase and its interaction with pesticide dichlorvos. Analyst 139(1): 273-279
Klein, M.; Morillas, M.; Vendrell, A.; Brive, L.; Gebbia, M.; Wallace, I.M.; Giaever, G.; Nislow, C.; Posas, F.; Grøtli, M. 2011: Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. Plos one 6(6): E20789
Topf, C.; Monkowius, U.; Knör, G.ün. 2012: Design, synthesis and characterization of a modular bridging ligand platform for bio-inspired hydrogen production. Inorganic Chemistry Communications 21(15): 147-150
Martín, I.; Teixidó, M.; Giralt, E. 2011: Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E). Chembiochem: a European Journal of Chemical Biology 12(6): 896-903
Pirone, L.; Correale, S.; de Paola, I.; Zaccaro, L.; De Simone, G.; Vitagliano, L.; Pedone, E.; Di Gaetano, S. 2011: Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition. Journal of Peptide Science: An Official Publication of the European Peptide Society 17(5): 373-376
Li, Y.; Wang, Y.; Gong, Y.; Xu, X.; Zhou, M. 2010: Design, synthesis and characterization of an orange-yellow long persistent phosphor: Sr3Al2O5Cl2:Eu(2+),Tm(3+). Optics Express 18(24): 24853-24858
Wang, W.; Jiang, H.; Pang, J.; Jiang, Z.; Xi, B. 2012: Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 inhibitors. Nan Fang Yi Ke da Xue Xue Bao 32(2): 177-180
Hu, Y.; Cheng, N.; Wu, H.; Kang, S.; Ye, R.D.; Cai, J. 2014: Design, synthesis and characterization of fMLF-mimicking AApeptides. Chembiochem: a European Journal of Chemical Biology 15(16): 2420-2426
Karad, S.C.; Purohit, V.B.; Raval, D.K. 2014: Design, synthesis and characterization of fluoro substituted novel pyrazolylpyrazolines scaffold and their pharmacological screening. European Journal of Medicinal Chemistry 84: 51-58
Lai, H.; Dou, D.; Aravapalli, S.; Teramoto, T.; Lushington, G.H.; Mwania, T.M.; Alliston, K.R.; Eichhorn, D.M.; Padmanabhan, R.; Groutas, W.C. 2013: Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases. Bioorganic and Medicinal Chemistry 21(1): 102-113
Giri, R.S.; Thaker, H.M.; Giordano, T.; Williams, J.; Rogers, D.; Sudersanam, V.; Vasu, K.K. 2009: Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappaB and AP-1 mediated transcription activation and as potential anti-inflammatory agents. European Journal of Medicinal Chemistry 44(5): 2184-2189
Banerjee, D.R.; Dutta, D.; Saha, B.; Bhattacharyya, S.; Senapati, K.; Das, A.K.; Basak, A. 2014: Design, synthesis and characterization of novel inhibitors against mycobacterial β-ketoacyl CoA reductase FabG4. Organic and Biomolecular Chemistry 12(1): 73-85
Duggineni, S.; Mitra, S.; Noberini, R.; Han, X.; Lin, N.; Xu, Y.; Tian, W.; An, J.; Pasquale, E.B.; Huang, Z. 2013: Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4. Biochemical Pharmacology 85(4): 507-513
Banappagari, S.; McCall, A.; Fontenot, K.; Vicente, M.G.H.; Gujar, A.; Satyanarayanajois, S. 2013: Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain. European Journal of Medicinal Chemistry 65: 60-69
Cui, Y.-M.; Yasutomi, E.; Otani, Y.; Yoshinaga, T.; Ido, K.; Sawada, K.; Ohwada, T. 2008: Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. Bioorganic and Medicinal Chemistry Letters 18(19): 5197-5200
Fontenot, S.A.; Cangelosi, V.M.; Pitt, M.A.W.; Sather, A.C.; Zakharov, L.N.; Berryman, O.B.; Johnson, D.W. 2011: Design, synthesis and characterization of self-assembled As2L3 and Sb2L3 cryptands. Dalton Transactions 40(45): 12125-12131
Dubey, S.K.; Sharma, A.K.; Narain, U.; Misra, K.; Pati, U. 2008: Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties. European Journal of Medicinal Chemistry 43(9): 1837-1846
Bineesh, K.V.; Kim, D.-K.; Kim, M.-I.; Selvaraj, M.; Park, D.-W. 2011: Design, synthesis and characterization of vanadia-doped iron-oxide pillared montmorillonite clay for the selective catalytic oxidation of H2S. Dalton Transactions 40(15): 3938-3945
Vijayaraghavan, K.; Iyyam Pillai, S.; Subramanian, S.P. 2012: Design, synthesis and characterization of zinc-3 hydroxy flavone, a novel zinc metallo complex for the treatment of experimental diabetes in rats. European Journal of Pharmacology 680(1-3): 122-129
Sendrayaperumal, V.; Iyyam Pillai, S.; Subramanian, S. 2014: Design, synthesis and characterization of zinc-morin, a metal flavonol complex and evaluation of its antidiabetic potential in HFD-STZ induced type 2 diabetes in rats. Chemico-Biological Interactions 219: 9-17
Luo, W.; Huang, K.; Zhang, Z.; Hong, C.; Wang, C.-J. 2013: Design, synthesis and cholinesterase inhibitory activity of quinoline-polyamine conjugates. Yao Xue Xue Bao 48(2): 269-275
Dos Santos Filho, J.é M.; Leite, A.C.L.; de Oliveira, B.G.; Moreira, D.R.M.ãe.; Lima, M.S.; Soares, M.B.P.; Leite, L.F.C.C. 2009: Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents. Bioorganic and Medicinal Chemistry 17(18): 6682-6691
Chuck, C.-P.; Chen, C.; Ke, Z.; Wan, D.C.-C.; Chow, H.-F.; Wong, K.-B. 2013: Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases. European Journal of Medicinal Chemistry 59: 1-6
Liu, G.; Ge, Z.; Zhao, M.; Zhou, Y. 2013: Design, synthesis and cytotoxic activities of novel aliphatic amino-substituted flavonoids. Molecules 18(11): 14070-14084
Yang, X.-D.; Wan, W.-C.; Deng, X.-Y.; Li, Y.; Yang, L.-J.; Li, L.; Zhang, H.-B. 2012: Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole. Bioorganic and Medicinal Chemistry Letters 22(8): 2726-2729
Chen, W.; Yang, X.-D.; Li, Y.; Yang, L.-J.; Wang, X.-Q.; Zhang, G.-L.; Zhang, H.-B. 2011: Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole. Organic and Biomolecular Chemistry 9(11): 4250-4255
Bai, B.; Li, X.-Y.; Li, Y.; Zhu, H.-J. 2011: Design, synthesis and cytotoxic activities of novel β-amino alcohol derivatives. Bioorganic and Medicinal Chemistry Letters 21(8): 2302-2304
Daniilides, K.; Lougiakis, N.; Pouli, N.; Marakos, P.; Samara, P.; Tsitsilonis, O. 2014: Design, synthesis and cytotoxic activity evaluation of new aminosubstituted benzofurans. Medicinal Chemistry 10(6): 619-627
Liu, Y.-Q.; Ohkoshi, E.; Li, L.-H.; Yang, L.; Lee, K.-H. 2012: Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives. Bioorganic and Medicinal Chemistry Letters 22(2): 920-923
Zhang, Z.-J.; Tian, J.; Wang, L.-T.; Wang, M.-J.; Nan, X.; Yang, L.; Liu, Y.-Q.; Morris-Natschke, S.L.; Lee, K.-H. 2014: Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorganic and Medicinal Chemistry 22(1): 204-210
Azmi, M.N.; Din, M.F.M.; Kee, C.H.; Suhaimi, M.; Ping, A.K.; Ahmad, K.; Nafiah, M.A.; Thomas, N.F.; Mohamad, K.; Hoong, L.K.; Awang, K. 2013: Design, synthesis and cytotoxic evaluation of o-carboxamido stilbene analogues. International Journal of Molecular Sciences 14(12): 23369-23389
Piotrowska, D.G.; Cieślak, M.; Królewska, K.; Wróblewski, A.E. 2011: Design, synthesis and cytotoxicity of a new series of isoxazolidine based nucleoside analogues. Archiv der Pharmazie 344(5): 301-310
Piotrowska, D.G.; Cieślak, M.; Królewska, K.; Wróblewski, A.E. 2011: Design, synthesis and cytotoxicity of a new series of isoxazolidines derived from substituted chalcones. European Journal of Medicinal Chemistry 46(4): 1382-1389
He, Y.-F.; Nan, M.-L.; Sun, J.-M.; Meng, Z.-J.; Li, W.; Zhang, M. 2013: Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Bioorganic and Medicinal Chemistry Letters 23(9): 2543-2547
Jiang, N.; Zhai, X.; Chen, Z.; Liang, C.; Sun, C.; Han, J.; Gong, P. 2012: Design, synthesis and cytotoxicity of novel 2-arylvinyl-4-aminoquinoline derivatives. Chemical and Pharmaceutical Bulletin 60(5): 659-664
Chang, J.; Hao, X.-D.; Hao, Y.-P.; Lu, H.-F.; Yu, J.-M.; Sun, X. 2013: Design, synthesis and cytotoxicity of novel 3'-N-alkoxycarbonyl docetaxel analogs. Bioorganic and Medicinal Chemistry Letters 23(24): 6834-6837
Brien, K.A.; Bandi, R.K.; Behera, A.K.; Mishra, B.K.; Majumdar, P.; Satam, V.; Savagian, M.; Tzou, S.; Lee, M.; Zeller, M.; Robles, A.J.; Mooberry, S.; Pati, H.; Lee, M. 2012: Design, synthesis and cytotoxicity of novel chalcone analogs derived from 1-cyclohexylpyrrolidin-2-one and 2,3-dihydrobenzo[f]chromen-1-one. Archiv der Pharmazie 345(5): 341-348
Yu, P.-F.; Chen, H.; Wang, J.; He, C.-X.; Cao, B.; Li, M.; Yang, N.; Lei, Z.-Y.; Cheng, M.-S. 2008: Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. Chemical and Pharmaceutical Bulletin 56(6): 831-834
Nakata, E.; Koizumi, M.; Yamashita, Y.; Onaka, K.; Sakurai, Y.; Kondo, N.; Ono, K.; Uto, Y.; Hori, H. 2011: Design, synthesis and destructive dynamic effects of BODIPY-containing and curcuminoid boron tracedrugs for neutron dynamic therapy. Anticancer Research 31(7): 2477-2481
Patel, P.D.; Patel, M.R.; Kocsis, B.; Kocsis, E.; Graham, S.M.; Warren, A.R.; Nicholson, S.M.; Billack, B.; Fronczek, F.R.; Talele, T.T. 2010: Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles. European Journal of Medicinal Chemistry 45(6): 2214-2222
Jia, Z.Jon.; Scarborough, R.Murry.; Zhang, P.; Halfon, S.; Arfsten, A.Elizabeth.; Sinha, U.; Zhu, B-Yan. 2009: Design, synthesis and discovery of 1-(2-(6-Chloro-3-methylsulfonyl)-naphthyl)-1H-pyrazole-5-carboxylamides as highly potent factor Xa inhibitors. Chemical and Pharmaceutical Bulletin 57(9): 1004-1007
Cheng, H.; Zhang, L.; Liu, Y.; Chen, S.; Cheng, H.; Lu, X.; Zheng, Z.; Zhou, G-Chun. 2010: Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines. European Journal of Medicinal Chemistry 45(12): 5950-5957
Yenugonda, V.M.; Xiao, Y.; Levin, E.D.; Rezvani, A.H.; Tran, T.; Al-Muhtasib, N.; Sahibzada, N.; Xie, T.; Wells, C.; Slade, S.; Johnson, J.E.; Dakshanamurthy, S.; Kong, H-Sik.; Tomita, Y.; Liu, Y.; Paige, M.; Kellar, K.J.; Brown, M.L. 2013: Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. Journal of Medicinal Chemistry 56(21): 8404-8421
Raghav, N.; Singh, M. 2014: Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 54: 28-39
Farag, N.A.H.; El-Tayeb, W. 2010: Design, synthesis and docking studies of new furobenzopyranones and pyranobenzopyranones as photoreagent towards DNA and as antimicrobial agents. European Journal of Medicinal Chemistry 45(1): 317-325
Thomas, K.D.; Adhikari, A.V.; Telkar, S.; Chowdhury, I.H.; Mahmood, R.; Pal, N.K.; Row, G.; Sumesh, E. 2011: Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents. European Journal of Medicinal Chemistry 46(11): 5283-5292
Thomas, K.D.; Adhikari, A.V.; Chowdhury, I.H.; Sandeep, T.; Mahmood, R.; Bhattacharya, B.; Sumesh, E. 2011: Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties. European Journal of Medicinal Chemistry 46(10): 4834-4845
Barot, K.P.; Jain, S.V.; Gupta, N.; Kremer, L.; Singh, S.; Takale, V.B.; Joshi, K.; Ghate, M.D. 2014: Design, synthesis and docking studies of some novel (R)-2-(4'-chlorophenyl)-3-(4'-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents. European Journal of Medicinal Chemistry 83: 245-255
Lu, A.; Luo, H.; Shi, M.; Wu, G.; Yuan, Y.; Liu, J.; Tang, F. 2011: Design, synthesis and docking studies on benzamide derivatives as histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry Letters 21(16): 4924-4927
Gupta, S.; Pandey, G.; Rahuja, N.; Srivastava, A.K.; Saxena, A.K. 2010: Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors. Bioorganic and Medicinal Chemistry Letters 20(19): 5732-5734
Wang, Z.; Liu, Z.; Lee, W.; Kim, S.-N.; Yoon, G.; Cheon, S.H. 2014: Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B. Bioorganic and Medicinal Chemistry Letters 24(15): 3337-3340
Khadka, D.B.; Le, Q.M.; Yang, S.H.; Van, H.T.M.; Le, T.N.; Cho, S.H.; Kwon, Y.; Lee, K.-T.; Lee, E.-S.; Cho, W.-J. 2011: Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase i inhibitors. Bioorganic and Medicinal Chemistry 19(6): 1924-1929
Linz, S.; Müller, J.ör.; Hübner, H.; Gmeiner, P.; Troschütz, R. 2009: Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. Bioorganic and Medicinal Chemistry 17(13): 4448-4458
Carotenuto, A.; Cipolletta, E.; Gomez-Monterrey, I.; Sala, M.; Vernieri, E.; Limatola, A.; Bertamino, A.; Musella, S.; Sorriento, D.; Grieco, P.; Trimarco, B.; Novellino, E.; Iaccarino, G.; Campiglia, P. 2013: Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors. European Journal of Medicinal Chemistry 69: 384-392
Silva, B.L.; S Filho, J.é D.; Andrade, P.; Carvalho, I.; Alves, R.J. 2014: Design, synthesis and enzymatic evaluation of 3-O-substituted aryl β-D-galactopyranosides as inhibitors of Trypanosoma cruzi trans-sialidase. Bioorganic and Medicinal Chemistry Letters 24(18): 4529-4532
Reddy, M.V.R.; Pallela, V.R.; Cosenza, S.C.; Mallireddigari, M.R.; Patti, R.; Bonagura, M.; Truongcao, M.; Akula, B.; Jatiani, S.S.; Reddy, E.P. 2010: Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. Bioorganic and Medicinal Chemistry 18(6): 2317-2326
Addla, D.; Jallapally, A.; Gurram, D.; Yogeeswari, P.; Sriram, D.; Kantevari, S. 2014: Design, synthesis and evaluation of 1,2,3-triazole-adamantylacetamide hybrids as potent inhibitors of Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry Letters 24(8): 1974-1979
Liu, D.; Tian, Z.; Yan, Z.; Wu, L.; Ma, Y.; Wang, Q.; Liu, W.; Zhou, H.; Yang, C. 2013: Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors. Bioorganic and Medicinal Chemistry 21(11): 2960-2967
Virdi, H.S.; Sharma, S.; Mehndiratta, S.; Bedi, P.M.S.; Nepali, K. 2014: Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 2014: 1-7
Mohamed, T.; Rao, P.P.N. 2010: Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(12): 3606-3609
Gangjee, A.; Zhao, Y.; Raghavan, S.; Ihnat, M.A.; Disch, B.C. 2010: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorganic and Medicinal Chemistry 18(14): 5261-5273
Vogt, D.; Weber, J.; Ihlefeld, K.; Brüggerhoff, A.; Proschak, E.; Stark, H. 2014: Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorganic and Medicinal Chemistry 22(19): 5354-5367
Chekanov, M.O.; Ostrynska, O.V.; Synyugin, A.R.; Bdzhola, V.G.; Yarmoluk, S.M. 2014: Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 29(3): 338-343
Friggeri, L.; De Vita, D.; Pandolfi, F.; Tortorella, S.; Costi, R.; Di Santo, R.; Scipione, L. 2015: Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 30(1): 166-172
Shangguan, S.; Wang, F.; Liao, Y.; Yu, H.; Li, J.; Huang, W.; Hu, H.; Yu, L.; Hu, Y.; Sheng, R. 2013: Design, synthesis and evaluation of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives as BACE-1 inhibitors. Molecules 18(3): 3577-3594
Giraud, F.; Loge, C.; Pagniez, F.; Crepin, D.; Barres, S.; Picot, C.; Le Pape, P.; Le Borgne, M. 2009: Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II. Journal of Enzyme Inhibition and Medicinal Chemistry 24(5): 1067-1075
Praveen Kumar, S.; Gut, J.; Guedes, R.C.; Rosenthal, P.J.; Santos, M.M.M.; Moreira, R. 2011: Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. European Journal of Medicinal Chemistry 46(3): 927-933
Cuenca, F.; Moore, M.J.B.; Johnson, K.; Guyen, B.ér.èr.; De Cian, A.; Neidle, S. 2009: Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells. Bioorganic and Medicinal Chemistry Letters 19(17): 5109-5113
Nielsen, M.C.; Borch, J.; Ulven, T. 2009: Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands. Bioorganic and Medicinal Chemistry 17(24): 8241-8246
Nagesh, H.N.; Naidu, K.M.; Rao, D.H.; Sridevi, J.P.; Sriram, D.; Yogeeswari, P.; Chandra Sekhar, K.V.G. 2013: Design, synthesis and evaluation of 6-(4-((substituted-1H-1,2,3-triazol-4-yl)methyl)piperazin-1-yl)phenanthridine analogues as antimycobacterial agents. Bioorganic and Medicinal Chemistry Letters 23(24): 6805-6810
Ye, Q.; Shen, Y.; Zhou, Y.; Lv, D.; Gao, J.; Li, J.; Hu, Y. 2013: Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors. European Journal of Medicinal Chemistry 68: 361-371
Wang, C.; Wang, T.; Zhou, N.; Pan, X-Yan.; He, H-Zhen. 2014: Design, synthesis and evaluation of 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives as new potential vasodilatory agents. Journal of Asian Natural Products Research 16(3): 304-311
Oda, Y.; Yanagisawa, H.; Maruyama, M.; Hattori, K.; Yamanoi, T. 2008: Design, synthesis and evaluation of D-galactose-beta-cyclodextrin conjugates as drug-carrying molecules. Bioorganic and Medicinal Chemistry 16(19): 8830-8840
Hassan, M.Z.; Khan, S.A.; Amir, M. 2012: Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective. European Journal of Medicinal Chemistry 58: 206-213
Fish, P.V.; Wakenhut, F.; Ryckmans, T.; Stobie, A. 2009: Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template. Bioorganic and Medicinal Chemistry Letters 19(16): 4579-4583
Pawar, S.K.; Badhwar, A.J.; Kharas, F.; Khandare, J.J.; Vavia, P.R. 2012: Design, synthesis and evaluation of N-acetyl glucosamine (NAG)-PEG-doxorubicin targeted conjugates for anticancer delivery. International Journal of Pharmaceutics 436(1-2): 183-193
Ma, Z.-Y.; Yang, Q.; Zhang, Y.-G.; Li, J.-J.; Yang, G.-L. 2014: Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors. Yao Xue Xue Bao 49(6): 813-818
Crocetti, L.; Giovannoni, M.P.; Schepetkin, I.A.; Quinn, M.T.; Khlebnikov, A.I.; Cilibrizzi, A.; Piaz, V.D.; Graziano, A.; Vergelli, C. 2011: Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Bioorganic and Medicinal Chemistry 19(15): 4460-4472
D'Ascenzio, M.; Carradori, S.; De Monte, C.; Secci, D.; Ceruso, M.; Supuran, C.T. 2014: Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XIi. Bioorganic and Medicinal Chemistry 22(6): 1821-1831
Song, S.; Chen, Z.; Li, S.; Huang, Y.; Wan, Y.; Song, H. 2013: Design, synthesis and evaluation of N13-substituted evodiamine derivatives against human cancer cell lines. Molecules 18(12): 15750-15768
Kaur, G.; Mahajan, M.P.; Pandey, M.K.; Singh, P.; Ramisetti, S.R.; Sharma, A.K. 2014: Design, synthesis and evaluation of Ospemifene analogs as anti-breast cancer agents. European Journal of Medicinal Chemistry 86: 211-218
Lu, C.; Kim, B.-M.; Chai, K.Y. 2011: Design, synthesis and evaluation of PEGylated lipoic acid derivatives with functionality as potent anti-melanogenic agents. European Journal of Medicinal Chemistry 46(10): 5184-5188
Ueno, H.; Iwata, T.; Koshiba, N.; Takahashi, D.; Toshima, K. 2013: Design, synthesis and evaluation of a boronic acid based artificial receptor for (L)-DOPA in aqueous media. Chemical Communications 49(88): 10403-10405
Zhou, G.-C.; Liu, F.; Wan, J.; Wang, J.; Wang, D.; Wei, P.; Ouyang, P. 2013: Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells. European Journal of Medicinal Chemistry 70: 631-639
Golsefidi, M.A.; Es'haghi, Z.; Sarafraz-Yazdi, A. 2012: Design, synthesis and evaluation of a molecularly imprinted polymer for hollow fiber-solid phase microextraction of chlorogenic acid in medicinal plants. Journal of Chromatography. a 1229: 24-29
Cho, K.; Ando, M.; Kobayashi, K.; Miyazoe, H.; Tsujino, T.; Ito, S.; Suzuki, T.; Tanaka, T.; Tokita, S.; Sato, N. 2009: Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide y Y1 receptor antagonists. Bioorganic and Medicinal Chemistry Letters 19(16): 4781-4785
McGuigan, C.; Madela, K.; Aljarah, M.; Gilles, A.; Brancale, A.; Zonta, N.; Chamberlain, S.; Vernachio, J.; Hutchins, J.; Hall, A.; Ames, B.; Gorovits, E.; Ganguly, B.; Kolykhalov, A.; Wang, J.; Muhammad, J.; Patti, J.M.; Henson, G. 2010: Design, synthesis and evaluation of a novel double pro-drug: INX-08189. a new clinical candidate for hepatitis C virus. Bioorganic and Medicinal Chemistry Letters 20(16): 4850-4854
Yedidi, R.S.; Muhuhi, J.M.; Liu, Z.; Bencze, K.Z.; Koupparis, K.; O'Connor, C.E.; Kovari, I.A.; Spaller, M.R.; Kovari, L.C. 2013: Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. Biochemical and Biophysical Research Communications 438(4): 703-708
Muscia, G.C.; Buldain, G.Y.; Asís, S.E. 2014: Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents. European Journal of Medicinal Chemistry 73: 243-249
Jia, Y.; Chiu, T.-L.; Amin, E.A.; Polunovsky, V.; Bitterman, P.B.; Wagner, C.R. 2010: Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. European Journal of Medicinal Chemistry 45(4): 1304-1313
Siddiqui, N.; Ahsan, W.; Alam, M.S.; Ali, R.; Srivastava, K. 2012: Design, synthesis and evaluation of anticonvulsant activity of pyridinyl-pyrrolidones: a pharmacophore hybrid approach. Archiv der Pharmazie 345(3): 185-194
Mahesh, R.; Dhar, A.K.; Jindal, A.; Bhatt, S. 2014: Design, synthesis and evaluation of antidepressant activity of novel 2-methoxy 1, 8 naphthyridine 3-carboxamides as 5-HT3 receptor antagonists. Chemical Biology and Drug Design 83(5): 583-591
Kumar, S.; Singh, R.K.; Sharma, R.; Murthy, R.S.R.; Bhardwaj, T.R. 2015: Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 66: 123-137
Bodapati, K.C.; Soudy, R.; Etayash, H.; Stiles, M.; Kaur, K. 2013: Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin a analogues. Bioorganic and Medicinal Chemistry 21(13): 3715-3722
Alagha, A.; Moman, E.; Adamo, M.F.A.; Nolan, K.B.; Chubb, A.J. 2009: Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity. Bioorganic and Medicinal Chemistry Letters 19(15): 4213-4216
Li, Z.; Huang, J.; Sun, H.; Zhou, S.; Guo, L.; Zhou, Y.; Zhen, X.; Liu, H. 2014: Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles. Bioorganic and Medicinal Chemistry 22(21): 5838-5846
Bravo, Y.; Teriete, P.; Dhanya, R.-P.; Dahl, R.; Lee, P.S.; Kiffer-Moreira, T.; Ganji, S.R.; Sergienko, E.; Smith, L.H.; Farquharson, C.; Millán, J.é L.; Cosford, N.D.P. 2014: Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorganic and Medicinal Chemistry Letters 24(17): 4308-4311
Luo, W.; Zhao, Y.-m.; Tian, R.-g.; Su, Y.-b.; Hong, C. 2013: Design, synthesis and evaluation of bis-nicotine derivatives as inhibitors of cholinesterases and beta-amyloid aggregation. Yao Xue Xue Bao 48(11): 1671-1676
Soda, M.; Hu, D.; Endo, S.; Takemura, M.; Li, J.; Wada, R.; Ifuku, S.; Zhao, H.-T.; El-Kabbani, O.; Ohta, S.; Yamamura, K.; Toyooka, N.; Hara, A.; Matsunaga, T. 2012: Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. European Journal of Medicinal Chemistry 48: 321-329
Takahashi, J.; Hijikuro, I.; Kihara, T.; Murugesh, M.G.; Fuse, S.; Tsumura, Y.; Akaike, A.; Niidome, T.; Takahashi, T.; Sugimoto, H. 2010: Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(5): 1721-1723
Ke, J.-H.; Wei, M.-F.; Shieh, M.-J.; Young, T.-H. 2011: Design, synthesis and evaluation of cationic poly(N-substituent acrylamide)s for in vitro gene delivery. Journal of Biomaterials Science. Polymer Edition 22(9): 1215-1236
Wang, Y.; Damu, G.L.V.; Lv, J.-S.; Geng, R.-X.; Yang, D.-C.; Zhou, C.-H. 2012: Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. Bioorganic and Medicinal Chemistry Letters 22(17): 5363-5366
Seth, P.P.; Siwkowski, A.; Allerson, C.R.; Vasquez, G.; Lee, S.; Prakash, T.P.; Kinberger, G.; Migawa, M.T.; Gaus, H.; Bhat, B.; Swayze, E.E. 2008: Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs. Nucleic Acids Symposium Series 52: 553-554
Vrudhula, V.M.; Dasgupta, B.; Pin, S.S.; Burris, K.D.; Balanda, L.A.; Fung, L.K.; Fiedler, T.; Browman, K.E.; Taber, M.T.; Zhang, J.; Macor, J.E.; Dubowchik, G.M. 2010: Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R). Bioorganic and Medicinal Chemistry Letters 20(6): 1905-1909
Miri, R.; Motamedi, R.; Rezaei, M.R.; Firuzi, O.; Javidnia, A.; Shafiee, A. 2011: Design, synthesis and evaluation of cytotoxicity of novel chromeno[4,3-b]quinoline derivatives. Archiv der Pharmazie 344(2): 111-118
Prasanthi, G.; Prasad, K.V.S.R.G.; Bharathi, K. 2013: Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction. European Journal of Medicinal Chemistry 66: 516-525
Aguilar, J.C.; Miguel, E.R.; Gyves, J.; Bartsch, R.A.; Kim, M. 2001: Design, synthesis and evaluation of diazadibenzocrown ethers as Pb(2+) extractants and carriers in plasticized cellulose triacetate membranes. Talanta 54(6): 1195-1204
Yu, L.; Cao, R.; Yi, W.; Yan, Q.; Chen, Z.; Ma, L.; Song, H. 2010: Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical and Pharmaceutical Bulletin 58(9): 1216-1220
Huang, L.; Shan, W.; Zhou, Q.; Xie, J.; Lai, K.; Li, X. 2014: Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Bioorganic and Medicinal Chemistry Letters 24(1): 249-253
Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. 2013: Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging. Molecules 18(6): 6425-6438
Sheng, R.; Lin, X.; Zhang, J.; Chol, K.S.; Huang, W.; Yang, B.; He, Q.; Hu, Y. 2009: Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. Bioorganic and Medicinal Chemistry 17(18): 6692-6698
Li, R.-S.; Wang, X.-B.; Hu, X.-J.; Kong, L.-Y. 2013: Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 23(9): 2636-2641
Jia, P.; Sheng, R.; Zhang, J.; Fang, L.; He, Q.; Yang, B.; Hu, Y. 2009: Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry 44(2): 772-784
Qiang, X.; Sang, Z.; Yuan, W.; Li, Y.; Liu, Q.; Bai, P.; Shi, Y.; Ang, W.; Tan, Z.; Deng, Y. 2014: Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 76: 314-331
Kapoerchan, V.V.; Wiesner, M.; Hillaert, U.; Drijfhout, J.W.; Overhand, M.; Alard, P.; van der Marel, G.A.; Overkleeft, H.S.; Koning, F. 2010: Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule. Molecular Immunology 47(5): 1091-1097
She, N.; Zhuo, L.; Jiang, W.; Zhu, X.; Wang, J.; Ming, Z.; Zhao, X.; Cong, X.; Huang, W. 2014: Design, synthesis and evaluation of highly selective pyridone-based class Ii MET inhibitors. Bioorganic and Medicinal Chemistry Letters 24(15): 3351-3355
Ardecky, R.J.; Welsh, K.; Finlay, D.; Lee, P.S.; González-López, M.; Ganji, S.R.; Ravanan, P.; Mace, P.D.; Riedl, S.J.; Vuori, K.; Reed, J.C.; Cosford, N.D.P. 2013: Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorganic and Medicinal Chemistry Letters 23(14): 4253-4257
Yan, J.-W.; Li, Y.-P.; Ye, W.-J.; Chen, S.-B.; Hou, J.-Q.; Tan, J.-H.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S. 2012: Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation. Bioorganic and Medicinal Chemistry 20(8): 2527-2534
Sharma, M.; Rakhi, A.; Dalal, N.; Sharma, N. 2011: Design, synthesis and evaluation of lantadene A congener with hydroxyl functionality in ring A as an antitumour agent. Natural Product Research 25(4): 387-396
Du, X.; Zhang, S.-E.; Liu, J.-Z.; Nie, F.-L.; Ye, F.; Tian, J.-Y.; Xiao, Z.-Y. 2012: Design, synthesis and evaluation of malonic acid-based PTP1B inhibitors. Yao Xue Xue Bao 47(3): 367-373
González-López, M.; Welsh, K.; Finlay, D.; Ardecky, R.J.; Ganji, S.R.; Su, Y.; Yuan, H.; Teriete, P.; Mace, P.D.; Riedl, S.J.; Vuori, K.; Reed, J.C.; Cosford, N.D.P. 2011: Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. Bioorganic and Medicinal Chemistry Letters 21(14): 4332-4336
Stokmaier, D.; Khorev, O.; Cutting, B.; Born, R.; Ricklin, D.; Ernst, T.O.G.; Böni, F.; Schwingruber, K.; Gentner, M.; Wittwer, M.; Spreafico, M.; Vedani, A.; Rabbani, S.; Schwardt, O.; Ernst, B. 2009: Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorganic and Medicinal Chemistry 17(20): 7254-7264
Jiang, N.; Li, S.-Y.; Xie, S.-S.; Li, Z.-R.; Wang, K.D.G.; Wang, X.-B.; Kong, L.-Y. 2014: Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 87: 540-551
Madhukar, M.; Sawraj, S.; Sharma, P.D. 2010: Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID. European Journal of Medicinal Chemistry 45(6): 2591-2596
Farard, J.; Lanceart, Gëtan.; Logé, C.; Nourrisson, M-Reneé.; Cruzalegui, F.; Pfeiffer, B.; Duflos, M. 2008: Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 23(5): 629-640
Ma, Z.-Y.; Zhang, Y.-G.; Yang, Q.; Li, J.-J.; Yang, G.-L. 2014: Design, synthesis and evaluation of new acetylcholinesterase inhibitors. Yao Xue Xue Bao 49(3): 346-351
Yurttaş, L.; Kaplancıklı, Z.A.ım.; Özkay, Y. 2013: Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 28(5): 1040-1047
Ruiz, J.ér.ém.; Mallet-Ladeira, S.; Maynadier, M.; Vial, H.; André-Barrès, C. 2014: Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents. Organic and Biomolecular Chemistry 12(28): 5212-5221
Wang, X.; Li, Y.; Zhao, Q.; Min, Z.; Zhang, C.; Lai, Y.; Ji, H.; Peng, S.; Zhang, Y. 2011: Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents. Organic and Biomolecular Chemistry 9(16): 5670-5681
Pecic, S.; Deng, S.-X.; Morisseau, C.; Hammock, B.D.; Landry, D.W. 2012: Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorganic and Medicinal Chemistry Letters 22(1): 601-605
Bansal, R.; Guleria, S.; Thota, S.; Bodhankar, S.L.; Patwardhan, M.R.; Zimmer, C.; Hartmann, R.W.; Harvey, A.L. 2012: Design, synthesis and evaluation of novel 16-imidazolyl substituted steroidal derivatives possessing potent diversified pharmacological properties. Steroids 77(6): 621-629
Park, B.; Awasthi, D.; Chowdhury, S.R.; Melief, E.H.; Kumar, K.; Knudson, S.E.; Slayden, R.A.; Ojima, I. 2014: Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Bioorganic and Medicinal Chemistry 22(9): 2602-2612
Ignasik, M.; Bajda, M.; Guzior, N.; Prinz, M.; Holzgrabe, U.; Malawska, B. 2012: Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors. Archiv der Pharmazie 345(7): 509-516
Addla, D.; Jallapally, A.; Kanwal, A.; Sridhar, B.; Banerjee, S.K.; Kantevari, S. 2013: Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors. Bioorganic and Medicinal Chemistry 21(15): 4485-4493
Giri, R.S.; Thaker, H.M.; Giordano, T.; Williams, J.; Rogers, D.; Vasu, K.K.; Sudarsanam, V. 2010: Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: their possible utilization as anti-inflammatory and anti-cancer agents. Bioorganic and Medicinal Chemistry 18(7): 2796-2808
Tang, Y.-B.; Zhang, C.-M.; Fang, C.; Hu, C.; Huang, L.; Chen, C.-H.; Xiao, Z.-Y. 2011: Design, synthesis and evaluation of novel 2H-1, 4-benzodiazepine-2-ones as inhibitors of HIV-1 transcription. Yao Xue Xue Bao 46(6): 688-694
Luo, W.; Su, Y.-B.; Hong, C.; Tian, R.-G.; Su, L.-P.; Wang, Y.-Q.; Li, Y.; Yue, J.-J.; Wang, C.-J. 2013: Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents. Bioorganic and Medicinal Chemistry 21(23): 7275-7282
Ali, M.A.; Yar, M.S.; Hasan, M.Z.; Ahsan, M.J.; Pandian, S. 2009: Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues. Bioorganic and Medicinal Chemistry Letters 19(17): 5075-5077
Cheng, J.; Qin, J.; Guo, S.; Qiu, H.; Zhong, Y. 2014: Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents. Bioorganic and Medicinal Chemistry Letters 24(19): 4768-4772
Pandey, M.K.; Kumar, S.; Thimmulappa, R.K.; Parmar, V.S.; Biswal, S.; Watterson, A.C. 2011: Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 43(1-2): 16-24
Hilmy, K.M.H.; Soliman, D.H.; Shahin, E.B.A.; El-Deeb, H.S.; El-Kousy, S.M. 2014: Design, synthesis and evaluation of novel diaryl pyrrolopyrimidine and pyrrolothiazine derivatives as inhibitors of tumor necrosis factor stimulated gene-14 (TSG-14) production. European Journal of Medicinal Chemistry 78: 419-424
Lu, C.; Tang, K.; Li, Y.; Li, P.; Lin, Z.; Yin, D.; Chen, X.; Huang, H. 2014: Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents. European Journal of Medicinal Chemistry 77: 351-360
Hu, Y.; Zhang, J.; Chandrashankra, O.; Ip, F.C.F.; Ip, N.Y. 2013: Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Bioorganic and Medicinal Chemistry 21(3): 676-683
Yang, D.; Wang, P.; Liu, J.; Xing, H.; Liu, Y.; Xie, W.; Zhao, G. 2014: Design, synthesis and evaluation of novel indole derivatives as AKT inhibitors. Bioorganic and Medicinal Chemistry 22(1): 366-373
Cheng, X.-C.; Wang, R.-L.; Dong, Z.-K.; Li, J.; Li, Y.-Y.; Li, R.-R. 2012: Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold. Bioorganic and Medicinal Chemistry 20(19): 5738-5744
Yang, Y.; Wang, Z.; Yang, J.; Yang, T.; Pi, W.; Ang, W.; Lin, Y.; Liu, Y.; Li, Z.; Luo, Y.; Wei, Y. 2012: Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents. Bioorganic and Medicinal Chemistry Letters 22(2): 954-957
Lu, P.; Liu, J.; Wang, Y.; Chen, X.; Yang, Y.; Ji, R. 2009: Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors. Bioorganic and Medicinal Chemistry Letters 19(24): 6918-6921
Ji, Q.; Yang, D.; Wang, X.; Chen, C.; Deng, Q.; Ge, Z.; Yuan, L.; Yang, X.; Liao, F. 2014: Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. Bioorganic and Medicinal Chemistry 22(13): 3405-3413
Li, W.; Zhai, X.; Zhong, Z.; Li, G.; Pu, Y.; Gong, P. 2011: Design, synthesis and evaluation of novel rhodanine-containing sorafenib analogs as potential antitumor agents. Archiv der Pharmazie 344(6): 349-357
Lan, J.-S.; Xie, S.-S.; Li, S.-Y.; Pan, L.-F.; Wang, X.-B.; Kong, L.-Y. 2014: Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic and Medicinal Chemistry 22(21): 6089-6104
Xie, S.-S.; Wang, X.-B.; Li, J.-Y.; Yang, L.; Kong, L.-Y. 2013: Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European Journal of Medicinal Chemistry 64: 540-553
Luo, W.; Li, Y.-P.; He, Y.; Huang, S.-L.; Tan, J.-H.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S. 2011: Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation. Bioorganic and Medicinal Chemistry 19(2): 763-770
Li, S.-Y.; Jiang, N.; Xie, S.-S.; Wang, K.D.G.; Wang, X.-B.; Kong, L.-Y. 2014: Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Organic and Biomolecular Chemistry 12(5): 801-814
McCarthy, O.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L.M.; Johansson, N.G.; Pacanowska, D.G.; Gilbert, I.H. 2009: Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. European Journal of Medicinal Chemistry 44(2): 678-688
Shibata, Y.; Kagechika, K.; Yamaguchi, M.; Kubo, H.; Usui, H. 2012: Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1). Bioorganic and Medicinal Chemistry Letters 22(23): 7075-7079
Johnson, J.A.; Xu, N.; Jeon, Y.; Finlay, H.J.; Kover, A.; Conder, M.L.; Sun, H.; Li, D.; Levesque, P.; Hsueh, M.-M.; Harper, T.W.; Wexler, R.R.; Lloyd, J. 2014: Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors. Bioorganic and Medicinal Chemistry Letters 24(14): 3018-3022
Rusch, M.; Zahov, S.; Vetter, I.R.; Lehr, M.; Hedberg, C. 2012: Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH. Bioorganic and Medicinal Chemistry 20(2): 1100-1112
Kawashima, E.; Kamaike, K. 2010: Design, synthesis and evaluation of polyamide-nucleoside hybrids and oligonucleotides conjugated hybrid as a novel gene expression control compound. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 130(3): 355-375
Zeinyeh, W.ël.; Alameh, G.; Radix, S.; Grenot, C.; Dumontet, C.; Walchshofer, N. 2010: Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Bioorganic and Medicinal Chemistry Letters 20(10): 3165-3168
Mountford, S.J.; Daly, R.; Robinson, A.J.; Hearn, M.T.W. 2014: Design, synthesis and evaluation of pyridine-based chromatographic adsorbents for antibody purification. Journal of Chromatography. a 1355: 15-25
Amano, Y.; Noguchi, M.; Nakagomi, M.; Muratake, H.; Fukasawa, H.; Shudo, K. 2013: Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures. Bioorganic and Medicinal Chemistry 21(14): 4342-4350
Agrawal, Y.P.; Agrawal, M.Y.; Gupta, A.K. 2015: Design, synthesis and evaluation of rhodanine derivatives as aldose reductase inhibitors. Chemical Biology and Drug Design 85(2): 172-180
Li, Y.; Peng, P.; Tang, L.; Hu, Y.; Hu, Y.; Sheng, R. 2014: Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy. Bioorganic and Medicinal Chemistry 22(17): 4717-4725
Hrast, M.; Anderluh, M.; Knez, D.; Randall, C.P.; Barreteau, H.él.èn.; O'Neill, A.J.; Blanot, D.; Gobec, S. 2014: Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold. European Journal of Medicinal Chemistry 73: 83-96
Canto, R.ôm.F.S.; Barbosa, F.A.R.; Nascimento, V.; de Oliveira, A.S.; Brighente, I.ês.M.C.; Braga, A.L. 2014: Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. Organic and Biomolecular Chemistry 12(21): 3470-3477
Patel, H.M.; Sing, B.; Bhardwaj, V.; Palkar, M.; Shaikh, M.S.; Rane, R.; Alwan, W.S.; Gadad, A.K.; Noolvi, M.N.; Karpoormath, R. 2015: Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-i receptor kinase (ALK5). European Journal of Medicinal Chemistry 93: 599-613
Dharmaraja, A.T.; Alvala, M.; Sriram, D.; Yogeeswari, P.; Chakrapani, H. 2012: Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors. Chemical Communications 48(83): 10325-10327
Chikhalia, K.H.; Patel, M.J. 2009: Design, synthesis and evaluation of some 1,3,5-triazinyl urea and thiourea derivatives as antimicrobial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 24(4): 960-966
Sinha, S.K.; Shrivastava, S.K. 2013: Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory. Bioorganic and Medicinal Chemistry Letters 23(10): 2984-2989
McClain, R.; Hyun, M.H.; Li, Y.; Welch, C.J. 2013: Design, synthesis and evaluation of stationary phases for improved achiral supercritical fluid chromatography separations. Journal of Chromatography. a 1302: 163-173
Chen, Y.; Sun, J.; Huang, Z.; Liao, H.; Peng, S.; Lehmann, J.; Zhang, Y. 2013: Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents. Bioorganic and Medicinal Chemistry 21(9): 2462-2470
Luo, W.; Zhao, Y.-M.; Zhang, Z.; Su, Y.-B.; Wang, C.-J. 2012: Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors. Yao Xue Xue Bao 47(7): 916-921
Lee, C.-C.; Huang, K.-F.; Chang, D.-M.; Hsu, J.-J.; Huang, F.-C.; Shih, K.-N.; Chen, C.-L.; Chen, T.-C.; Chen, R.-H.; Lin, J.-J.; Huang, H.-S. 2012: Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones. European Journal of Medicinal Chemistry 50: 102-112
Jiang, C.; You, Q.; Liu, F.; Wu, W.; Guo, Q.; Chern, J.; Yang, L.; Chen, M. 2009: Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors. Chemical and Pharmaceutical Bulletin 57(6): 567-571
Singh, P.; Bhardwaj, A.; Kaur, S.; Kumar, S. 2009: Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors. European Journal of Medicinal Chemistry 44(3): 1278-1287
Wu, C.; Liu, J.; Pan, X.; Xian, W.; Li, B.; Peng, W.; Wang, J.; Yang, D.; Zhou, H. 2013: Design, synthesis and evaluation of the antibacterial enhancement activities of amino dihydroartemisinin derivatives. Molecules 18(6): 6866-6882
Deng, X.-Q.; Song, M.-X.; Zheng, Y.; Quan, Z.-S. 2014: Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. European Journal of Medicinal Chemistry 73: 217-224
Mikstacka, R.; Rimando, A.M.; Dutkiewicz, Z.; Stefański, T.; Sobiak, S.ła. 2012: Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1. Bioorganic and Medicinal Chemistry 20(17): 5117-5126
Bengtsson, C.; Lindgren, A.E.G.; Uvell, H.; Almqvist, F. 2012: Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents. European Journal of Medicinal Chemistry 54: 637-646
Faucher, N.; Martres, P.; Laroze, A.; Pineau, O.; Potvain, F.; Grillot, D. 2008: Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. Bioorganic and Medicinal Chemistry Letters 18(2): 710-715
Khan, M.S.; Akhtar, S.; Siddiqui, S.A.; Siddiqui, M.S.; Srinivasan, K.V.; Arif, J.M. 2012: Design, synthesis and evaluation of unique 2,4,5-triaryl imidazole derivatives as novel potent aspartic protease inhibitors. Medicinal Chemistry 8(3): 428-435
Evans, D.G.; Brentnall, A.R.; Harvie, M.; Astley, S.; Harkness, E.F.; Stavrinos, P.; Donnelly, L.S.; Sampson, S.; Idries, F.; Watterson, D.; Cuzick, J.; Wilson, M.; Jain, A.; Harrison, F.; Maxwell, A.J.; Howell, A. 2018: Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK. Bmc Public Health 18(1): 178
Singh, P.; Kaur, J.; Yadav, B.; Komath, S.S. 2009: Design, synthesis and evaluations of acridone derivatives using Candida albicans--search for MDR modulators led to the identification of an anti-candidiasis agent. Bioorganic and Medicinal Chemistry 17(11): 3973-3979
Sharma, R.; Rawal, R.K.; Gaba, T.; Singla, N.; Malhotra, M.; Matharoo, S.; Bhardwaj, T.R. 2013: Design, synthesis and ex vivo evaluation of colon-specific azo based prodrugs of anticancer agents. Bioorganic and Medicinal Chemistry Letters 23(19): 5332-5338
Sharma, R.; Rawal, R.K.; Malhotra, M.; Sharma, A.K.; Bhardwaj, T.R. 2014: Design, synthesis and ex-vivo release studies of colon-specific polyphosphazene-anticancer drug conjugates. Bioorganic and Medicinal Chemistry 22(3): 1104-1114
Pal, A.K.; Hanan, G.S. 2014: Design, synthesis and excited-state properties of mononuclear Ru(II) complexes of tridentate heterocyclic ligands. Chemical Society Reviews 43(17): 6184-6197
Sprague, B.; Shi, Q.; Kim, M.T.; Zhang, L.; Sedykh, A.; Ichiishi, E.; Tokuda, H.; Lee, K-Hsiung.; Zhu, H. 2014: Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers. Journal of Computer-Aided Molecular Design 28(6): 631-646
Das, S.; Mitra, I.; Batuta, S.; Niharul Alam, M.; Roy, K.; Begum, N.A. 2014: Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues. Bioorganic and Medicinal Chemistry Letters 24(21): 5050-5054
Itoh, H.; Matsuoka, S.; Kreir, M.; Inoue, M. 2012: Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial peptide ion channel. Journal of the American Chemical Society 134(34): 14011-14018
Liu, X.-R.; Wu, H.; He, Z.-Y.; Ma, Z.-Q.; Feng, J.-T.; Zhang, X. 2014: Design, synthesis and fungicidal activities of some novel pyrazole derivatives. Molecules 19(9): 14036-14051
Xiao, Y.-s.; Yan, X.-j.; Xu, Y.-j.; Huang, J.-x.; Yuan, H.-z.; Liang, X.-m.; Zhang, J.-j.; Wang, D.-q. 2013: Design, synthesis and fungicidal activity of 11-alkoxyimino-5,6-dihydro-dibenzo[b,e] azepine-6-one derivatives. Pest Management Science 69(7): 814-826
Lin, L.; Mulholland, N.; Huang, S.-W.; Beattie, D.; Irwin, D.; Gu, Y.-C.; Clough, J.; Wu, Q.-Y.; Yang, G.-F. 2012: Design, synthesis and fungicidal activity of novel sclerotiorin derivatives. Chemical Biology and Drug Design 80(5): 682-692
Li, H.-C.; Liu, C.-L.; Chai, B.-S.; Li, M.; Li, Z.-N.; Yang, J.-C. 2009: Design, synthesis and fungicidal activity of novel strobilurin analogues containing substituted N-phenylpyrimidin-2-amines. Natural Product Communications 4(9): 1209-1214
Kar, K.; Krithika, U.; Mithuna; Basu, P.; Santhosh Kumar, S.; Reji, A.; Prashantha Kumar, B.R. 2014: Design, synthesis and glucose uptake activity of some novel glitazones. Bioorganic Chemistry 56: 27-33
Zhang, F.; Han, B.; Li, P.; Lin, Z.; Yin, D.; Li, Y.; Zhong, J.; Huang, H. 2013: Design, synthesis and hepatoprotective activity of analogs of the natural product goodyeroside a. Molecules 18(2): 1933-1948
Ma, H.-J.; Zhang, J.-H.; Xia, X.-D.; Xu, M.-H.; Ning, J.; Li, J.-H. 2014: Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives as potential pigment biosynthesis inhibitors. Pest Management Science 70(6): 946-952
Wang, D.-W.; Lin, H.-Y.; Cao, R.-J.; Ming, Z.-Z.; Chen, T.; Hao, G.-F.; Yang, W.-C.; Yang, G.-F. 2015: Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors. Pest Management Science 71(8): 1122-1132
Ma, H.-J.; Zhang, J.-H.; Xia, X.-D.; Kang, J.; Li, J.-H. 2015: Design, synthesis and herbicidal evaluation of novel 4-(1H-pyrazol-1-yl)pyrimidine derivatives. Pest Management Science 71(8): 1189-1196
Chhabria, M.T.; Patel, V.T.; Rajan, K.S.; Brahmkshatriya, P.S. 2009: Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittel-Forschung 59(5): 243-247
Mahdi, M.F.; Alsaad, H.N. 2012: Design, synthesis and hydrolytic behavior of mutual prodrugs of NSAIDs with gabapentin using glycol spacers. Pharmaceuticals 5(10): 1080-1091
Wang, Y.-l.; Zhong, Z.; Wu, G.-z.; Chang, Y. 2009: Design, synthesis and hypoglycemic activity of alpha-benzylsuccinic acid derivatives. Yao Xue Xue Bao 44(5): 491-495
Idrees, G.A.; Abuo-Rahma, G.e.-D.A.; Aly, O.M.; Radwan, M.F. 2009: Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives. European Journal of Medicinal Chemistry 44(6): 2679-2684
Idrees, G.A.; Aly, O.M.; Abuo-Rahma, G.E.-D.A.A.; Radwan, M.F. 2009: Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs. European Journal of Medicinal Chemistry 44(10): 3973-3980
Singh, M.; Schott, J.T.; Leon, M.A.; Granata, R.T.; Dhah, H.K.; Welles, J.A.; Boyce, M.A.; Oseni-Olalemi, H.S.; Mordaunt, C.E.; Vargas, A.J.; Patel, N.V.; Maitra, S. 2012: Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein e production. Bioorganic and Medicinal Chemistry Letters 22(19): 6252-6255
Tamura, Y.; Omori, N.; Kouyama, N.; Nishiura, Y.; Hayashi, K.; Watanabe, K.; Tanaka, Y.; Chiba, T.; Yukioka, H.; Sato, H.; Okuno, T. 2012: Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles. Bioorganic and Medicinal Chemistry Letters 22(17): 5498-5502
Chang, D.-J.; Yoon, E.-Y.; Lee, G.-B.; Kim, S.-O.; Kim, W.-J.; Kim, Y.-M.; Jung, J.-W.; An, H.; Suh, Y.-G. 2009: Design, synthesis and identification of novel colchicine-derived immunosuppressant. Bioorganic and Medicinal Chemistry Letters 19(15): 4416-4420
Liu, X.J.; Shi, X.X.; Zhong, Y.L.; Liu, N.; Liu, K. 2012: Design, synthesis and in vitro activities on anti-platelet aggregation of 4-methoxybenzene-1,3-isophthalamides. Bioorganic and Medicinal Chemistry Letters 22(21): 6591-6595
Han, B.; Huan, Y.; Lin, Z.-Y.; Li, P.; Shen, Z.-F.; Yin, D.-L.; Huang, H.-H. 2010: Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors. Yao Xue Xue Bao 45(11): 1379-1384
Shi, B.; Cao, R.; Fan, W.; Guo, L.; Ma, Q.; Chen, X.; Zhang, G.; Qiu, L.; Song, H. 2013: Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines. European Journal of Medicinal Chemistry 60: 10-22
Zheng, G.-h.; Shen, J.-j.; Zhan, Y.-c.; Yi, H.; Xue, S.-t.; Wang, Z.; Ji, X.-y.; Li, Z.-r. 2014: Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction. European Journal of Medicinal Chemistry 81: 277-288
Mowafy, S.; Farag, N.A.; Abouzid, K.A.M. 2013: Design, synthesis and in vitro anti-proliferative activity of 4,6-quinazolinediamines as potent EGFR-TK inhibitors. European Journal of Medicinal Chemistry 61: 132-145
Chai, Y.; Wang, J.; Liu, M.; Yi, H.; Sun, L.; You, X.; Guo, H. 2011: Design, synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl)fluoroquinolone derivatives. Bioorganic and Medicinal Chemistry Letters 21(11): 3377-3380
Yu, Z.; Shi, G.; Sun, Q.; Jin, H.; Teng, Y.; Tao, K.; Zhou, G.; Liu, W.; Wen, F.; Hou, T. 2009: Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. European Journal of Medicinal Chemistry 44(11): 4726-4733
Kothayer, H.; Elshanawani, A.A.; Abu Kull, M.E.; El-Sabbagh, O.I.; Shekhar, M.P.V.; Brancale, A.; Jones, A.T.; Westwell, A.D. 2013: Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Bioorganic and Medicinal Chemistry Letters 23(24): 6886-6889
Khan, A.A.; Alanazi, A.M.; Jabeen, M.; Chauhan, A.; Abdelhameed, A.S. 2013: Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. Anticancer Research 33(6): 2517-2524
Ma, Z.-Y.; He, Y.; Zhao, W.-G.; Yang, N.; Yang, G.-L.; Zheng, Y.-J. 2012: Design, synthesis and in vitro antifungal activity of 3-substituted-methylenechroman-4-ones. Yao Xue Xue Bao 47(5): 614-618
Guantai, E.M.; Ncokazi, K.; Egan, T.J.; Gut, J.; Rosenthal, P.J.; Smith, P.J.; Chibale, K. 2010: Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorganic and Medicinal Chemistry 18(23): 8243-8256
Al-Tel, T.H.; Al-Qawasmeh, R.A.; Zaarour, R. 2011: Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. European Journal of Medicinal Chemistry 46(5): 1874-1881
Abouzid, K.; Shouman, S. 2008: Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase. Bioorganic and Medicinal Chemistry 16(16): 7543-7551
Behnam Azad, B.; Rota, V.A.; Breadner, D.; Dhanvantari, S.; Luyt, L.G. 2010: Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT. Bioorganic and Medicinal Chemistry 18(3): 1265-1272
Tietz, O.; Kamaly, N.; Smith, G.; Shamsaei, E.; Bhakoo, K.K.; Long, N.J.; Aboagye, E.O. 2013: Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents. American Journal of Nuclear Medicine and Molecular Imaging 3(4): 372-383
Han, K.; Zhou, Y.; Liu, F.; Guo, Q.; Wang, P.; Yang, Y.; Song, B.; Liu, W.; Yao, Q.; Teng, Y.; Yu, P. 2014: Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. Bioorganic and Medicinal Chemistry Letters 24(2): 591-594
Gao, C.; Gou, S.; Fang, L.; Zhao, J. 2011: Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes. Bioorganic and Medicinal Chemistry Letters 21(6): 1763-1766
Lau, W.M.; Heard, C.M.; White, A.W. 2013: Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics 5(2): 232-245
Daumar, P.; Decombat, C.; Chezal, J.-M.; Debiton, E.; Madesclaire, M.; Coudert, P.; Galmier, M.-J.èp. 2011: Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs. European Journal of Medicinal Chemistry 46(7): 2867-2879
Bruder, M.; Vendramini-Costa, D.éb.B.; de Carvalho, J.ão.E.; Pilli, R.A. 2013: Design, synthesis and in vitro evaluation against human cancer cells of 5-methyl-5-styryl-2,5-dihydrofuran-2-ones, a new series of goniothalamin analogues. Bioorganic and Medicinal Chemistry 21(17): 5107-5117
Soriano-Ursúa, M.A.; Correa-Basurto, J.é; Valencia-Hernández, I.; Amezcua-Gutiérrez, M.A.; Padilla-Martínez, I.I.; Trujillo-Ferrara, J.é G. 2010: Design, synthesis and in vitro evaluation of (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrogen phenylboronate: a novel salbutamol derivative with high intrinsic efficacy on the β2 adrenoceptor. Bioorganic and Medicinal Chemistry Letters 20(19): 5623-5629
Yadav, D.K.; Kalani, K.; Singh, A.K.; Khan, F.; Srivastava, S.K.; Pant, A.B. 2014: Design, synthesis and in vitro evaluation of 18β-glycyrrhetinic acid derivatives for anticancer activity against human breast cancer cell line MCF-7. Current Medicinal Chemistry 21(9): 1160-1170
Ohashi, M.; Nakagome, I.; Kasuga, J-Ichi.; Nobusada, H.; Matsuno, K.; Makishima, M.; Hirono, S.; Hashimoto, Y.; Miyachi, H. 2012: Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry-activity relationship. Bioorganic and Medicinal Chemistry 20(21): 6375-6383
Kamdar, N.R.; Haveliwala, D.D.; Mistry, P.T.; Patel, S.K. 2010: Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines. European Journal of Medicinal Chemistry 45(11): 5056-5063
Al Hussainy, R.; Verbeek, J.; van der Born, D.; Booij, J.; Herscheid, J.Koos.D.M. 2011: Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor. European Journal of Medicinal Chemistry 46(12): 5728-5735
Pengpong, T.; Sangvanich, P.; Sirilertmukul, K.; Muangsin, N. 2014: Design, synthesis and in vitro evaluation of mucoadhesive p-coumarate-thiolated-chitosan as a hydrophobic drug carriers. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 86(3): 487-497
Joce, C.; White, R.; Stockley, P.G.; Warriner, S.; Turnbull, W.B.; Nelson, A. 2012: Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues. Bioorganic and Medicinal Chemistry Letters 22(1): 278-284
Conti, C.; Proietti Monaco, L.; Desideri, N. 2011: Design, synthesis and in vitro evaluation of novel chroman-4-one, chroman, and 2H-chromene derivatives as human rhinovirus capsid-binding inhibitors. Bioorganic and Medicinal Chemistry 19(24): 7357-7364
Huang, G.; Pemp, D.; Stadtmüller, P.; Nimczick, M.; Heilmann, J.ör.; Decker, M. 2014: Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure. Bioorganic and Medicinal Chemistry Letters 24(17): 4209-4214
Karaman, R.; Ghareeb, H.; Dajani, K.K.; Scrano, L.; Hallak, H.; Abu-Lafi, S.; Mecca, G.; Bufo, S.A. 2013: Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions. Journal of Computer-Aided Molecular Design 27(7): 615-635
Gopalakrishnan, M.; Thanusu, J.; Kanagarajan, V.; Govindaraju, R. 2009: Design, synthesis and in vitro microbiological evaluation of 6,6-dimethyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones--a new series of 'tailor-made' compounds. Journal of Enzyme Inhibition and Medicinal Chemistry 24(2): 406-412
Sköld, N.; Nielsen, B.; Olsen, J.; Han, L.; Olsen, L.; Madsen, U.; Kristensen, J.L.; Pickering, D.S.; Johansen, T.N. 2014: Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites. Bioorganic and Medicinal Chemistry 22(19): 5368-5377
Rautio, J.; Leppänen, J.; Lehtonen, M.; Laine, K.; Koskinen, M.; Pystynen, J.; Savolainen, J.; Sairanen, M. 2010: Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor. Bioorganic and Medicinal Chemistry Letters 20(8): 2614-2616
El-Araby, M.; Omar, A.; Hassanein, H.H.; El-Helby, A-Ghany.H.; Abdel-Rahman, A.A. 2012: Design, synthesis and in vivo anti-inflammatory activities of 2,4-diaryl-5-4H-imidazolone derivatives. Molecules 17(10): 12262-12275
Karakaya, G.ül.şa.; Aytemir, M.D.; Özçelik, B.; Calış, Ün. 2013: Design, synthesis and in vivo/in vitro screening of novel chlorokojic acid derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 28(3): 627-638
Jadhav, R.; Gupta-Rajoria, R.; Pal, T.; Subramanian, R.C. 2013: Design, synthesis and in-vivo hypoglycemic evaluation of novel non - TZD'S in a type - 2 diabetic model. Medicinal Chemistry 9(1): 104-111
Chandra, K.; Dutta, D.; Mitra, A.; Das, A.K.; Basak, A. 2011: Design, synthesis and inhibition activity of a novel cyclic enediyne amino acid conjugates against MPtpA. Bioorganic and Medicinal Chemistry 19(10): 3274-3279
Chandra, K.; Dutta, D.; Das, A.K.; Basak, A. 2010: Design, synthesis and inhibition activity of novel cyclic peptides against protein tyrosine phosphatase a from Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry 18(23): 8365-8373
Hu, S.; Nian, S.; Qin, K.; Xiao, T.; Li, L.; Qi, X.; Ye, F.; Liang, G.; Hu, G.; He, J.; Yu, Y.; Song, B. 2012: Design, synthesis and inhibitory activities of 8-(substituted styrol-formamido)phenyl-xanthine derivatives on monoamine oxidase B. Chemical and Pharmaceutical Bulletin 60(3): 385-390
Yoon, H.; Kim, T.W.; Shin, S.Y.; Park, M.J.; Yong, Y.; Kim, D.W.; Islam, T.; Lee, Y.H.; Jung, K.-Y.; Lim, Y. 2013: Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells. Bioorganic and Medicinal Chemistry Letters 23(1): 232-238
Familiar, O.; Munier-Lehmann, H.él.èn.; Aínsa, J.é A.; Camarasa, M.ía.-J.é; Pérez-Pérez, M.ía.-J.ús. 2010: Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. European Journal of Medicinal Chemistry 45(12): 5910-5918
Kore, A.R.; Shanmugasundaram, M. 2010: Design, synthesis and inhibitory effect of pentapeptidyl chloromethyl ketones on proteinase K. Bioorganic and Medicinal Chemistry 18(23): 8383-8387
Gundluru, M.K.; Pourpak, A.; Cui, X.; Morris, S.W.; Webb, T.R. 2011: Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold. Medchemcomm 2(9): 904-908
Kang, S.; Song, B.; Wu, J.; He, M.; Hu, D.; Jin, L.; Zeng, S.; Xue, W.; Yang, S. 2013: Design, synthesis and insecticidal activities of novel acetamido derivatives containing N-pyridylpyrazole carboxamides. European Journal of Medicinal Chemistry 67: 14-18
Wu, J.; Song, B.-A.; Hu, D.-Y.; Yue, M.; Yang, S. 2012: Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures. Pest Management Science 68(5): 801-810
Li, J.; Wang, Z.-Y.; Wu, Q.-Y.; Yang, G.-F. 2015: Design, synthesis and insecticidal activity of novel 1,1-dichloropropene derivatives. Pest Management Science 71(5): 694-700
Zhao, Q.; Li, Y.; Xiong, L.; Wang, Q. 2010: Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety. Journal of Agricultural and Food Chemistry 58(8): 4992-4998
An, H.; Kim, N.-J.; Jung, J.-W.; Jang, H.; Park, J.-W.; Suh, Y.-G. 2011: Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 21(21): 6297-6300
Tang, Y.-B.; Lu, D.; Chen, Z.; Hu, C.; Yang, Y.; Tian, J.-Y.; Ye, F.; Wu, L.; Zhang, Z.-Y.; Xiao, Z. 2013: Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors. Bioorganic and Medicinal Chemistry Letters 23(8): 2313-2318
Pieroni, M.; Wan, B.; Cho, S.; Franzblau, S.G.; Costantino, G. 2014: Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents. European Journal of Medicinal Chemistry 72: 26-34
Fortuna, C.G.; Barresi, V.; Bonaccorso, C.; Consiglio, G.; Failla, S.; Trovato-Salinaro, A.; Musumarra, G. 2012: Design, synthesis and in vitro antitumour activity of new heteroaryl ethylenes. European Journal of Medicinal Chemistry 47(1): 221-227
Chen, W.; Yang, X.; Liu, Y.; Dai, X. 2015: Design, synthesis and luminescence properties of Ba2 YB2 O6 Cl- and Ba2 YB2 O6 F-based phosphors. Luminescence: the Journal of Biological and Chemical Luminescence 30(3): 247-250
He, J.-B.; Ren, Y.-L.; Sun, Q.-S.; You, G.-Y.; Zhang, L.; Zou, P.; Feng, L.-L.; Wan, J.; He, H.-W. 2014: Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors. Bioorganic and Medicinal Chemistry 22(12): 3180-3186
Bashandy, M.S.; Alsaid, M.S.; Arafa, R.K.; Ghorab, M.M. 2014: Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents. Journal of Enzyme Inhibition and Medicinal Chemistry 29(5): 619-627
Mohammed, A.F.; Abdel-Moty, S.G.; Hussein, M.A.; Abdel-Alim, A.-A.M. 2013: Design, synthesis and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetohydrazide derivatives with anti-inflammatory-analgesic activities. Archives of Pharmacal Research 36(12): 1465-1479
Xu, Y.-Y.; Cao, Y.; Ma, H.; Li, H.-Q.; Ao, G.-Z. 2013: Design, synthesis and molecular docking of α,β-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity. Bioorganic and Medicinal Chemistry 21(2): 388-394
Pingaew, R.; Mandi, P.; Nantasenamat, C.; Prachayasittikul, S.; Ruchirawat, S.; Prachayasittikul, V. 2014: Design, synthesis and molecular docking studies of novel N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-based triazoles with potential anticancer activity. European Journal of Medicinal Chemistry 81: 192-203
Chai, X.; Zhang, J.; Cao, Y.; Zou, Y.; Wu, Q.; Zhang, D.; Jiang, Y.; Sun, Q. 2011: Design, synthesis and molecular docking studies of novel triazole as antifungal agent. European Journal of Medicinal Chemistry 46(7): 3167-3176
Chai, X.; Guan, Z.; Yu, S.; Zhao, Q.; Hu, H.; Zou, Y.; Tao, X.; Wu, Q. 2012: Design, synthesis and molecular docking studies of sinomenine derivatives. Bioorganic and Medicinal Chemistry Letters 22(18): 5849-5852
Ye, L.; Tian, Y.; Li, Z.; Jin, H.; Zhu, Z.; Wan, S.; Zhang, J.; Yu, P.; Zhang, J.; Wu, S. 2012: Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4'-piperidine]-2-ones as potential c-Met inhibitors. European Journal of Medicinal Chemistry 50: 370-375
Galal, S.A.; Khairat, S.H.M.; Ragab, F.A.F.; Abdelsamie, A.S.; Ali, M.M.; Soliman, S.M.; Mortier, J.ér.ém.; Wolber, G.; El Diwani, H.I. 2014: Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity. European Journal of Medicinal Chemistry 86: 122-132
Badr, M.H.; Elbayaa, R.Y.; El-Ashmawy, I.M. 2013: Design, synthesis and molecular docking study of some substituted 4,5- dihydro-2H-indazole derivatives as potential anti-inflammatory agents. Medicinal Chemistry 9(5): 718-730
Shi, D.-H.; Huang, W.; Li, C.; Liu, Y.-W.; Wang, S.-F. 2014: Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors. European Journal of Medicinal Chemistry 75: 289-296
Sangani, C.B.; Makawana, J.A.; Duan, Y.-T.; Yin, Y.; Teraiya, S.B.; Thumar, N.J.; Zhu, H.-L. 2014: Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 24(18): 4472-4476
He, J.-B.; Feng, L.-L.; Li, J.; Tao, R.-J.; Ren, Y.-L.; Wan, J.; He, H.-W. 2014: Design, synthesis and molecular modeling of novel N-acylhydrazone derivatives as pyruvate dehydrogenase complex E1 inhibitors. Bioorganic and Medicinal Chemistry 22(1): 89-94
Sangani, C.B.; Makawana, J.A.; Zhang, X.; Teraiya, S.B.; Lin, L.; Zhu, H.-L. 2014: Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents. European Journal of Medicinal Chemistry 76: 549-557
Abdel-Megeed, A.M.; Abdel-Rahman, H.M.; Alkaramany, G.-E.S.; El-Gendy, M.A. 2009: Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. European Journal of Medicinal Chemistry 44(1): 117-123
Smolnikar, I.; Perdih, A.; Stegnar, M.; Prezelj, A.; Solmajer, T.; Urleb, U.; Obreza, A. 2007: Design, synthesis and molecular modelling of 1-amidinopiperidine thrombin inhibitors. Die Pharmazie 62(4): 243-254
Rakse, M.; Karthikeyan, C.; Deora, G.S.; Moorthy, N.S.H.N.; Rathore, V.; Rawat, A.K.; Srivastava, A.K.; Trivedi, P. 2013: Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B. European Journal of Medicinal Chemistry 70: 469-476
Vontzalidou, A.; Zoidis, G.; Chaita, E.; Makropoulou, M.; Aligiannis, N.; Lambrinidis, G.; Mikros, E.; Skaltsounis, A.-L. 2012: Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors. Bioorganic and Medicinal Chemistry Letters 22(17): 5523-5526
Wu, J.B.; Lei, F.; Cui, X.J.; He, Y.; Hai, L.; Zhang, J.; Wu, Y. 2012: Design, synthesis and multidrug resistance reversal activity evaluation of 8-oxocoptisine derivatives. Medicinal Chemistry 8(4): 742-748
Keri, R.S.; Quintanova, C.; Marques, S.ér.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A.él. 2013: Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease. Bioorganic and Medicinal Chemistry 21(15): 4559-4569
Martini, E.; Salvicchi, A.; Ghelardini, C.; Manetti, D.; Dei, S.; Guandalini, L.; Martelli, C.; Melchiorre, M.; Cellai, C.; Scapecchi, S.; Teodori, E.; Romanelli, M.N. 2009: Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. Bioorganic and Medicinal Chemistry 17(21): 7606-7614
Xiao, J.; Loh, T.-P. 2009: Design, synthesis and optical resolution of new bifunctional ligand: 1,1'-dimethyl-octahydro-8,8'-biquinoline-7,7'-diol. Organic Letters 11(13): 2876-2879
Georgiev, N.I.; Bojinov, V.B.; Venkova, A.I. 2013: Design, synthesis and pH sensing properties of novel PAMAM light-harvesting dendrons based on rhodamine 6G and 1,8-naphthalimide. Journal of Fluorescence 23(3): 459-471
Pontiki, E.; Hadjipavlou-Litina, D.; Litinas, K.; Nicolotti, O.; Carotti, A. 2011: Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. European Journal of Medicinal Chemistry 46(1): 191-200
Hofer, A.; Kovacs, G.; Zappatini, A.; Leuenberger, M.; Hediger, M.A.; Lochner, M. 2013: Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic and Medicinal Chemistry 21(11): 3202-3213
Huynh, T.H.V.; Abrahamsen, B.; Madsen, K.K.; Gonzalez-Franquesa, A.; Jensen, A.A.; Bunch, L. 2012: Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorganic and Medicinal Chemistry 20(23): 6831-6839
Perlikowska, R.; Fichna, J.; Wyrebska, A.; Poels, J.; Vanden Broeck, J.; Toth, G.; Storr, M.; do Rego, J.-C.; Janecka, A. 2010: Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2. Basic and Clinical Pharmacology and Toxicology 106(2): 106-113
Brosseau, J.-P.; Neugebauer, W.A.; Gobeil, F.; D'Orléans-Juste, P. 2009: Design, synthesis and pharmacological characterization of fluorescein-derived endothelin antagonists Bq-123 and Bq-788. Advances in Experimental Medicine and Biology 611: 443-444
Ning, X.; Guo, Y.; Ma, X.; Zhu, R.; Tian, C.; Zhang, Z.; Wang, X.; Ma, Z.; Liu, J. 2013: Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury. Bioorganic and Medicinal Chemistry 21(17): 5589-5597
Liu, Z.; Yue, X.; Song, Z.; Peng, X.; Guo, J.; Ji, Y.; Cheng, Z.; Ding, J.; Ai, J.; Geng, M.; Zhang, A. 2014: Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. European Journal of Medicinal Chemistry 86: 438-448
Nirogi, R.V.S.; Badange, R.; Kambhampati, R.; Chindhe, A.; Deshpande, A.D.; Tiriveedhi, V.; Kandikere, V.; Muddana, N.; Abraham, R.; Khagga, M. 2012: Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N₁-arylsulfonyl indole derivatives as 5-HT₆ receptor ligands. Bioorganic and Medicinal Chemistry Letters 22(24): 7431-7435
Zhou, S.; Ren, J.; Liu, M.; Ren, L.; Liu, Y.; Gong, P. 2014: Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents. Bioorganic Chemistry 57: 30-42
Sadeghian, H.; Seyedi, S.Mohammad.; Saberi, M.Reza.; Nick, R.Shafiee.; Hosseini, A.; Bakavoli, M.; Mansouri, S.Mohammad.Taghi.; Parsaee, H. 2009: Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents. Journal of Enzyme Inhibition and Medicinal Chemistry 24(4): 918-929
Boechat, N.úb.; Kover, W.B.; Bongertz, V.; Bastos, M.ôn.M.; Romeiro, N.C.; Azevedo, M.L.G.; Wollinger, W. 2007: Design, synthesis and pharmacological evaluation of HIV-1 reverse transcriptase inhibition of new indolin-2-ones. Medicinal Chemistry 3(6): 533-542
Das, N.; Banerjee, A.G.; Shrivastava, S.K. 2014: Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents. Medicinal Chemistry 10(8): 800-809
Chhabria, M.T.; Shishoo, C.J.; Vaghela, D.K.; Patel, S.M.; Satia, M.C. 2009: Design, synthesis and pharmacological evaluation of a series of 5-carbethoxy-4-chloro-6-(substituted amino)pyrimidines as potential analgesic and anti-flammatory agents with very low ulcerogenic potential. Arzneimittel-Forschung 59(7): 350-356
Malawska, B.; Kulig, K.; Gajda, J.; Szczeblewski, D.; Musiał, A.; Wieckowski, K.; Maciag, D.; Stables, J.P. 2007: Design, synthesis and pharmacological evaluation of alpha-substituted N-benzylamides of gamma-hydroxybutyric acid with potential GABA-ergic activity. Part 6. Search for new anticonvulsant compounds. Acta Poloniae Pharmaceutica 64(2): 127-137
Liu, H.-r.; Liu, X.-j.; Fan, H.-q.; Tang, J.-j.; Gao, X.-h.; Liu, W.-K. 2014: Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors. Bioorganic and Medicinal Chemistry 22(21): 6124-6133
Nirogia, R.V.S.; Kambhampati, R.; Daulatabad, A.V.; Gudla, P.; Shaikh, M.; Achanta, P.K.; Shinde, A.K.; Dubey, P.K. 2011: Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands. Journal of Enzyme Inhibition and Medicinal Chemistry 26(3): 341-349
Nirogi, R.V.S.; Bandyala, T.R.; Reballi, V.; Konda, J.B.; Daulatabad, A.V.; Khagga, M. 2015: Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists. Journal of Enzyme Inhibition and Medicinal Chemistry 30(1): 85-97
Kulig, K.; Sapa, J.; Nowaczyk, A.; Filipek, B.; Malawska, B. 2009: Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity. European Journal of Medicinal Chemistry 44(10): 3994-4003
Ettaoussi, M.; Sabaouni, A.; Rami, M.; Boutin, J.A.; Delagrange, P.; Renard, P.; Spedding, M.; Caignard, D.-H.; Berthelot, P.; Yous, S.ïd. 2012: Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). European Journal of Medicinal Chemistry 49: 310-323
Zhang, Y.; Xu, J.; Li, Y.; Yao, H.; Wu, X. 2015: Design, synthesis and pharmacological evaluation of novel NO-releasing benzimidazole hybrids as potential antihypertensive candidate. Chemical Biology and Drug Design 85(5): 541-548
Amir, M.; Saifullah, K.; Akhter, W. 2011: Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry 26(1): 141-148
Mésangeau, C.; Pérès, B.; Descamps-François, C.; Chavatte, P.; Audinot, V.ér.; Coumailleau, S.; Boutin, J.A.; Delagrange, P.; Bennejean, C.; Renard, P.; Caignard, D.H.; Berthelot, P.; Yous, S.ïd. 2010: Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorganic and Medicinal Chemistry 18(10): 3426-3436
Das, S.; Harde, R.L.; Shelke, D.E.; Khairatkar-Joshi, N.; Bajpai, M.; Sapalya, R.S.; Surve, H.V.; Gudi, G.S.; Pattem, R.; Behera, D.B.; Jadhav, S.B.; Thomas, A. 2014: Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part i. Bioorganic and Medicinal Chemistry Letters 24(9): 2073-2078
Das, S.; Shelke, D.E.; Harde, R.L.; Avhad, V.B.; Khairatkar-Joshi, N.; Gullapalli, S.; Gupta, P.K.; Gandhi, M.N.; Bhateja, D.K.; Bajpai, M.; Joshi, A.A.; Marathe, M.Y.; Gudi, G.S.; Jadhav, S.B.; Mahat, M.Y.A.; Thomas, A. 2014: Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part Ii. Bioorganic and Medicinal Chemistry Letters 24(15): 3238-3242
Gouda, A.M.; Abdelazeem, A.H.; Arafa, E.-S.A.; Abdellatif, K.R.A. 2014: Design, synthesis and pharmacological evaluation of novel pyrrolizine derivatives as potential anticancer agents. Bioorganic Chemistry 53: 1-7
Vyas, V.K.; Variya, B.; Ghate, M.D. 2014: Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents. European Journal of Medicinal Chemistry 82: 385-393
Chao, X.; He, X.; Yang, Y.; Zhou, X.; Jin, M.; Liu, S.; Cheng, Z.; Liu, P.; Wang, Y.; Yu, J.; Tan, Y.; Huang, Y.; Qin, J.; Rapposelli, S.; Pi, R. 2012: Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioorganic and Medicinal Chemistry Letters 22(20): 6498-6502
Fedorova, E.V.; Buryakina, A.V.; Zakharov, A.V.; Filimonov, D.A.; Lagunin, A.A.; Poroikov, V.V. 2014: Design, synthesis and pharmacological evaluation of novel vanadium-containing complexes as antidiabetic agents. Plos one 9(7): E100386
El-Nezhawy, A.O.H.; Biuomy, A.R.; Hassan, F.S.; Ismaiel, A.K.; Omar, H.A. 2013: Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. Bioorganic and Medicinal Chemistry 21(7): 1661-1670
Rack, E.; Fröhlich, R.; Schepmann, D.; Wünsch, B. 2011: Design, synthesis and pharmacological evaluation of spirocyclic σ(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorganic and Medicinal Chemistry 19(10): 3141-3151
Bhandari, S.V.; Dangre, S.C.; Bothara, K.G.; Patil, A.A.; Sarkate, A.P.; Lokwani, D.K.; Gore, S.T.; Deshmane, B.J.; Raparti, V.T.; Khachane, C.V. 2009: Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs. European Journal of Medicinal Chemistry 44(11): 4622-4636
Ghogare, J.G.; Bhandari, S.V.; Bothara, K.G.; Madgulkar, A.R.; Parashar, G.A.; Sonawane, B.G.; Inamdar, P.R. 2010: Design, synthesis and pharmacological screening of potential anticonvulsant agents using hybrid approach. European Journal of Medicinal Chemistry 45(3): 857-863
Abdou, W.M.; Ganoub, N.A.; Sabry, E. 2014: Design, synthesis and pharmacological screening of β-amino-, thiadiazole/thiadiazine-phosphonate based triazole motifs as antimicrobial/cytotoxic agents. Acta Pharmaceutica 64(3): 267-284
Abdel-Aziz, H.A.; Aboul-Fadl, T.; Al-Obaid, A.-R.M.; Ghazzali, M.; Al-Dhfyan, A.; Contini, A. 2012: Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity. Archives of Pharmacal Research 35(9): 1543-1552
Kumar, A.B.; Anderson, J.M.; Manetsch, R. 2011: Design, synthesis and photoactivation studies of fluorous photolabels. Organic and Biomolecular Chemistry 9(18): 6284-6292
Ariyasu, S.; Mizuseda, Y.; Hanaya, K.; Aoki, S. 2014: Design, synthesis and photochemical reactivation of caged prodrugs of 8-hydroxyquinoline-based enzyme inhibitors. Chemical and Pharmaceutical Bulletin 62(7): 642-648
Bessette, A.é; Hanan, G.S. 2014: Design, synthesis and photophysical studies of dipyrromethene-based materials: insights into their applications in organic photovoltaic devices. Chemical Society Reviews 43(10): 3342-3405
Georgiev, N.I.; Bojinov, V.B. 2011: Design, synthesis and photostability of novel 1,8-naphthalimide PAMAM light-harvesting dendrons. Journal of Fluorescence 21(1): 51-63
Li, W.-Q.; Wang, X.-L.; Qian, K.; Liu, Y.-Q.; Wang, C.-Y.; Yang, L.; Tian, J.; Morris-Natschke, S.L.; Zhou, X.-W.; Lee, K.-H. 2013: Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives. Bioorganic and Medicinal Chemistry 21(8): 2363-2369
Kumar, P.; Shrivastava, B.; Pandeya, S.N.; Stables, J.P. 2011: Design, synthesis and potential 6 Hz psychomotor seizure test activity of some novel 2-(substituted)-3-{[substituted]amino}quinazolin-4(3H)-one. European Journal of Medicinal Chemistry 46(4): 1006-1018
Ghorab, M.M.; Al-Said, M.S.; Arafa, R.K. 2014: Design, synthesis and potential anti-proliferative activity of some novel 4-aminoquinoline derivatives. Acta Pharmaceutica 64(3): 285-297
Amala, K.; Bhujanga Rao, A.K.S.; Gorantla, B.; Gondi, C.S.; Rao, J.S. 2013: Design, synthesis and preclinical evaluation of NRC-AN-019. International Journal of Oncology 42(1): 168-178
Zhang, L.; Zhan, P.; Chen, X.; Li, Z.; Xie, Z.; Zhao, T.; Liu, H.; De Clercq, E.; Pannecouque, C.; Balzarini, J.; Liu, X. 2014: Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs. Bioorganic and Medicinal Chemistry 22(1): 633-642
Zhang, Y.; Feng, J.; Liu, C.; Zhang, L.; Jiao, J.; Fang, H.; Su, L.; Zhang, X.; Zhang, J.; Li, M.; Wang, B.; Xu, W. 2010: Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors. Bioorganic and Medicinal Chemistry 18(5): 1761-1772
Zhang, X.; Zhang, L.; Zhang, J.; Feng, J.; Yuan, Y.; Fang, H.; Xu, W. 2013: Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 28(3): 545-551
Han, L.; Wang, L.; Hou, X.; Fu, H.; Song, W.; Tang, W.; Fang, H. 2014: Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry 22(5): 1529-1538
Guan, P.; Sun, F.'e.; Hou, X.; Wang, F.; Yi, F.; Xu, W.; Fang, H. 2012: Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorganic and Medicinal Chemistry 20(12): 3865-3872
Jiao, J.; Fang, H.; Wang, X.; Guan, P.; Yuan, Y.; Xu, W. 2009: Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors. European Journal of Medicinal Chemistry 44(11): 4470-4476
Desbois, N.; Gardette, M.; Papon, J.; Labarre, P.; Maisonial, A.él.; Auzeloux, P.; Lartigue, C.; Bouchon, B.; Debiton, E.; Blache, Y.; Chavignon, O.; Teulade, J.-C.; Maublant, J.; Madelmont, J.-C.; Moins, N.; Chezal, J.-M. 2008: Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma. Bioorganic and Medicinal Chemistry 16(16): 7671-7690
Guandalini, L.; Cellai, C.; Laurenzana, A.; Scapecchi, S.; Paoletti, F.; Romanelli, M.N. 2008: Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. Bioorganic and Medicinal Chemistry Letters 18(18): 5071-5074
Guandalini, L.; Balliu, M.; Cellai, C.; Martino, M.V.; Nebbioso, A.; Mercurio, C.; Carafa, V.; Bartolucci, G.; Dei, S.; Manetti, D.; Teodori, E.; Scapecchi, S.; Altucci, L.; Paoletti, F.; Romanelli, M.N. 2013: Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring. European Journal of Medicinal Chemistry 66: 56-68
Li, N.; He, J.; Zhan, Y.; Zhou, N.; Zhang, J. 2011: Design, synthesis and preliminary evaluation of novel imperatorin derivatives as vasorelaxant agents. Medicinal Chemistry 7(1): 18-23
Cheng, X.-C.; Wang, Q.; Fang, H.; Tang, W.; Xu, W.-F. 2008: Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors. European Journal of Medicinal Chemistry 43(10): 2130-2139
Zhang, J.; Li, X.; Jiang, Y.; Feng, J.; Li, X.; Zhang, Y.; Xu, W. 2014: Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors. Bioorganic and Medicinal Chemistry 22(11): 3055-3064
Mahdi, M.F.; Mohammed, M.H.; Jassim, A.A.K. 2012: Design, synthesis and preliminary pharmacological evaluation of new non-steroidal anti-inflammatory agents having a 4-(methylsulfonyl) aniline pharmacophore. Molecules 17(2): 1751-1763
Mou, J.; Fang, H.; Liu, Y.; Shang, L.; Wang, Q.; Zhang, L.; Xu, W. 2010: Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors. Bioorganic and Medicinal Chemistry 18(2): 887-895
Zhang, Y.; Feng, J.; Jia, Y.; Xu, Y.; Liu, C.; Fang, H.; Xu, W. 2011: Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group. European Journal of Medicinal Chemistry 46(11): 5387-5397
Mou, J.; Fang, H.; Jing, F.; Wang, Q.; Liu, Y.; Zhu, H.; Shang, L.; Wang, X.; Xu, W. 2009: Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorganic and Medicinal Chemistry 17(13): 4666-4673
Ziedan, N.I.; Stefanelli, F.; Fogli, S.; Westwell, A.D. 2010: Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. European Journal of Medicinal Chemistry 45(10): 4523-4530
Li, P.; Sun, J.; Su, M.; Yang, X.; Tang, X. 2014: Design, synthesis and properties of artificial nucleic acids from (R)-4-amino-butane-1,3-diol. Organic and Biomolecular Chemistry 12(14): 2263-2272
Chen, D. 2008: Design, synthesis and properties of highly functional nanostructured photocatalysts. Recent Patents on Nanotechnology 2(3): 183-189
Evelyn, C.R.; Bell, J.L.; Ryu, J.G.; Wade, S.M.; Kocab, A.; Harzdorf, N.L.; Showalter, H.D.; Neubig, R.R.; Larsen, S.D. 2010: Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorganic and Medicinal Chemistry Letters 20(2): 665-672
Davood, A.; Shafaroodi, H.; Amini, M.; Nematollahi, A.; Shirazi, M.; Iman, M. 2012: Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore. Medicinal Chemistry 8(5): 953-963
Mahon, A.B.; Arora, P.S. 2012: Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices. Chemical Communications 48(10): 1416-1418
Al-Tel, T.H. 2010: Design, synthesis and qualitative structure-activity evaluations of novel hexahydropyrano[3,2-c][1,2]diazepin-3(4H)-one and tetrahydropyrano[3,2-b]pyrrol-2(1H)-one derivatives as anticancer agents. European Journal of Medicinal Chemistry 45(10): 4615-4621
Mitra, D.; Banerjee, D.R.; Das, A.K.; Basak, A. 2010: Design, synthesis and reactivity of C2-symmetric azobenzene-based amino acid-bis(propargyl sulfones). Bioorganic and Medicinal Chemistry Letters 20(22): 6831-6835
Torres-Gómez, H.éc.; Lehmkuhl, K.; Schepmann, D.; Wünsch, B. 2013: Design, synthesis and receptor affinity of novel conformationally restricted σ ligands based on the [4.3.3]propellane scaffold. European Journal of Medicinal Chemistry 70: 78-87
Kumar, S.; Kaushik, D.; Bawa, S.; Khan, S.A. 2012: Design, synthesis and screening of quinoline-incorporated thiadiazole as a potential anticonvulsant. Chemical Biology and Drug Design 79(1): 104-111
Kumar, B.V.S.S.; Lakshmi, N.; Kumar, M.R.; Rambabu, G.; Manjashetty, T.H.; Arunasree, K.M.; Sriram, D.; Ramkumar, K.; Neamati, N.; Dayam, R.; Sarma, J.A.R.P. 2014: Design, synthesis and screening studies of potent thiazol-2-amine derivatives as fibroblast growth factor receptor 1 inhibitors. Current Topics in Medicinal Chemistry 14(17): 2031-2041
Baron, P.S.; Neve, J.E.; Camp, D.; Suraweera, L.; Lam, A.; Lai, J.; Jovanovic, L.; Nelson, C.; Davis, R.A. 2013: Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold. Magnetic Resonance in Chemistry: Mrc 51(6): 358-363
Svobodová, H.; Nonappa; Wimmer, Z.ěk.; Kolehmainen, E. 2011: Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates. Journal of Colloid and Interface Science 361(2): 587-593
Haque, R.A.; Iqbal, M.A.; Khadeer Ahamed, M.B.; Majid, A.A.; Abdul Hameed, Z.A. 2012: Design, synthesis and structural studies of meta-xylyl linked bis-benzimidazolium salts: potential anticancer agents against 'human colon cancer'. Chemistry Central Journal 6(1): 68
Hossain, N.; Ivanova, S.; Bergare, J.; Mensonides-Harsema, M.ér.; Cooper, M.E. 2013: Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists. Bioorganic and Medicinal Chemistry Letters 23(12): 3500-3504
Pandurangan, K.; Murnaghan, K.D.; Walshe, A.; Müller-Bunz, H.; Paradisi, F.; Morgan, G.G. 2011: Design, synthesis and structure of novel para-quinones and their antibacterial activity. Chemical Biology and Drug Design 78(5): 787-799
Mohamed, T.; Zhao, X.; Habib, L.K.; Yang, J.; Rao, P.P.N. 2011: Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors. Bioorganic and Medicinal Chemistry 19(7): 2269-2281
Romagnoli, R.; Baraldi, P.G.; Carrion, M.D.; Cara, C.L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M.R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E. 2009: Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization. Bioorganic and Medicinal Chemistry 17(19): 6862-6871
Lainé, D.I.; Yan, H.; Xie, H.; Davis, R.S.; Dufour, J.; Widdowson, K.L.; Palovich, M.R.; Wan, Z.; Foley, J.J.; Schmidt, D.B.; Hunsberger, G.E.; Burman, M.; Bacon, A.M.; Webb, E.F.; Luttmann, M.A.; Salmon, M.; Sarau, H.M.; Umbrecht, S.T.; Landis, P.S.; Peck, B.J.; Busch-Petersen, J. 2012: Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists. Bioorganic and Medicinal Chemistry Letters 22(9): 3366-3369
Ahmed, N.S.; Gary, B.D.; Tinsley, H.N.; Piazza, G.A.; Laufer, S.; Abadi, A.H. 2011: Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors. Archiv der Pharmazie 344(3): 149-157
Kwiatkowska, A.; Lewandowska, M.; Borovičková, L.; Slaninová, J.ři.; Lammek, B.; Prahl, A. 2013: Design, synthesis and structure-activity relationship of new arginine vasopressin analogues containing proline derivatives in position 2. Chemical Biology and Drug Design 81(3): 420-428
Wexselblatt, E.; Kaspy, I.; Glaser, G.; Katzhendler, J.; Yavin, E. 2013: Design, synthesis and structure-activity relationship of novel Relacin analogs as inhibitors of Rel proteins. European Journal of Medicinal Chemistry 70: 497-504
Aubele, D.L.; Truong, A.P.; Dressen, D.B.; Probst, G.D.; Bowers, S.; Mattson, M.N.; Semko, C.M.; Sun, M.; Garofalo, A.W.; Konradi, A.W.; Sham, H.L.; Zmolek, W.; Wong, K.; Goldbach, E.; Quinn, K.P.; Sauer, J.-M.; Brigham, E.F.; Wallace, W.; Nguyen, L.; Bova, M.P.; Hemphill, S.S.; Basi, G. 2011: Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors. Bioorganic and Medicinal Chemistry Letters 21(19): 5791-5794
Guan, A.-Y.; Liu, C.-L.; Li, M.; Zhang, H.; Li, Z.-N.; Li, Z.-M. 2011: Design, synthesis and structure-activity relationship of novel coumarin derivatives. Pest Management Science 67(6): 647-655
Zhu, Z.; Li, R.; Xiao, G.; Chen, Z.; Yang, J.; Zhu, Q.; Liu, S. 2012: Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion. European Journal of Medicinal Chemistry 57: 211-216
Li, M.; Liu, C.-L.; Zhang, J.; Wu, Q.; Hao, S.-L.; Song, Y.-q. 2013: Design, synthesis and structure-activity relationship of novel insecticidal dichloro-allyloxy-phenol derivatives containing substituted pyrazol-3-ols. Pest Management Science 69(5): 635-641
Xie, Y.-Q.; Huang, Y.-B.; Liu, J.-S.; Ye, L.-Y.; Che, L.-M.; Tu, S.; Liu, C.-L. 2015: Design, synthesis and structure-activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans. Pest Management Science 71(3): 404-414
Mahesh, R.; Devadoss, T.; Pandey, D.K.; Bhatt, S.; Yadav, S.K. 2010: Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorganic and Medicinal Chemistry Letters 20(22): 6773-6776
Galal, S.A.; Abdelsamie, A.S.; Soliman, S.M.; Mortier, J.; Wolber, G.; Ali, M.M.; Tokuda, H.; Suzuki, N.; Lida, A.; Ramadan, R.A.; El Diwani, H.I. 2013: Design, synthesis and structure-activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor. European Journal of Medicinal Chemistry 69: 115-124
Ragab, F.A.; Yahya, T.A.A.; El-Naa, M.M.; Arafa, R.K. 2014: Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents. European Journal of Medicinal Chemistry 82: 506-520
Fukaya, T.; Kodo, T.; Ishiyama, T.; Nishikawa, H.; Baba, S.; Masumoto, S. 2013: Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands. Bioorganic and Medicinal Chemistry 21(5): 1257-1267
Pan, J.; Mason, N.S.; Debnath, M.L.; Mathis, C.A.; Klunk, W.E.; Lin, K.-S. 2013: Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents. Bioorganic and Medicinal Chemistry Letters 23(6): 1720-1726
Jolidon, S.ès.; Alberati, D.; Dowle, A.; Fischer, H.; Hainzl, D.; Narquizian, R.; Norcross, R.; Pinard, E. 2008: Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. Bioorganic and Medicinal Chemistry Letters 18(20): 5533-5536
Hayashi, S.; Ueno, N.; Murase, A.; Takada, J. 2014: Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs. Journal of Enzyme Inhibition and Medicinal Chemistry 29(6): 846-867
Farag, A.M.; Ali, K.A.K.; El-Debss, T.M.A.; Mayhoub, A.S.; Amr, A.-G.E.; Abdel-Hafez, N.A.; Abdulla, M.M. 2010: Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents. European Journal of Medicinal Chemistry 45(12): 5887-5898
Rodrigues, T.; Guedes, R.C.; dos Santos, D.J.V.A.; Carrasco, M.; Gut, J.; Rosenthal, P.J.; Moreira, R.; Lopes, F. 2009: Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorganic and Medicinal Chemistry Letters 19(13): 3476-3480
Ratcliffe, P.; Adam, J.M.; Baker, J.; Bursi, R.; Campbell, R.; Clark, J.K.; Cottney, J.E.; Deehan, M.; Easson, A-Marie.; Ecker, D.; Edwards, D.; Epemolu, O.; Evans, L.; Fields, R.; Francis, S.; Harradine, P.; Jeremiah, F.; Kiyoi, T.; McArthur, D.; Morrison, A.; Passier, P.; Pick, J.; Schnabel, P.G.; Schulz, J.; Steinbrede, H.; Walker, G.; Westwood, P.; Wishart, G.; Udo de Haes, J. 2011: Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate. Bioorganic and Medicinal Chemistry Letters 21(8): 2541-2546
Saitoh, M.; Kunitomo, J.; Kimura, E.; Hayase, Y.; Kobayashi, H.; Uchiyama, N.; Kawamoto, T.; Tanaka, T.; Mol, C.D.; Dougan, D.R.; Textor, G.S.; Snell, G.P.; Itoh, F. 2009: Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorganic and Medicinal Chemistry 17(5): 2017-2029
Fullam, E.; Talbot, J.; Abuhammed, A.; Westwood, I.; Davies, S.G.; Russell, A.J.; Sim, E. 2013: Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorganic and Medicinal Chemistry Letters 23(9): 2759-2764
Takeda, K.; Terauchi, T.; Shin, K.; Ino, M.; Shibata, H.; Yonaga, M. 2012: Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists. Bioorganic and Medicinal Chemistry Letters 22(14): 4756-4761
Li, H.-Q.; Zhu, T.-T.; Yan, T.; Luo, Y.; Zhu, H.-L. 2009: Design, synthesis and structure-activity relationships of antiproliferative 1,3-disubstituted urea derivatives. European Journal of Medicinal Chemistry 44(2): 453-459
Zhang, H.; Ryono, D.E.; Devasthale, P.; Wang, W.; O'Malley, K.; Farrelly, D.; Gu, L.; Harrity, T.; Cap, M.; Chu, C.; Locke, K.; Zhang, L.; Lippy, J.; Kunselman, L.; Morgan, N.; Flynn, N.; Moore, L.; Hosagrahara, V.; Zhang, L.; Kadiyala, P.; Xu, C.; Doweyko, A.M.; Bell, A.; Chang, C.; Muckelbauer, J.; Zahler, R.; Hariharan, N.; Cheng, P.T.W. 2009: Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorganic and Medicinal Chemistry Letters 19(5): 1451-1456
Wang, S.; Jin, G.; Wang, W.; Zhu, L.; Zhang, Y.; Dong, G.; Liu, Y.; Zhuang, C.; Miao, Z.; Yao, J.; Zhang, W.; Sheng, C. 2012: Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. European Journal of Medicinal Chemistry 53: 292-299
Zhou, S.; Liao, H.; He, C.; Dou, Y.; Jiang, M.; Ren, L.; Zhao, Y.; Gong, P. 2014: Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents. European Journal of Medicinal Chemistry 83: 581-593
Fukaya, T.; Kodo, T.; Ishiyama, T.; Kakuyama, H.; Nishikawa, H.; Baba, S.; Masumoto, S. 2012: Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. Bioorganic and Medicinal Chemistry 20(18): 5568-5582
Williams, D.K.; Chen, X.-T.; Tarby, C.; Kaltenbach, R.; Cai, Z.-W.; Tokarski, J.S.; An, Y.; Sack, J.S.; Wautlet, B.; Gullo-Brown, J.; Henley, B.J.; Jeyaseelan, R.; Kellar, K.; Manne, V.; Trainor, G.L.; Lombardo, L.J.; Fargnoli, J.; Borzilleri, R.M. 2010: Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(9): 2998-3002
Roman, B.I.; De Coen, L.M.; Thérèse F C Mortier, S.év.; De Ryck, T.; Vanhoecke, B.W.A.; Katritzky, A.R.; Bracke, M.E.; Stevens, C.V. 2013: Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes. Bioorganic and Medicinal Chemistry 21(17): 5054-5063
Stokes, N.R.; Baker, N.; Bennett, J.M.; Chauhan, P.K.; Collins, I.; Davies, D.T.; Gavade, M.; Kumar, D.; Lancett, P.; Macdonald, R.; Macleod, L.; Mahajan, A.; Mitchell, J.P.; Nayal, N.; Nayal, Y.N.; Pitt, G.R.W.; Singh, M.; Yadav, A.; Srivastava, A.; Czaplewski, L.G.; Haydon, D.J. 2014: Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ. Bioorganic and Medicinal Chemistry Letters 24(1): 353-359
Hossain, N.; Ivanova, S.; Timén, Ås.S.öh.; Bergare, J.; Mussie, T.; Bergström, L. 2013: Design, synthesis and structure-activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists. Bioorganic and Medicinal Chemistry Letters 23(14): 4026-4030
Xu, H.; Tang, H.; Feng, H.; Li, Y. 2014: Design, synthesis and structure-activity relationships studies on the D ring of the natural product triptolide. Chemmedchem 9(2): 290-295
Ramkumar, K.; Yarovenko, V.N.; Nikitina, A.S.; Zavarzin, I.V.; Krayushkin, M.M.; Kovalenko, L.V.; Esqueda, A.; Odde, S.; Neamati, N. 2010: Design, synthesis and structure-activity studies of rhodanine derivatives as HIV-1 integrase inhibitors. Molecules 15(6): 3958-3992
Fernandez, M.-C.; Escribano, A.; Mateo, A.I.; Parthasarathy, S.; Martin de la Nava, E.M.; Wang, X.; Cockerham, S.L.; Beyer, T.P.; Schmidt, R.J.; Cao, G.; Zhang, Y.; Jones, T.M.; Borel, A.; Sweetana, S.A.; Cannady, E.A.; Stephenson, G.; Frank, S.; Mantlo, N.B. 2012: Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors. Bioorganic and Medicinal Chemistry Letters 22(9): 3056-3062
Roucairol, C.; Azoulay, S.ép.; Nevers, M.-C.; Golebiowski, J.ér.ôm.; Créminon, C.; Grassi, J.; Burger, A.; Duval, D.èl. 2010: Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies. Bioorganic and Medicinal Chemistry Letters 20(3): 987-990
My Van, H.T.; Woo, H.; Jeong, H.M.; Khadka, D.B.; Yang, S.H.; Zhao, C.; Jin, Y.; Lee, E.-S.; Youl Lee, K.; Kwon, Y.; Cho, W.-J. 2014: Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors. European Journal of Medicinal Chemistry 82: 181-194
Apotrosoaei, M.; Vasincu, I.M.; Dragan, M.; Buron, F.éd.ér.; Routier, S.; Profire, L. 2014: Design, synthesis and the biological evaluation of new 1,3-thiazolidine-4-ones based on the 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one scaffold. Molecules 19(9): 13824-13847
Campo, V.L.; Sesti-Costa, R.; Carneiro, Z.A.; Silva, J.ão.S.; Schenkman, S.; Carvalho, I. 2012: Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase. Bioorganic and Medicinal Chemistry 20(1): 145-156
Franklim, T.N.; Freire-de-Lima, L.; de Nazareth Sá Diniz, J.; Previato, J.é O.; Castro, R.N.; Mendonça-Previato, L.; de Lima, M.E.F. 2013: Design, synthesis and trypanocidal evaluation of novel 1,2,4-triazoles-3-thiones derived from natural piperine. Molecules 18(6): 6366-6382
Huang, C.-W.; Li, Z.; Cai, H.; Chen, K.; Shahinian, T.; Conti, P.S. 2011: Design, synthesis and validation of integrin α2β1-targeted probe for microPET imaging of prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging 38(7): 1313-1322
Bi, Y.-F.; Wang, Z.-J.; Guan, R.-F.; Ye, Y.-T.; Chen, Y.-Y.; Zhang, Y.-B.; Liu, H.-M. 2012: Design, synthesis and vasodilative activity of tanshinone IIA derivatives. Bioorganic and Medicinal Chemistry Letters 22(15): 5141-5143
Amin, K.M.; Awadalla, F.M.; Eissa, A.A.M.; Abou-Seri, S.M.; Hassan, G.S. 2011: Design, synthesis and vasorelaxant evaluation of novel coumarin-pyrimidine hybrids. Bioorganic and Medicinal Chemistry 19(20): 6087-6097
Solomon, V.R.; Haq, W.; Srivastava, K.; Puri, S.K.; Katti, S.B. 2013: Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. Journal of Enzyme Inhibition and Medicinal Chemistry 28(3): 619-626
Sun, X.-Y.; Zhang, L.; Wei, C.-X.; Piao, H.-R.; Quan, Z.-S. 2009: Design, synthesis of 8-alkoxy-5,6-dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity. European Journal of Medicinal Chemistry 44(3): 1265-1270
Marepally, S.; Boakye, C.H.A.; Shah, P.P.; Etukala, J.Reddy.; Vemuri, A.; Singh, M. 2013: Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. Plos one 8(12): E82581
Das, B.C.; Smith, M.E.; Kalpana, G.V. 2008: Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumors. Bioorganic and Medicinal Chemistry Letters 18(14): 4177-4180
Zheng, Y.; Sun, M.; Liu, Y.; Li, M.; Ji, M. 2011: Design, synthesis of novel quinazolone alkaloids derivatives as potential antitumor agents. Medicinal Chemistry 7(4): 295-300
Chen, X.-f.; Wu, Y.-b.; Jin, J.; Wang, R.-z.; Wang, C.; Liu, J. 2010: Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity. Yao Xue Xue Bao 45(2): 263-267
Karuvalam, R.P.; Haridas, K.R.; Nayak, S.K.; Row, T.N.G.; Rajeesh, P.; Rishikesan, R.; Kumari, N.S. 2012: Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents. European Journal of Medicinal Chemistry 49: 172-182
Xiao, Q.; Liu, Y.; Qiu, Y.; Yao, Z.; Zhou, G.; Yao, Z.-J.; Jiang, S. 2011: Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities. Bioorganic and Medicinal Chemistry Letters 21(12): 3613-3615
Abdel-Atty, M.M.; Farag, N.A.; Kassab, S.E.; Serya, R.A.T.; Abouzid, K.A.M. 2014: Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents. Bioorganic Chemistry 57: 65-82
Gopinath, V.S.; Rao, M.; Shivahare, R.; Vishwakarma, P.; Ghose, S.; Pradhan, A.; Hindupur, R.; Sarma, K.D.; Gupta, S.; Puri, S.K.; Launay, D.; Martin, D. 2014: Design, synthesis, ADME characterization and antileishmanial evaluation of novel substituted quinoline analogs. Bioorganic and Medicinal Chemistry Letters 24(9): 2046-2052
Orioli, M.; Vistoli, G.; Regazzoni, L.; Pedretti, A.; Lapolla, A.; Rossoni, G.; Canevotti, R.; Gamberoni, L.; Previtali, M.; Carini, M.; Aldini, G. 2011: Design, synthesis, ADME properties, and pharmacological activities of β-alanyl-D-histidine (D-carnosine) prodrugs with improved bioavailability. Chemmedchem 6(7): 1269-1282
Carreño Otero, A.L.; Vargas Méndez, L.Y.; Duque L, J.E.; Kouznetsov, V.V. 2014: Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever. European Journal of Medicinal Chemistry 78: 392-400
Jiang, L.-L.; Tan, Y.; Zhu, X.-L.; Wang, Z.-F.; Zuo, Y.; Chen, Q.; Xi, Z.; Yang, G.-F. 2010: Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2(3H)-ones as protoporphyrinogen oxidase inhibitors. Journal of Agricultural and Food Chemistry 58(5): 2643-2651
Chavda, S.; Babu, B.; Patil, P.; Plaunt, A.; Ferguson, A.; Lee, M.; Tzou, S.; Sjoholm, R.; Rice, T.; Mackay, H.; Ramos, J.; Wang, S.; Lin, S.; Kiakos, K.; Wilson, W.D.; Hartley, J.A.; Lee, M. 2013: Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. Bioorganic and Medicinal Chemistry 21(13): 3907-3918
Ghosh, S.; Usharani, D.; Paul, A.; De, S.; Jemmis, E.D.; Bhattacharya, S. 2008: Design, synthesis, and DNA binding properties of photoisomerizable azobenzene-distamycin conjugates: an experimental and computational study. Bioconjugate Chemistry 19(12): 2332-2345
Garofalo, A.; Goossens, L.; Baldeyrou, B.; Lemoine, A.él.; Ravez, S.év.; Six, P.; David-Cordonnier, M.-H.él.èn.; Bonte, J.-P.; Depreux, P.; Lansiaux, A.él.; Goossens, J.-F.ço. 2010: Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives. Journal of Medicinal Chemistry 53(22): 8089-8103
Yu, R.; Zhou, Y-Li.; Huan, Y.; Liu, Q.; Shen, Z-Fang.; Liu, Z-Zhu. 2011: Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives. Yao Xue Xue Bao 46(3): 311-316
Qu, L-Li.; Ma, Y-Heng. 2013: Design, synthesis, and PPARgamma agonistic activity of novel indenone derivatives. Yao Xue Xue Bao 48(4): 508-513
Cioffi, C.L.; Wolf, M.A.; Guzzo, P.R.; Sadalapure, K.; Parthasarathy, V.; Dethe, D.; Maeng, J.-H.; Carulli, E.; Loong, D.T.J.; Fang, X.; Hu, M.; Gupta, P.; Chung, M.; Bai, M.; Moore, N.; Luche, M.; Khmelnitsky, Y.; Love, P.L.; Watson, M.A.; Mhyre, A.J.; Liu, S. 2013: Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Bioorganic and Medicinal Chemistry Letters 23(5): 1257-1261
Bach, P.; Knerr, L.; Fjellström, O.; Hansson, K.; Mattsson, C.; Gustafsson, D. 2014: Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorganic and Medicinal Chemistry Letters 24(3): 821-827
Yoshikawa, K.; Yokomizo, A.; Naito, H.; Haginoya, N.; Kobayashi, S.; Yoshino, T.; Nagata, T.; Mochizuki, A.; Osanai, K.; Watanabe, K.; Kanno, H.; Ohta, T. 2009: Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. Bioorganic and Medicinal Chemistry 17(24): 8206-8220
Yoshikawa, K.; Kobayashi, S.; Nakamoto, Y.; Haginoya, N.; Komoriya, S.; Yoshino, T.; Nagata, T.; Mochizuki, A.; Watanabe, K.; Suzuki, M.; Kanno, H.; Ohta, T. 2009: Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties. Bioorganic and Medicinal Chemistry 17(24): 8221-8233
Chen, F.; Zhang, G.; Hong, Z.; Lin, Z.; Lei, M.; Huang, M.; Hu, L. 2014: Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1). Bioorganic and Medicinal Chemistry Letters 24(10): 2379-2382
Liang, Y-Hong.; Feng, X-Qing.; Zeng, Z-Sen.; Chen, F-Er.; Balzarini, J.; Pannecouque, C.; De Clercq, E. 2009: Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Chemmedchem 4(9): 1537-1545
Lu, Y.; Li, C.-M.; Wang, Z.; Chen, J.; Mohler, M.L.; Li, W.; Dalton, J.T.; Miller, D.D. 2011: Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. Journal of Medicinal Chemistry 54(13): 4678-4693
Ye, X.-Y.; Chen, S.Y.; Nayeem, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.; Sleczka, B.G.; Li, Y.-X.; He, B.; Kirby, M.; Gordon, D.A.; Robl, J.A. 2011: Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Bioorganic and Medicinal Chemistry Letters 21(22): 6699-6704
Hanson, J.; Dogné, J.-M.; Ghiotto, J.ér.ém.; Moray, A.-L.; Kinsella, B.T.; Pirotte, B. 2007: Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor. Journal of Medicinal Chemistry 50(16): 3928-3936
Ibrahim, D.A.; Boucau, J.; Lajiness, D.H.; Veleti, S.K.; Trabbic, K.R.; Adams, S.S.; Ronning, D.R.; Sucheck, S.J. 2012: Design, synthesis, and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis antigen 85C. Bioconjugate Chemistry 23(12): 2403-2416
Peng, P.; Li, F.-F.; Neti, V.S.P.K.; Metta-Magana, A.J.; Echegoyen, L. 2014: Design, synthesis, and X-ray crystal structure of a fullerene-linked metal-organic framework. Angewandte Chemie 53(1): 160-163
Gangjee, A.; Li, W.; Kisliuk, R.L.; Cody, V.; Pace, J.; Piraino, J.; Makin, J. 2009: Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. Journal of Medicinal Chemistry 52(15): 4892-4902
Gangjee, A.; Li, W.; Lin, L.; Zeng, Y.; Ihnat, M.; Warnke, L.A.; Green, D.W.; Cody, V.; Pace, J.; Queener, S.F. 2009: Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorganic and Medicinal Chemistry 17(20): 7324-7336
Ganguly, A.K.; Alluri, S.S.; Caroccia, D.; Biswas, D.; Wang, C.-H.; Kang, E.; Zhang, Y.; McPhail, A.T.; Carroll, S.S.; Burlein, C.; Munshi, V.; Orth, P.; Strickland, C. 2011: Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors. Journal of Medicinal Chemistry 54(20): 7176-7183
Andaloussi, M.; Henriksson, L.M.; Więckowska, A.; Lindh, M.; Björkelid, C.; Larsson, A.M.; Suresh, S.; Iyer, H.; Srinivasa, B.R.; Bergfors, T.; Unge, T.; Mowbray, S.L.; Larhed, M.; Jones, T.A.; Karlén, A. 2011: Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Journal of Medicinal Chemistry 54(14): 4964-4976
Ganguly, K.; Wu, R.; Ollivault-Shiflett, M.; Goodwin, P.M.; Silks, L.A.; Iyer, R. 2011: Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles. Journal of Drug Targeting 19(7): 528-539
Zhou, X.; Wang, X.-B.; Wang, T.; Kong, L.-Y. 2008: Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorganic and Medicinal Chemistry 16(17): 8011-8021
Cynshi, O.; Tamura, K.; Niki, E. 2010: Design, synthesis, and action of antiatherogenic antioxidants. Methods in Molecular Biology 610: 91-107
Lu, J.; Lei, L.; Huan, Y.; Li, Y.; Zhang, L.; Shen, Z.; Hu, W.; Feng, Z. 2014: Design, synthesis, and activity evaluation of GK/PPARγ dual-target-directed ligands as hypoglycemic agents. Chemmedchem 9(5): 922-927
Zheng, C.-H.; Yang, H.; Zhang, M.; Lu, S.-H.; Shi, D.; Wang, J.; Chen, X.-H.; Ren, X.-H.; Liu, J.; Lv, J.-G.; Zhu, J.; Zhou, Y.-J. 2012: Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity. Bioorganic and Medicinal Chemistry Letters 22(1): 39-44
Kassa, T.W.; Zhang, N.; Palmer, A.F.; Matthews, J.S. 2013: Design, synthesis, and activity of 2,3-diphosphoglycerate analogs as allosteric modulators of hemoglobin O2 affinity. Artificial Cells Nanomedicine and Biotechnology 41(2): 109-115
Hogenkamp, D.J.; Ford-Hutchinson, T.A.; Li, W.-Y.; Whittemore, E.R.; Yoshimura, R.F.; Tran, M.B.; Johnstone, T.B.C.; Bascom, G.D.; Rollins, H.; Lu, L.; Gee, K.W. 2013: Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type i positive allosteric modulators of α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry 56(21): 8352-8365
Pollard, J.; Bell, S.D.; Ellington, A.D. 2001: Design, synthesis, and amplification of DNA pools for construction of combinatorial pools and libraries. Current Protocols in Molecular Biology Chapter 24: Unit 24.2
Hall, B.; Micheletti, J.M.; Satya, P.; Ogle, K.; Pollard, J.; Ellington, A.D. 2009: Design, synthesis, and amplification of DNA pools for in vitro selection. Current Protocols in Molecular Biology Chapter 24: Unit 24.2
Hall, B.; Micheletti, J.M.; Satya, P.; Ogle, K.; Pollard, J.; Ellington, A.D. 2009: Design, synthesis, and amplification of DNA pools for in vitro selection. Current Protocols in Nucleic Acid Chemistry Chapter 9: Unit 9.2
Kawashima, E.; Ohba, Y.; Terui, Y.; Kamaike, K. 2010: Design, synthesis, and analysis of minor groove binder pyrrolepolyamide-2'-deoxyguanosine hybrids. Journal of Nucleic Acids 2010
Zhao, J.; Zhang, J.; Xu, B.; Wang, Z.; Cheng, J.; Zhu, G. 2012: Design, synthesis, and analysis of the quantitative structure-activity relationships of 4-phenyl-acyl-substituted 3-(2,5-dimethylphenyl)-4-hydroxy-1-azaspiro[4.5]dec-3-ene-2,8-dione derivatives. Journal of Agricultural and Food Chemistry 60(19): 4779-4787
Breslin, H.J.; Lane, B.M.; Ott, G.R.; Ghose, A.K.; Angeles, T.S.; Albom, M.S.; Cheng, M.; Wan, W.; Haltiwanger, R.C.; Wells-Knecht, K.J.; Dorsey, B.D. 2012: Design, synthesis, and anaplastic lymphoma kinase (ALK) inhibitory activity for a novel series of 2,4,8,22-tetraazatetracyclo[14.3.1.1³,⁷.1⁹,¹³]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene macrocycles. Journal of Medicinal Chemistry 55(1): 449-464
Boojamra, C.G.; Parrish, J.P.; Sperandio, D.; Gao, Y.; Petrakovsky, O.V.; Lee, S.K.; Markevitch, D.Y.; Vela, J.E.; Laflamme, G.; Chen, J.M.; Ray, A.S.; Barron, A.C.; Sparacino, M.L.; Desai, M.C.; Kim, C.U.; Cihlar, T.; Mackman, R.L. 2009: Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry 17(4): 1739-1746
Hynes, J.; Dyckman, A.J.; Lin, S.; Wrobleski, S.T.; Wu, H.; Gillooly, K.M.; Kanner, S.B.; Lonial, H.; Loo, D.; McIntyre, K.W.; Pitt, S.; Shen, D.R.; Shuster, D.J.; Yang, X.; Zhang, R.; Behnia, K.; Zhang, H.; Marathe, P.H.; Doweyko, A.M.; Tokarski, J.S.; Sack, J.S.; Pokross, M.; Kiefer, S.E.; Newitt, J.A.; Barrish, J.C.; Dodd, J.; Schieven, G.L.; Leftheris, K. 2008: Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. Journal of Medicinal Chemistry 51(1): 4-16
Kinger, M.; Park, Y.Dae.; Park, J.Hoon.; Hur, M.Goo.; Jeong, H.Jae.; Park, S-Jin.; Lee, W.Song.; Kim, S.Wook.; Yang, S.Dae. 2012: Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors. Archives of Pharmacal Research 35(4): 633-638
Ran, Y.; Ma, L.; Wang, X.; Chen, J.; Wang, G.; Peng, A.; Chen, L. 2012: Design, synthesis, and anti-proliferative evaluation of [1,1'-biphenyl]-4-ols as inhibitor of HUVEC migration and tube formation. Molecules 17(7): 8091-8104
Wu, M.; Han, G.; Meng, C.; Wang, Z.; Liu, Y.; Wang, Q. 2014: Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of glycoconjugates of phenanthroindolizidines alkaloids. Molecular Diversity 18(1): 25-37
Wang, Z.; Wei, P.; Wang, L.; Wang, Q. 2012: Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues. Journal of Agricultural and Food Chemistry 60(41): 10212-10219
Chen, H.; Li, S.; Yao, Y.; Zhou, L.; Zhao, J.; Gu, Y.; Wang, K.; Li, X. 2013: Design, synthesis, and anti-tumor activities of novel triphenylethylene-coumarin hybrids, and their interactions with Ct-DNA. Bioorganic and Medicinal Chemistry Letters 23(17): 4785-4789
Jeong, L.Shin.; Lee, H.Woo.; Kim, H.Ok.; Jung, J.Young.; Gunaga, P.; Lee, S.Kook.; Lee, E-Jin.; Chun, M.Woo.; Gao, Z-Guo.; Jacobson, K.A.; Moon, H.Ryong. 2007: Design, synthesis, and anti-tumor activity of 4'-thionucleosides as potent and selective agonists at the human A3 adenosine receptor. Nucleosides Nucleotides and Nucleic Acids 26(10-12): 1565-1568
Liu, J-Hong.; Tang, J.; Zhu, Z-Fei.; Chen, L. 2014: Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives. Journal of Asian Natural Products Research 16(1): 34-42
Yang, Y.-H.; Cheng, M.-S.; Wang, Q.-H.; Nie, H.; Liao, N.; Wang, J.; Chen, H. 2009: Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles. European Journal of Medicinal Chemistry 44(4): 1808-1812
Lee, H.W.; Cho, C.S.; Kang, S.K.; Yoo, Y.S.; Shin, J.S.; Ahn, S.K. 2007: Design, synthesis, and antiangiogenic effects of a series of potent novel fumagillin analogues. Chemical and Pharmaceutical Bulletin 55(7): 1024-1029
Zhang, W.; Chen, Y.; Liang, Q.; Li, H.; Jin, H.; Zhang, L.; Meng, X.; Li, Z. 2013: Design, synthesis, and antibacterial activities of conformationally constrained kanamycin a derivatives. Journal of Organic Chemistry 78(2): 400-409
Bera, S.; Zhanel, G.G.; Schweizer, F. 2008: Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity. Journal of Medicinal Chemistry 51(19): 6160-6164
Tang, D.; Gai, Y.; Polemeropoulos, A.; Chen, Z.; Wang, Z.; Or, Y.S. 2008: Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. Bioorganic and Medicinal Chemistry Letters 18(18): 5078-5082
Li, P.; Shi, L.; Yang, X.; Yang, L.; Chen, X.-W.; Wu, F.; Shi, Q.-C.; Xu, W.-M.; He, M.; Hu, D.-Y.; Song, B.-A. 2014: Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative. Bioorganic and Medicinal Chemistry Letters 24(7): 1677-1680
Shi, W.; Duan, Y.; Qian, Y.; Li, M.; Yang, L.; Hu, W. 2010: Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. Bioorganic and Medicinal Chemistry Letters 20(12): 3592-3595
Chang, J.; Zhang, S.-J.; Jiang, Y.-W.; Xu, L.; Yu, J.-M.; Zhou, W.-J.; Sun, X. 2013: Design, synthesis, and antibacterial activity of demethylvancomycin analogues against drug-resistant bacteria. Chemmedchem 8(6): 976-984
Wang, X.; Yin, J.; Shi, L.; Zhang, G.; Song, B. 2014: Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one. European Journal of Medicinal Chemistry 77: 65-74
Ling, Y.; Wang, X.; Wang, H.; Yu, J.; Tang, J.; Wang, D.; Chen, G.; Huang, J.; Li, Y.; Zheng, H. 2012: Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring. Archiv der Pharmazie 345(8): 638-646
Silvers, M.A.; Robertson, G.T.; Taylor, C.M.; Waldrop, G.L. 2014: Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase. Journal of Medicinal Chemistry 57(21): 8947-8959
Pan, B.; Huang, R.-Z.; Han, S.-Q.; Qu, D.; Zhu, M.-L.; Wei, P.; Ying, H.-J. 2010: Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones. Bioorganic and Medicinal Chemistry Letters 20(8): 2461-2464
Park, S.M.; Yang, H.; Park, S.-K.; Kim, H.M.; Kim, B.H. 2010: Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines. Bioorganic and Medicinal Chemistry Letters 20(19): 5831-5834
Jin, X.; Yan, T.-H.; Yan, L.; Li, Q.; Wang, R.-L.; Hu, Z.-L.; Jiang, Y.-Y.; Sun, Q.-Y.; Cao, Y.-B. 2014: Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC "click" chemistry as potential anticancer agents. Drug Design Development and Therapy 8: 1047-1059
Lakshmi Ranganatha, V.; Zameer, F.; Meghashri, S.; Rekha, N.D.; Girish, V.; Gurupadaswamy, H.D.; Khanum, S.A. 2013: Design, synthesis, and anticancer properties of novel benzophenone-conjugated coumarin analogs. Archiv der Pharmazie 346(12): 901-911
Shu, B.; Zheng, Y.; Wang, S.-B.; Deng, X.-Q.; Quan, Z.-S. 2013: Design, synthesis, and anticonvulsant activity evaluation of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones. Archiv der Pharmazie 346(2): 127-133
Obniska, J.; Byrtus, H.; Kamiński, K.; Pawłowski, M.; Szczesio, M.łg.; Karolak-Wojciechowska, J. 2010: Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins. Bioorganic and Medicinal Chemistry 18(16): 6134-6142
Duan, H.; Ning, M.; Chen, X.; Zou, Q.; Zhang, L.; Feng, Y.; Zhang, L.; Leng, Y.; Shen, J. 2012: Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. Journal of Medicinal Chemistry 55(23): 10475-10489
Zhao, Q.-J.; Hu, H.-G.; Li, Y.-W.; Song, Y.; Cai, L.-Z.; Wu, Q.-Y.; Jiang, Y.-Y. 2007: Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (CYP51). Chemistry and Biodiversity 4(7): 1472-1479
Wang, W.; Sheng, C.; Che, X.; Ji, H.; Miao, Z.; Yao, J.; Zhang, W.N. 2009: Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. Archiv der Pharmazie 342(12): 732-739
Rezaei, Z.; Khabnadideh, S.; Pakshir, K.; Hossaini, Z.; Amiri, F.; Assadpour, E. 2009: Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. European Journal of Medicinal Chemistry 44(7): 3064-3067
Lv, Z.; Sheng, C.; Wang, T.; Zhang, Y.; Liu, J.; Feng, J.; Sun, H.; Zhong, H.; Niu, C.; Li, K. 2010: Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives. Journal of Medicinal Chemistry 53(2): 660-668
Chen, L.; Zhang, Y.; Kong, X.; Lan, E.; Huang, Z.; Peng, S.; Kaufman, D.L.; Tian, J. 2008: Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. Journal of Medicinal Chemistry 51(15): 4834-4838
Arya, N.; Munde, M.K.; Dwivedi, J.; Jagdale, A.Y.; Jain, K.S. 2013: Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones. Archiv der Pharmazie 346(8): 588-595
Zhang, M.-X.; Zhu, C.-F.; Zhou, Y.-J.; Kong, X.-L.; Hider, R.C.; Zhou, T. 2014: Design, synthesis, and antimicrobial evaluation of hexadentate hydroxypyridinones with high iron(III) affinity. Chemical Biology and Drug Design 84(6): 659-668
Kumar, N.Saravana.; Pradeep, T.; Jani, G.; Silpa, D.; Kumar, B.Vijaya. 2012: Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases. Journal of Advanced Pharmaceutical Technology and Research 3(1): 57-61
Kakkar, D.; Tiwari, A.K.; Chuttani, K.; Khanna, A.; Datta, A.; Singh, H.; Mishra, A.K. 2012: Design, synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. Chemical Biology and Drug Design 80(2): 245-253
El-Gamal, M.I.; Choi, H.Seok.; Cho, H-Guk.; Hong, J.Hee.; Yoo, K.Ho.; Oh, C-Hyun. 2011: Design, synthesis, and antiproliferative activity of 3,4-diarylpyrazole-1-carboxamide derivatives against melanoma cell line. Archiv der Pharmazie 344(11): 745-754
El-Gamal, M.I.; Jung, M.-H.; Lee, W.S.; Sim, T.; Yoo, K.H.; Oh, C.-H. 2011: Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. European Journal of Medicinal Chemistry 46(8): 3218-3226
Jung, M.-H.; El-Gamal, M.I.; Abdel-Maksoud, M.S.; Sim, T.; Yoo, K.H.; Oh, C.-H. 2012: Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2. Bioorganic and Medicinal Chemistry Letters 22(13): 4362-4367
Manna, K.; Agrawal, Y.K. 2010: Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs. European Journal of Medicinal Chemistry 45(9): 3831-3839
Lv, J.-L.; Wang, R.; Liu, D.; Guo, G.; Jing, Y.-K.; Zhao, L.-X. 2008: Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines. Molecules 13(6): 1427-1440
Bollini, M.; Casal, J.J.é; Bruno, A.M.ía. 2008: Design, synthesis, and antitumor activity of new bis-aminomethylnaphthalenes. Bioorganic and Medicinal Chemistry 16(17): 8003-8010
Liu, S.; Feng, J.; Liu, H.; Li, J.; Tian, X. 2015: Design, synthesis, and antitumor activity of novel acylate of 6-OH at 1- O-acetylbritannilactone. Medicinal Chemistry 11(2): 200-205
Liu, J.; Cao, B.; Gao, Y.; Bai, M.; Mei, X.; Chen, H.; Jiang, Y-Gen.; Huang, D-Jiang. 2013: Design, synthesis, and antitumor activity of novel podophyllotoxin derivatives as potent anticancer agents. Journal of Asian Natural Products Research 15(9): 985-992
Thapa, P.; Karki, R.; Yun, M.; Kadayat, T.M.; Lee, E.; Kwon, H.B.; Na, Y.; Cho, W.-J.; Kim, N.D.; Jeong, B.-S.; Kwon, Y.; Lee, E.-S. 2012: Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety. European Journal of Medicinal Chemistry 52: 123-136
Alafeefy, A.M. 2015: Design, synthesis, and antitumor screening of certain novel tetrahydroquinoline sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 30(2): 189-194
Wang, Z.; Wei, P.; Xizhi, X.; Liu, Y.; Wang, L.; Wang, Q. 2012: Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives. Journal of Agricultural and Food Chemistry 60(35): 8544-8551
Curreli, F.; Choudhury, S.; Pyatkin, I.; Zagorodnikov, V.P.; Bulay, A.K.; Altieri, A.; Kwon, Y.D.; Kwong, P.D.; Debnath, A.K. 2012: Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1. Journal of Medicinal Chemistry 55(10): 4764-4775
Wang, K.; Hu, Y.; Liu, Y.; Mi, N.; Fan, Z.; Liu, Y.; Wang, Q. 2010: Design, synthesis, and antiviral evaluation of phenanthrene-based tylophorine derivatives as potential antiviral agents. Journal of Agricultural and Food Chemistry 58(23): 12337-12342
D'hooghe, M.; Mollet, K.; De Vreese, R.; Jonckers, T.H.M.; Dams, G.ér.; De Kimpe, N. 2012: Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids. Journal of Medicinal Chemistry 55(11): 5637-5641
Peterson, M.A.; Ke, P.; Shi, H.; Jones, C.; McDougall, B.R.; Robinson, W.Edward. 2007: Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives. Nucleosides Nucleotides and Nucleic Acids 26(5): 499-519
Liu, Y.; Song, H.; Huang, Y.; Li, J.; Zhao, S.; Song, Y.; Yang, P.; Xiao, Z.; Liu, Y.; Li, Y.; Shang, H.; Wang, Q. 2014: Design, synthesis, and antiviral, fungicidal, and insecticidal activities of tetrahydro-β-carboline-3-carbohydrazide derivatives. Journal of Agricultural and Food Chemistry 62(41): 9987-9999
Han, B.; Stevens, J.F.; Maier, C.S. 2007: Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates. Analytical Chemistry 79(9): 3342-3354
Fraczyk, J.; Kaminski, Z.J. 2008: Design, synthesis, and application of a library of supramolecular structures formed by N-lipidated peptides immobilized on cellulose. Artificial receptors. Journal of Combinatorial Chemistry 10(6): 934-940
Tkachenko, A.N.; Radchenko, D.S.; Mykhailiuk, P.K.; Afonin, S.; Ulrich, A.S.; Komarov, I.V. 2013: Design, synthesis, and application of a trifluoromethylated phenylalanine analogue as a label to study peptides by solid-state 19F NMR spectroscopy. Angewandte Chemie 52(25): 6504-6507
Kolesinska, B.; Kaminski, Z.J. 2009: Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary. Organic Letters 11(3): 765-768
Hotz, N.; Wilcke, L.; Weber, W. 2013: Design, synthesis, and application of stimulus-sensing biohybrid hydrogels. Macromolecular Rapid Communications 34(20): 1594-1610
Waser, M.; Gratzer, K.; Herchl, R.; Müller, N. 2012: Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts. Organic and Biomolecular Chemistry 10(2): 251-254
Jing, C.; Cornish, V.W. 2013: Design, synthesis, and application of the trimethoprim-based chemical tag for live-cell imaging. Current Protocols in Chemical Biology 5(2): 131-155
Pindi, S.; Wu, J.; Li, G. 2013: Design, synthesis, and applications of chiral N-2-phenyl-2-propyl sulfinyl imines for group-assisted purification (GAP) asymmetric synthesis. Journal of Organic Chemistry 78(8): 4006-4012
Bélanger, Ét.; Pouliot, M.-F.; Courtemanche, M.-A.é; Paquin, J.-F.ço. 2012: Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates. Journal of Organic Chemistry 77(1): 317-331
El Khoury, G.; Wang, Y.; Wang, D.; Jacob, S.I.; Lowe, C.R. 2013: Design, synthesis, and assessment of a de novo affinity adsorbent for the purification of recombinant human erythropoietin. Biotechnology and Bioengineering 110(11): 3063-3069
Kusakabe, K.-i.; Tada, Y.; Iso, Y.; Sakagami, M.; Morioka, Y.; Chomei, N.; Shinonome, S.; Kawamoto, K.; Takenaka, H.; Yasui, K.; Hamana, H.; Hanasaki, K. 2013: Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists. Bioorganic and Medicinal Chemistry 21(7): 2045-2055
Lee, H.W.; Kim, H.O.; Choi, W.J.; Choi, S.; Lee, J.H.; Park, S.-g.; Yoo, L.; Jacobson, K.A.; Jeong, L.S. 2010: Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors. Bioorganic and Medicinal Chemistry 18(19): 7015-7021
Zhang, H.; Jin, H.; Ji, L-zhu.; Tao, K.; Liu, W.; Zhao, H-yu.; Hou, T-ping. 2011: Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products. Chemical Biology and Drug Design 78(1): 94-100
Zefirova, O.N.; Nurieva, E.V.; Lemcke, H.; Ivanov, A.A.; Shishov, D.V.; Weiss, D.G.; Kuznetsov, S.A.; Zefirov, N.S. 2008: Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core. Bioorganic and Medicinal Chemistry Letters 18(18): 5091-5094
Cai, J.; Liu, L.; Chen, J.; Cao, M.; Ji, M. 2013: Design, synthesis, and bioactivity of pyrazole acid derivatives as endothelin receptor antagonists. Medicinal Chemistry 9(8): 1113-1122
Sun, R.; Zhang, Y.; Bi, F.; Wang, Q. 2009: Design, synthesis, and bioactivity study of novel benzoylpyridazyl ureas. Journal of Agricultural and Food Chemistry 57(14): 6356-6361
Chu, H.; Gao, J.; Wang, Y. 2012: Design, synthesis, and biocompatibility of an arginine-based polyester. Biotechnology Progress 28(1): 257-264
Peng, D.-Y.; Sun, Q.; Zhu, X.-L.; Lin, H.-Y.; Chen, Q.; Yu, N.-X.; Yang, W.-C.; Yang, G.-F. 2012: Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic and Medicinal Chemistry 20(22): 6739-6750
Prior, A.M.; Kim, Y.; Weerasekara, S.; Moroze, M.; Alliston, K.R.; Uy, R.A.Z.; Groutas, W.C.; Chang, K.-O.; Hua, D.H. 2013: Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. Bioorganic and Medicinal Chemistry Letters 23(23): 6317-6320
Lu, Y.; Chen, J.; Janjetovic, Z.; Michaels, P.; Tang, E.K.Y.; Wang, J.; Tuckey, R.C.; Slominski, A.T.; Li, W.; Miller, D.D. 2012: Design, synthesis, and biological action of 20R-hydroxyvitamin D3. Journal of Medicinal Chemistry 55(7): 3573-3577
Honda, E.; Ishichi, Y.; Kimura, E.; Yoshikawa, M.; Kanzaki, N.; Nakagawa, H.; Terao, Y.; Suzuki, A.; Kawai, T.; Arakawa, Y.; Ohta, H.; Terauchi, J. 2014: Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors. Bioorganic and Medicinal Chemistry Letters 24(16): 3898-3902
Li, L.; Li, Z.; Wang, K.; Zhao, S.; Feng, J.; Li, J.; Yang, P.; Liu, Y.; Wang, L.; Li, Y.; Shang, H.; Wang, Q. 2014: Design, synthesis, and biological activities of aromatic gossypol Schiff base derivatives. Journal of Agricultural and Food Chemistry 62(46): 11080-11088
Zhao, H.; Liu, Y.; Cui, Z.; Beattie, D.; Gu, Y.; Wang, Q. 2011: Design, synthesis, and biological activities of arylmethylamine substituted chlorotriazine and methylthiotriazine compounds. Journal of Agricultural and Food Chemistry 59(21): 11711-11717
Garner, A.L.; Gloeckner, C.; Tricoche, N.; Zakhari, J.S.; Samje, M.; Cho-Ngwa, F.; Lustigman, S.; Janda, K.D. 2011: Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. Journal of Medicinal Chemistry 54(11): 3963-3972
Lu, H.; Su, H.; Yang, B.; You, Q.-D. 2011: Design, synthesis, and biological activities of histone deacetylase inhibitors with diketo ester as zinc binding group. Yao Xue Xue Bao 46(3): 293-298
Zhao, J.-H.; Xu, X.-J.; Ji, M.-H.; Cheng, J.-L.; Zhu, G.-N. 2011: Design, synthesis, and biological activities of milbemycin analogues. Journal of Agricultural and Food Chemistry 59(9): 4836-4850
Behrouz, S.; Rad, M.N.S.; Rostami, S.; Behrouz, M.; Zarehnezhad, E.; Zarehnezhad, A. 2014: Design, synthesis, and biological activities of novel azole-bonded β-hydroxypropyl oxime O-ethers. Molecular Diversity 18(4): 797-808
Shiokawa, Z.; Hashimoto, K.; Saito, B.; Oguro, Y.; Sumi, H.; Yabuki, M.; Yoshimatsu, M.; Kosugi, Y.; Debori, Y.; Morishita, N.; Dougan, D.R.; Snell, G.P.; Yoshida, S.; Ishikawa, T. 2013: Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. Bioorganic and Medicinal Chemistry 21(24): 7938-7954
Baran, A.; Çambul, S.; Nebioglu, M.; Balci, M. 2012: Design, synthesis, and biological activities of some branched carbasugars: construction of a substituted 6-oxabicyclo[3.2.1]nonane skeleton. Journal of Organic Chemistry 77(11): 5086-5097
Wang, L.; Sullivan, G.M.; Hexamer, L.A.; Hasvold, L.A.; Thalji, R.; Przytulinska, M.; Tao, Z.-F.; Li, G.; Chen, Z.; Xiao, Z.; Gu, W.-Z.; Xue, J.; Bui, M.-H.; Merta, P.; Kovar, P.; Bouska, J.J.; Zhang, H.; Park, C.; Stewart, K.D.; Sham, H.L.; Sowin, T.J.; Rosenberg, S.H.; Lin, N.-H. 2007: Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. Journal of Medicinal Chemistry 50(17): 4162-4176
Suzuki, T.; Muto, N.; Bando, M.; Itoh, Y.; Masaki, A.; Ri, M.; Ota, Y.; Nakagawa, H.; Iida, S.; Shirahige, K.; Miyata, N. 2014: Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. Chemmedchem 9(3): 657-664
Antoon, J.W.; Liu, J.; Gestaut, M.M.; Burow, M.E.; Beckman, B.S.; Foroozesh, M. 2009: Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. Journal of Medicinal Chemistry 52(18): 5748-5752
Jiang, S.; Tala, S.R.; Lu, H.; Zou, P.; Avan, I.; Ibrahim, T.S.; Abo-Dya, N.E.; Abdelmajeid, A.; Debnath, A.K.; Katritzky, A.R. 2011: Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41. Bioorganic and Medicinal Chemistry Letters 21(22): 6895-6898
Suzuki, T.; Khan, M.N.A.; Sawada, H.; Imai, E.; Itoh, Y.; Yamatsuta, K.; Tokuda, N.; Takeuchi, J.; Seko, T.; Nakagawa, H.; Miyata, N. 2012: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. Journal of Medicinal Chemistry 55(12): 5760-5773
Jadhav, V.D.; Duerfeldt, A.S.; Blagg, B.S.J. 2009: Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. Bioorganic and Medicinal Chemistry Letters 19(24): 6845-6850
Suzuki, N.; Suzuki, T.; Ota, Y.; Nakano, T.; Kurihara, M.; Okuda, H.; Yamori, T.; Tsumoto, H.; Nakagawa, H.; Miyata, N. 2009: Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. Journal of Medicinal Chemistry 52(9): 2909-2922
Shuto, S. 2007: Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca2+-mobilizing second messenger. Nucleic Acids Symposium Series 51: 109-110
Cheng, G.; Muench, S.P.; Zhou, Y.; Afanador, G.A.; Mui, E.J.; Fomovska, A.; Lai, B.Shiun.; Prigge, S.T.; Woods, S.; Roberts, C.W.; Hickman, M.R.; Lee, P.J.; Leed, S.E.; Auschwitz, J.M.; Rice, D.W.; McLeod, R. 2013: Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorganic and Medicinal Chemistry Letters 23(7): 2035-2043
Terracciano, S.; Chini, M.G.; Riccio, R.; Bruno, I.; Bifulco, G. 2012: Design, synthesis, and biological activity of hydroxamic tertiary amines as histone deacetylase inhibitors. Chemmedchem 7(4): 694-702
Boije af Gennäs, G.; Talman, V.; Aitio, O.; Ekokoski, E.; Finel, M.; Tuominen, R.K.; Yli-Kauhaluoma, J. 2009: Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. Journal of Medicinal Chemistry 52(13): 3969-3981
Dong, M.-x.; Lu, L.; Li, H.; Wang, X.; Lu, H.; Jiang, S.; Dai, Q.-y. 2012: Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors. Bioorganic and Medicinal Chemistry Letters 22(9): 3284-3286
Jiang, S.; Tala, S.R.; Lu, H.; Abo-Dya, N.E.; Avan, I.; Gyanda, K.; Lu, L.; Katritzky, A.R.; Debnath, A.K. 2011: Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41. Journal of Medicinal Chemistry 54(2): 572-579
Jubinsky, P.T.; Short, M.K.; Ghanem, M.; Das, B.C. 2011: Design, synthesis, and biological activity of novel Magmas inhibitors. Bioorganic and Medicinal Chemistry Letters 21(11): 3479-3482
Han, J.; Sun, L.; Chu, Y.; Li, Z.; Huang, D.; Zhu, X.; Qian, H.; Huang, W. 2013: Design, synthesis, and biological activity of novel dicoumarol glucagon-like peptide 1 conjugates. Journal of Medicinal Chemistry 56(24): 9955-9968
Xie, Y.-Q.; Huang, Z.-L.; Yan, H.-D.; Li, J.; Ye, L.-Y.; Che, L.-M.; Tu, S. 2015: Design, synthesis, and biological activity of oxime ether strobilurin derivatives containing indole moiety as novel fungicide. Chemical Biology and Drug Design 85(6): 743-755
Sasaki, S.; Kitamura, S.; Negoro, N.; Suzuki, M.; Tsujihata, Y.; Suzuki, N.; Santou, T.; Kanzaki, N.; Harada, M.; Tanaka, Y.; Kobayashi, M.; Tada, N.; Funami, M.; Tanaka, T.; Yamamoto, Y.; Fukatsu, K.; Yasuma, T.; Momose, Y. 2011: Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists. Journal of Medicinal Chemistry 54(5): 1365-1378
Saurat, T.; Buron, F.éd.ér.; Rodrigues, N.; de Tauzia, M.-L.; Colliandre, L.; Bourg, S.ép.; Bonnet, P.; Guillaumet, G.ér.; Akssira, M.; Corlu, A.; Guillouzo, C.; Berthier, P.; Rio, P.; Jourdan, M.-L.; Bénédetti, H.él.èn.; Routier, S. 2014: Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors. Journal of Medicinal Chemistry 57(3): 613-631
Liu, Y.; Zhang, L.; Gong, J.; Fang, H.; Liu, A.; Du, G.; Xu, W. 2011: Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 26(4): 506-513
Kar, M.; Basak, A. 2007: Design, synthesis, and biological activity of unnatural enediynes and related analogues equipped with pH-dependent or phototriggering devices. Chemical Reviews 107(7): 2861-2890
Af Gennäs, G.B.; Mologni, L.; Ahmed, S.; Rajaratnam, M.; Marin, O.; Lindholm, N.; Viltadi, M.; Gambacorti-Passerini, C.; Scapozza, L.; Yli-Kauhaluoma, J. 2011: Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. Chemmedchem 6(9): 1680-1692
Belluti, F.; Perozzo, R.; Lauciello, L.; Colizzi, F.; Kostrewa, D.; Bisi, A.; Gobbi, S.; Rampa, A.; Bolognesi, M.L.; Recanatini, M.; Brun, R.; Scapozza, L.; Cavalli, A. 2013: Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). Journal of Medicinal Chemistry 56(19): 7516-7526
Parai, M.K.; Huggins, D.J.; Cao, H.; Nalam, M.N.L.; Ali, A.; Schiffer, C.A.; Tidor, B.; Rana, T.M. 2012: Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry 55(14): 6328-6341
Kikuchi, K. 2010: Design, synthesis, and biological application of fluorescent sensor molecules for cellular imaging. Advances in Biochemical Engineering/Biotechnology 119: 63-78
Smith, G.; Glaser, M.; Perumal, M.; Nguyen, Q.-D.; Shan, B.; Arstad, E.; Aboagye, E.O. 2008: Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide. Journal of Medicinal Chemistry 51(24): 8057-8067
Kuo, G.-H.; Rano, T.; Pelton, P.; Demarest, K.T.; Gibbs, A.C.; Murray, W.V.; Damiano, B.P.; Connelly, M.A. 2009: Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor. Journal of Medicinal Chemistry 52(6): 1768-1772
Kormos, C.M.; Gichinga, M.G.; Maitra, R.; Runyon, S.P.; Thomas, J.B.; Brieaddy, L.E.; Mascarella, S.W.; Navarro, H.án.A.; Carroll, F.I. 2014: Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile. Journal of Medicinal Chemistry 57(17): 7367-7381
Reddy, M.V.R.; Mallireddigari, M.R.; Pallela, V.R.; Cosenza, S.C.; Billa, V.K.; Akula, B.; Subbaiah, D.R.C.V.; Bharathi, E.V.; Padgaonkar, A.; Lv, H.; Gallo, J.M.; Reddy, E.P. 2013: Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. Journal of Medicinal Chemistry 56(13): 5562-5586
Singh, S.; Prasad, N.R.; Kapoor, K.; Chufan, E.E.; Patel, B.A.; Ambudkar, S.V.; Talele, T.T. 2014: Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1). Chembiochem: a European Journal of Chemical Biology 15(1): 157-169
Ning, X.; Guo, Y.; Wang, X.; Ma, X.; Tian, C.; Shi, X.; Zhu, R.; Cheng, C.; Du, Y.; Ma, Z.; Zhang, Z.; Liu, J. 2014: Design, synthesis, and biological evaluation of (e)-3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents. Journal of Medicinal Chemistry 57(10): 4302-4312
Frotscher, M.; Ziegler, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Neugebauer, A.; Fetzer, L.; Scherer, C.; Müller-Vieira, U.; Messinger, J.; Thole, H.; Hartmann, R.W. 2008: Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. Journal of Medicinal Chemistry 51(7): 2158-2169
Yao, Y.; Liao, C.; Li, Z.; Wang, Z.; Sun, Q.; Liu, C.; Yang, Y.; Tu, Z.; Jiang, S. 2014: Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class i and IIb histone deacetylase inhibitors. European Journal of Medicinal Chemistry 86: 639-652
Liu, J.; Liu, Q.; Yang, X.; Xu, S.; Zhang, H.; Bai, R.; Yao, H.; Jiang, J.; Shen, M.; Wu, X.; Xu, J. 2013: Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates. Bioorganic and Medicinal Chemistry 21(24): 7742-7751
Meleddu, R.; Cannas, V.; Distinto, S.; Sarais, G.; Del Vecchio, C.; Esposito, F.; Bianco, G.; Corona, A.; Cottiglia, F.; Alcaro, S.; Parolin, C.; Artese, A.; Scalise, D.; Fresta, M.; Arridu, A.; Ortuso, F.; Maccioni, E.; Tramontano, E. 2014: Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase. Chemmedchem 9(8): 1869-1879
Duan, X.; Xin, H.; Yan, H. 2014: Design, synthesis, and biological evaluation of 1,4-diaryl-1,4-dihydropyrazines as novel 11β-HSD1 inhibitors. Biological and Pharmaceutical Bulletin 37(5): 840-846
Jiang, B.; Zeng, Y.; Li, M-Jie.; Xu, J-Yi.; Zhang, Y-Na.; Wang, Q-Juan.; Sun, N-Yue.; Lu, T.; Wu, X-Ming. 2010: Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors. Archiv der Pharmazie 343(9): 500-508
Reddy, M.V.Ramana.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.Premkumar. 2008: Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorganic and Medicinal Chemistry 16(7): 3907-3916
Wang, X.; Zhang, J.; Huang, Y.; Wang, R.; Zhang, L.; Qiao, K.; Li, L.; Liu, C.; Ouyang, Y.; Xu, W.; Zhang, Z.; Zhang, L.; Shao, Y.; Jiang, S.; Ma, L.; Liu, J. 2012: Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. Journal of Medicinal Chemistry 55(5): 2242-2250
Guillon, R.ém.; Pagniez, F.; Rambaud, C.; Picot, C.; Duflos, M.; Logé, C.éd.; Le Pape, P. 2011: Design, synthesis, and biological evaluation of 1-[(biarylmethyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as potent antifungal agents: new insights into structure-activity relationships. Chemmedchem 6(10): 1806-1815
La Pietra, V.; La Regina, G.; Coluccia, A.; Famiglini, V.; Pelliccia, S.; Plotkin, B.; Eldar-Finkelman, H.; Brancale, A.; Ballatore, C.; Crowe, A.; Brunden, K.R.; Marinelli, L.; Novellino, E.; Silvestri, R. 2013: Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors. Journal of Medicinal Chemistry 56(24): 10066-10078
Yuan, Y.; Zaidi, S.A.; Elbegdorj, O.; Aschenbach, L.C.K.; Li, G.; Stevens, D.L.; Scoggins, K.L.; Dewey, W.L.; Selley, D.E.; Zhang, Y. 2013: Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity. Journal of Medicinal Chemistry 56(22): 9156-9169
Cinelli, M.A.; Morrell, A.; Dexheimer, T.S.; Scher, E.S.; Pommier, Y.; Cushman, M. 2008: Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase i inhibitors. Journal of Medicinal Chemistry 51(15): 4609-4619
Mitchell, H.J.; Dankulich, W.P.; Hartman, G.D.; Prueksaritanont, T.; Schmidt, A.; Vogel, R.L.; Bai, C.; McElwee-Witmer, S.; Zhang, H.Z.; Chen, F.; Leu, C.-T.; Kimmel, D.B.; Ray, W.J.; Nantermet, P.; Gentile, M.A.; Duggan, M.E.; Meissner, R.S. 2009: Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs). Journal of Medicinal Chemistry 52(15): 4578-4581
Yuan, Y.; Elbegdorj, O.; Chen, J.; Akubathini, S.K.; Zhang, F.; Stevens, D.L.; Beletskaya, I.O.; Scoggins, K.L.; Zhang, Z.; Gerk, P.M.; Selley, D.E.; Akbarali, H.I.; Dewey, W.L.; Zhang, Y. 2012: Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents. Journal of Medicinal Chemistry 55(22): 10118-10129
Stolfa, D.A.; Stefanachi, A.; Gajer, J.M.; Nebbioso, A.; Altucci, L.; Cellamare, S.; Jung, M.; Carotti, A. 2012: Design, synthesis, and biological evaluation of 2-aminobenzanilide derivatives as potent and selective HDAC inhibitors. Chemmedchem 7(7): 1256-1266
Liu, Y.-X.; Zhang, P.-X.; Li, Y.-Q.; Song, H.-B.; Wang, Q.-M. 2014: Design, synthesis, and biological evaluation of 2-benzylpyrroles and 2-benzoylpyrroles based on structures of insecticidal chlorfenapyr and natural pyrrolomycins. Molecular Diversity 18(3): 593-598
Xu, S.; Xu, T.; Zhang, L.; Zhang, Z.; Luo, J.; Liu, Y.; Lu, X.; Tu, Z.; Ren, X.; Ding, K. 2013: Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties. Journal of Medicinal Chemistry 56(21): 8803-8813
Jung, J.-C.; Min, D.; Kim, H.; Jang, S.; Lee, Y.; Park, W.; Khan, I.A.; Moon, H.-I.; Jung, M.; Oh, S. 2010: Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents. Journal of Enzyme Inhibition and Medicinal Chemistry 25(1): 38-43
Ramnauth, J.; Speed, J.; Maddaford, S.P.; Dove, P.; Annedi, S.C.; Renton, P.; Rakhit, S.; Andrews, J.; Silverman, S.; Mladenova, G.; Zinghini, S.; Nair, S.; Catalano, C.; Lee, D.K.H.; De Felice, M.; Porreca, F. 2011: Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. Journal of Medicinal Chemistry 54(15): 5562-5575
Tomoo, T.; Nakatsuka, T.; Katayama, T.; Hayashi, Y.; Fujieda, Y.; Terakawa, M.; Nagahira, K. 2014: Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. Journal of Medicinal Chemistry 57(17): 7244-7262
Li, Y.; Shen, M.; Zhang, Z.; Luo, J.; Pan, X.; Lu, X.; Long, H.; Wen, D.; Zhang, F.; Leng, F.; Li, Y.; Tu, Z.; Ren, X.; Ding, K. 2012: Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant. Journal of Medicinal Chemistry 55(22): 10033-10046
Hughes, R.O.; Rogier, D.J.; Jacobsen, E.J.; Walker, J.K.; Macinnes, A.; Bond, B.R.; Zhang, L.L.; Yu, Y.; Zheng, Y.; Rumsey, J.M.; Walgren, J.L.; Curtiss, S.W.; Fobian, Y.M.; Heasley, S.E.; Cubbage, J.W.; Moon, J.B.; Brown, D.L.; Acker, B.A.; Maddux, T.M.; Tollefson, M.B.; Mischke, B.V.; Owen, D.R.; Freskos, J.N.; Molyneaux, J.M.; Benson, A.G.; Blevis-Bal, R.M. 2010: Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5). Journal of Medicinal Chemistry 53(6): 2656-2660
Yamamoto, S.; Kobayashi, H.; Kaku, T.; Aikawa, K.; Hara, T.; Yamaoka, M.; Kanzaki, N.; Hasuoka, A.; Baba, A.; Ito, M. 2013: Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists. Bioorganic and Medicinal Chemistry 21(1): 70-83
Zeng, W.; Miao, W.; Le Puil, M.; Shi, G.; Biggerstaff, J.; Kabalka, G.W.; Townsend, D. 2010: Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging. Biochemical and Biophysical Research Communications 398(3): 571-575
Tawari, N.R.; Bairwa, R.; Ray, M.K.; Rajan, M.G.R.; Degani, M.S. 2010: Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives as potent antitubercular agents. Bioorganic and Medicinal Chemistry Letters 20(21): 6175-6178
Yamamoto, S.; Tomita, N.; Suzuki, Y.; Suzaki, T.; Kaku, T.; Hara, T.; Yamaoka, M.; Kanzaki, N.; Hasuoka, A.; Baba, A.; Ito, M. 2012: Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists. Bioorganic and Medicinal Chemistry 20(7): 2338-2352
Yamamoto, S.; Matsunaga, N.; Hitaka, T.; Yamada, M.; Hara, T.; Miyazaki, J.; Santou, T.; Kusaka, M.; Yamaoka, M.; Kanzaki, N.; Furuya, S.; Tasaka, A.; Hamamura, K.; Ito, M. 2012: Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists. Bioorganic and Medicinal Chemistry 20(1): 422-434
Li, G.; Aschenbach, L.C.; Chen, J.; Cassidy, M.P.; Stevens, D.L.; Gabra, B.H.; Selley, D.E.; Dewey, W.L.; Westkaemper, R.B.; Zhang, Y. 2009: Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists. Journal of Medicinal Chemistry 52(5): 1416-1427
Smith, A.B.; Risatti, C.A.; Atasoylu, O.; Bennett, C.S.; Tendyke, K.; Xu, Q. 2010: Design, synthesis, and biological evaluation of EF- and ABEF- analogues of (+)-spongistatin 1. Organic Letters 12(8): 1792-1795
Crestey, F.ço.; Jensen, A.A.; Borch, M.; Andreasen, J.T.; Andersen, J.; Balle, T.; Kristensen, J.L. 2013: Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. Journal of Medicinal Chemistry 56(23): 9673-9682
Reddy, M.V.B.; Su, C.-R.; Chiou, W.-F.; Liu, Y.-N.; Chen, R.Y.-H.; Bastow, K.F.; Lee, K.-H.; Wu, T.-S. 2008: Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents. Bioorganic and Medicinal Chemistry 16(15): 7358-7370
Chen, W.; Seefeldt, T.; Young, A.; Zhang, X.; Guan, X. 2011: Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents. Bioorganic and Medicinal Chemistry 19(1): 287-294
Yu, W.; Gill, T.; Wang, L.; Du, Y.; Ye, H.; Qu, X.; Guo, J.-T.; Cuconati, A.; Zhao, K.; Block, T.M.; Xu, X.; Chang, J. 2012: Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. Journal of Medicinal Chemistry 55(13): 6061-6075
Liu, K.; Lu, H.; Hou, L.; Qi, Z.; Teixeira, C.át.; Barbault, F.; Fan, B.-T.; Liu, S.; Jiang, S.; Xie, L. 2008: Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41. Journal of Medicinal Chemistry 51(24): 7843-7854
Lv, P.-C.; Agama, K.; Marchand, C.; Pommier, Y.; Cushman, M. 2014: Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase i inhibitors. Journal of Medicinal Chemistry 57(10): 4324-4336
Sicinski, R.R.; Glebocka, A.; Plum, L.A.; DeLuca, H.F. 2007: Design, synthesis, and biological evaluation of a 1alpha,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation. Journal of Medicinal Chemistry 50(24): 6154-6164
Nicolaou, K.C.; Sanchini, S.; Sarlah, D.; Lu, G.; Wu, T.Robert.; Nomura, D.K.; Cravatt, B.F.; Cubitt, B.; de la Torre, J.C.; Hessell, A.J.; Burton, D.R. 2011: Design, synthesis, and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences of the United States of America 108(17): 6715-6720
Divsalar, A.; Saboury, A.A.; Mansoori-Torshizi, H.; Ahmad, F. 2010: Design, synthesis, and biological evaluation of a new palladium(II) complex: beta-lactoglobulin and K562 as targets. Journal of Physical Chemistry. B 114(10): 3639-3647
Rajasekar, M.; Khan, S.M.; Devaraj, S.N.; Das, T.M. 2011: Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines. Carbohydrate Research 346(13): 1776-1785
Hieke, M.; Ness, J.; Steri, R.; Dittrich, M.; Greiner, C.; Werz, O.; Baumann, K.; Schubert-Zsilavecz, M.; Weggen, S.; Zettl, H. 2010: Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. Journal of medicinal chemistry 53(12): 4691-4700
Zhang, R.; Wu, X.; Yalowich, J.C.; Hasinoff, B.B. 2011: Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents. Bioorganic and Medicinal Chemistry 19(23): 7023-7032
Hossion, A.M.L.; Otsuka, N.; Kandahary, R.K.; Tsuchiya, T.; Ogawa, W.; Iwado, A.; Zamami, Y.; Sasaki, K. 2010: Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. Bioorganic and Medicinal Chemistry Letters 20(17): 5349-5352
Van der Poll, D.G.; Kieler-Ferguson, H.M.; Floyd, W.C.; Guillaudeu, S.J.; Jerger, K.; Szoka, F.C.; Fréchet, J.M. 2010: Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer. Bioconjugate Chemistry 21(4): 764-773
Vaswani, R.G.; Limon, A.; Reyes-Ruiz, J.M.; Miledi, R.; Chamberlin, A.R. 2009: Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin. Bioorganic and Medicinal Chemistry Letters 19(1): 132-135
Billamboz, M.; Bailly, F.; Barreca, M.L.; De Luca, L.; Mouscadet, J.-F.ço.; Calmels, C.; Andréola, M.-L.; Witvrouw, M.; Christ, F.; Debyser, Z.; Cotelle, P. 2008: Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. Journal of Medicinal Chemistry 51(24): 7717-7730
Ye, N.; Chen, C.-H.; Chen, T.; Song, Z.; He, J.-X.; Huan, X.-J.; Song, S.-S.; Liu, Q.; Chen, Y.; Ding, J.; Xu, Y.; Miao, Z.-H.; Zhang, A. 2013: Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors. Journal of Medicinal Chemistry 56(7): 2885-2903
Kono, M.; Matsumoto, T.; Imaeda, T.; Kawamura, T.; Fujimoto, S.; Kosugi, Y.; Odani, T.; Shimizu, Y.; Matsui, H.; Shimojo, M.; Kori, M. 2014: Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorganic and Medicinal Chemistry 22(4): 1468-1478
McInnis, C.E.; Blackwell, H.E. 2011: Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorganic and Medicinal Chemistry 19(16): 4812-4819
Shen, Y.; Li, B.; Xu, H.; Zhang, G. 2013: Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. Die Pharmazie 68(5): 307-310
Vasiljevik, T.; Franks, L.N.; Ford, B.M.; Douglas, J.T.; Prather, P.L.; Fantegrossi, W.E.; Prisinzano, T.E. 2013: Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse. Journal of Medicinal Chemistry 56(11): 4537-4550
Watts, C.A.; Richards, F.M.; Bender, A.; Bond, P.J.; Korb, O.; Kern, O.; Riddick, M.; Owen, P.; Myers, R.M.; Raff, J.; Gergely, F.; Jodrell, D.I.; Ley, S.V. 2013: Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes. Chemistry and Biology 20(11): 1399-1410
Abd-Elgaliel, W.R.; Gallazzi, F.; Garrison, J.C.; Rold, T.L.; Sieckman, G.L.; Figueroa, S.D.; Hoffman, T.J.; Lever, S.Z. 2008: Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector. Bioconjugate Chemistry 19(10): 2040-2048
Tang, C.; Gu, G.; Wang, B.; Deng, X.; Zhu, X.; Qian, H.; Huang, W. 2014: Design, synthesis, and biological evaluation of andrographolide derivatives as potent hepatoprotective agents. Chemical Biology and Drug Design 83(3): 324-333
Burke, P.J.; Senter, P.D.; Meyer, D.W.; Miyamoto, J.B.; Anderson, M.; Toki, B.E.; Manikumar, G.; Wani, M.C.; Kroll, D.J.; Jeffrey, S.C. 2009: Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues. Bioconjugate Chemistry 20(6): 1242-1250
Wang, L.; Świtalska, M.; Wang, N.; Du, Z.-J.; Fukumoto, Y.; Diep, N.K.; Kiguchi, R.; Nokami, J.; Wietrzyk, J.; Inokuchi, T. 2014: Design, synthesis, and biological evaluation of artemisinin-indoloquinoline hybrids as potent antiproliferative agents. Molecules 19(11): 19021-19035
Matsuya, Y.; Kobayashi, Y.; Kawaguchi, T.; Hori, A.; Watanabe, Y.; Ishihara, K.; Ahmed, K.; Wei, Z.-L.; Yu, D.-Y.; Zhao, Q.-L.; Kondo, T.; Nemoto, H. 2009: Design, synthesis, and biological evaluation of artificial macrosphelides in the search for new apoptosis-inducing agents. Chemistry 15(23): 5799-5813
Qiao, Z.; Wang, W.; Wang, L.; Wen, D.; Zhao, Y.; Wang, Q.; Meng, Q.; Chen, G.; Wu, Y.; Zhou, H. 2011: Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorganic and Medicinal Chemistry Letters 21(21): 6389-6392
Abu Sheikha, G.; Abu Khalaf, R.; Melhem, A.; Albadawi, G. 2010: Design, synthesis, and biological evaluation of benzylamino-methanone based cholesteryl ester transfer protein inhibitors. Molecules 15(8): 5721-5733
Bridoux, A.; Khan, R.A.; Chen, C.; Chevé, G.ël.; Cui, H.; Dyskin, E.; Yasri, A.; Mousa, S.A. 2011: Design, synthesis, and biological evaluation of bifunctional thyrointegrin inhibitors: new anti-angiogenesis analogs. Journal of Enzyme Inhibition and Medicinal Chemistry 26(6): 871-882
Shimokawa, K.; Yamada, K.; Ohno, O.; Oba, Y.; Uemura, D. 2009: Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes. Bioorganic and Medicinal Chemistry Letters 19(1): 92-95
Agyin, J.K.; Santhamma, B.; Roy, S.S. 2013: Design, synthesis, and biological evaluation of bone-targeted proteasome inhibitors for multiple myeloma. Bioorganic and Medicinal Chemistry Letters 23(23): 6455-6458
Jiang, B.; Shi, D.; Cui, Y.; Guo, S. 2012: Design, synthesis, and biological evaluation of bromophenol derivatives as protein tyrosine phosphatase 1B inhibitors. Archiv der Pharmazie 345(6): 444-453
Shen, L.; Park, E-Jung.; Kondratyuk, T.P.; Guendisch, D.; Marler, L.; Pezzuto, J.M.; Wright, A.D.; Sun, D. 2011: Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorganic and Medicinal Chemistry 19(21): 6182-6195
Liu, G.; Ma, Y.-M.; Tai, W.-Y.; Xie, C.-M.; Li, Y.-L.; Li, J.; Nan, F.-J. 2008: Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues. Chemmedchem 3(1): 74-78
Singh, P.; Kumar, V.; Aggarwal, S.; Tiwari, A.K.; Chuttani, K.; Pratap, R.; Mishra, A.K. 2013: Design, synthesis, and biological evaluation of catecholamine vehicle for studying dopaminergic system. Chemical Biology and Drug Design 82(2): 226-232
Luo, Y.; Song, R.; Li, Y.; Zhang, S.; Liu, Z.-J.; Fu, J.; Zhu, H.-L. 2012: Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents. Bioorganic and Medicinal Chemistry Letters 22(9): 3039-3043
Dyrager, C.; Möllers, L.N.; Kjäll, L.K.; Alao, J.P.; Dinér, P.; Wallner, F.K.; Sunnerhagen, P.; Grøtli, M. 2011: Design, synthesis, and biological evaluation of chromone-based p38 MAP kinase inhibitors. Journal of Medicinal Chemistry 54(20): 7427-7431
Jiang, M.; Li, B.X.; Xie, F.; Delaney, F.; Xiao, X. 2012: Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcription. Journal of Medicinal Chemistry 55(8): 4020-4024
Duerfeldt, A.S.; Brandt, G.E.L.; Blagg, B.S.J. 2009: Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors. Organic Letters 11(11): 2353-2356
Wydysh, E.A.; Vadlamudi, A.; Medghalchi, S.M.; Townsend, C.A. 2010: Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors. Bioorganic and Medicinal Chemistry 18(17): 6470-6479
Pisani, L.; Catto, M.; Giangreco, I.; Leonetti, F.; Nicolotti, O.; Stefanachi, A.; Cellamare, S.; Carotti, A. 2010: Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. Chemmedchem 5(9): 1616-1630
Chen, S.-Y.; Chen, Y.; Li, Y.-P.; Chen, S.-H.; Tan, J.-H.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S. 2011: Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic and Medicinal Chemistry 19(18): 5596-5604
Yeo, H.L.; Song, Y.S.; Ryu, J.-H.; Kim, H.-D. 2013: Design, synthesis, and biological evaluation of cyclopropyl analogues of stilbene with raloxifene side chain as subtype-selective ligands for estrogen receptor. Archives of Pharmacal Research 36(9): 1096-1103
Xu, G.; Lv, B.; Roberge, J.Y.; Xu, B.; Du, J.; Dong, J.; Chen, Y.; Peng, K.; Zhang, L.; Tang, X.; Feng, Y.; Xu, M.; Fu, W.; Zhang, W.; Zhu, L.; Deng, Z.; Sheng, Z.; Welihinda, A.; Sun, X. 2014: Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 57(4): 1236-1251
Sallam, A.A.; Ramasahayam, S.; Meyer, S.A.; El Sayed, K.A. 2010: Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration. Bioorganic and Medicinal Chemistry 18(21): 7446-7457
Zhou, F.-W.; Lei, H.-S.; Fan, L.; Jiang, L.; Liu, J.; Peng, X.-M.; Xu, X.-R.; Chen, L.; Zhou, C.-H.; Zou, Y.-Y.; Liu, C.-P.; He, Z.-Q.; Yang, D.-C. 2014: Design, synthesis, and biological evaluation of dihydroartemisinin-fluoroquinolone conjugates as a novel type of potential antitubercular agents. Bioorganic and Medicinal Chemistry Letters 24(8): 1912-1917
Smith, A.B.; Risatti, C.A.; Atasoylu, O.; Bennett, C.S.; Liu, J.; Cheng, H.; TenDyke, K.; Xu, Q. 2011: Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned. Journal of the American Chemical Society 133(35): 14042-14053
Rountree, J.S.S.; Butters, T.D.; Wormald, M.R.; Boomkamp, S.D.; Dwek, R.A.; Asano, N.; Ikeda, K.; Evinson, E.L.; Nash, R.J.; Fleet, G.W.J. 2009: Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease. Chemmedchem 4(3): 378-392
Winkler, J.D.; Isaacs, A.é K.; Xiang, C.; Baubet, V.ér.; Dahmane, N. 2011: Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors. Tetrahedron 67(52): 10261-10266
Sugimoto, Y.; Konoki, K.; Murata, M.; Matsushita, M.; Kanazawa, H.; Oishi, T. 2009: Design, synthesis, and biological evaluation of fluorinated analogues of salicylihalamide. Journal of Medicinal Chemistry 52(3): 798-806
Cellamare, S.; Stefanachi, A.; Stolfa, D.A.; Basile, T.; Catto, M.; Campagna, F.; Sotelo, E.; Acquafredda, P.; Carotti, A. 2008: Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro. Bioorganic and Medicinal Chemistry 16(9): 4810-4822
Lavieri, R.R.; Scott, S.A.; Selvy, P.E.; Kim, K.; Jadhav, S.; Morrison, R.D.; Daniels, J.Scott.; Brown, H.Alex.; Lindsley, C.W. 2010: Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. Journal of Medicinal Chemistry 53(18): 6706-6719
Wang, C.; Shi, W.; Cai, L.; Lu, L.; Wang, Q.; Zhang, T.; Li, J.; Zhang, Z.; Wang, K.; Xu, L.; Jiang, X.; Jiang, S.; Liu, K. 2013: Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors. Journal of Medicinal Chemistry 56(6): 2527-2539
Amir, M.; Ali, I.; Hassan, M.Zaheen.; Mulakayala, N. 2014: Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents. Archiv der Pharmazie 347(12): 958-968
Paula, S.; Abell, J.; Deye, J.; Elam, C.; Lape, M.; Purnell, J.; Ratliff, R.; Sebastian, K.; Zultowsky, J.; Kempton, R.J. 2009: Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase. Bioorganic and Medicinal Chemistry 17(18): 6613-6619
Hu, C.; Li, X.; Wang, W.; Zhang, L.; Tao, L.; Dong, X.; Sheng, R.; Yang, B.; Hu, Y. 2011: Design, synthesis, and biological evaluation of imidazoline derivatives as p53-MDM2 binding inhibitors. Bioorganic and Medicinal Chemistry 19(18): 5454-5461
Stefanachi, A.; Favia, A.D.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.W.; Carotti, A. 2011: Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase. Journal of Medicinal Chemistry 54(6): 1613-1625
Conda-Sheridan, M.; Park, E-Jung.; Beck, D.E.; Reddy, P.V.Narasimha.; Nguyen, T.X.; Hu, B.; Chen, L.; White, J.J.; van Breemen, R.B.; Pezzuto, J.M.; Cushman, M. 2013: Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. Journal of Medicinal Chemistry 56(6): 2581-2605
Kondreddi, R.R.; Jiricek, J.; Rao, S.P.S.; Lakshminarayana, S.B.; Camacho, L.R.; Rao, R.; Herve, M.; Bifani, P.; Ma, N.L.; Kuhen, K.; Goh, A.; Chatterjee, A.K.; Dick, T.; Diagana, T.T.; Manjunatha, U.H.; Smith, P.W. 2013: Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents. Journal of Medicinal Chemistry 56(21): 8849-8859
Zarghi, A.; Ghodsi, R. 2010: Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors. Bioorganic and Medicinal Chemistry 18(16): 5855-5860
Müller, C.; Gomez-Zurita Frau, M.A.; Ballinari, D.; Colombo, S.; Bitto, A.; Martegani, E.; Airoldi, C.; van Neuren, A.S.; Stein, M.; Weiser, J.ör.; Battistini, C.; Peri, F. 2009: Design, synthesis, and biological evaluation of levoglucosenone-derived ras activation inhibitors. Chemmedchem 4(4): 524-528
Wu, J.; Yu, W.; Fu, L.; He, W.; Wang, Y.; Chai, B.; Song, C.; Chang, J. 2013: Design, synthesis, and biological evaluation of new 2'-deoxy-2'-fluoro-4'-triazole cytidine nucleosides as potent antiviral agents. European Journal of Medicinal Chemistry 63: 739-745
Russo, O.; Cachard-Chastel, M.; Rivière, C.él.; Giner, M.; Soulier, J.-L.; Berthouze, M.; Richard, T.; Monti, J.-P.; Sicsic, S.; Lezoualc'h, F.; Berque-Bestel, I. 2009: Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease. Journal of Medicinal Chemistry 52(8): 2214-2225
De, P.; Koumba Yoya, G.; Constant, P.; Bedos-Belval, F.; Duran, H.; Saffon, N.; Daffé, M.; Baltas, M. 2011: Design, synthesis, and biological evaluation of new cinnamic derivatives as antituberculosis agents. Journal of Medicinal Chemistry 54(5): 1449-1461
Mao, Y.; Lin, N.; Tian, W.; Han, X.; Han, X.; Huang, Z.; An, J. 2012: Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors. Journal of Medicinal Chemistry 55(3): 1346-1359
Antonini, I.; Volpini, R.; Dal Ben, D.; Lambertucci, C.; Cristalli, G. 2008: Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs. Bioorganic and Medicinal Chemistry 16(18): 8440-8446
Lucas, M.C.; Weikert, R.J.; Carter, D.S.; Cai, H.-Y.; Greenhouse, R.; Iyer, P.S.; Lin, C.J.; Lee, E.K.; Madera, A.M.; Moore, A.; Ozboya, K.; Schoenfeld, R.C.; Steiner, S.; Zhai, Y.; Lynch, S.M. 2010: Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain. Bioorganic and Medicinal Chemistry Letters 20(18): 5559-5566
Poutiainen, P.K.; Oravilahti, T.; Peräkylä, M.; Palvimo, J.J.; Ihalainen, J.A.; Laatikainen, R.; Pulkkinen, J.T. 2012: Design, synthesis, and biological evaluation of nonsteroidal cycloalkane[d]isoxazole-containing androgen receptor modulators. Journal of Medicinal Chemistry 55(14): 6316-6327
Minehira, D.; Takeda, D.; Urata, H.; Kato, A.; Adachi, I.; Wang, X.; Matsuya, Y.; Sugimoto, K.; Takemura, M.; Endo, S.; Matsunaga, T.; Hara, A.; Koseki, J.; Narukawa, K.; Hirono, S.; Toyooka, N. 2012: Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorganic and Medicinal Chemistry 20(1): 356-367
Chai, X.; Yu, S.; Jiang, Y.; Zou, Y.; Wu, Q.; Zhang, D.; Jiang, Y.; Cao, Y.; Sun, Q. 2012: Design, synthesis, and biological evaluation of novel 1, 2, 4-triazole derivatives as antifungal agent. Archives of Pharmacal Research 35(11): 1895-1901
Chen, Y.-T.; Tang, C.-L.; Ma, W.-P.; Gao, L.-X.; Wei, Y.; Zhang, W.; Li, J.-Y.; Li, J.; Nan, F.-J. 2013: Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy. European Journal of Medicinal Chemistry 69: 399-412
Tian, Y.; Rai, D.; Zhan, P.; Pannecouque, C.; Balzarini, J.; De Clercq, E.; Liu, H.; Liu, X. 2013: Design, synthesis, and biological evaluation of novel 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs. Chemical Biology and Drug Design 82(4): 384-393
Peifer, C.; Selig, R.; Kinkel, K.; Ott, D.; Totzke, F.; Schächtele, C.; Heidenreich, R.; Röcken, M.; Schollmeyer, D.; Laufer, S. 2008: Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors. Journal of Medicinal Chemistry 51(13): 3814-3824
Ding, L.; Tang, F.; Huang, W.; Jin, Q.; Shen, H.; Wei, P. 2013: Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors. Bioorganic and Medicinal Chemistry Letters 23(20): 5630-5633
Sun, L.; Geng, X.; Geney, Rël.; Li, Y.; Simmerling, C.; Li, Z.; Lauher, J.W.; Xia, S.; Horwitz, S.B.; Veith, J.M.; Pera, P.; Bernacki, R.J.; Ojima, I. 2008: Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids. Journal of Organic Chemistry 73(24): 9584-9593
Gogate, P.N.; Ethirajan, M.; Kurenova, E.V.; Magis, A.T.; Pandey, R.K.; Cance, W.G. 2014: Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction. European Journal of Medicinal Chemistry 80: 154-166
Chen, J.; Liu, T.; Wu, R.; Lou, J.; Cao, J.; Dong, X.; Yang, B.; He, Q.; Hu, Y. 2010: Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents. Bioorganic and Medicinal Chemistry 18(24): 8478-8484
Laufer, S.A.; Hauser, D.R.J.; Domeyer, D.M.; Kinkel, K.; Liedtke, A.J. 2008: Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. Journal of Medicinal Chemistry 51(14): 4122-4149