+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Detection of human papillomavirus in the upper respiratory tract in children without recurrent respiratory papillomatosis



Detection of human papillomavirus in the upper respiratory tract in children without recurrent respiratory papillomatosis



Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47(12): 974-977



The purpose of this prospective study was to investigate the presence of human papillomavirus (HPV) in tonsillectomy and adenoidectomy specimens from pediatric patients without juvenile-onset recurrent respiratory papillomatosis (JORRP), so as to understand the effect of HPV infection in the upper respiratory tract in children. Two hundred and forty-one pediatric patients without known JORRP or other HPV-related diseases undergoing tonsillectomy and/or adenoidectomy for hypertrophy or chronic tonsillitis were enrolled in this prospective study. One hundred and seventy-seven fresh samples of tonsillar tissues and 195 samples of adenoid tissues were collected and then examined for the presence of HPV DNA with the polymerase chain reaction (PCR) technique and typing. Laryngeal papilloma specimens from 17 patients obtained during routine debulking procedures were also analyzed and served as positive controls. All 17 papilloma specimens were positive for HPV DNA and the type was 6 or 11. This result confirmed that the methods used were valid for detecting HPV infection. HPV DNA was detected in 2 of the 177 tonsillar specimens and zero of the 195 adenoid specimens. The two positive samples were confirmed with typing. One was positive for HPV6 and the other for HPV11. Review of the medical records of these two cases confirmed that there were no history of HPV-related diseases. Histologic analysis of their specimens showed lymphoid hyperplasia, no specific changes suggesting HPV infection and no signs of malignancy. The HPV infection rate in upper respiratory tract was 0.8% (2/241). There is HPV infection in upper respiratory tract in Chinese children without JORRP, but maybe is not sufficient for the formation of JORRP.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052521074

Download citation: RISBibTeXText

PMID: 23328034


Related references

Detection of human papillomavirus infection in diseased and nondiseased sites of the respiratory tract in recurrent respiratory papillomatosis patients by DNA hybridization. Annals of Otology, Rhinology, and Laryngology 101(5): 408-412, 1992

Human papillomavirus infection in recurrent upper respiratory tract papillomatosis. Archiv fuer Geschwulstforschung 60(6): 429-434, 1990

Infection of the upper respiratory tract with human papilloma virus in children without clinical signs of respiratory papillomatosis. Vestnik Otorinolaringologii 2009(1): 16-19, 2009

Detection and cloning of human papillomavirus DNA associated with recurrent respiratory papillomatosis in Thailand. Japanese Journal Of Cancer Research. 85(7): 699-703, 1994

Human papillomavirus genotype detection in recurrent respiratory papillomatosis (RRP) in Colombia. Head and Neck 35(2): 229-234, 2013

Recurrent respiratory papillomatosis: an uncommon but potentially devastating effect of human papillomavirus in children. International Journal of Std and Aids 21(6): 381-385, 2010

Do human papillomavirus vaccines have any role in newborns and the prevention of recurrent respiratory papillomatosis in children?. Journal of Paediatrics and Child Health 43(9): 579-580, 2007

Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. International Journal of Pediatric Otorhinolaryngology 83: 94-98, 2016

Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. Archives of Otolaryngology--Head & Neck Surgery 119(5): 554-557, 1993

Antibody response to human papillomavirus (HPV) type 11 in children with juvenile-onset recurrent respiratory papillomatosis (RRP). Virology 188(1): 384-387, 1992

Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 132(7): 711-715, 2006

Microflora of the upper respiratory tract in young children under normal conditions and in respiratory tract diseases. Microbial count of the upper respiratory tract in healthy children and in children with pneumonia. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 1986(12): 24-31, 1986

Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. Head and Neck 37(11): 1625-1632, 2016

Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. Pediatric and Developmental Pathology 4(1): 68-72, 2001

Microflora of the upper respiratory tract in young children in health and in diseases of the respiratory organs the contamination of the upper respiratory tract in healthy children and in pneumonia patients. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii (12): 24-31, 1986