Section 53
Chapter 52,531

Determination of diosmin in pharmaceutical formulations using Fourier transform infrared spectrophotometry

Bunaciu, A.A.; Udristioiu, G.E.; Ruţă, L.L.; Fleschin, S.; Aboul-Enein, H.Y.

Saudi Pharmaceutical Journal Spj the Official Publication of the Saudi Pharmaceutical Society 17(4): 303-306


ISSN/ISBN: 1319-0164
PMID: 23960715
DOI: 10.1016/j.jsps.2009.10.008
Accession: 052530953

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A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of diosmin in different pharmaceutical drugs. Conventional KBr-spectra were compared for best determination of active substance in commercial preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.

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