+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Disintegrants combination: development and optimization of a cefadroxil fast disintegrating tablet

Disintegrants combination: development and optimization of a cefadroxil fast disintegrating tablet

Pakistan Journal of Pharmaceutical Sciences 27(5 Spec No): 1467-1475

Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and patient compliance. During the present study, cefadroxil fast disintegrating tablets formulations (n=9) were designed and optimized by central composite design with two independent variables (croscarmellose and crospovidone) using design expert® software. The effects of independent variables on formulation properties such as friability, hardness, in vitro dispersion and disintegration were assessed by drawing response surface graphs with design expert® software. Tablets were assessed for pharmacopeial and non-pharmacopeial parameters to ensure the quality of compressed tablets. Among all formulations, F3, F8 and F9 have shown better results. The formulation F9 containing 15mg croscarmellose and 33.075mg crospovidone showed good pharmacotechnical attributes as well as shelf life. F 9 showed improved dissolution with t90% of> 2 min and will lead to better bioavailability.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 052652053

Download citation: RISBibTeXText

PMID: 25176230

Related references

Fast Disintegrating Combination Tablet of Taste Masked Levocetrizine Dihydrochloride and Montelukast Sodium: Formulation Design, Development, and Characterization. Journal of Pharmaceutics 2014: 568320, 2014

Preparation and Optimization of Fast-Disintegrating Tablet Containing Naratriptan Hydrochloride Using D-Optimal Mixture Design. Aaps Pharmscitech 19(6): 2472-2487, 2018

Evaluation of coprocessed disintegrants produced from tapioca starch and mannitol in orally disintegrating paracetamol tablet. Acta Poloniae Pharmaceutica 71(5): 803-811, 2014

Formulation study for lansoprazole fast-disintegrating tablet. III. Design of rapidly disintegrating tablets. Chemical and Pharmaceutical Bulletin 51(10): 1121-1127, 2003

Design, development and in vitro-in vivo study of a colon-specific fast disintegrating tablet. Pharmaceutical Development and Technology 16(5): 449-456, 2011

Fast-disintegrating sublingual epinephrine tablets: effect of tablet dimensions on tablet characteristics. Drug Development and Industrial Pharmacy 33(5): 523-530, 2007

Development and optimization of a meloxicam/β-cyclodextrin complex for orally disintegrating tablet using statistical analysis. Pharmaceutical Development and Technology 23(5): 464-475, 2018

A randomized two-way crossover bioequivalence study in healthy adult volunteers of paediatric zidovudine/lamivudine/nevirapine fast-disintegrating fixed-dose combination tablet. Journal of Pharmacy and Pharmacology 69(4): 463-470, 2017

RP-HPLC analytical method development and optimization for quantification of donepezil hydrochloride in orally disintegrating tablet. Pakistan Journal of Pharmaceutical Sciences 26(5): 961-966, 2013

Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics. Journal of Pharmaceutics 2014: 808167, 2014

Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics. Aaps Pharmscitech 18(5): 1624-1633, 2017

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets. Journal of Drug Delivery 2014: 827035, 2014

An integrated, quality by design (QbD) approach for design, development and optimization of orally disintegrating tablet formulation of carbamazepine. Pharmaceutical Development and Technology 22(7): 889-903, 2017

Formulation design of a novel fast-disintegrating tablet. International Journal of Pharmaceutics 306(1-2): 83-90, 2005

A novel fast disintegrating tablet fabricated by three-dimensional printing. Drug Development and Industrial Pharmacy 35(12): 1530-1536, 2009