+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Domain formation in the plasma membrane: roles of nonequilibrium lipid transport and membrane proteins



Domain formation in the plasma membrane: roles of nonequilibrium lipid transport and membrane proteins



Physical Review Letters 100(17): 178102



Compositional lipid domains ("lipid rafts") in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.

(PDF emailed within 0-6 h: $19.90)

Accession: 052697737

Download citation: RISBibTeXText

PMID: 18518341

DOI: 10.1103/PhysRevLett.100.178102


Related references

Influence of nonequilibrium lipid transport, membrane compartmentalization, and membrane proteins on the lateral organization of the plasma membrane. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 81(1 Pt 1): 011908, 2010

Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. Biochemical & Biophysical Research Communications 308(2): 270-275, August 22, 2003

Isolation and characterization of hydrophobic proteins h proteins in the membrane fraction of bacillus subtilis involvement in membrane biosynthesis and the formation of biochemically active membrane vesicles by combining h proteins with lipid. European Journal of Biochemistry 71(2): 451-458, 1976

Cytoplasmic domains of cellular and viral integral membrane proteins substitute for the cytoplasmic domain of the vesicular stomatitis virus glycoprotein in transport to the plasma membrane. Journal of Cell Biology 102(6): 2147-2157, 1986

Lipid domain structure of the plasma membrane revealed by patching of membrane components. Journal Of Cell Biology. 141(4): 929-942, 18, 1998

Interaction of membrane skeletal proteins with membrane lipid domain. Acta Biochimica Polonica 47(3): 565-578, 2001

Membrane domain formation by calcium-dependent, lipid-binding proteins: insights from the C2 motif. Biochimica et Biophysica Acta 1448(2): 227-235, 1999

Membrane domain formation by calcium-dependent, lipid-binding proteins: Insights from the C2 motif. Biochimica et Biophysica Acta 1448(2): 227-235, Dec 10, 1998

Determination of the dissociation constants for Ca2+ and calmodulin from the plasma membrane Ca2+ pump by a lipid probe that senses membrane domain changes. Journal of Biological Chemistry 285(1): 123-130, 2010

Characterization of (Ca2+ + Mg2+) adenosine triphosphatase activity and calcium transport in boar sperm plasma membrane vesicles and their relation to phosphorylation of plasma membrane proteins. Biology of Reproduction 31(5): 1061-1071, 1984

The plasma membrane calcium ATPase isoform 2B binds to membrane cytosekeleton-associated PDZ domain proteins. Society for Neuroscience Abstracts 24(1-2): 1801, 1998

Hepatocyte plasma membrane lipid fluidity a regulator of membrane transport. Gut 25(10): A1176, 1984

The lateral transport of surface proteins and a lipid probe on the plasma membrane of a cultured myo blast. Journal of Cell Biology 70(2 PT 2): 137A, 1976

Involvement of microtubules in the transport of bile canalicular proteins from the basolateral bl to the apical ap plasma membrane pm domain in rat hepatocytes. Journal of Cell Biology 107(6 PART 3): 447A, 1988

Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane. Physiology 22: 7-14, 2007