+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex

Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex

Neuroscience 183: 108-120

Chronic stress causes neuronal adaptation and maladaptation in the widespread brain regions including the prefrontal cortex (PFC) and limbic structures, resulting in cognitive and affective dysfunctions. In this study, we examined the impacts of chronic stress on functional interaction between the medial PFC and limbic structures in rats. In vivo electrophysiological recordings in rats exposed to chronic stress unveiled disturbance of correlated local field potential activity between the PFC and limbic structures as well as impairment of synaptic plasticity induction in the limbic-PFC pathways. However, these stress-induced alterations in limbic-PFC interaction were distinct along with the dorsal-ventral axis within the PFC, with greater stress vulnerability in the dorsal than the ventral PFC, such that alterations in the dorsal PFC became evident with much shorter duration of repeated stress exposure than those occurring in the ventral PFC. In agreement with the stress-induced alterations in limbic-PFC interaction, spike firing patterns of neurons in the dorsal and ventral PFC were also differently modulated by chronic stress. These results suggest that chronic stress produces heterogeneous cellular and neural network adaptation and maladaptation within the PFC that affect limbic information integration mechanisms.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052703023

Download citation: RISBibTeXText

PMID: 21440605

DOI: 10.1016/j.neuroscience.2011.03.039

Related references

Stress - induced alterations in medial prefrontal cortex and dorsal hippocampus of prenatal protein malnourished rats a dual - probe microdialysis study. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 713 12, 2003

Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. European Journal of Neuroscience 30(6): 1111-1116, 2009

Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. Journal of Neuroscience 26(51): 13264-13272, 2006

Disrupted MEK/ERK signaling in the medial orbital cortex and dorsal endopiriform nuclei of the prefrontal cortex in a chronic restraint stress mouse model of depression. Neuroscience Letters 580: 163-168, 2015

The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neuroscience and Biobehavioral Reviews 27(6): 555-579, 2003

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery. Neuroscience 164(2): 798-808, 2010

Functional dissociation between dorsal and ventral regions of the medial prefrontal cortex in rats. Psychobiology 28(2): 248-260, 2000

Lesions to the ventral, but not the dorsal, medial prefrontal cortex enhance latent inhibition. European Journal of Neuroscience 31(8): 1474-1482, 2010

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence. Experimental Neurology 269: 1-7, 2015

Stress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats. Brain Research 1148: 226-233, 2007

Electrophysiological evidence that the mediodorsal nucleus of the thalamus is a relay between the ventral pallidum and the medial prefrontal cortex in the rat. Brain Research 344(2): 329-337, 1985

Neuron number decreases in the rat ventral, but not dorsal, medial prefrontal cortex between adolescence and adulthood. Neuroscience 144(3): 961-968, 2006

Differential contributions of ventral and dorsal areas of medial prefrontal cortex to fear conditioning. Society for Neuroscience Abstracts 19(1-3): 1227, 1993

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations. Frontiers in Systems Neuroscience 8: 160, 2014

Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest. Cerebral Cortex 21(7): 1667-1673, 2012