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Duplicity of protein kinase C-θ: Novel insights into human T-cell biology

Duplicity of protein kinase C-θ: Novel insights into human T-cell biology

Transcription 2(4): 189-192

ISSN/ISBN: 2154-1264

PMID: 21922062

DOI: 10.4161/trns.2.4.16565

We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design.

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Accession: 052730253

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