+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

E2F5 as an independent prognostic factor in esophageal squamous cell carcinoma



E2F5 as an independent prognostic factor in esophageal squamous cell carcinoma



Anticancer Research 33(12): 5415-5420



E2F Transcription Factor 5 Protein (E2F5) is considered to act primarily as a transcriptional repressor in the cell cycle. However, its expression and role in esophageal squamous cell carcinoma (ESCC) have not been investigated. We examined whether the expression of E2F5 is related to the clinicopathological features and prognosis of patients with ESCC. The expression of E2F5 was analyzed by immunohistochemistry in 64 primary tumor samples obtained from patients with ESCC who had undergone curative esophagectomy between 1998 and 2009. According to the expression of E2F5 in tumor cells, cases were divided into E2F5-positive (27 cases) and -negative groups (37 cases). The relationship of various clinicopathological features and prognosis with the E2F5 status, were analyzed. In the clinicopathological analysis, the proportion of poorly-differentiated tumors was significantly higher in the E2F5-positive group than in the E2F5-negative group (p=0.027). The 5-year survival rate of the E2F5-positive group was 39.3%, which was significantly poorer than that of the E2F5-negative group (83.8%) (p=0.006). In multivariate analysis, the expression of E2F5 was one of the most important independent prognostic factors after radical esophagectomy. The expression of E2F5 in ESCC may be correlated with a worse prognosis of patients with ESCC.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052745185

Download citation: RISBibTeXText

PMID: 24324077


Related references

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma. Oncotarget 8(26): 43397-43405, 2017

Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology 143(2): 243-254, 2017

XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma. Annals of Surgical Oncology 20(9): 3140-3150, 2013

CD51 is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Pathology Research and Practice 214(9): 1352-1355, 2018

Monocarboxylate transporter 1 is an independent prognostic factor in esophageal squamous cell carcinoma. Oncology Reports 41(4): 2529-2539, 2019

The modified glasgow prognostic score is an independent prognostic factor in patients with inoperable thoracic esophageal squamous cell carcinoma undergoing chemoradiotherapy. Journal of Cancer 5(8): 689-695, 2014

Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma. World Journal of Surgical Oncology 11: 278, 2013

The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma. Biomed Research International 2014: 936401, 2014

Ki-67 labeling index as an independent prognostic factor in human esophageal squamous cell carcinoma. Esophagus 9(4): 195-202, 2012

C-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target. Bmc Cancer 15: 451, 2015

Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma. Plos one 11(4): E0153100, 2016

PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Research 65(11): 4963-4968, 2005

Anti-phosphohistone H3 as an independent prognostic factor in human esophageal squamous cell carcinoma. Anticancer Research 33(2): 461-467, 2013

Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma. Journal of Cancer 6(10): 922-929, 2015

Endoscopic tumor length is an independent prognostic factor in esophageal squamous cell carcinoma. Annals of Surgical Oncology 19(7): 2149-2158, 2012