+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Early post-transplant immune monitoring can predict long-term kidney graft survival: soluble CD30 levels, anti-HLA antibodies and IgA-anti-Fab autoantibodies



Early post-transplant immune monitoring can predict long-term kidney graft survival: soluble CD30 levels, anti-HLA antibodies and IgA-anti-Fab autoantibodies



Human Immunology 75(1): 47-58



This study aimed to investigate the predictive power of anti-HLA antibodies, sCD30 levels and IgA-anti-Fab autoantibody before and early after transplantation in relation to long-term kidney allograft survival. Pre- and post-transplant sera samples of 59 living-unrelated donor kidney recipients were tested for above risk factors by enzyme-linked immunoabsorbent assay. 15 out of 59 cases experienced rejection episodes (failure group). Pre- and post-transplant high sCD30 levels were significantly associated with graft failure (P=0.02 and P=0.004) and decreased 4 year graft survival (P = 0.009 and P = 0.001). Higher frequency of post-transplant HLA class-II antibody in the absence of class-I antibody was observed in failure group (P=0.007). Patients with post-transplant HLA class-I and class-II antibodies either alone or in combination showed significant lower 4 year graft survival. Recipients with high sCD30 levels in the presence of HLA class-I or class-II antibodies within 2 weeks post-transplant had poor graft survival (P = 0.004 and P = 0.002, respectively). High levels of post-transplant IgA-anti-Fab antibody was more frequent in functioning-graft patients (P = 0.00001), correlated with decreased serum creatinine levels (P = 0.01) and associated with improved graft survival (P = 0.008). Our findings indicate the deleterious effect of early post-transplant HLA antibodies and increased sCD30 levels dependently and protective effect of IgA-anti-Fab antibodies on long-term renal graft outcomes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052761971

Download citation: RISBibTeXText

PMID: 24055694

DOI: 10.1016/j.humimm.2013.09.010


Related references

Post-transplant HLA class II antibodies and high soluble CD30 levels are independently associated with poor kidney graft survival. American Journal of Transplantation 7(4): 847-856, 2007

Pre- and Posttransplant IgA Anti-Fab Antibodies to Predict Long-term Kidney Graft Survival. Transplantation Proceedings 47(4): 1110-1113, 2015

Anti-HLA and anti-MICA antibodies in liver transplant recipients: effect on long-term graft survival. Clinical and Developmental Immunology 2013: 828201, 2013

Association between long-term kidney graft survival and the presence of pre-transplant cytotoxic anti-HLA and/or non-MHC 'Fc gamma RII blocking' (anti-TLX) alloantibody. Clinical Transplantation 10(5): 455-460, 1996

Post-transplant levels of neopterin predict long-term graft survival. Journal of the American Society of Nephrology 14(Abstracts Issue): 664A, 2003

The impact of anti hla antibodies anti idiotypic antibodies and hla antigen anti hla antibody immune complexes on long term survival of renal allografts. Human Immunology (ABSTR ED): 11, 1990

Influence of pre-transplant serum level of soluble CD30 on the long-term survival rates of kidney transplant recipients and grafts. Zhonghua Yi Xue Za Zhi 85(22): 1560-1563, 2005

High regulatory T-cell levels at 1 year posttransplantation predict long-term graft survival among kidney transplant recipients. Transplantation Proceedings 44(9): 2538-2541, 2012

Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation. Transplant Immunology 32(2): 61-65, 2015

Relative reductions in soluble CD30 levels post-transplant predict acute graft function in islet allograft recipients receiving three different immunosuppression protocols. Transplant Immunology 23(4): 209-214, 2010

Association between long term kidney graft survival and the presence of pre transplant cytotoxic anti-HLA and/or non-MHC Fc-GAMMA-RII blocking alloantibody. Human Immunology 47(1-2): 134, 1996

Prediction of long-term kidney transplant survival rates by monitoring early graft function and clinical grades. Transplantation 25(4): 212-215, 1978

Higher calcineurin inhibitor levels predict better kidney graft survival in patients with de novo donor-specific anti-HLA antibodies: a cohort study. Transplant International 30(5): 502-509, 2017

Absence of C4d urinary excretion in the early post-transplant period is associated with improved long-term kidney graft survival. Transplant Immunology 30(1): 7, 2014

An adjustable predictive score of graft survival in kidney transplant patients and the levels of risk linked to de novo donor-specific anti-HLA antibodies. Plos one 12(7): E0180236, 2017