+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial



Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial



Surgical Infections 8(4): 445-454



Current guidelines recommend using antiseptic- or antibiotic-impregnated central venous catheters (CVCs) if, following a comprehensive strategy to prevent catheter-related blood stream infection (CR-BSI), infection rates remain above institutional goals based on benchmark values. The purpose of this study was to determine if chlorhexidine/silver sulfadiazine-impregnated CVCs could decrease the CR-BSI rate in an intensive care unit (ICU) with a low baseline infection rate. Pre-intervention and post-intervention observational study in a 24-bed surgical/trauma/burn ICU from October, 2002 to August, 2005. All patients requiring CVC placement after March, 2004 had a chlorhexidine/silver sulfadiazine-impregnated catheter inserted (post-intervention period). Twenty-three CR-BSIs occurred in 6,960 catheter days (3.3 per 1,000 catheter days)during the 17-month control period. After introduction of chlorhexidine/silver sulfadiazine-impregnated catheters, 16 CR-BSIs occurred in 7,732 catheter days (2.1 per 1,000 catheter days; p = 0.16). The average length of time required for an infection to become established after catheterization was similar in the two groups (8.4 vs. 8.6 days; p = 0.85). Chlorhexidine/silver sulfadiazine-impregnated catheters did not result in a statistically significant change in the microbiological profile of CR-BSIs, nor did they increase the incidence of resistant organisms. Although chlorhexidine/silver sulfadiazine-impregnated catheters are useful in specific patient populations, they did not result in a statistically significant decrease in the CR-BSI rate in this study, beyond what was achieved with education alone.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052798918

Download citation: RISBibTeXText

PMID: 17883361

DOI: 10.1089/sur.2006.073


Related references

Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial. Journal of the American College of Surgeons 221(3): 739-747, 2015

Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study. Journal of Hospital Infection 72(3): 227-233, 2009

Evaluation of chlorhexidine and silver-sulfadiazine impregnated central venous catheters for the prevention of bloodstream infection in leukaemic patients: a randomized controlled trial. Journal of Hospital Infection 37(2): 145-156, 1997

Inhibitory effect of explanted chlorhexidine-silver sulfadiazine impregnated central venous catheters on Staphylococcus epidermidis. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 40: 422, 2000

Reduction of central venous catheter-related infection in cancer patients with severe neutropenia A prospective controlled randomized trial using a chlorhexidine and silver-sulfadiazine impregnated central venous line. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 447, 2001

Effectiveness of Minocycline/Rifampin vs Chlorhexidine/Silver Sulfadiazine-Impregnated Central Venous Catheters. Journal of the American College of Surgeons 221(4): 891-892, 2015

Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria. Journal of Clinical Microbiology 34(10): 2640-2641, 1996

Comparison of triple-lumen central venous catheters impregnated with silver nanoparticles (AgTive®) vs conventional catheters in intensive care unit patients. Journal of Hospital Infection 82(2): 101-107, 2012

Effect of chlorhexidine/silver sulfadiazine coating on microbial colonization of central venous catheters in a multicenter trial. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 439, 2001

Chlorhexidine-silver sulfadiazine-impregnated central venous catheters: in vitro antibacterial activity and impact on bacterial adhesion. New Microbiologica 35(2): 175-182, 2012

Comparison of Oligon catheters and chlorhexidine-impregnated sponges with standard multilumen central venous catheters for prevention of associated colonization and infections in intensive care unit patients: a multicenter, randomized, controlled study. Critical Care Medicine 40(2): 420-429, 2012

Chlorhexidine-silver sulfadiazine- or rifampicin-miconazole-impregnated venous catheters decrease the risk of catheter-related bloodstream infection similarly. American Journal of Infection Control 44(1): 50-53, 2016

The effectiveness of chlorhexidine-silver sulfadiazine impregnated central venous catheters in patients receiving high-dose chemotherapy followed by peripheral stem cell transplantation. European Journal of Cancer Care 18(5): 477-482, 2009

Chlorhexidine-silver sulfadiazine-impregnated venous catheters save costs. American Journal of Infection Control 42(3): 321-324, 2014

Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trial. Annals of Internal Medicine 143(8): 570-580, 2005