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Effect of exercise training on pulmonary oxygen uptake kinetics in heart transplant recipients



Effect of exercise training on pulmonary oxygen uptake kinetics in heart transplant recipients



American Journal of Cardiology 112(9): 1489-1492



Pulmonary oxygen uptake (V˙O2p) at exercise onset is severely delayed in heart transplant recipients (HTRs). The role of exercise training to improve V˙O2p kinetics in HTRs has not been studied. We examined V˙O2p kinetics before and after 12 weeks of aerobic and strength training (HTR-T; n = 19, mean ± SD age: 57 ± 10 years) or usual care (HTR-UC; n = 16, mean age: 58 ± 12 years). Phase II V˙O2p kinetics, reflecting the rate of muscle metabolic adaptation, improved 37% after training compared with usual care (HTR-UC, 15 ± 19 vs 2 ± 13 seconds improvement, p = 0.02). The change in rest to steady-state heart rate reserve before and after 12 weeks was not different in HTR-T (-2 ± 9 beats/min) and HTR-UC (-1 ± 7 beats/min; p = 0.78). No significant relation was found between the change in V˙O2p kinetics and rest to steady-state heart rate reserve. Changes in leg lean tissue mass and V˙O2p kinetics were significantly related (r = -0.46, p = 0.008). In conclusion, a favorable adaptation in skeletal muscle oxidative function may underpin our finding of faster V˙O2p kinetics in HTRs after exercise training.

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Accession: 052806332

Download citation: RISBibTeXText

PMID: 23992956

DOI: 10.1016/j.amjcard.2013.06.037


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