Effect of heart tablets on cardiac hemodynamics and myocardial oxygen consumption in anesthetized dogs
Cai, G.; Wang, Y.
Zhongguo Zhong Yao Za Zhi 35(18): 2480-2487
ISSN/ISBN: 1001-5302 PMID: 21141505 Accession: 052809664
To observe the pharmacological effects of Heart tablets on cardiac function and its mechanism, the effects on cardiac hemodynamics and myocardial oxygen consumption in anesthetized dogs were observed. Observe the effect of Heart tablets on coronary blood flow, cardiac output, myocardial oxygen consumption and other indicators in normal anesthetized dogs. The Heart tablets can increase femoral arterial blood pressure, while no effect is found on the heart rate, standard II ECG PR interval, QRS interval, QT interval, T wave and other parameters. The tablets can expand coronary artery and peripheral vessel, increase coronary blood flow, lower coronary resistance and increase cardiac blood supply capacity, improve left ventricular function, ameliorate cardiovascular adaptability, increase dp/dt(max), enhance myocardial activity and have a positive regulatory role in heart. At the meantime raise the cardiac output and stroke volume were raised, so that blood pressure can be increased, while the total peripheral resistance was decreased. The coronary vein sinus oxygen content were significantly increased and myocardial oxygen consumption index and myocardial oxygen utilization were reduced. The tablets can adjust and improve the cardiovascular system.