+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of high-dose paracetamol on needle procedures in children with cancer--an RCT



Effect of high-dose paracetamol on needle procedures in children with cancer--an RCT



Acta Paediatrica 103(3): 314-319



The aim was to investigate whether children experience less pain, fear and/or distress when they receive high-dose paracetamol compared with placebo, using a needle insertion in a subcutaneously implanted intravenous port as a model. Fifty-one children ranging from 1 to 18 years of age being treated in a paediatric oncology setting were included consecutively when undergoing routine needle insertion into a subcutaneously implanted intravenous port. All children were subjected to one needle insertion following topical anaesthetic (EMLA) application in this double-blind, placebo-controlled RCT, comparing orally administered paracetamol (n = 24) 40 mg/kg body weight (max 2000 mg) with placebo (n = 27). The patients' pain, fear and distress were reported by parents, nurses and children (≥7 years of age) using 0- to 100-mm visual analogue scales (VAS). In addition, pain observation, procedure time and cortisol reduction were assessed. No differences between the paracetamol and the placebo group were found with respect to demographic characteristics. According to VAS reports, paracetamol did not reduce pain, fear and distress compared with placebo. Pain observation, cortisol reduction and procedure time did not differ between the study groups. Paracetamol provides no additive effect in reducing pain, fear and distress when combined with topical anaesthesia in children undergoing port needle insertion.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 052810271

Download citation: RISBibTeXText

PMID: 24219618

DOI: 10.1111/apa.12509


Related references

Low-dose oral midazolam reduces fear and distress during needle procedures in children with cancer. Pediatric Blood and Cancer 53(7): 1200-1204, 2009

Effect of morphine in needle procedures in children with cancer. European Journal of Pain 15(10): 1056-1060, 2011

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °C or above. International Journal of Stroke 10(3): 457-462, 2015

Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study. Bmc Clinical Pharmacology 12: 11, 2012

Randomized interventions for needle procedures in children with cancer. European Journal of Cancer Care 18(4): 358-363, 2009

The pharmacokinetics of a high intravenous dose of paracetamol after caesarean delivery: the effect of gestational age. European Journal of Anaesthesiology 29(10): 484-488, 2012

Glutathione, glutathione-dependent enzymes and antioxidant status in erythrocytes from children treated with high-dose paracetamol. British Journal of Clinical Pharmacology 55(3): 234-240, 2003

Effect of high-dose cyclophosphamide plus high-dose etoposide in malignant brain tumors of children followed by autologous bone marrow rescue. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(2): 263-268, 1989

Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. Journal of Clinical Oncology 22(13): 2691-2700, 2004

N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology 30(3): 263-275, 2016

Pharmacology and phase I trial of high-dose oral leucovorin plus 5-fluorouracil in children with refractory cancer: a report from the Children's Cancer Study Group. Cancer Research 51(18): 4871-4875, 1991

Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial. Journal of Pain and Symptom Management 39(3): 548-554, 2010

The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay. Journal of Pharmaceutical and Biomedical Analysis 34(3): 585-593, 2004

An evaluation of implant needle motion with high-dose-rate brachtherapy for prostate cancer. BrachyTherapy 8(2): 167-168, 2009

Needle applicator displacement during high-dose-rate interstitial brachytherapy for prostate cancer. BrachyTherapy 9(1): 36-41, 2010