+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls



Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls



Pakistan Journal of Biological Sciences 10(2): 255-260



The aim of this study was to determine whether iron supplementation in iron-deficient adolescent girls would improve thyroid function. A double-blind clinical trial was performed in a region in southern I.R. Iran. A total of 103 iron deficient participants were chosen. In all, 94 participants successfully completed this study. Participants were randomly assigned to one of two groups and treated with a 300 mg ferrous sulfate 5 times/week (n = 47) and placebo 5 times/week (n = 47) for 12 weeks. Blood samples were collected and assayed for hemoglobin, hematocrit, serum ferritin, iron, total iron binding capacity (TIBC), Thyroid stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), free thyroid hormones (FT4 and FT3), triiodothyronine resin uptake (T3RU), reverse triiodothyronine (rT3), selenium and albumin concentrations. Statistical analysis was performed with parametric and non-parametric methods as appropriate. Data analysis revealed a significant increase in TT4, TT3, T3RU and a significant decrease in rT3 concentration in comparison to initial values in iron treated group (12%, p<0.001; 3.5%, p<0.001; 16%, p<0.05 and 47%, p<0.001, respectively). At 12 week there were significant differences between control and placebo in TT4, TT3, T3RU and rT3 concentrations (9.9 vs 8.4 microg dL(-1), 145.2 vs 130.4 microg dL(-1), 32.5 vs 28.4% and 23 vs 41 microg dL(-1), respectively, all p<0.001). Alterations in FT3 and TSH concentration were not significant, but concentration of FT4 revealed a significant difference between the beginning and the end of the study in iron treated group (10.3 vs 11.4, p<0.001). Iron supplementation improves some indices of thyroid function in iron-deficient adolescent girls.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 052813658

Download citation: RISBibTeXText

PMID: 19070025


Related references

Effects of administration of iron, iodine and simultaneous iron-plus-iodine on the thyroid hormone profile in iron-deficient adolescent Iranian girls. European journal of clinical nutrition 60(4): 545-552, 2006

The relationship between iron status and thyroid hormone concentration in iron-deficient adolescent Iranian girls. Asia Pacific Journal of Clinical Nutrition 15(1): 50-55, 2006

The relationship between BMI and iron status in iron-deficient adolescent Iranian girls. Public Health Nutrition 12(12): 2377-2381, 2010

Effects of iron repletion and correction of anemia on norepinephrine turnover and thyroid metabolism in iron deficiency. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 193(4): 306-312, 1990

Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers. Journal of Pediatric Gastroenterology and Nutrition 63(3): 379-385, 2016

Increased intestinal iron absorption in rats with normal hepatic iron stores. Kinetic aspects of the adaptative response to parenteral iron repletion in dietary iron deficiency. Biochimica et Biophysica Acta 1033(3): 277-281, 1990

The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls. Recent Advances in Dna and Gene Sequences 9(1): 58-64, 2015

Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. Journal of Nutrition 127(10): 2030-2038, 1997

Effects of developmental iron deficiency and post-weaning iron repletion on the levels of iron transporter proteins in rats. Nutrition Research and Practice 9(6): 613-618, 2015

Different degrees of dietary iron repletion on the hepatic iron activities and regulatory proteins in iron deficiency anemic rats. Nutritional Sciences Journal 25(1): 17-28, 2000

Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet 348(9033): 992-996, 1996

A method to estimate prevalence of iron deficiency and iron deficiency anemia in adolescent Jamaican girls. American Journal of Clinical Nutrition 65(3): 831-836, 1997

Decreased antibody formation in iron-deficient rat pups--effect of iron repletion. American Journal of Clinical Nutrition 41(2): 278-284, 1985

Cellular growth in iron-deficient rats: effect of pre- and postweaning iron repletion. Journal of Nutrition 115(2): 279-287, 1985

The effect of iron repletion on exercise induced lactate production in minimally iron deficient subjects. Clinical Research 29(2): 452A, 1981