EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of neoadjuvant chemoradiation and postoperative radiotherapy on expression of heat shock protein 70 (HSP70) in head and neck vessels


, : Effect of neoadjuvant chemoradiation and postoperative radiotherapy on expression of heat shock protein 70 (HSP70) in head and neck vessels. Radiation Oncology 6(): 81-81

Preoperative radiotherapy and chemotherapy in patients with head and neck cancer result in changes to the vessels that are used to construct microsurgical anastomoses. The aim of the study was to investigate quantitative changes and HSP70 expression of irradiated neck recipient vessels and transplant vessels used for microsurgical anastomoses. Of 20 patients included in this study five patients received neoadjuvant chemoradiation, another five received conventional radiotherapy and 10 patients where treated without previous radiotherapy. During surgical procedure, vessel specimens where obtained by the surgeon. Immunhistochemical staining of HSP70 was performed and quantitative measurement and evaluation of HSP70 was carried out. Conventional radiation and neoadjuvant chemoradiation revealed in a thickening of the intima layer of recipient vessels. A increased expression of HSP70 could be detected in the media layer of the recipient veins as well as in the transplant veins of patients treated with neoadjuvant chemoradiation. Radiation and chemoradiation decreased the HSP70 expression of the intima layer in recipient arteries. Conventional radiation led to a decrease of HSP70 expression in the media layer of recipient arteries. Our results showed that anticancer drugs can lead to a thickening of the intima layer of transplant and recipient veins and also increase the HSP70 expression in the media layer of the recipient vessels. In contrast, conventional radiation decreased the HSP70 expression in the intima layer of arteries and the media layer of recipient arteries and veins. Comparing these results with wall thickness, it was concluded, that high levels of HSP70 may prevent the intima layer of arteries and the media layer of vein from thickening.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 052818732

PMID: 21745403

DOI: 10.1186/1748-717X-6-81

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Uludag Altun, H.; Meral, T.; Turk Aribas, E.; Gorpelioglu, C.; Karabicak, N., 2014: A Case of Onychomycosis Caused by Rhodotorula glutinis. Rhodotorula spp. have emerged as opportunistic pathogens, particularly in immunocompromised patients. The current study reports a case of onychomycosis caused by Rhodotorula glutinis in a 74-year-old immunocompetent female. The causative agent was...

Gritsenko O.F., 1974: Systematics of far eastern rudd of the genus tribolodon brandti cyprinidae. Journal of Ichthyology 14(5): (1975)

Khare, M. N.; Bhale, M. S., 2007: Diversity in fungi associated with seeds. A great diversity in mycoflora is observed with seeds. A number of fungal genera and species are found associated with seeds of a sample and even with a single seed. Some such diversified fungi are described in this chapter as observed associated...

Hänsler, M.; Jakubke, H.D., 1996: Reverse action of hydrolases in frozen aqueous solutions. The reverse action of hydrolases provides an attractive alternative to the chemical synthesis. of peptides, oligosaccharides and oligonucleotides. Freezing the reaction mixture has proved to suppress competitive reactions in enzyme-catalysed pepti...

van Lindert, E.J.; Delye, H.; Leonardo, J., 2014: Prospective review of a single center's general pediatric neurosurgical intraoperative and postoperative complication rates. The authors conducted a study to compare the complication rate (CR) of pediatric neurosurgical procedures in a general neurosurgery department to the CRs that are reported in the literature and to establish a baseline of CR for further targeted im...

Nadzhafov, Ig, 1975: The prevalence of cysticercosis in Zebu cattle in Tanzania. Meditsinskaia parazitologiia i parazitarnye bolezni: 44 (6) 654-658

WILLIAMSON, M.B., 1948: Growth of the liver in fetal rats. Data were obtained relating the liver wt. to the total body wt. in fetal albino rats. It was found that in fetuses from 1.3 to 2.3 g., the relationship could be expressed by the following equation: Y = 72 X107. In the fetal rats 3 g. and over, the...

Rao, P. N.; Rao, K. K. P.; Rao, B. R.; Lingam, C. S.; Reddy, P. R.; Rao, B. A., 1978: Enhancing cane yield in Regur soils by improving soil structure. The root system of sugar cane crops growing on Regur (black) soil in the Nizamabad district was often shallow, resulting in frequent lodging. Of 5 methods of soil treatment tried, deep ploughing (45 cm) broke the pan (at 22cm), improved root penet...

Chuachoowong, R.; Shaffer, N.; VanCott, T.C.; Chaisilwattana, P.; Siriwasin, W.; Waranawat, N.; Vanprapar, N.; Young, N.L.; Mastro, T.D.; Lambert, J.S.; Robb, M.L., 2000: Lack of association between human immunodeficiency virus type 1 antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand. To determine the association between human immunodeficiency virus type 1 (HIV)-specific antibody and RNA levels in cervicovaginal lavage (CVL) samples and plasma, zidovudine treatment, and perinatal transmission, HIV subtype E gp160-specific IgG a...

Agosta, S.; Castiello, U.; Rigoni, D.; Lionetti, S.; Sartori, G., 2012: The detection and the neural correlates of behavioral (prior) intentions. Prior intentions are abstract mental representations that are believed to be the prime cause of our intentional actions. To date, only a few studies have focused on the possibility that single prior intentions could be identified in people's...