+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis

Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis

Endocrine 3(1): 39-47

A single dose of ethanol increases cellular levels of the mRNA encoding thyrotropin-releasing hormone (TRH) in neurons of the paraventricular nucleus (PVN), but blocks the cold-induced increase in the levels of this mRNA. Because the thyrotropic response to cold is dependent upon TRH secretion, we hypothesized that ethanol uncouples the stimulus-induced regulation of TRH secretion from the stimulus-induced regulation of TRH expression. We employed two complementary strategies to test this hypothesis. The first was to determine whether ethanol alters pituitary sensitivity to TRH. Animals given a single intraperitoneal injection of ethanol (3 g/kg) that produced a blood alcohol concentration of nearly 300 mg/100 mL exhibited the same increase in circulating levels of TSH following an intravenous infusion of TRH. Thus, ethanol does not appear to alter pituitary sensitivity to TRH. Second, we tested whether ethanol blocks the cold induction of c-fos expression in TRH neurons of the PVN. Both cold exposure and ethanol induced the expression of c-fos in the PVN and in TRH neurons; the effects of cold and ethanol on c-fos expression were additive. Thus, ethanol clearly does not block the cold activation of TRH neurons.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052853455

Download citation: RISBibTeXText

PMID: 21153235

DOI: 10.1007/BF02917447

Related references

The effects of continuous and intermittent cold exposure on hypothalamic-pituitary-thyroid axis in rats. Society for Neuroscience Abstracts 18(1-2): 350, 1992

Activity of the hypothalamic-pituitary-thyroid axis during exposure to cold. Pharmacology & Therapeutics 41(1-2): 85-142, 1989

Effects of cold stress on hypothalamic-pituitary-thyroid-axis in chicken. Chinese Journal Of Animal Science: 9, 39-42&48, 2008

Effects of chronic methadone administration on the hypothalamic-pituitary-thyroid axis. Journal of Clinical Endocrinology and Metabolism 35(1): 169-170, 1972

Effects of ethanol administration in a preovulatory period on hypothalamic pituitary gonadal axis in female rat. Research Communications in Substances of Abuse 5(3): 221-232, 1984

Influence of tri-iodothyronine or lipid administration on the response of the pituitary-thyroid axis to exposure to cold in the newborn lamb. Journal of Endocrinology 121(2): 361-365, 1989

Effect of acute exposure to cold on the activity of the hypothalamic-pituitary-thyroid system. Endocrinology 97(5): 1185-1195, 1975

Effect of prenatal exposure to ethanol on the activity of the hypothalamic-pituitary-adrenal axis of the offspring: Importance of the time of exposure to ethanol and possible modulating mechanisms. Molecular and Cellular Neurosciences 1(2): 168-177, 1990

Effects of extended cold exposure on antioxidant defense system of rat hypothalamic-pituitary-adrenal axis. Journal of Thermal Biology 31(4): 313-317, 2006

Effects of ethanol and control liquid diets on the hypothalamic-pituitary-thyroid axis of male Fischer-344 rats. Alcoholism, Clinical and Experimental Research 16(6): 1130-1137, 1992

Effects of Levothyroxine Administration and Withdrawal on the Hypothalamic-Pituitary-Thyroid Axis in Euthyroid Dogs. Journal of Veterinary Internal Medicine 31(3): 705-710, 2017

Effects of chronic ethanol (EtOH) administration on pro-inflammatory cytokines of the hypothalamic-pituitary-gonadal (HPG) axis in female rats. Endocrine Research 31(1): 9-16, 2005

The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels. Progress in Neuro-Psychopharmacology & Biological Psychiatry 26(5): 823-830, June, 2002

The acute effects of oral ethanol on the hypothalamic-pituitary-adrenal axis in normal human subjects. Clinical Endocrinology 42(1): 65-71, 1995

Effects of thyroxine and cold exposure on hypothalamic TRH levels in rats with various pituitary-thyroid states. Endocrinologia Japonica 24(6): 537-543, 1977