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Effects of androgen on embryo implantation in the mouse delayed-implantation model


Effects of androgen on embryo implantation in the mouse delayed-implantation model



Fertility and Sterility 90(4): 1376-1383



ISSN/ISBN: 0015-0282

PMID: 18053999

DOI: 10.1016/j.fertnstert.2007.07.1341

To examine the effects of androgen on implantation and decidualization in the mouse delayed-implantation model. Experimental animal study. University research laboratory. Sexually mature female mice (Kunming White strain). Delayed and activated implantation; pseudopregnancy; embryo transfer (ET); E(2) assay; inhibitor. Effects of androgen on embryo implantation were determined by treating the mice under delayed implantation with different doses of testosterone propionate (TP); the effects of androgen on the expression of implantation-related genes were examined by in situ hybridization. Delayed implantation could be initiated by TP. Dihydrotestosterone was also able to initiate implantation in the delayed-implantation model. The implantation window could be maintained for at least 48 hours by 5 mg TP per mouse. Prostaglandin endoperoxide synthase 2 (Ptgs2) and microsomal prostaglandin E synthase (mPtges) were aberrantly expressed in mouse uterus at implantation sites after delayed implantation was activated by high doses of TP. A low dose of TP led to a delay in embryo implantation, but a high dose caused aberrant expression of both Ptgs2 and mPtges at the implantation site. It is possible that high doses of TP may disturb peri-implantation development or may be involved in early pregnancy loss by disturbing the uterine prostaglandin system.

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Accession: 052855546

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