+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Effects of bovine colostrum supplementation on upper respiratory illness in active males

Effects of bovine colostrum supplementation on upper respiratory illness in active males

Brain Behavior and Immunity 39: 194-203

ISSN/ISBN: 0889-1591

PMID: 24200515

DOI: 10.1016/j.bbi.2013.10.032

Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction and increased risk of upper respiratory illness (URI) in athletic populations, however, the mechanisms remain unclear. During winter months, under double-blind procedures, 53 males (mean training load±SD, 50.5±28.9 MET-hweek(-1)) were randomized to daily supplementation of 20g of COL (N=25) or an isoenergetic/isomacronutrient placebo (PLA) (N=28) for 12weeks. Venous blood was collected at baseline and at 12weeks and unstimulated saliva samples at 4 weeks intervals. There was a significantly lower proportion of URI days and number of URI episodes with COL compared to PLA over the 12weeks (p<0.05). There was no effect of COL on in vitro neutrophil oxidative burst, salivary secretory IgA or salivary antimicrobial peptides (p>0.05), which does not support previously suggested mechanisms. In a subset of participants (COL=14, PLA=17), real-time quantitative PCR, targeting the 16S rRNA gene showed there was an increase in salivary bacterial load over the 12 weeks period with PLA (p<0.05) which was not as evident with COL. Discriminant function analysis of outputs received from serum metabolomics showed changes across time but not between groups. This is the first study to demonstrate that COL limits the increased salivary bacterial load in physically active males during the winter months which may provide a novel mechanism of immune-modulation with COL and a relevant marker of in vivo (innate) immunity and risk of URI.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052857901

Download citation: RISBibTeXText

Related references

Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. European Journal of Nutrition 42(4): 228-232, 2003

Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials. Bmc Sports Science Medicine and Rehabilitation 8: 21, 2016

The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 17(3): 243-247, 2001

Effect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmers. International Journal of Sport Nutrition and Exercise Metabolism 20(3): 224-235, 2010

Enhanced Bovine Colostrum Supplementation Shortens the Duration of Respiratory Disease in Thoroughbred Yearlings. Journal of Equine Veterinary Science 42: 77-81, 2016

OR082 Bovine colostrum supplementation in respiratory allergies according to sensitization: subgroup analysis of randomized controlled trial. Annals of Allergy, Asthma and Immunology 119(5): S11-S12, 2017

Analysis of BRCA1 and RAD51C Promoter Methylation in Italian Families at High-Risk of Breast and Ovarian Cancer. Cancers 12(4), 2020

Comparison of levels and duration of detection of antibodies to bovine viral diarrhea virus 1, bovine viral diarrhea virus 2, bovine respiratory syncytial virus, bovine herpesvirus 1, and bovine parainfluenza virus 3 in calves fed maternal colostrum or a colostrum-replacement product. Canadian Journal of Veterinary Research 78(2): 81-88, 2014

The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency. Clinical Respiratory Journal 7(1): 21-26, 2013

Effects of bovine colostrum supplementation on serum Igf-I, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology 83(4): 1144-1151, 1997

Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology 83(4): 1144-1151, 1997

Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice. Plos one 13(8): E0202929, 2018

Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. Yearbook of Sports Medicine 2007: 231-232, 2007

Effects of oral supplementation with bovine colostrum on the immune system of weaned piglets. Research in Veterinary Science 83(1): 91-101, 2007

Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. Journal of Applied Physiology 102(3): 1113-1122, 2007