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Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats



Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats



Addiction Biology 13(1): 63-69



We examined nicotine-induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28-37] and adult (P60-67) rats were restrained for 2 hours once daily for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or nicotine (0.4 mg/kg subcutaneously). Nicotine-induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Exposure to stress did not affect the nicotine-induced locomotor- or corticosterone-activating effects in both ages.

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Accession: 052859684

Download citation: RISBibTeXText

PMID: 17850415

DOI: 10.1111/j.1369-1600.2007.00080.x


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