+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants

Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants

Kaohsiung Journal of Medical Sciences 26(5): 244-250

The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mg/kg dexmedetomidine (Group D, n = 30) or 2 mg/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine-lidocaine-propofol combination than with the fentanyl-lidocaine-propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 052867169

Download citation: RISBibTeXText

PMID: 20466334

DOI: 10.1016/s1607-551x(10)70035-8

Related references

A combination of alfentanil-lidocaine-propofol provides better intubating conditions than fentanyl-lidocaine-propofol in the absence of muscle relaxants. Canadian Journal of Anaesthesia 50(2): 116-120, 2003

Comparison of propofol-dexmedetomidine, tiopental-dexmedetomidine and etomidate-dexmedetomidine combinations' effects on the tracheal intubation conditions without using muscle relaxants. Bratislavske Lekarske Listy 114(9): 514-518, 2013

Tracheal intubation without muscle relaxants using propofol and varying doses of fentanyl. Masui. Japanese Journal of Anesthesiology 50(10): 1129-1132, 2001

Minimum infusion rate and hemodynamic effects of propofol, propofol-lidocaine and propofol-lidocaine-ketamine in dogs. Veterinary Anaesthesia and Analgesia 39(2): 160-173, 2012

Using fentanyl and propofol for tracheal intubation during sevoflurane induction without muscle relaxants in children: A randomized prospective study. Saudi Journal of Anaesthesia 11(3): 312-318, 2017

Comparative evaluation of different doses of propofol preceded by fentanyl on intubating conditions and pressor response during tracheal intubation without muscle relaxants. Paediatric Anaesthesia 16(4): 399-405, 2006

Intubation with propofol without neuromuscular blockade. Effect of premedication on fentanyl and lidocaine. Revista Espanola de Anestesiologia Y Reanimacion 40(3): 132-136, 1993

Effects of esmolol, lidocaine and fentanyl on P wave dispersion, QT, QTc intervals and hemodynamic responses to endotracheal intubation during propofol induction: a comparative study. Brazilian Journal of Anesthesiology 63(3): 235-244, 2014

Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain. Comparative study. Revista Brasileira de Anestesiologia 57(1): 32-38, 2007

Transtracheal lidocaine: An alternative to intraoperative propofol infusion when muscle relaxants are not used. Journal of Anaesthesiology Clinical Pharmacology 30(2): 199-202, 2014

Comparison of effects of thoracic epidural and intravenous administration of lidocaine on target-controlled infusion of propofol and tracheal intubation response during induction of anesthesia. Journal of Cardiothoracic and Vascular Anesthesia 27(6): 1295-1300, 2013

Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial. Regional Anesthesia and Pain Medicine 36(1): 41-45, 2011

Propofol for facilitation of tracheal intubation: an alternative to muscle relaxants?. Acta Anaesthesiologica Scandinavica 55(9): 1148-9; Author Reply 1149-50, 2011

Tracheal intubation after induction of anaesthesia with propofol, alfentanil and lidocaine without neuromuscular blocking drugs in children. Acta Anaesthesiologica Scandinavica 37(8): 725-729, 1993

Dosing study of remifentanil and propofol for tracheal intubation without the use of muscle relaxants. Anaesthesia 54(11): 1037-1040, 1999